• The Korean Journal of Physiology and Pharmacology
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• 제10권6호
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• pp.297-302
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• 2006

Melittin, a major component of bee venom, produces a sustained decrease in mechanical threshold, and an increase in spontaneous flinchings and paw thickness, which are characteristics similar to those induced by whole bee venom. Melittin-induced nociception has been known to be modulated by the changes in the activity of excitatory amino acid receptors, voltage-dependent calcium channels, cyclooxygenase and serotonin receptors. The present study was undertaken to investigate the role of calcium chelators (TMB-8 & Quin 2) in melittin-induced nociceptive responses. Changes of mechanical threshold and spontaneous flinching behaviors were measured at a given time point following intraplantar injection of melittin ($30{\mu}g/paw$). Intrathecal or intraplantar pre-administration and intrathecal posttreatment of TMB-8 and Quin 2 significantly prevented the melittin-induced reduction of mechanical threshold, and intraplantar or intrathecal pre-treatment of TMB-8 and Quin 2 suppressed melittininduced flinching behaviors. These results indicate that calcium ion in the spinal dorsal horn neurons and peripheral nerves plays an important role in the production and maintenance of mechanical allodynia and spontaneous pain by melittin.

• 한국수학교육학회지시리즈A:수학교육
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• 제53권2호
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• pp.291-312
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• 2014

This study has to do with creative product in mathematics. We analyze Taylor's creative product according to a different developmental level of creativity, Taylor's creative product inventory, Besemer & Treffinger's creative products analysis matrix, O'Quin & Besemer's creative products semantic scale(CPSS) etc. The purpose of this study is to make creative products semantic scale in mathematics. O'Quin & Besemer's CPSS consists of 55 items, bipolar adjective checklist. We confirm that O'Quin & Besemer's CPSS is not fit to use for mathematics creative products. So we develop Creative Product Semantic Scale in Mathematics(MCPSS) which consists of 33 items, bipolar adjective checklist. Our result will provide convenience to mathematics teacher who guides a student make a creative product.

• 약학회지
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• 제35권1호
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• pp.11-14
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• 1991

Ro09-0198, a cyclic peptide isolated from culture filtrates of Streptoverticillium griseove-rticillatum, induced platelet aggregation and serotonin release simultaneously. LDH release was not observed. Addition of peptide to rat platelet, loaded with $Ca^{2+}$ chelator quin-2, caused immediate rise in cytosolic free $Ca^{2+}$. Liposomal membrane containing phosphatidylethanolamine was damaged by peptide and released $^{45}Ca$ dose dependently.

• Carbon letters
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• 제17권1호
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• pp.45-52
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• 2016

The attachment of 2-aminobenzamide to carboxylated multi-wall carbon nanotubes (MWCNTs)-COOH was achieved through the formation of amide bonds. Then, the functionalized MWCNTs, MWCNT-amide, were treated by phosphoryl chloride to produce MWCNT-quin. The products were characterized by Fourier transform infrared spectroscopy, Raman spectroscopy, scanning electron microscopy, thermogravimetric analysis, derivative thermogravimetric, steady-state fluorescence spectroscopy, and solubility testing. MWCNT-quin showed photo-electronic properties, which is due to the attachment of the 4-hydroxyquinazoline groups to them as proved by steady-state fluorescence spectroscopy. This suggests intramolecular interactions between the tubes and the attached 4-hydroxyquinazoline. The toxicity of the samples was evaluated in human embryonic kidney HEK293 and human breast cancer SKBR3 cell lines, and the viable cell numbers were measured by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyltetrazolium bromide (MTT) after the cells were cultured for 24 h. Cellular investigations showed that the modified MWCNTs, particularly MWCNT-quin, have considerably significant toxic impact on SKBR3 as compared to HEK293 at the concentration of 5 µg/mL.

• Toxicological Research
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• 제6권1호
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• pp.109-119
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• 1990

Ro09-0198, a cyclic peptide isolated from culture filtrates of Streptoverticillium griseoverticillatum, induced lysis of erythrocytes. Ro-09-0198-induced hemolysis was temperature-dependent and the sensitivity of hemolysis differed greatly among animal species. Preincubation of the peptide with phosphatidylethanolamine reduced the hemolytic activity, whereas other phospholipids present in erythrocytes in nature had no effect. A study of the structural requirements on phosphatidylethanolamine necessary for interaction with the peptide indicates that Ro09-0198 recognizes strictly a particular chemical structure of phosphatidylethanolamine: dialkylphosphoethanolamine as well as 1-acylglycerophosphoethanolamine showed the same inhibitory effct on hemolysis induced by Ro09-0198 as diacylphosphatidyl-ethanolamine, whereas phosphoethanolamine gave no inhibitory effect. Neither phosphatidyl-N-monomethylethanolamine nor alkylphosphopropanolamine had an inhibitory effect. Proton resonances of the peptide were observed in dimethyl sulfoxide solution in the presence of 1-dodecanoyl-sn-glycerophosphoethanolamine. This peptide caused permeability increase and aggregation of liposomes containing phosphatidylethanolamine. A glycerol backbone and a primary amino group of phosphatidylethanolamine are necessary for interaction with Ro09-0198 to cause membrane damage. Ro09-0198 induced a selective permeability change on liposomes. Glucose and umbelliferyl phosphate were effluxed significantly, but sucrose was only slightly permeable and inulin could not be released. Platelet aggregation and serotonin release simultaneously induced by Ro09-0198. Addition of peptide to rat platelet, loaded with the fluorescent $Ca^{++}$ chelator quin-2, caused immediate rise in cytosolic free $Ca^{++}$ to liposomal membrane containing phosphatidylethanolamine was observed dose dependently.

