• 한국한의학연구원논문집
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• 제17권3호
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• pp.61-68
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• 2011

Through analyzing the frequencies of medicinal herb combinations in the prescriptions of "Wenbingtiaobian(溫病條辨)", we could understand the characteristics of prescription composition and author's medical thoughts. So we conducted this study that analyze combination of 258 medicinal herbs in 206 prescriptions, and found meaningful combinations of 700. Among these, the most meaningful combinations are the two of 8 herbs. One consists of Glycyrrhiza uralensis Fischer, Platycodon grandiflorum, Lonicera japonica Thunberg, Sojae Semen Praeparatum, Mentha piperascens (Malinv.) Holmes, Forsythia suspensa, Phyllostachys nigra var henonis, Schizonepeta tenuifolia var. japonic, the other consists of Glycyrrhiza uralensis Fischer, Platycodon grandiflorum, Lonicera japonica Thunberg, Mentha piperascens (Malinv.) Holmes, Forsythia suspensa, Arctium lappa, Phyllostachys nigra var henonis, Schizonepeta tenuifolia var. japonica. The former is Yeonkyo-san without Arctium lapp, the letter is Yeonkyo-san without Sojae Semen Praeparatum. It means these combinations are kind of modified Yeonkyo-san which is effective in outthrustting through the exterior with pungent-cool and clearing heat and detoxify. In conclusion, prescriptions of "Wenbingtiaobian(溫病條辨)" involve herbs mostly used to outthrust through the exterior with pungent-cool and clear heat and detoxify. Through this study, we know the author' s one of medical view points on outthrustting through the exterior with pungent-cool and clearing heat and detoxify.

• 보건의료생명과학 논문지
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• 제9권1호
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• pp.141-146
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• 2021

호신용 스프레이의 자극성 액체에 포함된 capsaicin, dihydrocapsaicin 및 nonivamide의 함량을 기체 크로마토그래피로 정량하는 방법에 대해 연구하였다. Capsaicin과 거의 동등한 수준의 매운맛을 내는 nonivamide는 천연물 내에도 극히 소량 존재하므로 합성된 nonvamide를 합성 캡사이신(Synthetic capsaicinoid) 또는 PAVA(Pelargonic Acid Vanillyl Amide)라고 부르며 식품 향미 재료나 폭동진압용 무능화 작용제로 이용되어왔다. 호신용품이 난립하는 요즘 각종 불법 호신용 스프레이의 품질관리가 제대로 이행되지 않는 사례가 종종 발견되고 있다. 따라서 기체크로마토그래피로 합성 캡사이신이 포함된 제품이 천연 유래인 것처럼 도용되거나 허용농도를 준수하는 지를 판별할 수 있는 간단한 분석방법을 개발하고자 하였다. 마지막으로 분석방법이 확립되면 시판되는 호신용 스프레이 내에 존재하는 자극성 액체의 성분과 함량 조사에 응용하여 보았다.

• 산업식품공학
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• 제13권4호
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• pp.360-364
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• 2009

추출방법과 $\beta$-cyclodextrin, soluble starch 및 calcium chloride 혼합용액(MIX) 처리가 양파추출물의 색도에 미치는 영향을 분석한 결과 추출방법에 관계없이 처리구가 대 조구보다 L(명도) 값은 크게 나타났으며 a(적색도)와 b(황색도)는 작은 값을 나타내었다. 갈변도는 100${^{\circ}C}$ 열수추출의 경우 대조구와 처리구의 O.D.값은 각각 0.296 과 0.093 으로서 처리구가 대조구의 약 31%의 O.D.값을 보였다. 열수추출과 초음파추출 모두 대조구가 처리구보다 높은 pyruvic acid 함량을 나타내었다. 관능검사의 갈변정도와 매운맛 강도에서는 대조구가 처리구에 비하여 높은 값을 보였다. 양파추출물의 총균수와 대장균군수는 저장기간이 길어짐에 따라서 계속적으로 증가를 보였고 저장기간 내내 처리구가 대조구보다 매우 적은 수치를 나타내었다.

