Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2002.05a
- /
- Pages.97-97
- /
- 2002
EVALUATION OF CELL PROLIFERATION IN EAR AND LYMPH NODE USING BRDU IMMUNOHISTOCHEMISTRY FOR MOUSE EAR SWELLING TEST
- Lee, Jong-Kwon (National Institute of Toxicological Research, KFDA) ;
-
Park, Jae-Hyun
(National Institute of Toxicological Research, KFDA)
;
- Kim, Hyung-Soo (National Institute of Toxicological Research, KFDA) ;
- Jung, Seung-Tae (National Institute of Toxicological Research, KFDA)
- Published : 2002.05.01
Abstract
A mouse ear swelling test (MEST) has been developed as an alternative to guinea pig models for contact sensitization potential. However, the MEST relies on a quantitative measurement of ear swelling as an endpoint by micrometer. In this study, we aimed to investigate the cell proliferation in ear and lymph node using Bromodeoxyuridine (BrdU) immunohistochemistry as a possible reliable marker for MEST.(omitted)