• Title/Summary/Keyword: radioactive medicine

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Current status of disposal and measurement analysis of radioactive components in linear accelerators in Korea

  • Kwon, Na Hye;Shin, Dong Oh;Kim, Jinsung;Yoo, Jaeryong;Park, Min Seok;Kim, Kum Bae;Kim, Dong Wook;Choi, Sang Hyoun
    • Nuclear Engineering and Technology
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    • v.54 no.2
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    • pp.507-513
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    • 2022
  • When X-ray energy above 8 MV is used, photoneutrons are generated by the photonuclear reaction, which activates the components of linear accelerator (linac). Safely managing the radioactive material, when disposing linac or replacing components, is difficult, as the standards for the radioactive material management are not clear in Korea. We surveyed the management status of radioactive components occurred from medical linacs in Korea. And we also measured the activation of each part of the discarded Elekta linac using a survey meter and portable High Purity Germanium (HPGe) detector. We found that most medical institutions did not perform radiation measurements when disposing of radioactive components. The radioactive material was either stored within the institution or collected by the manufacturer. The surface dose rate measurements showed that the parts with high surface dose rates were target, primary collimator, and multileaf collimator (MLC). 60Co nuclide was detected in most parts, whereas for the target, 60Co and 184Re nuclides were detected. Results suggest that most institutions in Korea did not have the regulations for disposing radioactive waste from linac or the management procedures and standards were unclear. Further studies are underway to evaluate short-lived radionuclides and to lay the foundation for radioactive waste management from medical linacs.

Acute Myelogenous Leukemia Developed after Radioactive Iodine Therapy and Palliative Radiation Therapy in Metastatic Papillary Thyroid Cancer (갑상선 유두암환자에서 방사성 옥소 치료와 고식적 방사선 치료 후 발생한 급성 골수성 백혈병)

  • Ko, Tae-Young;Kwag, Jae-Sik;Oh, Kyung-Suk;Lee, Seung-Bai;Chung, Byung-Sun;Kim, Eun-Sil;Kim, Chong-Soon
    • The Korean Journal of Nuclear Medicine
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    • v.32 no.5
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    • pp.436-442
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    • 1998
  • Radioactive iodine treatment has been widely used for nearly 50 years in the treatment of thyroid cancer to ablate residual thyroid tissue after thyroidectomy and to treat metastatic disease. Leukemia is a rare complication associated with the radioactive iodine therapy. The occurrence of leukemia is known to be related to the cumulative dosage of I-131 more than 37 GBq (1 Ci) and also associated with the intervals of less than 12 months between the repeated doses. We report a case of a 52 year-old female patient with papillary cancer of thyroid who developed acute myelogenous leukemia after the total 20.4 GBq (550 mCi) of I-131 therapy over 3.2 years and palliative radiation therapy (3000 cGy) due to multiple bone metastasis of papillary cancer.

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Discussion about the Self Disposal Guideline of Medical Radioactive Waste (의료용 방사성폐기물 자체처분 가이드라인에 관한 고찰)

  • Lee, Kyung-Jae;Sul, Jin-Hyung;Lee, In-Won;Park, Young-Jae
    • The Korean Journal of Nuclear Medicine Technology
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    • v.21 no.2
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    • pp.13-27
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    • 2017
  • Purpose In the procedure of domestic medical radioactive self-disposal, there are many requests of supplementation and difficulties on the screening process. In this regard, presentation of basic guideline will improve the work processing efficiency of medical institution radioactive waste. From 2015 to 2016, We reviewed and compared a supplementary requests of domestic fifteen medical institution radioactive self-disposal Plan & Procedure manual. In connection with this, we derive the details of the radioactive waste document based on the relative regulation of nuclear safety Act. The representative supplementary requests of Korea Institute of Nuclear Safety are disposal method of non-flammability radioactive waste, storage method of scheduled self-disposal waste, the legitimacy of self-disposal and pre-treatment of self-disposal, reference radioactivity of disused filter and output of storage period, attachment the evidential matter of measurement efficiency when using a gamma counter. Through establishing a medical radioactive waste guideline, we can clearly suggest a classification standard of radioactive nuclide and the type of occurrence. As a result, we can confirm the reduction of examination processing period while preparing a self-disposal document and there is no spending expenses for business agency. Also, the storage efficiency of facility will better and reduce the economic expenses. On the basis of this guideline, we will expect a contribution to the improvement of work efficiency for officials who has a working-level difficulty of radioactive waste self-disposal.

