• 분석과학
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• 제13권1호
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• pp.121-126
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• 2000

이 연구의 목적은, 톨루엔에 노출된 근로자의 생물학적모니터링에 있어 혼재하는 유기산의 종류와 분석방법에 따른 요중 마뇨산 분석값을 비교하여, 다른 유기산이 혼재할 경우 UV법으로 분석했을 때 일어날수 있는 방해효과를 측정하는데 있다. 마뇨산만 포함된 소변 표준시료와 마뇨산, 메틸마뇨산, 페닐글리옥실산, 만델산 등 각각 다른 유기용제의 대사물이 포함된 소변 표준시료를 UV법, HPLC법으로 분석하고 유기산의 방해효과(IE; Inteference Efect)를 계산하였다. 또한 이들 소변 표준시료에 대해 전국 100개 검진기관을 대상으로 한 외부정도관리 결과, 참가기관들이 사용한 분석방법에 따른 요중 마뇨산 분석값을 비교하였다. 톨루엔과 크실렌에 노출된 근로자의 소변을 UV법으로 분석할 경우 크실렌 대사물인 메틸마뇨산은 마뇨산 분석값에 영향을 주어, 마뇨산 농도 0.33 g/L에서 0.5-2.0 g/L의 농도로 공존시 60-82%의 방해 영향을 가진 것으로 나타났다. 그러나 스티렌 대사물인 만델산, 페닐글리옥실산은 마뇨산 분석값에 거의 영향이 없었다. 따라서 톨루엔과 크실렌이 함께 노출되는 경우 소변 모니터링시 UV법을 사용하는 것보다 GC법이나 HPLC법을 사용하는 것이 바람직하다. 특히 특수검진기관의 의무 보유장비인 GC법은 경제적이고 신속하며 정확도가 높은 방법으로 UV법에 대체하여 사용할 수 있는 것으로 나타났다.

• 한국치위생학회지
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• 제8권3호
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• pp.115-126
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• 2008

Purpose : The research which sees width for a wide gain and loss is about brush qualitative management of the child about dental hygiene of the child is investigated the brush qualitative actual condition. Methods : The data which is collected used SPSS(Statistical Package for the Social Science) WIN 11.5 programs and analyzed, a frequency and a percentage with analytical technique, in order to grasp the general quality of the investigation object person produced to examine is about the brush quality control actual condition of the children opinion t-test (verification) frequency analyses and $x^2$(Chi-square) verifications, executed. Result : The followings are the findings of this research. First, the children about the reason which wipes this 83.4% the thing protection dental caries answer back, followed in grade and considers the difference which was visible(p<0.001). Second, wipes whether to experience is educated answer back 83.0% was educated, followed in sex and considers the difference which was visible(p<0.05). Third, when 1 time is brush quality of the children doing, in grade and the time when becomes disturbance was, most between 2~3 minutes followed considers the difference which was visible(p<0.01). Fourth, when 1 time is brush quality of the children doing, in grade and the time when becomes disturbance was, most between 2~3 minutes followed considers the difference which was visible(p<0.01). Fifth, when 1 time is brush quality of the children doing, in grade and the time when becomes disturbance was, most between 2~3 minutes followed considers the difference which was visible(p<0.05, p<.001). Sixth, Use duration of the toothbrush the child of most was 3~6 months, according to grade and sex was visible the difference which considers. Conclusion : Are oral healthily of the children is the knowledge which relates with a brush quality and practical degree important. Therefore this there must be dental health education program development will be able to improve, means must reflect the dental health education at the time of.

• 한국환경복원기술학회지
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• 제20권4호
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• pp.1-13
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• 2017

The purpose of this study is to analyze a term of decade of water quality data of the Mulgum intake station on the Nakdong river(dam) to find the cause of algal blooms and to set an alternative to prevent artificial lake water pollution. Our study shows that water quality changes have regular periodic regularity and there was a certain correlation between specific analytical items. According to the analysis results of each factor, the decline in precipitation was not the main reason for algal blooms. TP concentration had a slight effect on Chl-a concentration but was not a limiting nutrient of a bloom. TN concentration had a strong correlation with Chl-a and strongly negative correlation with temperature, but was not a bloom's limiting nutrient, and was only a dependent variable. As the temperature was negatively correlated with the Chl-a concentration, it is found that the aspect of the ecological influence of the temperature was the most important factor of the phytoplankton concentration change. The N/P ratio lies under a power function with a high degree of reliability by the TP concentration, and the phenomenon appeared to be the same as the results of two other comparative areas. This result confirms that TN is dependent on TP and the biota in the lake that TN is a dependent variable whose concentration is determined by TP it. In conclusion, the increase in lake bloom is the result of a food chain change, and it is necessary to control the ecosystem by the food chain in the lake in order to reduce the lake's bloom. In particular, it is important to keep the benthic ecosystem as wide as possible in the aerobic state.