• 산업식품공학
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• 제14권1호
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• pp.35-40
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• 2010

고춧가루의 매운 맛 등급화 가능성을 검토하고자 mass spectrometer를 바탕으로 한 전자코를 활용하여 순한 맛 고춧가루와 매운 맛 고춧가루의 비율 달리하여 측정하였다. 고춧가루의 질량 스펙트럼을 토대로 판별 함수 분석을 수행한 결과 매운 맛 고춧가루의 비율과 고춧가루의 무게에 따라 판별이 이루어졌으며 DF1의 $R^{2}$는 0.9946, F값은 355.65이고, DF2의 $R^2$는 0.9889, F값은 172.60으로 나타났다. 매운 맛 고춧가루의 비율이 증가할수록 DF1의 양의 방향에서 음의 방향으로 이동되며 막대그래프상의 상대적 비교치와 비례적인 관계를 보여주었다. 한편 같은 비율에서 고춧가루의 무게가 증가할수록 DF2의 음의 방향에서 양의 방향으로 향하는 경향을 보이며 분리되었다. 고춧가루를 각각의 매운 맛 비율별로 2.0 g만을 취하여 분석한 결과, 매운 맛 비율이 증가할수록 DF1의 양의 방향에서 음의 방향으로 이동되는 경향을 보이며 분리가 되었고 DF1의 $R^{2}$는 0.9977, F값은 766.98이고 DF2 의 $R^{2}$는 0.8677, F값은 11.80으로 나타났다. Capsaicin을 무게를 달리하여 측정한 후 DFA를 수행한 결과 DF1의 $R^{2}$는 0.9890, F값은 165.17이고 DF2의 $R^{2}$는 0.9219, F값은 21.64로 나타났다. Capsaicin의 무게가 증가할수록 DF1의 양에 방향에서 음에 방향으로 향하는 경향으로 분리되어 MS를 바탕으로 한 전자코를 이용하여 고추의 매운 맛 등급화가 가능하였다. 전자코에 의한 분석결과는 HPLC에 의한 분석결과와 높은 상관관계를 나타냈다 ($R^{2}$=0.962).

• 한국식품위생안전성학회지
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• 제4권3호
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• pp.191-198
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• 1989

고속 액체크로마토그래피를 이용하여 고추 중의 주요 신미성분인 Capsaicin 및 Dihydrocapsaicin을 분석하기 위한 최적 조건을 검토하고 고추의 품종, 재배지역 및 건조 방법에 따른 함량의 차이를 비교 검토하였다. 시료중의 Capsaicin 및 Dihydrocapsaicin을 70% ethanol, $60^{\circ}C$에서 1시간 동안 처리함으로써 효과적으로 추출할 수 있었으며 재현성 및 회수율시험 결과 분석데이타의 해석은 피이크의 면적을 기준으로 하는 것이 바람직함을 알수 있었다. 고추의 품종, 재배지역 및 건조 방법에 따라 함량의 차이가 큰 것으로 나타났으며 특히 건조방법에 의한 차이가 더욱 현저하여 태양건조의 경우가 기계건조의 경우에 비하여 capsaicin의 경우는 최고 80%, dihydrocapsaicin의 경우는 최고 60% 정도 높게 나타났다.

• 동아시아식생활학회지
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• 제16권3호
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• pp.242-250
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• 2006

The purpose of this study was to identify tourist product factor combinations which confer the highest utility to tourists and to establish the relative importance of factors in terms of their contribution to total utility across gender. Among 250 questionnaires, 230 questionnaires were utilized for the analysis. $X^2$ analysis, Conjoint model, Max. Utility model, BTL model, Logit model, K-means cluster analysis, and one-way anova analysis were used for this study. The findings from this study were as follows. First, the Pearson's R and Kendall's tau statistics showed that the model fitted the data well across gender. Second, it was found that total respondents and three clusters regarded taste price as the very important factor across gender. Third, it was found that the male and female tourists most preferred product with light red color, shaped package, and highly pungent taste sold at a cheap price in factory. Fourth, it was found that the male tourists most preferred simulation product with light red color, shaped package, and highly pungent taste sold at a cheap price in factory. The female tourists most preferred simulation product with light red color, shaped package, and mild taste sold at a cheap price in factory. Finally, the results of the study provide some insights into the types of effective product designs that can be successfully developed by marketers.