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Adsorption Study on the Radioactive Liquids by Korean Vermiculite (한국산(韓國産) Vermiculite에 의(依)한 방사성동위원소(放射性同位元素) 흡착연구(吸着硏究))

  • Moon, Suc-Hyong
    • The Korean Journal of Nuclear Medicine
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    • v.7 no.1
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    • pp.51-54
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    • 1973
  • The use of ion-exchange resins for the treatment of radioactive wastes has many advantages, but thes eare rather expensive as compared with the Korean vermiculite. The Korean vermiculite has slightly different chemical constituents from the ones produced in other countries, and its physical properties might be applicable to the management of radioactive waste, in a small nuclear installation. The decontaminating effect of Korean vermiculite for the low-level radioactive liquid was investigated. $^{106}Ru,\;^{90}Sr,\;and\;^{137}Cs$ were utilized for the experiments. The removal rates by Korean vermiculite were calculated for $^{106}Ru,\;^{90}Sr\;and\;^{137}Cs$ and the removal rates increased as the weight of vermiculite in the exchange column increased. The decontaminating constants, $K_d$ of the Korean vermiculite for $^{106}Ru,\;^{90}Sr\;and\;^{137}Cs$ were 2.7, 69.3 and 263ml/g respectively. Through the results of experiments, the application of Korean vermiculite column to the treatment of low-level radioactive waste is quite feasible.

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Determination of Self-Disposal date by the Analysis of Radioactive Waste Contamination for 1131I Therapy Ward (131I 치료입원실 폐기물 방사능 오염도 분석 및 자체처분가능일자 산출)

  • Kim, Gi-sub;Jung, Haijo;Park, Min-seok;Jeon, Gjin-seong
    • The Korean Journal of Nuclear Medicine Technology
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    • v.17 no.1
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    • pp.3-6
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    • 2013
  • Purpose: The treatment of thyroid cancer patients was continuously increased. According to the increment of thyroid cancer patients, the establishment of iodine therapy site was also increased in each hospital. This treatment involves the administration of radioactive iodine, which will be given in the form of a capsule. Therefore, protections and managements for radioactive source pollution and radiation exposure should be necessary for radiation safety. Among the many problems, the problem of disposing the radioactive wastes was occurred. In this study, The date for self-disposal for radioactive wastes, which were contaminated in clothes, bedclothes and trash, were calculated. Materials and Methods: The number of iodine therapy ward was 15 in Korea Institute of Radiological Medical and Sciences. Recently, 8 therapy wards were operated for iodine therapy patients and others were on standby for emergency treatment ward of any radiation accidents. Radioactive wastes, which were occurred in therapy ward, were clothes, bedclothes, bath cover for patients washing water and food and drink which was leftover by patients. Each sample was hold into the marinelli beaker (clothes, bedclothes, bath covers) and 90 ml beaker (food, drink, and washing water). The activities of collected samples were measured by HpGe MCA device (Multi Channel Analysis, CANBERRA, USA) Results: The storage period for the each kind of radioactive wastes was calculated by equation of storage periods based on the measurement outcomes. The average storage period was 60 days for the case of clothes, and the maximum storage period was 93 days for patient bottoms. The average storage period and the maximum storage period for the trash were 69 days and 97 days, respectively. The leftover foods and drinks had short storage period (the average storage period was 25 days and maximum storage period was 39 days), compared with other wastes. Conclusion: The proper storage period for disposing the radioactive waste (clothes, bedclothes and bath cover) was 100 days by the regulation on self-disposal of radioactive waste. In addition, the storage period for disposing the liquid radioactive waste was 120 days. The current regulation for radioactive waste self-disposing was not suitable for the circumstances of each radioactive therapy facility. Therefore, it was necessary to reduce the leftover food and drinks by adequate table setting for patients, and improve the process and regulation for disposing the short-half life radioactive wastes.

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Observation on The Frequency of Chromosomal Aberration and Changes in Number of Peripheral Lymphocytes in Radioactive Iodine Treatment (방사성옥소 투여에 따른 말초혈액 림프구 수의 변화 및 염색체이상 빈도의 관찰)

  • Koo, Chun-Hee;Shin, Min-Ho;Park, Young-Ju;Lee, Jung-Yim;Park, Tae-Yong;Lee, Jae-Yong;Kim, Chong-Soon;Han, Seung-Soo;Kim, Kwang-Hoe;Kim, Hee-Geun;Kang, Duck-Won;Song, Myung-Jae
    • The Korean Journal of Nuclear Medicine
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    • v.29 no.3
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    • pp.343-349
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    • 1995
  • Background : For biological dosimetry of radiation exposure, both observing hematologic change and calculating Ydr by chromosomal analysis as biological indicators are widely used. However, due to the lack of studies on biological dosimetry of radiation dose absorbed in the body such as in the cases of radioactive iodine therapy, the maximal and safe dose is not well known, nor is the extent to which the body can safely endure radiation exposure. Purpose : To investegate the practical applicability of hematologic changes and Ydr as an indicator for estimating radiation exposure, to patients with thyroid diseases after doses of radioactive iodine. Material and Methods : 5 patients with hyperthyroidism and 35 patients who have had thyroid cancer operation were under treatment with radioactive iodine, changes in number of lymphocytes were tracked and Ydr was calculated for more than 2 months by chromosomal analysis in peripheral lymphocytes. Results ; 1) The number of lymphocytes began to decrease 2 weeks after doses of radioactive iodine, and reached the nadir after 6 and 8 weeks, then gradually recovered. 2) The nadir count of lymphocytes was reversely correlated with the administered dosage of radioactive iodine. 3) Ydr was generally stable between 2 and 8 weeks. 4) The maximal value of Ydr was correlated with the administered dosage of radioactive iodine. 5) Ydr value at the 2nd week increased with augmented dosage of radioactive iodine. 6) Ydr value at the 2nd week was correlated with fall of lymphocyte count. Conclusion : Patients must be closely observed, because temporary bone marrow suppression and slight chromosomal aberration can be produced by even generally used dosages of radioactive iodine for diagnosis and therapy. Maximal percent fall of lymphocyte count, Ydr at the 2 week interval and maximal Ydr can be used as the biological predictor of administered dosage of radioactive iodine.

