• The Korean Journal of Physiology and Pharmacology
• /
• 제19권2호
• /
• pp.111-118
• /
• 2015

Osteoprotegerin (OPG), receptor activator of NF-${\kappa}B$ ligand (RANKL)/receptor activator of NF-${\kappa}B$ (RANK) axis, and TNF-related apoptosis-inducing ligand (TRAIL) participate in vascular calcification process including atherosclerosis, but their contributions under high glucose (HG) and phosphate (HP) condition for a long-term period (more than 2 weeks) have not been fully determined. In this study, we evaluated the effects of HG and HP levels over 2 or 4 weeks on the progression of vascular calcification in rat vascular smooth muscle cells (VSMCs). Calcium deposition in VSMCs was increased in medium containing HG (30 mmol/L D-glucose) with ${\beta}$-glycerophosphate (${\beta}$-GP, 12 mmol/L) after 2 weeks and increased further after 4 weeks. OPG mRNA and protein expressions were unchanged in HG group with or without ${\beta}$-GP after 2 weeks. However, after 4 weeks, OPG mRNA and protein expressions were significantly lower in HG group with ${\beta}$-GP. No significant expression changes were observed in RANKL, RANK, or TRAIL during the experiment. After 4 weeks of treatment in HG group containing ${\beta}$-GP and rhBMP-7, an inhibitor of vascular calcification, OPG expressions were maintained. Furthermore, mRNA expression of alkaline phosphatase (ALP), a marker of vascular mineralization, was lower in the presence of rhBMP-7. These results suggest that low OPG levels after long term HG and phosphate stimulation might reduce the binding of OPG to RANKL and TRAIL, and these changes could increase osteo-inductive VSMC differentiation, especially vascular mineralization reflected by increased ALP activity during vascular calcification.

• 패션비즈니스
• /
• 제6권4호
• /
• pp.113-124
• /
• 2002

The purpose on this study identified the purchasing conditions of Sports wear of the Chinese men residing in Beijing, Shanghai, Dalian, Tianjin, Harbin and Guangzhou, so that it helped sports wear manufacturers and retailers offer the basic data. For the study, a questionnaire used as a method of measurement, the 863 Chinese men were selected as a sample, SAS(Statistical Analysis System) program was used to analyze the data. The results from the study were as follows: 1. According to the investigation, the most preferred sports of Chinese men is soccer, as a whole. Swimming, basketball and ping-pong keep rank the next to soccer. 2. Accordingly age, area, profession and income, Chinese men maintained sports suit in order of training suit, swimming suit, soccer suit, tennis suit. It is found that holding amount of high-quality sports wears as ski, golf is on a low level. 3. It is appeared that Chinese men purchased in good order as follow brand: No-bran, Nike, Lening, Adidas. And except Nike, they purchased more Lening brand than foreign sports brand. 4. As the result of researching on the item of sports wear, it is found that they purchased various kind items in a higher rank 5 brands. 5. Sports wear's color that Chinese men purchased is blue, white, black, red. 6. The purchasing price that Chinese men favored is 200$\sim$599RMB. Thus, they expend average per head for sports suit buying, 486.0RMB. 7. Chinese men purchased very often at specialty store. And, coefficient of utilization at the usual market is on a low level. 8. In purchasing satisfaction, 80 % Chinese men were satisfied with goods(sports wear) that purchased in a higher rank 5 brands. So, average satisfaction degree showed over 3.8 as a high rate. 9. According to the result of satisfaction on Chinese men, 70% Chinese men showed satisfaction. Therefore, the average of satisfaction degree appeared 3.81 as a high rate.

• 한국연소학회지
• /
• 제14권3호
• /
• pp.16-23
• /
• 2009

It is strongly desired for coal-fired power plants to utilize not only low-rank coals with high moisture contents, but also lowering cost with diversifying fuel sources. In this study, combustion characteristics of low rank coal with high moisture, and standard pulverized coals are experimentally investigated using TGA (Thermogravimetric Analysis) and DTF (drop tube furnace). The coals tested are three kinds of coal with moisture content ranging from 8.32 to 26.82%. The results show that under the air combustion condition, the burn-out time at TGA rises as moisture content increases, and standard pulverized coal with 8.32% moisture content showed the lowest activation energy of 55.73 kJ/mol. In case of the high amount of moisture, the combustion efficiency decreases due to evaporation heat loss, and unburned carbon in ash produced at combustion process in DTF increased. Aslo, initial deformation temperature of slag attached in alumina tube of DTF decreased with lowering the crytallinity of anorthite and augite. To improve the combustion reactivity and efficiency, it is effective to upgrade through drying the high moisture coal to moisture level (less than 10%) of standard pulverized coal.

