• 한국독성학회:학술대회논문집
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• 한국독성학회 2002년도 Current Trends in Toxicological Sciences
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• pp.97-97
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• 2002

A mouse ear swelling test (MEST) has been developed as an alternative to guinea pig models for contact sensitization potential. However, the MEST relies on a quantitative measurement of ear swelling as an endpoint by micrometer. In this study, we aimed to investigate the cell proliferation in ear and lymph node using Bromodeoxyuridine (BrdU) immunohistochemistry as a possible reliable marker for MEST.(omitted)

• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 2001년도 봄 학술발표회 논문집
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• pp.241-247
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• 2001

A Fire Safety Evaluation Module(FSEM), which quantitatively evaluates the risk of evacuees when fire occurs in buildings or ships, is presented in this paper. The developed FSEM can be applied to multi-room structure. Basic input data for the FSEM are prepared by fire model and evacuation model. CFAST which is one of the existing fire models is used as fire model and MonteDEM evacuation model was developed for evacuation model, respectively. MonteDEM evacuation model makes use of distinct element method and Monte-Carlo simulation, and it can also take into consideration ground inclination by ship motions in order to simulate the real situation of evacuation. Some typical situations are modelled for illustrative examples and quantitative assessment of evacuee's risk under fire accident is carried out.

• 항공우주시스템공학회지
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• 제6권2호
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• pp.23-27
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• 2012

The evaluation of simulation models against ADS-33 quantitative rotorcraft handling qualities metrics has, in the past, been a time consuming effort, involving many individual analyses in both the time and frequency domains. Manual tuning of control system parameters to meet handling qualities and performance specifications has been cumbersome and complicated. Performing rigorous trade-off studies for numerous variations in the control system is too time consuming to be practicable. With the complex interaction of time- and frequency based specifications for the closed- and broken-loop responses, it is difficult to know if the design makes the most effective use of the available control power. The Control Designer's Unified Interface (CONDUIT) software makes possible rapid optimization and trade-offs of design configurations against handling qualities specifications.

• 한국문헌정보학회지
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• 제8권
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• pp.183-207
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• 1981

Library standards have been the source of considerable controversy, whereas many problems are involved in developing stardard for university library collections. For evaluation purposes, standards should be precise, quantifiable and measurable. In the United States, however, standards for academic libraries are limited to qualitative statements and principles. Quantitative standards, when given, are ususally related to the number of population in the institution being served, or the prescribed quantitative objectives are often arbitrarily formulated by value judgements. The study in this paper attempts to explain the problems involved in developing quantitative standard for academic library collections. Two problems facing in the formulation of the optimal size of collection are identified. One is the theoretically faulty concept of adequacy of collection to meet the situations of diversity of university libraies, and the other is the difficulties in quantification and measurement, along with the lack of concept of adequacy of collection. However, quantification of adequate size of collection is proved to be useful on the pratical level, even though not valid theoretically. ACRL, Clapp/Jordan and Voigt developed formulas or models for setting the optimal size of a library collection for any particular university library. The main purpose of this study is the analysis of the above formulas. ACRL standard was drawn from obervation and analysis of statistcs in leading library collections. In academic field, this judgement appears to have been based on the assumption that a high-grade institution would be apt to have a good library collection. This study criticizes ACRL standard for its failure to include some determinants of measurements, and points out the limitations of the standard. In contrast. Clapp/Jordan developed a formula rather scientifically based upon bibliographical sources. This is similarly empirical but has the advantage of bringing into play the elements which make universities diverse in nature. Both ACRL and Clapp/Jordan formulas share two major defects. (1) the specific subject needs of the collection are not indiacted directly, and (2) percentage rate of growth is an indicator in measuring the potential utility of a collection. Thus both formulas failed to provide a basis for meaningful evaluation. Voigt further developed a model for determining acquisition rates for currently published materials based on bibliographic technique. Voigt model encourages experimentation with different programs and different allocations of input resources, designed to meet the needs of the library's particular population. Standard for university library collections can be formulated in terms of input(traditional indicator), or additionally, in terms of output(cost-effectiveness). Cost effectiveness is expressed as user satisfaction, ability to provide wanted materials within a reasonable time period. Thus simple quantitative method does not cover all the situations of diversity of university library collections, nor measures the effectiveness of collections. Valid standard could not be established without further research.

• KIEAE Journal
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• 제13권6호
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• pp.83-91
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• 2013

Cool roofs are currently being emerged as one of important mechanism to save energy in relation to the building. It is specifically proposed that the changing trends of rooftop surface temperature in the flat roof building model could be used effectively as an indicator to reduced cooling load reduced by cool roof since it can present stable temperature record, that is not influenced according to the nearby physical as well as human variables. The temperature of cool roof in summer was lower around $20^{\circ}C$, compared to the general roofs. Such a seasonal or daily comparative study for rooftop temperature in the building model will highlight that the cool roof efficiency could be calculated in much area-wide context according to rooftop color distribution in urban residential area. It is anticipated that this research output could be used as a valuable reference in identifying energy saving by cool roof since an objective monitoring has been proposed based on the rooftop temperature in the building model, fully quantitative performance of thermal infrared image.