• 약학회지
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• 제59권3호
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• pp.98-106
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• 2015

Analytical method for related substances can be categorized into two methods depending on the necessity of reference standard (RS). The analytical method of related substances with RS is fast and accurate, but it's very expensive and technically difficult to synthesize RS due to their complicated structure. Another method is using relative retention time (RRT) and relative response factor (RRF) which are already validated with RS. Validation of this method is not easy and time consuming, but once it has been developed, it can save cost and time. In this study, we developed the analytical method for related substances of fenofibrate using RRT and RRF. We validated the method by evaluating specificity, linearity, accuracy and precision according to the "Manual for Guideline Application for Validation of Analytical Procedures" of MFDS. Also, we calculated RRT and RRF between fenofibrate and fenofibrate related substances. The results of this study showed high specificity for fenofibrate and fenofibrate related substances. Correlation coefficient(r) of all substances were more than 0.99, and the recovery of fenofibrate, fenofibrate related substance I, II and III were 99.44%, 100.84%, 99.14% and 101.58%, respectively. Precision of fenofibrate and its related substances were ranged between RSD 0.29% and 0.93%. Quantification limits of fenofibrate, fenofibrate related substance I, II and III were determined to be $0.03{\mu}g/ml$, $0.05{\mu}g/ml$, $0.04{\mu}g/ml$ and $0.02{\mu}g/ml$, respectively by confirming signal to noise ratio of each chromatogram. The RRT for fenofibrate related substance I, II and III were determined to be 0.35, 0.41 and 1.34, respectively. Also, the RRF for fenofibrate related substance I, II and III were determined to be 1.28, 0.98 and 0.79, respectively. The developed method was applied to determine contents for fenofibrate related substances in commercial fenofibrate (active pharmaceutical ingredient). As a result, developed analytical methods of related substances will be used for revising the monograph of fenofibrate in Korean Pharmacopoeia revision and contribute quality control of drugs by improving cost and time consuming problem of RS.

• 분석과학
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• 제35권3호
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• pp.93-115
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• 2022

의약품의 제조, 유통, 보관 과정에서 발생할 수 있는 잠재적 불순물은 의약품의 품질과 안전에 영향을 미치며 반응성이 높은 불순물의 경우 인체에 대한 발암성(변이원성)을 나타내기도 한다. 이를 위해 국제의약품규제조화위원회(International Conference on Harmonisation, ICH)에서는 "잠재적 발암 위해를 제한하기 위한 의약품 중 DNA 반응성(변이원성) 불순물의 평가 및 관리"에 대한 내용을 담은 M7(R1) 가이드라인을 제공하여 채택을 권고하였다. 하지만 가이드라인에서도 잠재적 불순물에 대한 분류, 섭취 허용량, 관리방안 등과 대표적인 불순물 14 종에 대한 가이드라인 적용을 소개하는데 그치고 있어 제약회사와 규제 당국에서 실제 관리를 위한 의약품 중 잠재적 불순물의 분석에 어려움을 겪고 있다. 이에 따라 본 총설에서는 비의도적 변이원성 불순물의 정의와 ICH M7(R1) 가이드라인에 소개된 내용을 간략하게 살펴보는 한편 현재까지 보고된 주요 잠재적 불순물의 분석 동향을 살펴보고자 한다. 이를 통해 식약처를 비롯한 감독 기관과 제약회사 등에서 의약품 중 잠재적 불순물 관리에 조금이나마 도움이 되고자 한다.