• 한국방송∙미디어공학회:학술대회논문집
• /
• 한국방송공학회 2012년도 하계학술대회
• /
• pp.164-166
• /
• 2012

In this paper, we proposed a method for extracting predominant melody of polyphonic music based on harmonic structure. Harmonic structure is an important feature parameter of monophonic signal that has spectral peaks at the integer multiples of its fundamental frequency. We extract all fundamental frequency candidates contained in the polyphonic signal by verifying the required condition of harmonic structure. Then, we combine those harmonic peaks corresponding to each extracted fundamental frequency and assign a rank to each after calculating its harmonic average energy. We run pitch tracking based on the rank of extracted fundamental frequency and continuity of fundamental frequency, and determine the predominant melody. For the query by singing/humming (QbSH) task, we proposed Dynamic Time Warping (DTW) based matching engine. Our system reduces false alarm by combining the distances of multiple DTW processes. To improve the performance, we introduced the asymmetric sense, pitch level compensation, and distance intransitiveness to DTW algorithm.

• 복식
• /
• 제58권9호
• /
• pp.129-141
• /
• 2008

Jikgeum(woven with supplementary golden wefts) hyungbae(rank badge) of danryung(official uniform) excavated from Im Backryung'tomb($1498{\sim}1546$) of the Joseon dynasty($1392{\sim}1910$) at Goyang, Gyunggi-Do in 2007, was in a critical condition because of serious collapse of substrate in metal thread. For conservation of hyungbae, metal thread was examined by different scientific methods(Light Microscope, Scanning Electron Microscope and Energy Dispersive X-Rray Spectrometry(SEM-EDS), Fourier Transform Infrared Spectroscopy(FT-IR)). Analytical data showed that metal thread was gilt membrane strip composed of gold leaves and proteinaceous substrate which was probably parchment. To protect collapse of substrate, 1% solution of Paraloid B-72 was infilterated into substrate for consolidation of substrate and it was adhered to warp of fabric in hyungbae, before wet cleaning. After wet cleaning, the most of the gold leaves were restored, which was confirmed by both the examination with the naked eye and the microscopic examination.

• IMMUNE NETWORK
• /
• 제19권1호
• /
• pp.2.1-2.13
• /
• 2019

The enhanced differentiation and activation of osteoclasts (OCs) in the inflammatory arthritis such as rheumatoid arthritis (RA) and gout causes not only local bone erosion, but also systemic osteoporosis, leading to functional disabilities and morbidity. The induction and amplification of NFATc1, a master regulator of OC differentiation, is mainly regulated by receptor activator of NF-κB (RANK) ligand-RANK and calcium signaling which are amplified in the inflammatory milieu, as well as by inflammatory cytokines such as TNFα, IL-1β and IL-6. Moreover, the predominance of CD4⁺ T cell subsets, which varies depending on the condition of inflammatory diseases, can determine the fate of OC differentiation. Anti-citrullinated peptide antibodies which are critical in the pathogenesis of RA can bind to the citrullinated vimentin on the surface of OC precursors, and in turn promote OC differentiation and function via IL-8. In addition to adaptive immunity, the activation of innate immune system including the nucleotide oligomerization domain leucine rich repeat with a pyrin domain 3 inflammasome and TLRs can regulate OC maturation. The emerging perspectives about the diverse and close interactions between the immune cells and OCs in inflammatory milieu can have a significant impact on the future direction of drug development.

• 한국정밀공학회지
• /
• 제17권9호
• /
• pp.95-101
• /
• 2000

This paper proposes a general structure observer and shows the characteristic of external noise reduction in linear discrete system. First we propose a simple genera structured observer which includes high gain term or PI(proportional integral) term to eatimate the states of system and show that the observer can estimate the states of system even if an external noise is added to the system's output. An existence condition of the observer is derived and checked by system's rank condition. Through a numerical example we can verify that the proposed observer is effective to estimate the state of system with external noise compared to that of conventional high gain observer.

