• 약학회지
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• 제59권4호
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• pp.151-157
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• 2015

The purpose of this study is to demonstrate how lead compounds are best optimized with the application of in silico QSAR and PBPK modeling at the early drug discovery stage. Several predictive QSAR models such as $IC_{50}$ potency model, intrinsic clearance model and brain penetration model were built and applied to a set of virtually synthesized library of the BACE1 inhibitors. Selected candidate compounds were also applied to the PBPK modeling for comparison between the predicted animal pharmacokinetic parameters and the observed ones in vivo. This novel lead optimization strategy using QSAR and PBPK modelings could be helpful to expedite the drug discovery process.

• 수산해양교육연구
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• 제28권1호
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• pp.289-299
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• 2016

The purpose of the study was to develop evaluation methods which would measure student achievement and progress without traditional paper-pencil tests such as mid-term and final examinations. More specifically, the main research focus were to establish general directions of student assessment during free semester, to build evaluation models supporting student's participation and learning, and to report and record various student evaluation results. As research results, we found that student evaluation of free semester should be organized to improve a) experience learning activity, self-regulatory and collaboratory study, b) high-order thinking ability and character-building, and c) teacher-student-parent cooperation. Since traditional paper-pencil tests were restricted in free semester, student achievement should be provided by a way of performance descriptions on transcripts rather than quantitative grade points. Student performance descriptions had to show not only subject knowledge but also students efforts, motivation, and participation. These multiple and educationally meaningful information would be collected by teacher-student-parent communication and collaboration.

• 수산해양교육연구
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• 제29권1호
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• pp.306-314
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• 2017

The purpose of this study is to explore the possibility of qualitative evaluation and applicable models in the evaluation area of educational program. To this end, the concept and characteristics of qualitative evaluation are examined, and grounded theory is selected as a suitable methodology for evaluation, and its characteristics and procedures are described. Because qualitative evaluation focuses on the spontaneous practice elements of the site, it can supplement the quantitative evaluation of the variables set in advance. The researcher presented the theory of qualification as a methodology for qualitative evaluation, aiming to extract the theory explaining the phenomenon among the qualitative methodologies.

• 한국독성학회:학술대회논문집
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• 한국독성학회 2002년도 Current Trends in Toxicological Sciences
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• pp.97-97
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• 2002

A mouse ear swelling test (MEST) has been developed as an alternative to guinea pig models for contact sensitization potential. However, the MEST relies on a quantitative measurement of ear swelling as an endpoint by micrometer. In this study, we aimed to investigate the cell proliferation in ear and lymph node using Bromodeoxyuridine (BrdU) immunohistochemistry as a possible reliable marker for MEST.(omitted)

• 대한원격탐사학회:학술대회논문집
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• 대한원격탐사학회 2008년도 International Symposium on Remote Sensing
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• pp.37-40
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• 2008

The purpose of this paper is to extract DEMs from Spot-3 strips using orbit modeling technique. Spot-3 stereo strip images along 420km in distance were used for experiments. The orbit modeling technique has been suggested to establish accurate geometric models for a whole strip taken on the same orbit using only a small number of GCPs on the top area of the strip. This method enables extraction of orientation parameters of the scene along the strip that is needed to generate DEMs. Consequently, we were able to extract DEMs over the areas without accurate GCPs obtained by GPS surveying per each scene. Assessment of accuracy was carried out using USGS DTED. DEMs generated from the orbit modelling technique suggested showed satisfactory performance when quantitative analysis of accuracy assessment was carried out.

• 산업공학
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• 제11권1호
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• pp.1-14
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• 1998

Various problems on logistics systems have been dealt with recently as research issues since they were regarded critical for taking up a better position in the increasingly competitive global market. In particular, the freight transportation is considered as a key factor which affects the economic competitiveness of a whole nation as well as the production cost of individual companies. The objective of this study is to identify main issues and review recent foreign and domestic studies related to the freight transportation. The studies are classified into two categories according to the hierarchical level in the decision making process: infra structure design and transportation strategies, service design and operation. Main issues are introduced with a brief review on the related literature and methodologies applied.

• Nuclear Medicine and Molecular Imaging
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• 제40권6호
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• pp.279-292
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• 2006

Recent progress in the development of non-invasive imaging technologies continues to strengthen the role of biomedical research. These tools have been validated recently in variety of research models, and have born shown to provide continuous quantitative monitoring of the location(s), magnitude, and time-variation of gene delivery and/or expression. This article reviews the use of PET technologies as they have been used in imaging biological processes for molecular imaging applications. The studies published to date demonstrate that noninvasive imaging tools will help to accelerate pre-clinical model validation as well as allow for clinical monitoring of human diseases.

• Management Science and Financial Engineering
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• 제9권2호
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• pp.21-45
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• 2003

Various organizational factors effect successful implementation of IT enabled business transformation. Among them, the most critical success factor is deemed to overcoming change management problem. Lots of studies have been made on implementation methodologies and business process formalizations to encourage organizational members to accept new business process changes. However, the logic of process redesign still depends on qualitative problem solving techniques mostly depending on basically human intuition such as brainstorming, cause-and-effect analysis, and so on. In this paper, we develop algorithmic procedure applicable to designing various business process changes such as process automation, business process resequencing, and more radical process integration. The framework is employed from dynamic programming approach in the literature, which is based on the decision making paradigm of organizations to abstract business processes as quantitative decision models. As such, our research can fill the gap of limited development of theory based analytic methodologies for business process design, by providing objective rationale to reach the consensus among the organizational members including senior management.

• Asia pacific journal of information systems
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• 제11권2호
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• pp.23-55
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• 2001

It is generally agreed that realizing the full potential of the internet shopping mall(ISM) requires careful identification of customer needs and expectations. However, a quantitative framework to explain and predict users' behavior toward ISM has not been well established because the research on the user acceptance of ISM is still in its infancy. This study proposes a model which uses factor analysis to identify factors of ISM characteristics and individual characteristics affecting user acceptance of ISM. Predictive models based on the multiple regression analyses select the factors and their interactions with individual characteristics that significantly influence user acceptance. Results show that five factors including economy, convenience, credibility, reliability, information risks, and performance risks affects user acceptance. In addition, individual differences in terms of innovativeness, playfulness, and recreational shopping traits have both direct and interaction effects on user acceptance. The implication of this study is that, although user attitudes towards ISM characteristics in general are important to their acceptance behavior, the level of importance depends upon different user groups.

• Molecular & Cellular Toxicology
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• 제2권3호
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• pp.216-221
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• 2006

The cholinesterase-inhibiting organophosphorous (OP) compounds known as nerve agents are highly toxic. The principal toxic mechanism of OP compounds is the inhibition of acethylcholine esterase (AChE) by phosphorylation of its catalytic site. The reversible competitive inhibition of AChE may prevent the subsequent OP intoxication. In this study, three-dimensional quantitative structure-activity relationship (3D-QSAR) was performed to investigate the relationship between the 29 compounds with structural diversity and their bioactivities against AChE. In particular, predictive models were constructed using the comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA). The results indicate reasonable model for CoMFA ($q^{2}=0.453,\;r^{2}=0.697$) and CoMSIA ($q^{2}=0.518,\;r^{2}=0.696$). The presence of steric and hydophobic group at naphtyl moiety of the model may lead to the design of improved competitive inhibitors for organophosphorous intoxication.