• 대한한의학방제학회지
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• 제26권2호
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• pp.123-127
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• 2018

Objective : This research was performed In order to establish the standard of the proper and taste in Korean Medicine. Methods : The change of the proper and taste of Mahwang(麻黃), Gyeji(桂枝), Jagyak(芍藥) and the change of the interpretation of the effect was investigated literally. Results : The hypotheses could be induced as follows. The pungent taste of Mahwang(麻黃) and the sweet taste of Gyeji(桂枝) was inserted by Bonchogyeongso(本草經疏) in Ming Dynasty. In case of Jagyak(芍藥), the proper and taste was changed into sour and cold at Myeonguibyeollok(名醫別錄). It can be proposed that bitter, warm of Mahwang(麻黃), the pungent and warm of Gyeji(桂枝) and the bitter and neutral of Jagyak(芍藥) in Sinnongbonchogyeong(神農本草經) is the adequate proper and taste Conclusions : Therefore it can be hypothesized that the taste and property of Sinnongbonchogyeong(神農本草經) can be established as the standard of the taste and property of Korean Medicine. But in the case of Baekduong(白頭翁), there is the fault of transcribing. So the caution is needed to decide the adequate taste and property.

• 약학회지
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• 제48권5호
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• pp.266-271
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• 2004

Ginger (Zingiber officinale Roscoe) is widely used as a common condiment for a variety of foods and beverages. In addition to its extensive utilization as a spice, the fresh or the processed rhizome is a useful crude drug in traditional Chinese medicine. It is considered to possess stomachic, carminative, stimulant, diuretic and antiemetic properties. Chemical studies on the pungent principles of ginger have been carried out by a number of investigators, and 6-gingerol and 6-shogaol as a major pungent substance have been isolated. In this study, the constituents inhibiting a drug metabolizing enzyme CYP3A4 from ginger were investigated. CYP3A4 is responsible for drug metabolism as heme-containing monooxygenases. As a result of experiment, 10-gingerol (lC$_{50}$ 5.75$\mu$M) isolated from EtOAc extract of ginger showed remarkable inhibitory activity compared to 6-gingerol ($IC_{50}$/ 14.56 $\mu$M) and zingerone ($IC_{50}$/ 379.63 $\mu$M). This paper describes the isolation, structure elucidation, and CYP3A4 inhibitory activity of these compounds. The structure of the compounds were identified by instrumental analysis such as LC-mass spectrometer and NMR.R.

• 대한한의학원전학회지
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• 제32권1호
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• pp.191-204
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• 2019

Objectives : Focusing on Wujutong's critiques for Xiebaisan misuse, this study investigates how Xiebaisan and its constituent drugs have historically been used by medical doctors and analyzes the disputes in the controversial context with a summary. Methods : The contents of Xiebaisan prescription were collected and examined from the past literature and medical database, and the issues related to the debate were examined by analyzing the contents. Results : In the results of exploring the opinions of medical doctors, in general, Xiebaisan and Sangbaipi, a major medicinal drug, were seen to play a role in the work of reinforcing and reducing. In particular, Ye Tianshi was used with cold and pungent medicine to Xiebaisan as a method of releasing heat with pungent medicine for acute fever in spring, and at the same time, care was taken to avoid depletion of secretion in the stomach. Conclusions : Wujutong's critique is that in early symptoms of viral infection, the misuse of Xiebaisan seems to emphasize the adverse effects of the illness. It is hoped that further research on Xiebaisan incremental medication will be conducted in the future to help clinical applications of Xiebaisan system medication.

