• 농약과학회지
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• 제9권2호
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• pp.146-152
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• 2005

분자 홀로그램(H) QSAR 방법으로 일련의 새로운 2-alkoxyphenyl-3-phenylthioisoindoline-1-one 유도체들의 구조 변화에 따른 저항성(RPC) 및 감수성(SPC) 고추역병균주(Phytopthora capsici)에 대한 살균활성 관계를 연구하였다. 두 균주에 대한 살균활성에 관한 HQSAR 모델(RPC: RI-B 및 SPC: SII-A)들은 예측성($r^2_{cv.}$ 또는 $q^2=0.806{\sim}0.865$)과 상관성($r^2_{ncv.}=0.921{\sim}0.952$)에 근거하여 매우 높은 통계값들을 나타내었다. 이에 근거하여 HQSAR 모델들은 RPC 보다는 SPC에 대하여 양호한 살균활성을 나타내는 경향을(SPC> RPC) 보였다. 특히, atomic contribution map으로부터 RPC 균주의 선택적인 살균활성은 2-fluoro-4-chloro-5-alkoxyanilino 기에 의존적임을 확인하였다.

• 정보교육학회논문지
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• 제10권1호
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• pp.143-152
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• 2006

기업에서 실제로 수행된 블렌디드 학습(Blended Learning)의 효과성을 규명해보고 이를 토대로 온라인 학습과 오프라인 학습을 효과적으로 병행하기 위한 시사점을 도출하고자 본 연구가 수행되었다. 연구 목적을 달성하기 위해 블렌디드 학습의 효과성에 대한 설명적 혼합설계 방식으로 체제적 분석을 시도하였다. 블렌디드 학습의 효과에 대한 양적 분석 결과, 종합진단과 타인진단에서는 블렌디드 학습이 리더십 역량을 향상시키는데 유의미한 영향을 미치는 것으로 나타났고, 사후 설문조사 및 핵심 면담대상자집단과의 면담 결과 블렌디드 학습의 유용성을 확인할 수 있었다. 이러한 연구 결과를 바탕으로, 블렌디드 학습 방식으로 운영한 프로그램의 분석을 통해 블렌디드 학습 효과에 영향을 주는 특성을 분석하고, 블렌디드 학습의 효과성 검증에 대한 방향을 제시하고자 하였다.

• BMB Reports
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• 제31권5호
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• pp.459-467
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• 1998

A new set of functional group interaction energy descriptors relevant to the ACE (Angiotensin-Converting Enzyme) inhibitory peptide, QSAR (Quantitative Structure Activity Relationships), is presented. The functional group interaction energies approximate the charged interactions and distances between functional groups in molecules. The effective energies of the computationally derived geometries are useful parameters for deriving 3D-QSAR models, especially in the absence of experimentally known active site conformation. ACE is a regulatory zinc protease in the renin-angiotensin system. Therapeutic inhibition of this enzyme has proven to be a very effective treatment for the management of hypertension. The non bond interaction energy values among functional groups of six-feature of ACE inhibitory peptides were used as descriptor terms and analyzed for multivariate correlation with ACE inhibition activity. The functional group interaction energy descriptors used in the regression analysis were obtained by a series of inhibitor structures derived from molecular mechanics and semi-empirical calculations. The descriptors calculated using electrostatic and steric fields from the precisely defined functional group were sufficient to explain the biological activity of inhibitor. Application of the descriptors to the inhibition of ACE indicates that the derived QSAR has good predicting ability and provides insight into the mechanism of enzyme inhibition. The method, functional group interaction energy analysis, is expected to be applicable to predict enzyme inhibitory activity of the rationally designed inhibitors.

• 한국작물학회:학술대회논문집
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• 한국작물학회 2017년도 9th Asian Crop Science Association conference
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• pp.146-146
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• 2017