• Bulletin of the Korean Chemical Society
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• 제31권11호
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• pp.3297-3300
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• 2010

In this study, the 3D-QSARs (three-dimensional quantitative structure-activity relationships: CoMFA and CoMSIA) between structural changes of N-phenyl-O-phenylthionocarbamate analogues (1-30) and their fungicidal activities against the capsicum phytophthora (Phyophthora capsici) fungi were analyzed, then considered quantitatively in terms of minimum structural requirements for fungicidal evaluation. The statistical qualities ($r^2_{cv.}$ = 0.510 and $r^2_{ncv.}$ = 0.948) of the optimal CoMFA 1 model are improved over the other models in the conditions of field combinations, and the two alignments. In the optimal CoMFA 1 model, relative contribution percentages of the CoMFA field were: steric field, 52.3%; electrostatic field, 37.8%; hydrophobic field, 9.9%. Results were similar for the CoMFA 2 model. Therefore, the steric field of the analogues had the highest contribution ratio for fungicidal activity. Specifically, with the contour map of steric fields, the fungicidal activity increased when bulky steric Y-substituents were introduced to the meta-position on the N-phenyl ring and small steric Y-subsituents were introduced to its para-position.

• Nuclear Engineering and Technology
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• 제46권1호
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• pp.73-80
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• 2014

A concrete cask is an option for spent nuclear fuel interim storage. A concrete cask usually consists of a metallic canister which confines the spent nuclear fuel assemblies and a concrete overpack. When the overpack undergoes a missile impact, which might be caused by a tornado or an aircraft crash, it should sustain an acceptable level of structural integrity so that its radiation shielding capability and the retrievability of the canister are maintained. A missile impact against a concrete overpack produces two damage modes, local damage and global damage. In conventional approaches [1], those two damage modes are decoupled and evaluated separately. The local damage of concrete is usually evaluated by empirical formulas, while the global damage is evaluated by finite element analysis. However, this decoupled approach may lead to a very conservative estimation of both damages. In this research, finite element analysis with material failure models and element erosion is applied to the evaluation of local and global damage of concrete overpacks under high speed missile impacts. Two types of concrete overpacks with different configurations are considered. The numerical simulation results are compared with test results, and it is shown that the finite element analysis predicts both local and global damage qualitatively well, but the quantitative accuracy of the results are highly dependent on the fine-tuning of material and failure parameters.

• The Korean Journal of Physiology and Pharmacology
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• 제25권6호
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• pp.545-553
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• 2021

Fixed-dose combinations development requires pharmacokinetic drugdrug interaction (DDI) studies between active ingredients. For some drugs, pharmacokinetic properties such as long half-life or delayed distribution, make it difficult to conduct such clinical trials and to estimate the exact magnitude of DDI. In this study, the conventional (non-compartmental analysis and bioequivalence [BE]) and model-based analyses were compared for their performance to evaluate DDI using amlodipine as an example. Raw data without DDI or simulated data using pharmacokinetic models were compared to the data obtained after concomitant administration. Regardless of the methodology, all the results fell within the classical BE limit. It was shown that the model-based approach may be valid as the conventional approach and reduce the possibility of DDI overestimation. Several advantages (i.e., quantitative changes in parameters and precision of confidence interval) of the model-based approach were demonstrated, and possible application methods were proposed. Therefore, it is expected that the model-based analysis is appropriately utilized according to the situation and purpose.

• Smart Structures and Systems
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• 제30권3호
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• pp.287-301
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• 2022

The machine-vision based structural displacement measurement methods are widely used due to its flexible deployment and non-contact measurement characteristics. The accuracy of vision measurement is directly related to the image resolution. In the field of computer vision, super-resolution reconstruction is an emerging method to improve image resolution. Particularly, the deep-learning based image super-resolution methods have shown great potential for improving image resolution and thus the machine-vision based measurement. In this article, we firstly review the latest progress of several deep learning based super-resolution models, together with the public benchmark datasets and the performance evaluation index. Secondly, we construct a binocular visual measurement platform to measure the distances of the adjacent corners on a chessboard that is universally used as a target when measuring the structure displacement via machine-vision based approaches. And then, several typical deep learning based super resolution algorithms are employed to improve the visual measurement performance. Experimental results show that super-resolution reconstruction technology can improve the accuracy of distance measurement of adjacent corners. According to the experimental results, one can find that the measurement accuracy improvement of the super resolution algorithms is not consistent with the existing quantitative performance evaluation index. Lastly, the current challenges and future trends of super resolution algorithms for visual measurement applications are pointed out.

• 응용통계연구
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• 제30권6호
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• pp.901-916
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• 2017

최근 4차 산업으로의 산업 패러다임의 변화가 이미 시작되었으며, 이러한 4차 산업 시대에 무형 지식재산인 특허의 중요성은 날로 증대되고 있다. 특허의 기술가치평가는 전문가의 의견에 따라서 산정되기 때문에 많은 비용과 시간이 소모되므로 비전문가들의 주관적인 의견에 기인하여 특허의 질적 수준을 판단하게 된다. 따라서 특허의 질적 수준에 대한 객관적이고 합리적인 평가 체계 개발이 필요하다. 본 논문에서는 특허의 가치평가를 기술성, 권리성, 활용성으로 구분하고 베이지안 구조방정식을 사용하여 특허의 정량화되고 객관적인 평가 모델링에 대해 고려하였다. 특히, 한국발명진흥회에서 수집한 자료를 토대로, 직접적으로 측정되기 어려운 질적 성과들을 모형화하고 평가하는데 탁월한 구조방정식과 사전 정보를 활용함으로써 작은 표본 하에서도 안정적인 모형화가 가능한 베이지안 접근법을 함께 적용하여 특허 평가 모형을 개발하였다.