• Asian Pacific Journal of Cancer Prevention
• /
• v.13 no.8
• /
• pp.3687-3693
• /
• 2012

Objective: The current meta-analysis was performed to address a more accurate estimation of the association between glutathione S-transferase P1 (GSTP1) codon 105 polymorphism and risk of gastric cancer (GC), which has been widely reported with conflicting results. Methods: A comprehensive literature search was conducted to identify all the relevant studies. Fixed or random effect models were selected based on the heterogeneity test. Publication bias was estimated using Begg's funnel plots and Egger's regression test. Results: A total of 20 studies containing 2,821 GC cases and 6,240 controls were finally included in the analyses. Overall, no significant association between GSTP1 polymorphism and GC risk was observed in worldwide populations. However, subgroup analysis stratified by ethnicity showed that GSTP1 polymorphism was significantly associated with increased risk of GC in Asians (G vs. A, OR = 1.273, 95%CI=1.011-1.605; GG vs. AA, OR=2.103, 95%CI=1.197-3.387; GG vs. AA+AG, OR =2.103, 95%CI=1.186-3.414). In contrast, no significant association was found in Caucasians in any genetic models, except for with AG vs. AA (OR=0.791, 95%CI=0.669-0.936). Furthermore, the GSTP1 polymorphism was found to be significantly associated with GC in patients with H. pylori infection and in those with a cardiac GC. Subgroup analysis stratified by Lauren's classification and smoking status showed no significant association with any genetic model. No studies were found to significantly influence the pooled effects in each genetic mode, and no potential publication bias was detected. Conclusion: This meta-analysis suggested that the GSTP1 polymorphism might be associated with increased risk of GC in Asians, while GSTP1 heterozygote genotype seemed to be associated with reduced risk of GC. Since potential confounders could not be ruled out completely, further studies are needed to confirm these results.

• Asian Pacific Journal of Cancer Prevention
• /
• v.13 no.8
• /
• pp.3917-3925
• /
• 2012

Background: The relationship between postmenopausal hormone therapy (HT) and invasive breast cancer has been extensively investigated, but that with breast carcinoma in situ (BCIS) has received relatively little attention. The aim of our present study was to review and summarize the evidence provided by longitudinal studies on the association between postmenopausal HT use and BCIS risk. Methods: A comprehensive literature search for articles published up to May 2012 was performed. Prior to performing a meta-analysis, the studies were evaluated for publication bias and heterogeneity. Relative risk (RR) or odds ratio (OR) values were calculated using 14 reports (8 case-control studies and 6 cohort studies), published between 1986 and 2012. Results: There was evidence of an association between ever postmenopausal estrogen use and BCIS based on a random-effects model (RR = 1.25, 95% confidence interval (CI) = 1.01, 1.55). However, we found no strong evidence of an association between ever postmenopausal estrogen combined with progesterone use and BCIS using a randomeffects model (RR = 1.55, 95% CI = 0.95, 2.51). Furthermore, our analysis showed a strong association between "> 5 years duration" of estrogen or estrogen combined with progesterone use and BCIS. Furthermore, current use of any HT is associated with increased risk of BCIS in cohort studies. Additional well-designed large studies are now required to validate this association in different populations.

• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.20
• /
• pp.8765-8774
• /
• 2014