The pod shattering or dehiscence is essential for the propagation of pod-bearing plant species in the wild, but it causes significant yield losses during harvest of domesticated crop plants. Identifying novel molecular makers, which are linked to seed-shattering genes, is needed to employ the molecular marker-assisted selection for efficiently developing shattering-resistant soybean varieties. In this study, a genetic linkage map was constructed using 115 recombinant inbred lines (RILs) developed from crosses between the pod shattering susceptible variety, Keunol, and resistant variety, Sinpaldal. A 180 K Axiom(R) SoyaSNPs data and pod shattering data from two environments in 2001 and 2015 were used to identify quantitative trait loci (QTL) for pod shattering. A major QTL was identified between two flanking single nucleotide polymorphism (SNP) markers, AX-90320801 and AX-90306327 on chromosome 16 with 1.3 cM interval, 857 kb of physical range. In sequence, genotype distribution analysis was conducted using extreme phenotype RILs. This could narrow down the QTL down to 153 kb on the physical map and was designated as qPDH1-KS with 6 annotated gene models. All exons within qPDH1-KS were sequenced and the 6 polymorphic SNPs affecting the amino acid sequence were identified. To develop universally available molecular markers, 38 Korean soybean cultivars were investigated by the association study using the 6 identified SNPs. Only two SNPswere strongly associated with the pod shattering. These two identified SNPs will help to identify the pod shattering responsible gene and to develop pod shattering-resistant soybean plants using marker-assisted selection.

• 대한원격탐사학회:학술대회논문집
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• 대한원격탐사학회 2008년도 International Symposium on Remote Sensing
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• pp.3-5
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• 2008

An increase in oil and gas plants caused by development of process industry have brought into the increase in use of flammable and toxic materials in the complex process under high temperature and pressure. There is always possibility of fire and explosion of dangerous chemicals, which exist as raw materials, intermediates, and finished goods whether used or stored in the industrial plants. Since there is the need of efforts on disaster damage reduction or mitigation process, we have been conducting a research to relate explosion model on the background of real 3D terrain model. By predicting the extent of damage caused by recent disasters, we will be able to improve efficiency of recovery and, sure, to take preventive measure and emergency counterplan in response to unprepared disaster. For disaster damage prediction, it is general to conduct quantitative risk assessment, using engineering model for environmental description of the target area. There are different engineering models, according to type of disaster, to be used for industry disaster such as UVCE (Unconfined Vapour Cloud Explosion), BLEVE (Boiling Liquid Evaporation Vapour Explosion), Fireball and so on, among them, we estimate explosion damage through UVCE model which is used in the event of explosion of high frequency and severe damage. When flammable gas in a tank is released to the air, firing it brings about explosion, then we can assess the effect of explosion. As 3D terrain information data is utilized to predict and estimate the extent of damage for each human and material. 3D terrain data with synthetic environment (SEDRIS) gives us more accurate damage prediction for industrial disaster and this research will show appropriate prediction results.

• Journal of Power Electronics
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• 제16권2호
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• pp.717-730
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• 2016

The harmonic components of grid voltage result in oscillations of the calculated phase obtained via phase synchronization. This affects the security and stability of grid-connected converters. Moving average filter, delayed signal cancellation and their related harmonic elimination algorithms are major methods for such issues. However, all of the existing methods have their limitations in dealing with multiple harmonics issues. Furthermore, few studies have focused on a comparison and evaluation of these algorithms to achieve optimal algorithm selections in specific applications. In this paper, these algorithms are quantitatively analyzed based on the derived mathematical models. Moreover, an enhanced moving average filter and enhanced delayed signal cancellation algorithms, which are applicable for eliminating a group of selective harmonics with only one calculation block, are proposed. On this basis, both a comprehensive comparison and a quantitative evaluation of all of the aforementioned algorithms are made from several aspects, including response speed, required data storage size, sensitivity to sampling frequency, and elimination of random noise and harmonics. With the conclusions derived in this paper, better overall performance in terms of harmonic elimination can be achieved. In addition, experimental results under different conditions demonstrate the validity of this study.

• 보건의료산업학회지
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• 제8권2호
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• pp.197-208
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• 2014

This study examined the relationship between social support and depressive symptom among the middle and old-aged people, using dataset of the Korean Longitudinal Study of Ageing(KLoSA 3rd). The subjects were 7,874 persons aged 45 and over. Using this data, social support variables and its relation to depressions was observed based on social network model. A multiple regression model was used to study an association between social support and depressive symptom, controlling for socio-economic characteristics, health status and behavior. Also, this paper run two subgroup regression models based on gender of subjects (male, female), controlling for confounding variables. Authors found that there was lower the number of meetings with friends (1~3 times in a week: b=0.597, p<0.0001; 1~2 times in a month: b=0.609, p<0.0001; 1~6 times in a year or under: b=1.598, p<0.0001) and negative relationship between spouse satisfaction (b=-0.007, p=0.0237), children satisfaction (b=-0.019, p<0.0001) and depressive symptom. Also quantitative effect differences were compared according to gender and its effect on depression. Compared to the male group, female group showed significant difference in quantitative effect with number of meetings with friends and spouse satisfaction, but children satisfaction didn't show clear differences according to gender. This study suggested the importance of social support for promoting mental health among the middle and old-aged people.

