• International conference on construction engineering and project management
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• 2005.10a
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• pp.830-835
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• 2005

4D models help construction planners to develop and evaluate construction plans. However, current analyses using 4D models are mainly visual and limit the quantitative comparison of construction alternatives. This paper explores the usefulness of extracting quantitative information from 4D models to support time-space analyses. We use two 4D models of an industry test case to illustrate how to analyze 4D content quantitatively (i.e., work space areas and distances between concurrent activities). This paper shows how these two types of 4D content can be extracted from 4D models to support 4D-based-analysis and novel presentation of construction planning information. We suggest further research to formalize the content of 4D models to enable comparative quantitative analyses of construction planning alternatives. Formalized 4D content will enable the development of reasoning mechanisms that automate 4D-model-based analyses and provide the information content for informative presentations of construction planning information.

• Journal of Forest and Environmental Science
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• v.39 no.3
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• pp.119-127
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• 2023

In this study, quantitative models were applied to case parks to estimate the carbon reduction by trees, which was compared and analyzed at the tree and park levels. At the tree level, quantitative models of carbon storage and uptake differed by up to 7.9 times, even for the same species and size. At the park level, the carbon reduction from quantitative models varied by up to 3.7 times for the same park. In other words, carbon reduction by quantitative models exhibited considerable variation at the tree and park levels. These differences are likely due to the use of different growth environment coefficients and annual diameter at breast height growth rates and the overestimation of carbon reduction due to the substitution of the same genus and group model for each tree species. Extending the annual carbon uptake per unit area of the case park to the total park area of Chuncheon a carbon uptake ranging from a minimum of 370.4 t/yr and a maximum of 929.3 t/yr, and the difference can reach up to 558.9 t/yr. This is equivalent to the carbon emissions from the annual household electricity consumption of approximately 2,430 people. These results suggest that the indiscriminate application of quantitative models to estimate carbon reduction in urban trees can lead to significant errors and deviations in estimating carbon storage and uptake in urban greenspaces. The findings of this study can serve as a basis for estimating carbon reduction in urban greening research, projects, and policies.

• Molecules and Cells
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• v.45 no.7
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• pp.444-453
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• 2022

Multivalent macromolecular interactions underlie dynamic regulation of diverse biological processes in ever-changing cellular states. These interactions often involve binding of multiple proteins to a linear lattice including intrinsically disordered proteins and the chromosomal DNA with many repeating recognition motifs. Quantitative understanding of such multivalent interactions on a linear lattice is crucial for exploring their unique regulatory potentials in the cellular processes. In this review, the distinctive molecular features of the linear lattice system are first discussed with a particular focus on the overlapping nature of potential protein binding sites within a lattice. Then, we introduce two general quantitative frameworks, combinatorial and conditional probability models, dealing with the overlap problem and relating the binding parameters to the experimentally measurable properties of the linear lattice-protein interactions. To this end, we present two specific examples where the quantitative models have been applied and further extended to provide biological insights into specific cellular processes. In the first case, the conditional probability model was extended to highlight the significant impact of nonspecific binding of transcription factors to the chromosomal DNA on gene-specific transcriptional activities. The second case presents the recently developed combinatorial models to unravel the complex organization of target protein binding sites within an intrinsically disordered region (IDR) of a nucleoporin. In particular, these models have suggested a unique function of IDRs as a molecular switch coupling distinct cellular processes. The quantitative models reviewed here are envisioned to further advance for dissection and functional studies of more complex systems including phase-separated biomolecular condensates.

• Bulletin of the Korean Chemical Society
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• v.33 no.5
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• pp.1527-1535
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• 2012

Selection of the most informative molecular descriptors from the original data set is a key step for development of quantitative structure activity/property relationship models. Recently, mutual information (MI) has gained increasing attention in feature selection problems. This paper presents an effective mutual information-based feature selection approach, named mutual information maximization by replacing collinear variables (MIMRCV), for nonlinear quantitative structure-property relationship models. The proposed variable selection method was applied to three different QSPR datasets, soil degradation half-life of 47 organophosphorus pesticides, GC-MS retention times of 85 volatile organic compounds, and water-to-micellar cetyltrimethylammonium bromide partition coefficients of 62 organic compounds.The obtained results revealed that using MIMRCV as feature selection method improves the predictive quality of the developed models compared to conventional MI based variable selection algorithms.