This study aimed at summarizing epidemiological research findings on associations between tobacco, alcohol and tea consumption and risk of gastric cancer (GC) in the Chinese population. The review searched PubMed, Embase, China National Knowledge Infrastructure (CNKI) and China Biology Medicine (CBM) databases and reference lists of review papers for all studies published in English or Chinese languages. Information extracted, via two independent researchers, from retrieved articles included first author, year of publication, study design, sample size, source of controls and adjusted odds ratio (OR) or relative risk (RR) with the corresponding 95% confidence intervals (CIs) for each category. Statistical analyses used software STATA version 12.0. The systematic search found 89 articles containing 25,821 GC cases and 135,298 non-cases. The overall random effects in terms of pooled OR and 95%CI for tobacco, alcohol and tea consumption were 1.62 (95%CI: 1.50-1.74), 1.57 (95%CI: 1.41-1.76) and 0.67 (95%CI: 0.59-0.76) respectively; while the heterogeneity among included studies ranged from 80.1% to 87.5%. The majority of subgroup analyses revealed consistent results with the overall analyses. All three behavioral factors showed statistically significant dose-dependent effects on GC (P<0.05). The study revealed that tobacco smoking and alcohol drinking were associated with over 1/2 added risk of GC, while tea drinking conferred about 1/3 lower risk of GC in the Chinese population. However, these results should be interpreted with caution given the fact that most of the included studies were based on a retrospective design and heterogeneity among studies was relatively high.

• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.15
• /
• pp.6131-6136
• /
• 2014

Objective: Epidemiology studies have reported conflicting results between glutathione S-transferase Mu-1 (GSTM1), glutathione S-transferase theta-1 (GSTT1) and glutathione S-transferase pi-1 (GSTP1) and ovarian cancer (OC) susceptibility. In this study, an updated meta-analysis was applied to determine whether the deletion of GSTM1, GSTT1 and GSTP1 has an influence on OC susceptibility. Methods: A published literature search was performed through PubMed, Embase, Cochrane Library, and Science Citation Index Expanded database for articles published in English. Pooled odds ratios (ORs) and 95% confidence intervals (95%CIs) were calculated using random or fixed effects models. Heterogeneity between studies was assessed using the Cochrane Q test and $I^2$ statistics. Sub-group analysis was conducted to explore the sources of heterogeneity. Sensitivity analysis was employed to evaluate the respective influence of each study on the overall estimate. Results: In total, 10 published studies were included in the final analysis. The combined analysis revealed that there was no significant association between GSTM1 null genotype and OC risk (OR=1.01, 95%CI: 0.91-1.12). Additionally, there was no significant association between GSTT1 genetic polymorphisms and OC risk (OR=0.98, 95% CI: 0.85-1.13). Similalry, no significant associations were found concerning the GSTP1 rs1695 locus and OC risk. Meanwhile, subgroup analysis did not show a significant increase in eligible studies with low heterogeneity. However, sensitivity analysis, publication bias and cumulative analysis demonstrated the reliability and stability of the current meta-analysis. Conclusions: These findings suggest that GSTs genetic polymorphisms may not contribute to OC susceptibility. Large epidemiological studies with the combination of GSTM1 null, GSTT1 null and GSTP1 Ile105Val polymorphisms and more specific histological subtypes of OC are needed to prove our findings.

• KIISE Transactions on Computing Practices
• /
• v.21 no.2
• /
• pp.126-131
• /
• 2015

As flash-based storage systems have been actively employed in large-scale servers and data centers, reliability has become an indispensable element. One promising technique for enhancing reliability is static wear-leveling, which distributes erase operations evenly among blocks so that the lifespan of storage systems can be prolonged. However, increasing the capacity makes the processing overhead of this technique non-trivial, mainly due to searching for blocks whose erase count would be minimum (or maximum) among all blocks. To reduce this overhead, we introduce a new randomized block selection method in static wear-leveling. Specifically, without exhaustive search, it chooses n blocks randomly and selects the maximal/minimal erased blocks among the chosen set. Our experimental results revealed that, when n is 2, the wear-leveling effects can be obtained, while for n beyond 4, the effect is close to that obtained from traditional static wear-leveling. For quantitative evaluation of the processing overhead, the scheme was actually implemented on an FPGA board, and overhead reduction of more than 3 times was observed. This implies that the proposed scheme performs as effectively as the traditional static wear-leveling while reducing overhead.