• 대한한의학방제학회지
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• 제15권1호
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• pp.137-144
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• 2007

Background and Objectives : There are three kinds of formulas for purging the spleen to cure its sthenic syndrome based on the types of preparation formulas : Sabeetang, Sabeehwan, Sabeesan and Sabeeeum. Another formulas called Sahwangtang, Sahwangsan. Sahwangeum is to purge the yellow colour of spleen. There are 8 kinds of Sabeetang, 3 kinds of Sabeehwan, 3 kinds of Sabeesan, 1 kind of Sabeeeum, 4 kinds of Sahwangtang, 7 kinds of Sahwangsan, and 1 kind of Sahwangeum. Combination of herbal medicines, carried out in formulas for purging the spleen, consists of various kinds depending on medical scientists' personal experience in medical treatment without any general principles, which makes it difficult to apply it to clinical use. The objectives of this study lie in theoretical establishment of Sabeetang for curing the sthenic syndrome of spleen through analyzing the component medicines and combination principles of Hyeongok's Sabeetang, and furthermore, maximizing the clinical use of Sabeetang. Methods : This study analyzed the component medicines and combination principles of Hyeongok's Sabeetang based on the theory for properties and tastes of herbal medicines from the ${\ulcorner}$Yellow Emperor's Canon of Internal Medicine${\lrcorner}$ , the theory for principal herbal medicine, assistant herbal medicine, adjuvant herbal medicine, dispatcher herbal medicine, and the five elements doctrine. Hyeongok's Sabeetang is an odd prescription, composed of 7 kinds of ingredients : No.1 Rhizoma Coptidis (2don;7.5g), No.2 Fructus Gardeniae (1don;3.75g), No.3 Ramulus Cinnamomi (1don), No.4 Gypsum Fibrosum (1don), No.5 Fructus Aurantii Immaturus (1don), No.6 Cortex Magnoliae Omcinalis (1don), and No.7 Radix Et Rhizoma Rhei (1don) Results : There are three methods for curing the sthenic syndrome of spleen according to the five elements doctrine : purging the spleen, purging the lung and invigorating the liver. First, if you suffer from the sthenic syndrome of the spleen, you need to purge your spleen. There are two available methods, including taste and property purgation according to the theory for properties and tastes of herbal medicines. They each imply the bitter taste and the cool property purge the spleen. In the case of taste purgation, two herbal medicines with bitter taste. Rhizoma Coptidis and Fructus Gardeniae, are combined into the principal and assistant herbal medicine, respectively. For property purgation, three herbal medicines with the cool property, Gypsum Fibrosum, Fructus Aurantii Immaturus and Radix Et Rhizoma Rhei, are combined into adjuvant herbal medicines. Secondly, if you suffer from the sthenic syndrome of the spleen, you need to purge your lung which is child in the mother-child relationship in inter-promotion among the five elements. There are two methods to purge the lung, including taste and property purgation according to the theory for properties and tastes of herbal medicines. They each mean the pungent taste and the warm property purge the lung. Therefore, it is important to use pungent herbal medicines for taste purgation and warm ones for property purgation. Both pungent and warm herb and property invigoration to invigorate the liver with warm property. Therefore, it is important to use pungent herbal medicines for taste invigoration and warm ones for property invigoration. Both pungent and warm herbal medicines, Ramulus Cinnamomi and Cortex Magnoliae Officinalis, were combined to invigorate the liver and purge the lung. In addition, Gypsum Fibrosum are combined as dispatcher herbal medicine, leading all the herbal medicines composing the formula to the spleen. Conclusions : First, to cure the sthenic syndrome of the spleen, the methods of purging the spleen and the lung, and invigorating the liver should be used according to the five elements doctrine. Secondly, herbal medicines appropriate for those treatment methods should be chosen according to the theory for properties and tastes of herbal medicine and thirdly, the combination of those herbal medicines should be carried out according to the theory for principal herbal medicine, assistant herbal medicine, adjuvant herbal medicine, dispatcher herbal medicine. As a good example, Hyeongok's Sabeetang is combined according to the above theories. In conclusion, this formula was created by applying to the theory for properties and tastes of herbal medicines.