• The Journal of Advanced Prosthodontics
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• 제7권6호
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• pp.460-467
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• 2015

PURPOSE. The aim of this study is to evaluate the appropriate impression technique by analyzing the superimposition of 3D digital model for evaluating accuracy of conventional impression technique and digital impression. MATERIALS AND METHODS. Twenty-four patients who had no periodontitis or temporomandibular joint disease were selected for analysis. As a reference model, digital impressions with a digital impression system were performed. As a test models, for conventional impression dual-arch and full-arch, impression techniques utilizing addition type polyvinylsiloxane for fabrication of cast were applied. 3D laser scanner is used for scanning the cast. Each 3 pairs for 25 STL datasets were imported into the inspection software. The three-dimensional differences were illustrated in a color-coded map. For three-dimensional quantitative analysis, 4 specified contact locations(buccal and lingual cusps of second premolar and molar) were established. For two-dimensional quantitative analysis, the sectioning from buccal cusp to lingual cusp of second premolar and molar were acquired depending on the tooth axis. RESULTS. In color-coded map, the biggest difference between intraoral scanning and dual-arch impression was seen (P<.05). In three-dimensional analysis, the biggest difference was seen between intraoral scanning and dual-arch impression and the smallest difference was seen between dual-arch and full-arch impression. CONCLUSION. The two- and three-dimensional deviations between intraoral scanner and dual-arch impression was bigger than full-arch and dual-arch impression (P<.05). The second premolar showed significantly bigger three-dimensional deviations than the second molar in the three-dimensional deviations (P>.05).

• 한국건축시공학회지
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• 제17권3호
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• pp.287-294
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• 2017

최근 건설프로젝트가 대형화 복잡화되어 감에 따라, 건설공사에서의 리스크 및 불확실성이 급증하고 있다. 증가하고 있는 건설 공사의 위험을 정량적으로 평가하고 관리 할 수 있는 모델 개발을 위해서는 위험 인자를 식별하고 위험인자의 발생 빈도와 심도를 계량화하는 연구가 우선되어야 한다. 이에 본 연구에서는 건설현장에서 발생한 사고 데이터를 기반으로 하여 위험요인의 확률분포 및 리스크 레벨별 위험의 발생 확률과 위험의 발생 빈도를 몬테카를로 기법을 통해 시뮬레이션하였다. 시뮬레이션을 통해 사고 원인의 확률 분포 및 사고 원인별 위험도를 분석하여 계량적 분석 결과를 도출하였다. 본 연구의 결과는 향후 정량적 위험관리모델 및 위험관리 연구를 위한 기초 자료가 될 것이다.

• 한국실내디자인학회논문집
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• 제24권5호
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• pp.117-127
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• 2015

This paper depicts a case study of the BIM (Building Information Modeling)-enabled evaluation of design alternatives for an actual remodeling project in Yeongwol, Korea. The increase of urban population and income followed by the growth of economy has derived massive supply of grand scale housing project in Korea since 1970s. Consequently, building remodeling became one of the feasible resolutions for renovating such old housings in these days. This paper aims to introduce a technical approach to such remodeling projects based on BIM-enabled applications focusing on quantitative analysis of design alternatives. Among the technical issues of such building remodeling projects, this paper focuses on the BIM-enabled area analysis and comparison between design alternatives to support decision-making even in early phase of remodeling design process. BIM and its variety of applications have broadly influenced the domain of AEC-FM (Architecture, Engineering, Construction, and Facility Management) within the lifecycle of buildings. As one of the applications facilitated by BIM, the automated area calculation and scenario-based comparison between alternatives can play an important role in the early phase of remodeling project. We modeled three design alternatives (buildings) and three housing modules (units) based on the actual case in Yeongwol city, Korea using a BIM design authoring tool. Nine combinatorial BIM models were demonstrated for the BIM-enabled review process described in this paper. To determine the most optimal design scenario among nine alternatives, this paper demonstrates a result of the conducted spatial program review. The main subject includes specific spatial program issues on; 1) the number of unit spaces; and 2) area of individual/grouped and private/shared spaces.