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http://dx.doi.org/10.5012/bkcs.2010.31.8.2341

One Pot Synthesis of Substituted [1,2,4]-Triazolo [1',2':1,2]pyrimido [6,5-b]-quinoline and Its Antibacterial Activity  

Joshi, Ratnadeep S. (Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University)
Mandhane, Priyanka G. (Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University)
Chate, Asha V. (Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University)
Khan, Wajid (Department of Microbiology, Maulana Azad College)
Gill, Charansingh H. (Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University)
Publication Information
Bulletin of the Korean Chemical Society / v.31, no.8, 2010 , pp. 2341-2344 More about this Journal
Abstract
A convenient synthesis of substituted [1,2,4]-triazolo [1',2':1,2]pyrimido[6,5-b]-quinoline 4(a-i) from substituted 2-chloroquinoline-3-carbaldehyde 1(a-i) and 4H-1,2,4-triazol-3-amine 2 by using $SiO_2/K_2CO_3$ under microwave irradiation. This method affords the [1,2,4]-Triazolo [1',2':1,2]pyrimido[6,5-b]-quinoline 4(a-i) under the influence of microwave irradiation in solvent-free conditions within short span (12 - 20 min), & gaves excellent yields (89 - 95%). All the synthesized compounds were further screened for their antibacterial activities. Some of our compounds showed excellent antibacterial activities against control drugs.
Keywords
[1,2,4]-Triazolo [1',2':1,2]pyrimido[6,5-b]-quinoline; $SiO_2/K_2CO_3$; Microwave irradiation; Antibacterial activity;
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