• Journal of the Optical Society of Korea
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• v.17 no.3
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• pp.249-254
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• 2013

In ophthalmology, a pupillometer, a device to measure the diameter of the pupil of the eye, can provide information on the function of the autonomic nervous system. The current pupillometers on the market are either too large to be a handheld instrument, or relatively expensive. In this study, a pupillometer based on a smartphone was designed. Both white and infrared LEDs and a 3M pixel camera of a smartphone were applied for the visual stimuli to an eye and for the acquisition of the eye images, respectively. Contrary to the existing method of pupil measurement that usually observe the variation of pupil diameter, the proposed algorithm in this study was applied to calculate the constriction ratio of the pupillary area in response to pupillary light reflex. The results showed that the constriction ratio of the pupillary area were all in the normal range (above 4.0) from the sixteen healthy participants. It is believed that the approach to pupil measurement used in this study is suitable for a mobile interface, and this system can be applied to clinical research, home-use healthcare, and distributed to some areas which suffer from problems like a lack of medical support.

• Journal of Veterinary Clinics
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• v.32 no.1
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• pp.130-134
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• 2015

A 13-year-old, castrated male Yorkshire terrier was presented with acute blepharospasm 2 months after phacoemulsification with intraocular lens implantation in the left eye. Menace response was weakly positive in the left eye. Intraocular pressure (IOP) was 98 mmHg in the left eye. On ophthalmic examination using slit lamp biomicroscope, episcleral injection and corneal edema were observed in the left eye. Aqueous flare (1+) and iris bombe with peripheral anterior synechia were also detected in the left eye. In spite of medical treatments, IOP was remained more than 50 mmHg. Synechiolysis and radial iridectomy with irrigation/aspiration of anterior chamber were performed in the left eye. One week after the surgery, tissue plasminogen activator was injected to resolve the blood and fibrin clot in the left anterior chamber. Menace response was recovered completely 1 month after the surgery and IOP was maintained less than 20 mmHg more than 6 months.

• Science of Emotion and Sensibility
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• v.21 no.4
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• pp.43-54
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• 2018

The aim of this study is to determine the effect of motion sickness on pupil rhythm. Sixteen volunteers of both genders (8 male, 8 female, mean age $25.67{\pm}2.43$ years) experienced VR contents in both 2D and HMD versions for 15 minutes, and their pupillary rhythms were compared. The irregular pattern of the pupillary rhythms, as demonstrated by increasing mean pupil diameter (mPD) and standard deviation of the pupil diameter (sPD), revealed motion sickness after experiencing HMD condition. The pupillary response is strongly related to the cognitive load, and the motion sickness can be interpreted as a change in the cognitive load caused by the increasing volume of visual information that must be processed and the conflict or inconsistency between different sensory modalities. The method proposed in this study could be a non-contact measurement method for the monitoring of motion sickness using a web-camera rather than previous sensor-based methods.

• The Korean Journal of Physiology and Pharmacology
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• v.12 no.3
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• pp.89-94
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• 2008

In order to reproduce chronic cerebral hypoperfusion as it occurs in human aging and Alzheimer's disease, we introduced permanent, bilateral occlusion of the common carotid arteries (BCCAO) in rats (Farkas et al, 2007). Here, we induced BCCAO in two different rat strains in order to determine whether there was a strain difference in the pathogenic response to BCCAO. Male Wistar and Sprague-Dawley (SD) rats (250-270 g) were subjected to BCCAO for three weeks. Kluver-Barrera and cresyl violet staining were used to evaluate white matter and gray matter damage, respectively. Wistar rats had a considerably higher mortality rate (four of 14 rats) as compared to SD rats (one of 15 rats) following BCCAO. Complete loss of pupillary light reflex occurred in all Wistar rats that survived, but loss of pupillary light reflex did not occur at all in SD rats. Moreover, BCCAO induced marked vacuolation in the optic tract of Wistar rats as compared to SD rats. In contrast, SD rats showed fewer CA1 hippocampal neurons than Wistar rats following BCCAO. These results suggest that the neuropathological process induced by BCCAO takes place in a region-specific pattern that varies according to the strain of rat involved.

• Korean Journal of Veterinary Research
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• v.59 no.2
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• pp.109-111
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• 2019

A 10-year-old intact female Jindo dog was presented with a 1-week history of conjunctival redness and ocular discharge in the left eye. There was an absence of menace response, dazzle reflex, and direct pupillary light reflex. Slit-lamp biomicroscopy revealed corneal edema, ciliary flush, and aqueous flare. Intraocular pressure was 68 mmHg. Based on the information available, a diagnosis of glaucoma and uveitis was made. Subsequent histopathologic examination showed the glaucoma was produced by the effects of goniodysgenesis, posterior synechia, and pigment dispersion in the trabecular meshwork. This is the first report of primary glaucoma caused by goniodysgenesis in Jindo dogs.

• Korean Journal of Veterinary Research
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• v.59 no.2
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• pp.113-117
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• 2019

A 6-year-old intact male Maltese dog presented with a history of blindness and ataxia. Neuro-ophthalmic examination revealed dilated pupils with absent pupillary light reflexes and menace response in both eyes. Mild peripapillary edema was noted in the fundus of the right eye. After magnetic resonance imaging, the dog was provisionally diagnosed with meningoencephalitis of unknown etiology. Follow-up funduscopy was performed to monitor the condition of the optic discs for three years. Despite of the treatment with prednisolone, the optic nerve progressed to atrophy and the dog couldn't restore vision.