• 지능정보연구
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• 제24권1호
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• pp.125-140
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• 2018

품질검사는 중간상품이나 최종상품을 품질관리 표준을 만족하는 양품과 불량품으로 분리하는 일을 수행한다. 대량생산체계에서 품질을 수작업으로 검사하는 것은 일관성과 효율성을 저하시키므로 대량으로 생산되는 상품의 품질을 검사하는 것은 다수의 공정에서 기계에 의한 자동 확인과 분류를 포함하게 된다. 생산공정에서 발생하는 데이터를 활용하여 공정을 개선하고 최적화하려는 선행 연구들이 많았음에도 불구하고, 실시간에 많은 데이터를 처리하는데 있어서의 기술적인 한계로 인해 실제 구현에서의 제약이 많이 있었다. 최근 빅데이터에 관한 연구에서는 데이터 처리기술을 개선하였고, 실시간에 데이터를 수집, 처리, 분석하는 과정을 가능하게 하게 하고 있다. 본 논문에서는 품질검사를 위한 빅데이터 적용의 단계와 세부사항을 제안하고, 유제품 산업에 적용 사례를 제시하려고 한다. 먼저 선행 연구들을 조사하고, 제조 부문에 적용할 수 있는 빅데이터 분석절차를 제안하며 제안된 방법의 실현가능성을 평가하기 위해서, 유제품 산업 분야의 품질검사과정 중 하나에 회선신경망(Convolutional Neural Network) 기술 및 랜덤포레스트(Random Forest) 기술을 적용하였다. 품질검사를 위해 제품의 뚜껑 및 빨대의 사진을 수집, 처리, 분석하여, 결함 여부를 판단하고, 과거 품질 검사결과와 비교하였다. 제안된 방법은 과거에 수행되었던 품질검사에 비해 분류 정확성 측면에서 의미 있는 개선을 확인할 수 있었다. 본 연구를 통해, 유제품 산업의 빅데이터 활용을 통한 품질검사 정확도 개선 가능성을 확인하였다.

• 간호행정학회지
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• 제4권2호
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• pp.307-319
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• 1998

This study is an empirical investigation and study on the measurement of nursing service quality as perceived by patients. A series of H1. H2. H3 alternative hypotheses were tested using a sample of 250 patients in Taegu City. Korea. HI hypothese were tested for application of five component of service quality (SERVQlTAL and SE RPERF : tangiblity. reliability. responsiveness. accessibility. understandability) in Taegu area Hospitals. Validity test - the five components of service quality were rearranged into two components of service quality (personal factor. nonpersonal factor). Although SERVQUAL was verified in USA. application for five components of service quality in Korea indicated that it need more analytical studies. Nobody can deny the fact that the recent growth of the nursing service quality is one of the most important driving forces of hospital management. In many hospitals. the nursing quality charges more than 50% of the medical service quality. As a result. many hospital managers should be enormous interests in the investment potentiality of the nursing service. However. doesn't many researchers invest their time and effort on the research of the quality control in nursing service. Nursing service management is the process to satisfy customer's desires and expectations through the various service activities. Presently nursing service are being faced with three Common tasks of improving quality of nursing service. competitively differential advantage and productivity because of quantitative expansion of Nursing service. Such a phenomenon is also found in our medical service industry. resulting from increasing demands for medical service owing to national medical insurance policy and consumer's attitude change emphasizing prevention of illness. excessiveness of medical facilities in large cities and increasing medical lawsuits due to influence of consumerism. Therefore. under such circumstances. this research on nursing service is conducted from nursing managements to improve the nursing service quality problems faced by medical institutions. The results of this theoretical/empirical research are as follows: 1. Nursing service Quality is regarded as patients' perceived quality and evaluated on the basis (5 dimension) of technical and functional quality. 2. Nursing service Quality is a concept of patients evaluation on the measurable multi-dimensions intrinsic and extrinsic attributes of service. 3. Nursing service Quality is conceptually defined as the difference between the perceived service and the expected service. 4. Korean consumers trend to evaluate nursing service quality based on such dimensions as responsiveness and reliability. understandability. accessibility. tangibility. 5. After analyzing whether or not there are some differences in respective medical institution. it was found that there are significant difference on understandability. reliability. communicability. courtesy. competence. 6. After analyzing the difference between the expected nursing service and the nursing perceived service, it was found that the expected nursing service is higher than the perceived service in every medical institution. 7. HI hypothesis was tested with regard to the validity test between SERVQUAL and SERVPERF in nursing service quality. The result of validity test between SERVQUAL and SERVPERF was found to have differential result. That is the R2 of SERVPERF is higher than that of SERVQUAL. Therefore. HI was verified in nursing management. H2. H3 hypotheses were tested whether or not the nursing service quality and patient satisfaction is the preceding variable. The result of H2 hypothes is that the nursing service quality is the preceding variable of patient satisfaction and the patient satisfaction is that of revisiting intention. After analyzing whether or not there is any differences on the demographic variable of five nursing service quality factor. it was found that there are statistically significant differences on communicability and courtesy at the sex. understand ability. accessibility and tangibility at the age. understandability at the academic background respectively.

