• Biomedical Science Letters
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• v.9 no.4
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• pp.215-222
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• 2003

As the obesity has been known to be related with the hyperlipidemia, cardiovascular disease, cerebral apoplexy, fatty liver, and other chronic diseases, recent researches have focused on the functional food materials and their anti-obesity activities. This study was performed to study the effects of vanilloid family capsaicin, major pungent ingredient of hot chillies and peppers, on anti-obesity activities. ICR male mice were fed one of the pellet diet, basal diet, and high fat diet with capsaicin (45 $\mu\textrm{g}$/day) solution for 5 days. Mice in the corresponding control groups were given water for 5 days. In results, capsaicin reduced body weights in any diet groups. Percent weight and cell size of the abdominal white adipose tissue in mice on the high fat diet with capcaicin were significantly lower compared with those in mice on the high fat diet with water. However, percent brown adipose tissue weight per body weight in mice on the high fat diet was not affected by capsaicin. Capsaicin reduced the levels of s-triglyceride and s-total cholesterol in the pellet diet or high fat diet groups. There was no difference in the s-protein levels between the capsaicin group and the control water group. These data indicate that 1) orally administered capsaicin has a reducing effect on the blood triglyceride and total cholesterol levels, and 2) capsaicin has lowering effects on the body weight, percent weight and cell size of the abdominal white adipose tissue.

• Journal of Korean Medical classics
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• v.33 no.1
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• pp.135-147
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• 2020

Objectives : This study focuses on the condition Yinynagjiao, which was first mentioned in 『Huangdineijing』, on the cause, mechanism and reason for it being described as fatal. Later doctors's understanding and treatment of this condition were examined subsequently. Methods : Verses related to Yinyangjiao from texts such as 『Huangdineijing』, 『Jinkuiyuhanjing』, 『Maijing』 were cross-examined focusing on their context and difference in expression with reference to annotations and later texts that mention Yinyangjiao. Based on the findings, its mechanism and treatment methods as found in Wenbing texts were compared with descriptions from previous texts. Results & Conclusions : According to 『Huangdineijing』, heat disease belongs to the Shanghan category, treated through promoting perspiration. In the confrontational position between JingQi and XieQi, perspiration could be understood as the result of JingQi's victory that lead to the discharge of XieQi in the form of sweat. Yinyangjiao is the opposite situation where Jing is discharged while heat toxin sinks into the body, thus being fatal, and treatment aimed for perspiration not adequately addressing the main problem which was ultimately expected to resolve through means of solid Yin Jing that would stabilize the pulse in due time. On the other hand, Wenbing scholars saw the pathogen as heat, shifting previous perspectives entirely. As a result, instead of applying pungent/warm medicinals to promote sweating, they suggested the use of cool, sweet/moist medicinals to cool the heat and nourish Yin as means of treating the condition.

• Journal of the East Asian Society of Dietary Life
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• v.6 no.2
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• pp.153-166
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• 1996

This study was carried out to investigate food behaviors of 349 college students (male 233, female 116) in Jeon Buk area by questionnaires. 89.1 percent of the students were living in city and 48.8% of those were residing in their own home or relatives. The average height and weight was 172.9cm, 64.2kg for male and 161.0cm, 50.1kg for female. Drinking and smoking rate of males were 88.0% and 61.8%, respectively. Both of male and female were most preferring the kind of rice and the skipping rate of breakfast was highest. Mean score of interest In eating attitudes was 11.7 in male and 13.2 in female(p＜0.001), and score for regular eating time was highest and that for reducing pungent food intake was lowest. The score of interest in eating attitudes was higher In subjects who exercise regularly(p＜0.001), no drinking(p＜0.05), had a good health status (p＜0.01) and attended a lecture related to food and nutrition(p＜0.001) than others. In the sense of value on eating, male had a meal for the physiological needs and famale had a meal for enjoy(p＜0.05). The score of interest in eating attitudes had a negative correlation with drinking(p＜0.001) and smoking(p＜0.05), and had a positive correlation with health status(p＜0.01), effort for a balance of life(p＜0.001), the sense of value on eating and attending a lecture related to food and nutrition(p＜0.001).