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Consideration on supplementary matters when preparing radioactive waste self-disposal (방사성폐기물 자체처분 작성시 보완사항에 관한 고찰)

  • Lee, Kyung-Jae;Park, Sung-woo;Park, Young-Jae;Park, In-Sik
    • The Korean Journal of Nuclear Medicine Technology
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    • v.26 no.1
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    • pp.15-26
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    • 2022
  • Purpose Recently, in the process of examining the self-disposal of radioactive waste by the Korea Institute of Nuclear Safety, it is difficult to reach the final approval process for self-disposal. In connection with this, we intend to increase the processing efficiency of self-disposal and strengthen safety by analyzing cases of recent supplementary matters. Materials and Methods From 2018 to 2021, we compare and review a supplementary requests that preparing the procedures and plans for the self-disposal of radioactive waste by 20 institutions. In this regard, based on the provisions of the Atomic Energy Safety Act, we derive a detailed proposals for the self-disposal of radioactive waste by arranging the review processing period calculation and supplementary requests that occurred during the review process. Results The representative supplementary requests of the Korea Institute of Nuclear Safety are the calculation of the storage period by type and nuclide of radioactive waste, the contents of the packaging container, the RASIS reporting method, the planned storage method for self-disposal, confirmation of the final disposal company, and the storage period of the waste filter Calculation, radioactive labeling, etc. And it is emphasized as important. Conclusion The expected effects of the guidelines reflecting the latest supplements include reduction of the time required for document preparation and increase of work processing efficiency, improvement of storage efficiency in the radioactive waste storage room, and economic cost reduction. If the radioactive waste self-disposal guideline presented in this study is applied to the field, it is thought that it will be helpful in improving the work efficiency of those who are experiencing difficulties.

A Study on Medical Waste Contaminated by Radioactivity in Nuclear Medicine Department (핵의학과 일반 의료폐기물에서의 방사능 오염에 관한 고찰)

  • Yoo, Jae-Sook;Jang, Jung-Chan;Lee, Dong-Hoon;Cha, Min-Kyeong;Nam, Ki-Pyo
    • The Korean Journal of Nuclear Medicine Technology
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    • v.15 no.1
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    • pp.70-74
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    • 2011
  • Purpose: In the Nuclear Medicine department of Asan Medical Center, radioactive waste has been disposed of by using several disposal boxes designed for nuclear waste. However, some quantity of radioactivity has been detected occasionally due to some radiologists' carelessness not only from radioactive waste, but also from medical waste such as uncontrolled radioactive waste related to patients, poly gloves or saline solution bottles from radiopharmaceuticals laboratory. Thus, this study is going to suggest a solution to maintain the medical wastes made from controlled areas that can be below maximum permissible surface dose limits by finding the cause of radioactive contamination. Materials and methods: This study was taken place in 17 different places-2 medical wastebaskets in the waiting room, 2 medical wastebaskets in the PET room, 5 medical wastebaskets in the in vitro laboratory and 6 medical wastebaskets in the radiopharmaceuticals laboratory of the East building, 2 medical wastebaskets in the waiting room of the New building of Nuclear Medicine Department in Asan Medical Center from April to August 2010. Mean radioactivity and its standard deviation of each place have been found by measuring surface contamination of medical wastebaskets and backgrounds twice a week, totaling 30 times. An independent t-test of SPSS (Ver. 12.0) statistic program has been used for statistical analysis. Swabs, saline solution bottles and poly gloves collected from each place also measured 30 times, respectively. Results: This study analyzed medical waste and the backgrounds of each place by using survey meter detectors that significant differences of five places did not exist, but existed statistically in twelve places (p<0.05). Also, swabs, saline solution bottles and poly gloves collected from each radioactive waste partly exceed the legal dose limit as a result of measuring by a gamma counter. Conclusion: Backgrounds and the surface doses of radioactive disposal box in all 17 places measured by the survey meter did not exceed the legal dose limit; however, it obviously showed that there were prominent differences in 12 places. Assuming that the cause of the differences was swabs, saline solution bottles and gloves, we examined them by gamma counter, and the results showed remarkably high doses of radioactivity. Consequently, swabs and poly gloves which are normally disposed in the general medical waste box should be disposed in the radioactive waste box furnished by radiopharmaceuticals laboratory. Also, saline solution discharged from radioactive pharmaceutical places is considered as radioactive liquid waste so that it should be disposed of by the septic tank specifically designed for radioactive liquid.

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