• Therapeutic Science for Rehabilitation
• /
• v.9 no.4
• /
• pp.107-120
• /
• 2020

Objective : The purpose of this study was to investigate the effectiveness and basis of rehabilitation intervention in patients with spinal cord injury by systematic review and meta-analysis of randomized controlled studies. Methods : Two researchers independently searched and selected a study published in an academic journal using a search term in an international thesis database. A total of 21 studies met the selection criteria, and qualitative evaluation of the study was conducted using the PEDro Scale. Meta-analysis was performed using Comprehensive Meta-Analysis 3.0 program. Results : A total of 713 subjects were included. The results of the meta-analysis showed a score of 0.406 (95.0% confidence interval: 0.221 ~ 0.591) for intervention using physical activity and 0.505 (95.0% confidence interval: 0.449 ~ 1.528) for electronic stimulation therapy, which showed medium effect; educational intervention had a 0.248 (95.0% confidence interval: 0.033 ~ 0.464), and mixed intervention 0.280 (95.0% confidence interval: 0.122 ~ 0.438). It was shown that the effect of small (small). There was a significant heterogeneity in the statistical heterogeneity test, and thus the random effects model was selected and analyzed. Conclusion : The results showed that rehabilitation interventions were effective for patients with spinal cord injury. During the rehabilitation of spinal cord injury patients, clinicians are expected to contribute to the development of programs to improve their lifestyles.

• Journal of the Korean Institute of Intelligent Systems
• /
• v.22 no.5
• /
• pp.540-548
• /
• 2012

The Weapon Target Allocation(WTA) problem is the NP-Complete problem. The WTA problem is that the threatful air targets are assigned by weapon of allies for killing the targets. A good solution of NP-complete problem is heuristic algorithms. Genetic algorithms are commonly used heuristic for global optimization, and it is good solution on the diverse problem domain. But there has been very little research done on the generation of their initial population. The initialization of population is one of the GA step, and it decide to initial value of individuals. In this paper, we propose to the population initialization method to improve a Genetic Algorithm. When it initializes population, the proposed algorithm reflects the characteristics of the WTA problem domain, and inherits the dominant gene. In addition, the search space widely spread in the problem space to find efficiently the good quality solution. In this paper, the proposed algorithm to verify performance examine that an analysis of various properties and the experimental results by analyzing the performance compare to other algorithms. The proposed algorithm compared to the other initialization methods and a general genetic algorithm. As a result, the proposed algorithm showed better performance in WTA problem than the other algorithms. In particular, the proposed algorithm is a good way to apply to the variety of situation WTA problem domain, because the proposed algorithm can be applied flexibly to WTA problem by the adjustment of RMI.

• Journal of Korean Home Economics Education Association
• /
• v.14 no.2
• /
• pp.37-52
• /
• 2002

This study was made on the concerns and implementation of the ICT(Inormation and Communication Technology)-utilized lesson by home economics teacher. The objective of this study is to investigate the stages of concern and the level of use of the ICT-utilized lesson by home economics teachers in Kyunggi Province through the concerns based adoption model(CBAM) and to provide assistance for ICT-utilizing lesson to be efficiently adopted to home economics. This study made selected 200 schools by random sampling among 233 middle schools which have two or more home economic teachers and 21 or more classes in Kyunggi Province which has a total of 395 middle schools and mail-surveyed on 400 home economics teachers by means of questionnaire. The stages of concern. the levels of use and the types of implementation were used as instruments in this survey. The results of this study on the stages of concern. the levels of use and the type of implementation of the ICT-utilized lesson by home economics teachers in Kyunggi Province were as following: First. the highest point of the concern of home economics teachers of ICT-utilized lesson was the stage of awareness. the second highest point was the stage of management. the 3rd stage. and the stage of information. the lst stage. Second. the highest level of implementation of ICT-utilized lesson by home economics teachers was the level of mechanical use. the 3rd stage(30.4％), which followed by the level of orientation. the 1st stage(22.5％). and the level of nonuse(16.7％). the level of rountine use. the 4th stage(13.7％) the level of integration. the 5th stage(11.8％). the level of preparation 2(3.9％). and the level of renewal. the 6th stage(1.0％) Third, information search was the most in the type of ICT-use and in the course of lesson CD-ROM was used the most.. During ICT-utilized lesson. most of teachers used computer one to two hours a week mainly in the lessons of clothing life and eating life. Home economics teachers took the most training of how to use word-processor(68.6％) during computer education. and 60 teachers(66.0％) gave positive response about the effect of computer education on teacher's learning. Finally. the biggest problem with ICT-use in the teacher's learning was the long preparation time for lesson. and problem with ICT-utilized lesson was the burden of time and effort spent to buy needed materials and to recompose the existing materials for the lesson. Therefore. so as to adopt ICT-utilized lesson efficiently into school it is needed that active promotion for the lesson should be made to teachers. training teachers to raise their ability to use computer and various kinds of software should be expanded. and school authorities' financial and administrative assistance should be given for the smooth proceeding of the lesson.

