• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2008년도 춘계 학술발표회 제20권1호
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• pp.473-476
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• 2008

순환잔골재를 구조체용 콘크리트의 잔골재로 이용하는 것은 아직까지 품질관리 및 불확실한 내구성 등으로 활성화가 어려운 실정이다. 따라서 구조체용 보다는 2차제품 분야에서의 순환잔골재의 재활용성을 기대해 볼 수 있는데, 특히 미장용 모르터의 경우, 입도 및 흡수율 등의 요구성능을 만족한다면 일반 잔골재의 대체재로써 순환잔골재를 사용 가능할 것으로 판단된다. 이에 본 연구에서는 미장용 모르터의 일반 잔골재를 순환잔골재의 대체율에 따른 특성을 검토하기위해, 플로우, 공기량, 단위용적중량, 부착강도, 압축강도 실험을 실시하였다. 실험결과, 순환골재 대체율에 따른 플로우 및 공기량은 감소하는 결과를 보였으며, 단위용적중량 및 압축강도는 순환골재 대체율이 증가함에 따라 각각 단위용 적중량과 압축강도가 증가하는 결과를 나타냈다. 따라서 본 실험결과 순환잔골재를 미장용 모르터의 일반잔골재 대체재로써 적용이 가능한 것으로 나타났다.

• 약학회지
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• 제56권4호
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• pp.211-216
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• 2012

Drug dissolution test has been used for the purpose of both quality control of solid oral dosage forms and predicting in vivo drug release profiles. In this study, the dissolution profiles of buflomedil hydrochloride tablets and ticlopidine hydrochloride tablets were investigated according to the "Guidelines on Specifications of Dissolution tests for Oral dosage forms" of Korean Pharmacopoeia (KP). The analytical method using HPLC was validated. The validation was performed in terms of specificity, linearity, accuracy, precision and limit of quantitation.

• 한국철도학회논문집
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• 제18권1호
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• pp.33-42
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• 2015

궤도 안전을 위한 핵심 용품인 레일체결장치의 구성품 중 레일패드 또는 베이스플레이트 패드의 정적 수직강성은 궤도 전체의 강성 결정 시 중요 인자이며, 패드 제품의 제조과정에서 품질관리 기준이 된다. 패드의 정적 수직강성 확인은 시험을 통해 가능하며, 시험방법으로는 철도분야에 널리 사용되고 있는 EN 13146-9 및 이를 부합화한 KRS TR 0014 규격이 있다. 본 논문에서는 상기 규격의 정적 수직강성 시험방법 중 예비하중 단계, 하중 제거 수준 및 하중 유지시간 관련 문제점 개선을 위해, 패드 관련 국내외 시험규격을 분석한 후 시험방법 안을 제시하였고, 철도현장에 사용되고 있는 패드 4종을 이용하여 시험방법 안을 적용한 정적 수직강성 시험을 수행하였다. 또한 시험방법 안의 적합성을 판단하기 위하여 시험결과에 대한 유효성 평가를 수행하였다.

• 대한기계학회논문집A
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• 제36권9호
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• pp.979-984
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• 2012

Antiroll-bar Assembly는 철도 차량의 롤링을 제어하도록 설계된 정밀 부품이고 안전과 편안한 승차감을 위해 중요하다. Antiroll-bar Assembly의 주부품인 토션바는 소모품으로써 프랑스에서 전량 수입되고 있다. 따라서 비용절감과 성능향상을 위해 국내 환경에 적합한 토션바 국산화 개발이 필요하다. 본 연구에서는 국내 철도에서 측정된 로드 히스토그램을 활용하여 개발된 토션바에 대한 해석 및 시험을 진행하였고, 수입품과의 비교 시험 결과 만족할만한 결과를 얻었다. 또한 토션바의 부식현상을 방지하기 위해서 스테인리스강 소재의 Ring cover를 씌울 수 있도록 설계를 변경하였다. 변경된 설계 안전성은 CAE해석과 마모시험을 통해서 검증하였다. 이 결과 설계변경에 의한 정적 및 피로에 대한 안전성은 큰 차이가 없었다. 그리고 2종류의 스테인리스강 중에서 내마모성이 우수한 소재를 채택하였다.