• 한국연초학회지
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• 제35권1호
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• pp.1-6
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• 2013

Near InfraRed Spectroscopy(NIRS) is a quick and accurate analytical method to measure multiple components in tobacco manufacturing process. This study was carried out to develop calibration equation of near infrared spectroscopy for the prediction of the amount of chemical components and hot water solubles(HWS) of reconstituted tobacco leaf. Calibration samples of reconstituted tobacco leaf were collected from every lot produced during one year. The calibration equation was formulated as modified partial least square regression method (MPLS) by analyzing laboratory actual values and mathematically pre-treated spectra. The accuracy of the acquired equation was confirmed with the standard error of prediction(SEP) of chemical components in reconstituted tobacco leaf samples, indicated as coefficient of determination($R^2$) and prediction error of sample unacquainted, followed by the verification of model equation of laboratory actual values and these predicted results. As a result of monitoring, the standard error of prediction(SEP) were 0.25 % for total sugar, 0.03 % for nicotine, 0.03 % for chlorine, 0.16 % for nitrate, and 0.38 % for hot water solubles. The coefficient of determination($R^2$) were 0.98 for total sugar, 0.97 for nicotine, 0.96 for chlorine, 0.98 for nitrate and 0.92 for hot water solubles. Therefore, the NIRS calibration equation can be applicable and reliable for determination of chemical components of reconstituted tobacco leaf, and NIRS analytical method could be used as a rapid and accurate quality control method.

• 분석과학
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• 제23권6호
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• pp.607-614
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• 2010

필적을 감정할 경우 음주상태에서 작성된 필적들을 비교해야 하는 어려움에 자주 직면하게 된다. 알콜 섭취에 따른 소뇌 기능 장애로 인하여 가속과 감속, 떨리는 움직임 등의 동작 능력 통제에 장애가 발생하므로 개인 필적에서 상당한 차이가 관찰된다. 음주상태에서 작성된 필적이 기재된 협박메모를 확보하더라도 작성자가 검거된 후 자신이 작성한 것이 아니라고 부인하는 경우 필적감정에 의한 범인 특정이 어렵게 된다. 외국의 많은 연구에서 알콜의 필적에 대한 영향이 다루어지고 있지만 국내에서는 거의 없으며 대부분 통계적 처리 없이 약간 또는 증가와 같이 경험적인 표현에 그치고 있어 통계적인 평가 및 비교가 요구되고 있다. 본 연구에서는 음주에 의한 필적의 변화에 대하여 서명의 길이, 높이와 서명에 포함된 한글 자음 ㄱ, ㄴ을 추출하여 각각의 내각, 외각, 길이비율의 계측값을 통계적 방법을 사용하여 확인하였다.

• 분석과학
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• 제23권2호
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• pp.138-146
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• 2010

환경부에서는 오염물질 다량 방출 건축자재의 효율적인 관리를 위해 다중이용시설 등의 실내 공기질 관리법의 시행 규칙 일부를 개정하였다. 특히 액상건축 자재인 실란트의 경우 시험방법과 초과기준이 함께 개정되어 기존 관리 수준과 개정 관리 수준의 직접적인 비교가 불가능하다. 따라서 이 연구에서는 실란트의 개정 시험방법의 각 요소들이 오염물질 방출강도에 미치는 영향과 타당성을 기존 시험방법에 대비하여 검토하였다. 이를 통하여 개정된 오염물질 방출 관리기준을 평가하였다. 특히 실란트는 제품마다 완전경화에 소요되는 시간의 편차가 커서 시험기간 내에 완전히 경화되지 않는 제품들도 다수 있는 것으로 나타났다. 그래서 경화시간이 빠른 제품들만 대상으로 개정된 시험방법을 적용하여 실험하였다. 그 결과 개정된 실란트의 관리기준은 기존의 관리기준에 비해 2.5 배 이상 약화된 것으로 나타났다. 개정된 실란트의 시험방법을 모든 실란트 제품에 적용하기 위해서는 시험기간을 연장하거나 실란트 시험편을 빨리 경화시킬 수 있는 시험방법으로 개선이 필요하다.