• KIPS Transactions on Computer and Communication Systems
• /
• v.7 no.8
• /
• pp.195-202
• /
• 2018

With the development of location-based applications such as smart phones and GPS navigation, active research is being conducted to protect location and trajectory privacy. To receive location-related services, users must disclose their exact location to the server. However, disclosure of users' location exposes not only their locations but also their trajectory to the server, which can lead to concerns of privacy violation. Furthermore, users request from the server not only location information but also multimedia information (photographs, reviews, etc. of the location), and this increases the processing cost of the server and the information to be received by the user. To solve these problems, this study proposes the EGTC (Enhanced Grid-based Trajectory Cloaking) technique. As with the existing GTC (Grid-based Trajectory Cloaking) technique, EGTC method divides the user trajectory into grids at the user privacy level (UPL) and creates a cloaking region in which a random query sequence is determined. In the next step, the necessary information is received as index by considering the sub-grid cell corresponding to the path through which the user wishes to move as c(x,y). The proposed method ensures the trajectory privacy as with the existing GTC method while reducing the amount of information the user must listen to. The excellence of the proposed method has been proven through experimental results.

• Journal of Korean Medical Ki-Gong Academy
• /
• v.16 no.1
• /
• pp.1-58
• /
• 2016

Objects : The purpose of this study is to understand trends of "Qigong"-related study since 2008 and to help guide the research direction of Qigong study. Methods : The computerized Korean database was searched from January 2008 until September 2016. The search terms used were 'Qi', 'Qigong', 'Doin', 'Meditation', 'bioenergy', 'training', 'life nurturing' and random or Korean language terms. Results : 1. A total of 140,914 studies were searched in this study. A total of 2,147 studies were finally selected as Qigong-related studies. 2. The average number of Qigong-related studies published in Korea since 2008 is 252.6 per year and there was no significant difference in the number of studies published by year 3. Results according to the subject categories, 805 cases were in the humanities and 2 cases were in the agriculture & maritime field. 4. Results according to the middle subject categories, philosophy was the largest with 280 studies. 5. As a result of Qigong categories showed that meditation was the highest with 1,043 (48.58%) not including duplication. 6. As a result of research method, the most frequent method was Analysis research with 1,138(53.00%) cases and the experimental research was the least with 118(5.50%) cases. 7. When the authors were investigated, the result was the most in 35 cases by Kim Byung-chae. 8. The journal that published the most Qigong-related studies was "J. of The Studies of Taoism and Culture" (52), and Dongguk University (75) had the largest number of Qigong-related studies. Conclusions : 1. Since 2008, there is no significant difference between the yearly and yearly the number of Qigong-related studies. 2. Since 2008, Qigong-related studies have been the most successful in the field of humanities, but it has been regularly published in various other field. 3. Since 2008, Qigong-related studies has shown a remarkable decline in category on External Qigong Therapy(外氣發功) and Science of Qi(氣科學). However, category on Nae-Dan(內丹), meditation, Do-In (導引) has continued steadily every year. And did not show a tendency to increase or decrease.