• 대한화학회지
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• 제30권1호
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• pp.76-83
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• 1986

카르복실기를 갖는 리간드들과 옥소바나듐(IV) 사이에 형성되는 착화합물 ($VO(picn)_2$, $VO(htmq)_2$, $VO(quin)_2$ 및 $VO(pyra)_2{\cdot}2H_2O)$들을 합성하여 그들의 IR 및 자기적 특성을 조사하였다. 이들의 자화율 값과 V=O결합의 신축진동수 값으로부터 $VO(picn)_2$ 및 $VO(htmq)_2$착화합물에 있어 강한 분자간 상호작용이 존재하는 것으로 추정하였다. IR데이타를 근거로 할 때 4개의 옥소바나듐(IV) 착물들에 있어 카르복실기는 모두 한자리 배위자로서 작용함을 알 수 있었다. 자유리간드와 옥소바나듐 착물의 IR스펙트럼을 비교 검토하므로서 중심원자와 리간드주게원자들로 구성되는 배위권에서의 기본 진동 형태를 분류하고 착물 형성 후 나타난 새로운 IR흡수띠들을 분류한 진동 형태와 대응시켰다.

• 한국항만경제학회지
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• 제29권3호
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• pp.1-23
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• 2013

본 연구는 1992년부터 2011년까지 월별자료를 사용하여 여러 가지 시계열 추정모델과 승법 계절 ARIMA 모형을 설정하여 부산항의 컨테이너 물동량을 추정하고 예측하였다. 여러 가지 모델로 추정한 결과 부산항의 컨테이너 물동량과 물동량 변동 모두 계절을 승법한 ARIMA 모델 $(1,0,1){\times}(1,0,1)_{12}$로 추정하였을 때, 추정결과와 Akaike information, Schwarz, Hannan-Quin 기준 등으로 보아, 가장 좋은 ARIMA 추정과 예측 모형으로 나타났다. 그리하여 부산항 물동량 추정의 최적모형인 ARIMA $(1,0,1){\times}(1,0,1)_{12}$ 모형에 의해 향후 8년간 96개월에 대한 부산항 물동량 미래 예측치(2013-2020년)를 월별로 추정하여 예측한 결과 2013년부터 부산의 물동량은 연도별로 조금씩 지속적으로 증가하는 추세를 보일 것으로 나타났다. ARIMA $(1,0,1){\times}(1,0,1)_{12}$ 모형에 의한 부산항의 컨테이너 물동량의 연도별 예측량은 2013년 1천 891만 TEU, 2014년 2천 34만 TEU, 2015년 2천 188만 TEU, 2016년 2천 353만 TEU, 2017년 2천 531만 TEU, 2018년 2천 722만 TEU 그리고 2020년 3천 148만 TEU 등으로 나타났다.

• 약학회지
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• 제40권1호
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• pp.19-24
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• 1996

The 6,7-dichloroquinolone-5,8-dione(I) was reacted with ethyl acetoacetate in the presence of sodium ethoxide to yield 6-(${\alpha}$-acetyl-${\alpha$-ethoxycarbonyl-methyl)-7-chloro-quin oline-5,8-dione(II). When this compound II was reacted with some alkylamine (methylamine, ethylamine, propylamine, isopropylamine, cyclopropylamine, methoxyethylamine, ethanolamine, benzylamine, furfurylamine), 1N-alkyl-2-methyl-3-ethoxycarbonyl-pyridino(2,3f)-indole-4,9-dione(IIIa-i) were obtained via intramolecular cyclization.

• 음성과학
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• 제12권1호
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• pp.123-134
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• 2005

Confidence measure (CM) is used for the rejection of mis-recognized words in an automatic speech recognition (ASR) system. Rahim, Lee, Juang and Cho's confidence measure (RLJC-CM) is one of the widely-used CMs [1]. The RLJC-CM is calculated by averaging phone-level CMs. An extension of the RLJC-CM was achieved by Kim et al [2]. They devised the normalized CM (NCM), which is a statistically normalized version of the RLJC-CM by using the tri-phone based CM normalization. In this paper we verify the NCM by generalizing tri-phone to n-phone unit. To apply various units for the normalization, mono-phone, tri-phone, quin-phone and $\infty$-phone are tested. By the experiments in the domain of the isolated word recognition we show that tri-phone based normalization is sufficient enough to enhance the rejection performance of the ASR system. Also we explain the NCM in regard to two class pattern classification problems.

• Ocean and Polar Research
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• 제23권2호
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• pp.189-194
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• 2001

A practical algorithm for prediction of the sea surface temperatures (SST)from the satellite remote sensing data is presented in this paper. The fluctuations of SST consist of deterministic normals and stochastic anomalies. Due to large thermal inertia of sea water, the SST anomalies can be modelled by autoregressive or Markov process, and its near future values can be predicted provided the recent values of SST are available. The actual SST is predicted by superposing the pre-known SST normals and the predicted SST anomalies. We applied this prediction algorithm to the NOAA AVHRR weekly SST data for 18 years (1981-1998) in the seas adjacent to Korea (115-$145^{\circ}E$, 20-$55^{\circ}N$). The algorithm is applicable not only for prediction of SST in near future but also for nowcast of SST in the cloud covered regions.