• Journal of Korean Medical Science
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• 제33권51호
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• pp.340.1-340.14
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• 2018

Background: Various pneumococcal vaccines have been evaluated for immunogenicity by opsonophagocytic assay (OPA). A multiplexed OPA (MOPA) for 13 pneumococcal serotypes was developed by Nahm and Burton, and expanded to 26 serotypes in 2012. The development of new conjugate vaccines with increased valence has necessitated expanded MOPAs to include these additional serotypes. In this study, we validated this expanded MOPA platform and applied to measure antibodies against 11 additional serotypes (2, 8, 9N, 10A, 11A, 12F, 15B, 17F, 20B, 22F, and 33F) in human sera. Methods: All materials, including serum, complement, bacterial master stocks, and HL-60 cells, were evaluated for assay optimization. Following optimization, the assay was validated for accuracy, specificity, and intra- and inter-assay precision with sera from adult donors following standard protocols. The assay was applied to evaluate functional antibodies of 42 sera immunized with 23-valent pneumococcal polysaccharide vaccine (PPV23). Results: The expanded MOPA platform was specific for all serotypes, with the exception of serotype 20. The assay results were highly correlated with those obtained from single-serotype OPA, indicating acceptable accuracy. The coefficients of variation were 7%-24% and 13%-39% in tests of intra- and inter-assay precision, respectively, using three quality-control samples. A MOPA that included 11 additional serotypes in the PPV23 was established and validated with respect to accuracy, specificity, and precision. The opsonic indices of immune sera were obtained using this validated assay. Conclusion: The expanded MOPA will be useful for evaluation of the immunogenicity of PPV23 and future conjugate vaccine formulations.

• 설비공학논문집
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• 제17권6호
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• pp.505-513
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• 2005

We measured the time-dependent concentration of VOCs emitted from Ondol floor, furniture, and the wall made of various building materials. After obtaining results from the previous measurement, we developed the estimation equations of the concentration decay, and obtained the estimated graphs for the concentration decay under different air change rates and loading factor conditions by using the estimated equations. We conducted our tests by applying our measurements to real residences for 110 days in the case of furniture and for 40 days in the case of the floor. We also conducted experiments in the cases of various wall materials for 7 days which totaled 10 times. We used the GC/FID for experiments for real residences accord-ing to the specified procedures of the NIOSH 1501, and carried out experiments for wall materials according to the specified procedures of the ASTM 5116-97. When conducting experiments for wall materials, we set the temperature and relative humidity at $23^{\circ}C$ and $50\%$, respectively. We also set the air change rate and loading factor at 0.7/h and $1.617 m^2/m^3$, respectively. Our results showed that it is possible to predict proplrly the time-dependent concentration decay of VOCs by using logarithmic functions in both cases of experiments for real residences and for wall materials. Furthermore, we found that the concentration decay rate of VOCs increased rapidly as the air exchange rate increased while the concentration decay rate decreased as the loading factor increased.

• 대한건축학회논문집:구조계
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• 제33권12호
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• pp.45-52
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• 2017

The precast concrete (PC) method has many advantages in fast construction, quality control, etc. In domestic construction market, however, its application has been quite limited because of the concerns about structural integrity and seismic performances due to the discrete connections between precast concrete members. By applying the post-tensioning method, the precast beam-column connection can be well tightened, allowing improved structural integrity, and proper seismic performances can be also achieved. In this study, reversed cyclic tests have been conducted on the beam-column connection specimens, where the test variables included the compressive strength of grouting mortar and the tensile strengths of prestressing strands, based on which their seismic performances have been examined in detail. The post-tensioned PC beam-column connections showed good seismic performances comparable to that of the monolithic reinforced concrete connection specimen. When 2400 MPa prestressing strands are applied to the beam-column connection, it is preferable to adjust the prestress level similar to that applied for the 1860 MPa prestressing strands to avoid premature local crushing failures at the beam-column connections.