• Journal of Veterinary Clinics
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• v.16 no.1
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• pp.203-209
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• 1999

A 4-year-old female Shih-tzu with severe episcleral congestion and buphthalmos in left eye was referred to the Veterinary Teaching Hospital, Chonnam National University in October 1998. During two months in local veterinary clinics, the dog had been treated unsuccessfully with tarsorrhaphy and antibiotics. By history taking, cause of the glaucoma was ascertained as accidental nonpenetrated cornea trauma by owner, Ophthalmic examination revealed that the left eye was buphthalmic with severe episcleral congestion, pain and fever. The direct pupillary light response could not be evaluated in the left eye, but right eye had normal reaction. The intraocular pressure was 4.5 mmHg in the right eye and 33 mmHg in the left eye, as measured with a Schiotz tonometer, Ultrasonographic finding revealed hyperechoic vitrous body and central echofree material. The Schirmer tear test showed 20 mm in the left eye and 8 mm in the right eye. The hematologic examination revealed monocytosis. The initial medical treatment was admitted, but there was no response. Transpalpebral enucleation in the left eye under inhalation anesthesia with enflurane 1.2 vol% in oxygen was performed. The day after operation the left eye ravealed no exudate, and pain, and the systemic vital signs were normal. The prognosis is excellent.

• Journal of Korean Academy of Nursing
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• v.36 no.4
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• pp.621-629
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• 2006

Purpose. The purpose of this study was to identify the clinical variables that predict functional and cognitive recovery at 1- and 6-month in both severe and moderate/mild traumatic brain injury patients. Methods. The subjects of this study were 82 traumatically brain-injured patients who were admitted to a Neurological Intensive Care Unit at a university hospital. Potential prognostic factors included were age, motor and pupillary response, systolic blood pressure, heart rate, and the presence of intracranial hematoma at admission. Results. The significant predictors of functional disability in severe traumatic brain injury subjects were, age, systolic blood pressure, the presence of intracranial hematoma, motor response, and heart rate at admission. In moderate/mild traumatic brain injury patients, motor response, abnormal pupil reflex, and heart rate at admission were identified as significant predictors of functional disability. On the other hand, the significant predictors of cognitive ability for severe traumatic brain injury patients were motor response and the presence of intracranial hematoma at admission, whereas those for moderate/mild patients were motor response, pupil reflex, systolic blood pressure at admission, and age. Conclusions. The results of the present study indicate that the significant predictors of TBI differ according to TBI severity on admission, outcome type, and outcome measurement time. This can be meaningful to critical care nurses for a better understanding on the prediction of brain injury patients. On the other hand, the model used in the present study appeared to produce relatively low explicabilities for functional and cognitive recovery although a direct comparison of our results with those of others is difficult due to differences in outcome definition and validation methods. This implies that other clinical variables should be added to the model used in the present study to increase its predicting power for determining functional and cognitive outcomes.

• Journal of Broadcast Engineering
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• v.25 no.6
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• pp.973-979
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• 2020

This study aims to objectively and quantitatively determine the social emotion of empathy by collecting pupillary response. 52 subjects (26 men and 26 women) voluntarily participated in the experiment. After the measurement of the reference of 30 seconds, the experiment was divided into the task of imitation and spontaneously self-expression. The two subjects were interacted through facial expressions, and the pupil images were recorded. The pupil data was processed through binarization and circular edge detection algorithm, and outlier detection and removal technique was used to reject eye-blinking. The pupil size according to the empathy was confirmed for statistical significance with test of normality and independent sample t-test. Statistical analysis results, the pupil size was significantly different between empathy (M ± SD = 0.050 ± 1.817)) and non-empathy (M ± SD = 1.659 ± 1.514) condition (t(92) = -4.629, p = 0.000). The rule of empathy according to the pupil size was defined through discriminant analysis, and the rule was verified (Estimation accuracy: 75%) new 12 subjects (6 men and 6 women, mean age ± SD = 22.84 ± 1.57 years). The method proposed in this study is non-contact camera technology and is expected to be utilized in various virtual reality with smart glasses.

• Journal of Korean Physical Therapy Science
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• v.9 no.1
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• pp.103-111
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• 2002

The purpose of this study was NIHSS(National Institutes of Health stroke scale) to activities of Daily Living stroke patient. We designed a 17 item neurogic Examination NIHSS use in acute stroke therapy trials. In a study of stroke patient. Assessment were measured by the NIHSS and by the MBI (Modified Barthel Index) to evaluate activities of daily living(ADL). Fifty patients were subject in this study. Collected data analysis were completed by using t-test, ANOVA, correlation analysis and Multiple regression analysis. The following were as follow; Among the test of NIHSS(National Institutes of Health stroke scale) was significantly correlated with changes in MBI(Modified Barthel Index) score in 50 stroke patients. Among the subitems of NIHSS, Pupillary Response, a level of consciousness, best motor arm, best motor leg were the best predictors of functional improvement.