• Journal of the Korean Society of Food Science and Nutrition
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• v.27 no.6
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• pp.1189-1196
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• 1998

The antiatherogenic effect of kimchi ingredients was studied in terms of antioxidative effect against Newzealand white rabbits that fed 1% cholesterol. Experimental groups was fed 8% Baechu (Brassica pekiinensis), or 1% red pepper(Capsium annum), or 1% garlic(Allium sativum) for 12 weeks. Blood samples were drawn every 2 weeks to analyze vitamin E, POV, and TBARS. Hepatic antioxidative enzyme activity, vitamin E, and carotene concentration also were measured. Plasma TBARS and POV level were markedly lowered in both red pepper and garlic fed rabbits(p<0.05) compared to control. Hepatic POV and protein carbonyl values were lowered in the rabbits fed kimchi ingredients compared to control(p<0.05). Plasma vitamin E concentration was increased in the rabbits fed red pepper and garlic compared to control(p<0.05). Hepatic vitamin E concentration was increased in red pepper and garlicfed rabbits compared to control. For the hepatic antioxidative enzyme acitivity, catalase activity was significantly increased in red pepper and garlic fed rabbits compared to control. Therefore, Baechu, red pepper, and garlic exert an antioxidative effect against rabbits fed 1% cholesterol for 3 months.

• YAKHAK HOEJI
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• v.44 no.6
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• pp.539-544
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• 2000

Many diabetic patients develop serious complications during the course of the disease, including cardiovascalar disorders, nepropathy, neuropathy and retinopathy. Because some physiological changes occurring in diabetes mellitus patients could alter the pharmacokinetics of drugs used to treat the disease, the pharmacokinetics of gentamycin was investigated after intravenous administration (2 mg/kg) to control rabbits and acute or chronic alloxan-induced diabetes mellitus rabbits (AIDRs). After intravenous administration, the serum concentrations of gentamycin were significantly higher between 6 and 12 hr in chronic AIDRs compared with those in control rabbits. The AUC was significant greater in chronic ($31.91\;{\pm}\;3.76\;{\mu}g/ml{\cdot}hr$) AIDRs than that in control ($21.60\;{\pm}\;2.45\;{\mu}g/ml{\cdot}hr$) rabbits. Total body clearance (CLt) in AIDRs were significantly decreased compared with that in control rabbits. Cumulative urinary excretion of gentamycin was decreased, although not significantly, in AIDRs compared with that in control rabbits.

• Parasites, Hosts and Diseases
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• v.52 no.3
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• pp.321-323
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• 2014

Encephalitozoon cuniculi is a microsporidian parasite commonly found in rabbits that can infect humans, causing encephalitozoonosis. The prevalence of encephalitozoonosis is not well documented, even when many clinics suspect pet rabbits as being highly infected. This study investigated the seropositivity of E. cuniculi using ELISA. The examination of 186 rabbits using ELISA showed that 22.6% (42/186) were seropositive against E. cuniculi. In analysis with healthy status, all 42 seropositive sera were collected from clinically normal rabbits. Moreover, the gender and age of pet rabbits did not have anysignificant effect on E. cuniculi infection. To the best of our knowledge, this is the first report to describe the seroprevalence of E. cuniculi in pet rabbits and suggests that pet rabbits could act as an important reservoir of encephalitozoonosis for both pet animals and humans in Korea.

• Korean Journal of Veterinary Research
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• v.39 no.2
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• pp.359-364
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• 1999

We investigated the pathological changes in young rabbits which were experimentally infected with rabbit hemorrhagic disease virus (RHDV). Experimental infection of RHDV was carried out in both thymectomized and non-thymectomized young immature rabbits and adult rabbits. None of young rabbits infected with RHDV died during the experiment. Histologically, single or focal hepatocellular degeneration and necrosis with mild lymphocyte infiltration were observed in the rabbits killed at 30 hours and 5 days PI. Lymphocyte infiltration was more severe at 5 days PI than at 30 hours PI. RHDV antigens were mainly detected in the degenerating hepatocytes adjacent to the infiltrated lymphocytes at 30 hours PI and 5 days PI. In electron microscopical observation, infiltrated lymphocytes in the lesions had large nuclei without cytoplasmic granules and interdigitated with adjacent hepatocytes. It is assumed that infiltrated lymphocytes in hepatic lesions in RHDV infected young rabbits are T-lymphocytes and originate from peripheral lymphoid organs or tissues rather than from thymus.