• Animal Bioscience
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• 제36권1호
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• pp.19-28
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• 2023

Objective: The objective of this study was to perform genome (genome wide association studies [GWAS]) and chromosome (CWAS) wide association analyses to identify single nucleotide polymorphisms (SNPs) associated with growth traits in registered Simmental and Simbrah cattle. Methods: The phenotypes were deregressed BLUP EBVs for birth weight, weaning weight direct, weaning weight maternal, and yearling weight. The genotyping was performed with the GGP Bovine 150k chip. After the quality control analysis, 105,129 autosomal SNP from 967 animals (473 Simmental and 494 Simbrah) were used to carry out genotype association tests. The two association analyses were performed per breed and using combined information of the two breeds. The SNP associated with growth traits were mapped to their corresponding genes at 100 kb on either side. Results: A difference in magnitude of posterior probabilities was found across breeds between genome and chromosome wide association analyses. A total of 110, 143, and 302 SNP were associated with GWAS and CWAS for growth traits in the Simmental-, Simbrah- and joint -data analyses, respectively. It stands out from the enrichment analysis of the pathways for RNA polymerase (POLR2G, POLR3E) and GABAergic synapse (GABRR1, GABRR3) for Simmental cattle and p53 signaling pathway (BID, SERPINB5) for Simbrah cattle. Conclusion: Only 6,265% of the markers associated with growth traits were found using CWAS and GWAS. The associated markers using the CWAS analysis, which were not associated using the GWAS, represents information that due to the model and priors was not associated with the traits.

• Clinical and Experimental Pediatrics
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• 제65권2호
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• pp.85-89
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• 2022

Background: There is evidence of a relationship between prenatal excess androgen exposure and central nervous developmental problems and attention-deficit/hyperactivity disorder (ADHD) in the offspring of mothers with polycystic ovary syndrome (PCOS). Purpose: Here we aimed to use a meta-analysis to investigate whether the offspring of mothers with PCOS are at an increased chance of developing ADHD. Methods: Three main English databases were searched for articles published through December 2020. The Newcastle-Ottawa Scale was used to assess study quality. Study heterogeneity was determined using I² statistics and publication bias was assessed using Begg and Egger tests. The results are presented as odds ratio (OR) and relative ratio (RR) estimates with 95% confidence intervals (CIs) using a random-effects model. Results: Six articles (3 cohort and 3 case-control studies; 401,413 total ADHD cases) met the study criteria. Maternal PCOS was associated with an increased risk of ADHD in the offspring based on OR and RR (OR, 1.42; 95% CI, 1.27-1.57) and (RR, 1.43; 95% CI, 1.35-1.51), respectively. There was no heterogeneity among the included articles based on OR (I²=0.0%, P=0.588) and RR (I²=0.0%, P=0.878). Conclusion: Our study showed that maternal PCOS is a risk factor for ADHD. Therefore, screening their offspring for ADHD should be considered part of the comprehensive clinical care of women with PCOS.

• 대한토목학회논문집
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• 제29권1A호
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• pp.101-108
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• 2009

급속 포장 콘크리트는 타설 직후 공기 중에 노출되어 물리적, 화학적 영향을 많이 받아 유해물질들의 콘크리트 구조물 내부로 침투하여 사용연한이 감소하게 된다. 이와 같이 콘크리트 투과 특성은 내구성능을 결정하는데 중요한 요소이다. 또한 조강시멘트와 조강제의 성능으로 인하여 급격한 수화반응으로 인한 수화열로 열과 수분의 이동이 증가하여 구조물에 인장응력을 발생시켜 미소균열을 발생시킨다. 본 연구에서는 대단면 포장체의 급속 시공용으로 도출된 배합을 바탕으로 물투수시험, 동결융해반복시험, 마모저항성시험, 표면박리시험 및 소성수축, 건조수축, 자기수축 등의 시험을 실시하였다. 시험결과 조강제 및 섬유를 혼입한 배합이 가장 우수한 결과를 보여주었다.