• Title/Summary/Keyword: quinoline

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Kinetic Study on the Oxidation Reaction of Alcohols by Cr(VI)-Quinoline Compound (크롬(VI)-퀴놀린 화합물에 의한 알코올류의 산화반응에 대한 반응속도론적 연구)

  • Park, Young-Cho;Kim, Soo-Jong
    • Journal of Convergence for Information Technology
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    • v.11 no.9
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    • pp.109-114
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    • 2021
  • Cr(VI)-quinoline compound[(C9H7NH)2Cr2O7] was synthesized by the reaction between of quinoline and chromium(VI) trioxide, and structure was FT-IR, elemental analysis. The oxidation ability of benzyl alcohol greatly depends upon the dielectric constant of the used organic solvent, where carbon tetrachloride was worst and N,N'-dimethylformamide was best solvent. Noticeably, in N,N'-dimethylformamide solvent, Cr(VI)-quinoline compound oxidized substituted benzyl alcohols. The Hammett reaction constant(ρ)=-0.69(303K). As a resuit, Cr(VI)-quinoline compound was found as efficicent oxidizing agent that converted benzyl alcohol, allyl alcohol, primary alcohol and secondary alcohols to the corresponding aldehydes or ketones. Cr(VI)-quinoline compound was selective oxidizing agent of benzyl alcohol, allyl alcohol and primary alcohol in the presence of secondary alcohol ones.

One Pot Synthesis of Substituted [1,2,4]-Triazolo [1',2':1,2]pyrimido [6,5-b]-quinoline and Its Antibacterial Activity

  • Joshi, Ratnadeep S.;Mandhane, Priyanka G.;Chate, Asha V.;Khan, Wajid;Gill, Charansingh H.
    • Bulletin of the Korean Chemical Society
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    • v.31 no.8
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    • pp.2341-2344
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    • 2010
  • A convenient synthesis of substituted [1,2,4]-triazolo [1',2':1,2]pyrimido[6,5-b]-quinoline 4(a-i) from substituted 2-chloroquinoline-3-carbaldehyde 1(a-i) and 4H-1,2,4-triazol-3-amine 2 by using $SiO_2/K_2CO_3$ under microwave irradiation. This method affords the [1,2,4]-Triazolo [1',2':1,2]pyrimido[6,5-b]-quinoline 4(a-i) under the influence of microwave irradiation in solvent-free conditions within short span (12 - 20 min), & gaves excellent yields (89 - 95%). All the synthesized compounds were further screened for their antibacterial activities. Some of our compounds showed excellent antibacterial activities against control drugs.

Synthesis of 8-Alkoxy-4,5-dihydro-[1,2,4]triazole[4,3-a]quinoline-1-ones and Evaluation of their Anticonvulsant Properties

  • Sun, Xian-Yu;Jin, Yun-Zhe;Li, Fu-Nan;Li, Gao;Chai, Kyu-Yun;Quan, Zhe-Shan
    • Archives of Pharmacal Research
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    • v.29 no.12
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    • pp.1080-1085
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    • 2006
  • A series of 8-alkoxy-4,5-dihydro-[1,2,4]triazole[4,3-a]quinoline-1-one derivatives were synthesized using 7-hydroxy-3,4-dihydro-2(1H)-quinolone as the starting material. Their anticonvulsant activities were evaluated by the maximal electroshock test (MES) and the subcutaneous pentylenetetrazole test (sc-PTZ), and their neurotoxicities were measured by the rotarod neurotoxicity test (Tox). The tests demonstrated that 8-hexyloxy-4,5-dihydro-[1.2.4]triazole[4.3-a]quinoline-1-one (4e) and 8-heptyloxy-4,5-dihydro-[1,2,4]triazole[4, 3-a]quinoline-1-one (4f) were the most potent anticonvulsants, with 4e having $ED_{50}$ values of 17.17 mg/kg and 24.55 mg/kg and protective index ($PI=TD_{50}/ED_{50}$) values of 41.9 and 29.3 in the MES and sc-PTZ tests, respectively, and 4f having $ED_{50}$ values of 19.7 mg/kg and 21.2 mg/kg and PI values of 36.5 and 33.9 in the MES and sc-PTZ tests, respectively. The PI values of 4e and 4f were many fold better than that of the marketed drugs phenytoin, carbamazepine, phenobarbital and valproate, which have PI values in the range of 1.6-8.1 in the MES test and <0.22-5.2 in the sc-PTZ test. Structure-activity relationships were also discussed.

Fluorescence Sensing Properties of 2-(2'-Hydroxyphenyl)quinoline and Derivatives

  • Helal, Aasif;Lee, Sang-Hoon;Ren, Wen Xiu;Cho, Chan-Sik;Kim, Hong-Seok
    • Bulletin of the Korean Chemical Society
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    • v.32 no.5
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    • pp.1599-1603
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    • 2011
  • Novel chemosensors based on 2-(2'-hydroxyphenyl)quinoline were prepared and evaluated for sensing metal cations. The photophysical properties of chemosensors 1-3 were examined and their ion-selectivity was evaluated by measuring their fluorescent emission responses to alkali, alkaline earth, and transition metal ions. Chemosensors 1, 2 and 3 show ratiometric and enhanced fluorescence changes with transitional metals that are efficient fluorescence quenchers, especially 3 has a high binding constant with $Hg^{+2}$ in $CH_3CN$.