• YAKHAK HOEJI
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• v.24 no.2
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• pp.101-110
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• 1980

To investigate the effects of Siegesbeckiae Herba on the blood pressure, this study was carried out in the whole and the spinal rabbits, using its water and ethanol extracts. When Sigesbeckiae Herba water extract (SGWE) and ethanol extract (SGEE) were administered into the whole rabbits by route of e ear vein, both of them produced fall of blood pressure. The difference between these two extracts was that SGEE is more potent than SGWE. The depressor effects of SGWE and SGEE were not affected by vagoto minization but inhibited by pretreatment of atropine. The depressor responses of the whole rabbits to intravenous SGWE and SGEE were weakened by treatment of animals with bethanidine or phentolamine but not by propranolol. Pretreatment of the whole rabbits with diphenhydramine significantly weakened the d depressor effects of SGEE. Infusion of SGWE and SGEE in the whole rabbits did not influence the pressor effects caused by angiotensin, norepinephrine or carotid artery occlusion. SGEE, when given into the lateral ventricle of the whole rabbits or into the vein of the spinal rabbits, elicited fall of blood pressure, respectively.

• The Korean Journal of Physiology
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• v.8 no.2
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• pp.55-58
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• 1974

Inulin space was measured in the normal control rabbits and abdominal vena cava partially ligated (to about 1/2 of normal lumen) rabbits. Eleven rabbits served as the control and 12 rabbits after 7 to 10 days of abdominal vena cava ligation were used. Inulin space in the normal rabbits was $376{\pm}102.70\;ml\;(Mean{\pm}S.D.)\;or\;18.0{\pm}5.21%$ body weight. After 7 to 10 days of abdominal vena cava partial ligation inulin space decreased and the values were; $253{\pm}145.79\;ml\;or\;14.4{\pm}8.55%$ body weight.

• Korean Journal of Veterinary Research
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• v.12 no.1
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• pp.1-5
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• 1972

In oder to investigate the effects of cobalt-60 gamma ray irradiation on the body gains of rabbits aging approximately 50-day-old rabbits were subjected to single whole-body gamma irradiation externally. The results obtained were as follows: 1. There were significant differences of the body gains between control and treated groups except the 100 rads gamma-rays exposure group. 2. There were no differences in body gains between male and female rabbits. 3. Generally, the relation between gamma irradiated doses and the growth rates of rabbits were inversly proportional. 4. The $LD_{50}$ of the rabbits was 600 rads in case of single external whole-body gamma irradiation.

• Korean Journal of Clinical Pharmacy
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• v.3 no.2
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• pp.139-145
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• 1993

This study was attempted to investigate the pharmacokinetics of phenytoin(4mg/kg iv,) in rabbits pretreated with diltiazem(l and 2.5mg/kg) for 7 days. The plasma concentration and area under the curve(AUC) of phenytoin were increased significantly(p<0.05) in rabbits pretreated with diltiazem(2.5mg/kg) compared with those of control rabbits. Volume of distribution and total body clearance were decreased significantly(p<0,05) in rabbits pretreated with diltiazem compared with those of control rabbits. From the results of this experiment, it is desirable that dosage ragimen of phenytoin should be adjusted and that therapeutic drug monitoring should be practiced for reduction of side or toxic effect when phenytoin will be administered with diltiazem in clinical practice.

• The Journal of Internal Korean Medicine
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• v.1 no.1
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• pp.35-43
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• 1976

The effects of root of the Bupleurum falcatum L. on the serum transaminase (SGP-T, SGO-T) activities and the content of total cholesterol in serum from normal and alloxan-diabetic rabbits were observed. The preparations were extracted by methanol, and extracted samples were orally administrated to the normal and alloxandiabetic rabbits. The transaminase activities and the content of total cholesterol in serum of normal rabbits were significantly increased by administration of the alloxan. The increased serum transaminase activities of the alloxandiabetic rabbits were significantly decreased after 96 hours by administration of the extracted samples. The increased content of total cholesterol in serum of the alloxan-diabetic rabbits were gradually decreased by administration of the extracted samples and were recovered to the control levels after 12 days. According to the above results, it would be concluded that the extract of Bupleuri Radix influences for the recovery of the increased contents of total cholesterol and serum transaminase activities by alloxan.

• Journal of Pharmaceutical Investigation
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• v.8 no.3
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• pp.1-10
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• 1978

The purpose of this paper was to investigate the bioavailability of sulfadimethoxine in pathological rats and rabbits pretreated with carbon tetrachloride and mercuric chloride. The results are as follows: The absorption of sulfadimethoxine was decreased in rats damaged liver and kidney as compared with that of normal rats. Especially, absorption of sulfadimethoxine in rats damaged liver was more decreased than that of rats damaged kidney. Blood level of sulfadimethoxine administered orally was mostly decreased significantly in rabbits damaged kidney and liver, and in rabbits severely damaged kidney the blood level of sulfadimethoxine was not significant at 4 to 6 hours. Urinary clearance of sulfadimethoxine in rabbits severely damaged kidney was inhibited at 5 to 6 hours. but in rabbit damaged liver. Hepatic clearance of sulfadimethoxine was accelerated in rabbits damaged kidney but in rabbits damaged liver. Protein binding percentage of sulfadimethoxine was not affected by the various concentration of carbon tetrachloride and mercuric chloride respectively.