• Journal of Electrical Engineering and Technology
• /
• 제6권5호
• /
• pp.706-712
• /
• 2011

Necessary and sufficient conditions for the existence of diagonal, block-diagonal, and triangular decoupling controllers in linear multivariable systems for the most general setting are presented. The plant model in this study is sufficiently general to accommodate non-square plant and non-unity feedback cases with one-degree-of-freedom (1DOF) or two-degree-of-freedom (2DOF) controller configuration. The existence condition is described in terms of rank conditions on the coefficient matrices in partial fraction expansions.

• 생태와환경
• /
• 제40권4호
• /
• pp.495-502
• /
• 2007

Species biotic index (SBI), based on a fish assemblage, was applied to a stream assessment using long-term ecological fish data set (1996 to 2001) in Boryong dam area, which is located in the mainstream of Ungchun Stream of Chungnam province, Korea. According to the methods of Hilsenhoff (1988), the scores of tolerance guild assigned 10 classes to each species by its habitat and feeding guild, but modified current 7 criteria to 5 scoring standards due to unclear borderline among species. Relative abundance in the species number of upper stream guilds was only 7% of the total, whereas the abundance in the species number of middle to downstream upper stream guilds was 64%. Mean SBI, based on dataset in Site 1 during 1995-2001 averaged 5.10, which was judged as a "good" condition by the rank criteria of SBI. Before the dam construction, mean SBI in the Site 1 was 4.61, indicating a "good" condition, but after the dam construction, mean SBI was 5.60, indicating a "fair" condition. Trajectory analysis in the Site 1 showed significantly (One-way ANOVA, $F_{6,21}=3.26$, p=0.02) different among years, reflecting the changes of fish composition and population density by the dam construction, whereas Site 2 showed no significant changes ($F_{6,21}=1.00$, P =0.45) difference among years. Mean SBI prior to the dam construction in the Site 3 was 4.52 but after the construction, the value was 6.30, indicating a distinct difference between the pre- and post-dam construction. Trajectory analysis at the Site 3 supported this fact: Values of SBI showed significantly ($F_{6,21}$=14.37, p<0.01) different. Mean SBI was 4.67 in the Site 4, indicating a "good" condition in the health and the health rank was same as the sampling sites 1, 2, and 4. Trajectory in the Site 4 showed no significant ($F_{6,21}=2.35$, p=0.07) difference among the years. Overall, our trajectory analysis indicated that three of four sampling sites (sites 1, 3, 4) showed significant decreases (n=7, p<0.05) and that the proportions of sensitive species declined evidently in the sites 1 and 2 and the tolerant species increased in the dam sites. Our outcomes may be used as a key data for diagnosis of the long-term ecological impact in the future in the watershed.

• 한국식품위생안전성학회지
• /
• 제17권4호
• /
• pp.183-187
• /
• 2002

난각 칼슘을 천연의 칼슘 소재로 사용하는 방법으로 식초에 난각을 침지하여 흡수율이 좋은 칼슘 이온상태로 퐁출시키는 방법과 여러 가지 조건에 따른 용출량과 이온화율의 변화에 관한 비교 시험 결과는 다음과 같다. 1 식초를 이용하여 난각의 칼슘을 용출시키는 방법은 식초량과 식초에 함유되어 있는 초산량이 증가할 수록 용출량 또한 증가하는 것으로 나타났다. 또한 이온화율은 식초 200ml에 용출시키는 실험군이 가장 높게 나타났다. 2. 난각칼슘의 용출 및 이온화에 작용하는 요인 중 온도는 20~3$0^{\circ}C$일 때가 가장 효과적이며 4$0^{\circ}C$에서는 난각칼슘의 용출량은 증가하였으나 이온화 정도가 감소하는 것으로 나타났다. 또한 4$0^{\circ}C$에서는 식초에서 이취가 발생하는 현상을 나타내어 식품 첨가물로써의 활용에 문제가 있을 것으로 사료된다. 3. 난각 칼슘의 용출량 및 이온화율에 있어서 통기조건은 밀폐조건보다 우수한 것으로 나타났다. 그러나 현미식초의 경우는 유의적 차이를 나타내지는 않았으나 다른 실험군에 비하여 용출량과 이온화율이 우수한 것으로 나타났다. 4. 난각칼슘의 용출과 이온화를 위한 가장 최적의 조건으로는 3$0^{\circ}C$에서 현미식초 200ml에서 용출시키는 것이 가장 효과적인 것으로 나타났다. 아울러 이들 이온화된 칼슘의 흡수율에 대해서도 연구해 볼 필요가 있을 것으로 사료된다.