• Structural Monitoring and Maintenance
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• v.10 no.2
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• pp.175-190
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• 2023

This article aims to quantitatively predict the snowmelt in extreme cold regions, considering a combination of grayscale and neural models. The traditional non-equidistant GM(1,1) prediction model is optimized by adjusting the time-distance weight matrix, optimizing the background value of the differential equation and optimizing the initial value of the model, and using the BP neural network for the first. The adjusted ice forecast model has an accuracy of 0.984 and posterior variance and the average forecast error value is 1.46%. Compared with the GM(1,1) and BP network models, the accuracy of the prediction results has been significantly improved, and the quantitative prediction of the ice sheet is more accurate. The monitoring and maintenance of the structure by quantitative prediction model by gray models was clearly demonstrated in the model.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.32 no.1
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• pp.117-129
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• 2009

The bullwhip effect is known as the significant factor which causes unnecessary inventory, lost sales or cost increase in supply chains. Therefore, the causes of the bullwhip effect must be examined and removed. In this paper, we develop two analytical tools for the bullwhip effect control in supply chains. First, we develop the quantitative models for computing the bullwhip effect in a three-stage supply chain consisted of a single retailer, a single distributor and a single manufacturer when the fixed-interval replenishment policy is applied at each stage. The quantitative models are developed under the different conditions for the demand forecasting and share of customer demand information. They are validated through the computational experiments. Second, we develop a simulation-based decision support system for the bullwhip effect control in a more diverse dynamic supply chain environment. The system includes a what-if analysis function to examine the effects of varying input parameters such as operating policies and costs on the bullwhip effect.

• Journal of the Korean Chemical Society
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• v.58 no.6
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• pp.543-552
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• 2014

A quantitative structure activity relationship (QSAR) study is performed for modeling and prediction of oral bioavailabilities of 216 diverse set of drugs. After calculation and screening of molecular descriptors, linear and nonlinear models were developed by using multiple linear regression (MLR), artificial neural network (ANN), support vector machine (SVM) and random forest (RF) techniques. Comparison between statistical parameters of these models indicates the suitability of SVM over other models. The root mean square errors of SVM model were 5.933 and 4.934 for training and test sets, respectively. Robustness and reliability of the developed SVM model was evaluated by performing of leave many out cross validation test, which produces the statistic of $Q^2_{SVM}=0.603$ and SPRESS = 7.902. Moreover, the chemical applicability domains of model were determined via leverage approach. The results of this study revealed the applicability of QSAR approach by using SVM in prediction of oral bioavailability of drugs.

• 대한예방의학회:학술대회논문집
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• 1994.02a
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• pp.469-475
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• 1994

This paper presents a brief survey of current methodology available for quantitative risk assessment of environmental carcinogens. Four current models for low-dose extrapolation are reviewed. Current problems and controversies and possible options in doing quantitative risk assessments based on chronic animal studies are discussed.

• Environmental Analysis Health and Toxicology
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• v.30 no.sup
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• pp.7.1-7.10
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• 2015

Objectives For successful adoption of legislation controlling registration and assessment of chemical substances, it is important to obtain sufficient toxicological experimental evidence and other related information. It is also essential to obtain a sufficient number of predicted risk and toxicity results. Particularly, methods used in predicting toxicities of chemical substances during acquisition of required data, ultimately become an economic method for future dealings with new substances. Although the need for such methods is gradually increasing, the-required information about reliability and applicability range has not been systematically provided. Methods There are various representative environmental and human toxicity models based on quantitative structure-activity relationships (QSAR). Here, we secured the 10 representative QSAR-based prediction models and its information that can make predictions about substances that are expected to be regulated. We used models that predict and confirm usability of the information expected to be collected and submitted according to the legislation. After collecting and evaluating each predictive model and relevant data, we prepared methods quantifying the scientific validity and reliability, which are essential conditions for using predictive models. Results We calculated predicted values for the models. Furthermore, we deduced and compared adequacies of the models using the Alternative non-testing method assessed for Registration, Evaluation, Authorization, and Restriction of Chemicals Substances scoring system, and deduced the applicability domains for each model. Additionally, we calculated and compared inclusion rates of substances expected to be regulated, to confirm the applicability. Conclusions We evaluated and compared the data, adequacy, and applicability of our selected QSAR-based toxicity prediction models, and included them in a database. Based on this data, we aimed to construct a system that can be used with predicted toxicity results. Furthermore, by presenting the suitability of individual predicted results, we aimed to provide a foundation that could be used in actual assessments and regulations.

• Proceedings of the Korea Concrete Institute Conference
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• 1999.04a
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• pp.123-128
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• 1999

Recently, as a performance based design concept is introduced, assurance of expected performances on serviceability and safety in the whole span of life is exactly requested. So, quantitative assessments about durability related properties of concrete in early-age long term are come to necessary, Especially in early age, deterioration which affects long-term durability performance can be occurred by hydration heat and shrinkage, so development of reasonable hydration heat model which can simulate early age behavior is necessary. The micor-pore structure formation property also affects shrinkage behavior in early age and carbonations and chloride ion penetration characteristic in long term, So, for the quantitative assessment on durability performance of concrete, modelings of early age concrete based on hydration process and micor-pore structure formation characteristics are important. In this paper, a micromechanics based hydration heat evolution model is adopted and a quantitative model which can simulate micro-pore structure development is also verified with experimental results. The models can be used effectively to simulate the early-age behavior of concrete composed of different mix proportions.