Optimization of the Reaction Conditions for Synthesis of 3-(Aryloxy)quinoline Derivatives via Friedländer's Cyclization Reaction

  • Khan, Mohammad Ashrafuddin;El-Gamal, Mohammed I.;Oh, Chang-Hyun
    • Bulletin of the Korean Chemical Society
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    • v.34 no.6
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    • pp.1848-1852
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    • 2013
  • 6,7-Dimethoxy-2-methyl-3-(4-nitrophenoxy)quinoline was synthesized by Friedl$\ddot{a}$nder's cyclization reaction. Different bases and solvents were tested in order to optimize the reaction conditions. The highest yields were obtained using piperidine in refluxing ethanol. Further reactions were carried out in order to prepare different diarylamide and diarylurea derivatives in moderate to high yields in order to examine their anticancer activities.

Spectrophotometric Study on the Complex of the Copper by 8-(p-Ethylbenzenesulfonamido) quinoline (분광광도법에 의한 8-(p-Ethylbenzenesulfonamido) quinoline과 구리와의 착물에 관한 연구)

  • Heung Lark Lee;Yung Kyu Park;Chul Heui Lee
    • Journal of the Korean Chemical Society
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    • v.15 no.6
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    • pp.378-384
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    • 1971
  • A new analytical reagent 8-(p-ethylbenzenesulfonamido)quinoline(EBSQ) has been synthesized, and identified its structure. EBSQ forms copper chloroform-soluble complex in a basic solution (pH = 7.5∼10.5). The other optimum conditions for the spectrophotometric study of Cu-EBSQ have been established at 380 $m{\mu}$. Beer's law is followed in the concentration range of 0~44.5 ${\mu}g$ per 10 ml of chloroform. The composition of complex has been found to be $Cu(EBSQ-H)_2$and the over-all instability constant is calculated to be $1.22{\times}10^{-7}$. The absorption coefficient of the $Cu(EBSQ-H)_2$ complex is ${\varepsilon}$ = 15,800.

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Kinetics and Mechanism for Reactions of Substituted Phenacyl Bromides with Quinoline (치환 브롬화페나실과 퀴놀린과의 반응에 관한 반응속도론적 연구)

  • Kim, Chang-Suk;Hong, Soon-Yung
    • Journal of the Korean Chemical Society
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    • v.28 no.4
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    • pp.265-268
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    • 1984
  • Rates of reactions of nine m-or p-substituted phenacyl bromides with quinoline in methanol were measured by an electric conductivity method. These reactions were found to proceed through an $S_N2$ path and were accelerated by both electron-donating and electron-withdrawing substituents. A plausible reaction mechanism for this observation was proposed. Some activation parameters for these reactions were also calculated.

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Preparation of Isotropic Carbon with High Density (고밀도, 등방성 탄소의 제조에 관한 연구)

  • 오종기;이선우;박광원
    • Journal of the Korean Ceramic Society
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    • v.28 no.11
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    • pp.908-916
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    • 1991
  • The characteristics of the carbonized and calcined products made from coal tar pitch coke and coal tar pitch, were investigated in the aspect of the manufacture of isotropic graphite with high density. The mesophase from the pitch was rapidly formed at higher heat-treatment temperature between 410$^{\circ}C$ and 450$^{\circ}C$, where the insolubes in the pitch accelerated the rate of nucleation and growth of the mesophase. The benzene insolubles and the quinoline insolubes were increased as the heat treatment temperature and the heat-treatment time increased. The ratio of benzene insolubles and quinoline solubles (BI/QS) was decreased as the heat-treatment temperature was higher and maintained to be nearly constant regardless of heat-treatment time at fixed heat treatment temperature. The bulk density of the calcined carbon was linearly proportional to the ratio of quinoline solubes to volatile matter in the green coke. Anisotropic ratio of electrical resistance was measured to be between 0.98 and 1.10.

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Novel Organic Sensitizers with a Quinoline Unit for Efficient Dye-sensitized Solar Cells

  • Choi, Hye-Ju;Choi, Hyun-Bong;Paek, Sang-Hyun;Song, Ki-Hyung;Kang, Moon-Sung;Ko, Jae-Jung
    • Bulletin of the Korean Chemical Society
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    • v.31 no.1
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    • pp.125-132
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    • 2010
  • Three organic sensitizers, JK-128, JK-129, and JK-130 containing quinoline unit are designed and synthesized. Under standard global AM 1.5 solar condition, the JK-130 sensitized solar cell gave a short circuit photocurrent density of 11.52 mA $cm^{-2}$, an open circuit voltage of 0.70 V, and a fill factor of 0.75, corresponding to an overall conversion efficiency of 6.07%. We found that the $\eta$ of JK-130 was higher than those of other two cells due to the higher photocurrent. The higher $J_{sc}$ value is attributed to the broad and intense absorption spectrum of JK-130.