• Proceedings of the Korean Society of Applied Pharmacology
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• 2001.11a
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• pp.107-107
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• 2001

During the last decade, enormous progress has been made on the biological significance of apoptosis. Since ras is among the most central molecule in signaling, we asked if ras regulates apoptotic pathway. We have previously shown that H-ras, but not N-ras, induces an invasiveness and motility in human breast epithelial cells (MCF10A), while both H-ras and N-ras induce transformed phenotype. In this study, we wished to seek a chemopreventive agent that effectively induces apoptosis in H-ras-activated cells. Here we show that capsaicin, the major pungent phytochemical in red pepper, induces caspase 3-involved apoptosis selectively in H-ras activated MCF10A cells while the parental MCF10A cells are not effected. In order to study the molecular mechanisms for the increased sensitivity of H-ras MCF10A cells to capsaicin-induced apoptosis, activation of ras downstream signaling molecules, mitogen-activated protein kinases (MAPKinases), upon capsaicin treatment was investigated. Phosphorylated forms of JNK1 and p38 MAPKinase were prominently increased whereas activated ERK-1/2 was decreased by capsaicin in ras-activated cells. The parental cells did not respond to capsaicin, suggesting that capsaicin selectively induces apoptosis through modulating activities of ras downstream signaling molecules in H-ras-activated cells. Studies using chemical inhibitors (CPT-cAMP, SB203580 and PD98059) and dominant negative constructs of JNKl, p38 and MEK show that activation of JNK1 and p38 MAPKinase, but not ERK-1/2, is critical for ras-mediated apoptosis by capsaicin.

• The Journal of Korean Medical History
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• v.22 no.1
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• pp.57-67
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• 2009

The results of analyzing "Shanghanlun-Shanghan examples" of Song Dynasty Text and Liuwansu's writings in the pursuit of comprehending his views written in "Fire-Heat" & "Warm disease" -are as follow. 1.He introduced Exterior-Interior Shanghan and Latent in the Winter & recurrent in the Spring Shanghan concept in the Febrile disease pathology as the link and the bifurcation point. His perception on Febrile disease encompassed Shanghan and Febrile disease on the same plane but actually discriminated in the treatment and medication between the two actually. 2.He suggested Febrile disease pathology in the concept of Shanghan and Febrile disease, which is coherent in the formation of interior heat as the result of the invasion of the lung by warm pathogen described in Warm disease Wei, Qi, Ying and Xue Fen Syndrome differentiation. He expanded the concept of esoteric portal 玄府 of "Suwon Tiaojinglun", to that of the omni-present portal & way of Qi's all directions movement, which is in accordance of invasion of upper energizer 上焦 by warm or hot pathogen via mouth and nose as used in Warm disease three-energizer differentiation. 3.He recognized both exterior-interior febrile disease in the context of both exterior-interior contact cause disease. He prescribed pungent-cool exterior releasing medicinal similar to that of exterior-releasing treatment adopted in warm disease. As lily-talc powder百合散 introduced in "Golden chamber synopsis" dispells heat by promoting excretion of urine and defecation, it is regarded as the original formula of later ikwonsan yiyuansan 益元散.

• Journal of the Korean Society of Food Culture
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• v.10 no.3
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• pp.185-200
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• 1995

In this survey, we investigated the way of thinking about meal management of housewives including the sincerity to meal preparation, the eating practices and cronic degenerative diseases related dietary behaviors, and studied the effects of above factors on the real food intakes. We also investigated the trends of health-foods and nutrient supplements usage. The results obtained from 506 housewives in Seoul were summarized as follows. Although our subjects prepared their meals habitually without special concern, they did not prefer the use of convenient foods. The food prefrence of housewivess who had more child and refered higher life status was similar with other family members. The dietary attitudes were good in large family, the higher income and the more child group. The highly educated group skipped breakfast more frequently. The mealmanagers with better education career and good living status considered for the restriction of salty foods, sweet foods, animal fats and pungent foods, and for the nutritionally balanced diet. The high income group showed great concerns about weight gain at meal times. The nutritional qualities expressed by the frequency of food group intakes were high in the better educated and living status groups, and their eating frequencies of animal protein foods and calcium sources were significantly high. Mealmanagers who had no job intaked vegetable oils through frying foods frequently. The use of health-foods and nutrient supplements was influenced by age, educational and economic level and self-estimated living status, but the trends in prevalence of both were not consistent. Health-foods were prefered by the groups of high educational career, affluent income and advanced living status, and low educational career, low income and low living status groups favored the nutrient supplements. The restrictive intake of animal fat and the use of health-food were positively correlated, which seemed that the subjects used health-foods as supplements in compensation for nutritional unbalance caused by the avoidance of animal protein foods.

• The Korean Journal of Food And Nutrition
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• v.30 no.1
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• pp.67-73
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• 2017

This study was to investigate the perception about the popularization of temple food, known as health food and adult disease prevention food as an object of total 248 residents in Youngnam region. From the result of this research above, it may be summed up as follows. This study has found out that the advantages of temple food showed the statistical significant difference according to the gender, age, and size of family (p<0.01). The reason 'because of health food' (66.7%) had such high percentage. The necessity of popularization of temple food had big difference according to the gender and age (p<0.01). In addition, this study has shown the statistical significant difference in the cooking form for popularization by age, and future improvement for popularization by age and size of family (p<0.001). And, this study has found out that the 'traditional way as it is' (57.3%) was high in the cooking form, and 'use of various materials' (27.4%) in the improvement. Furthermore, the necessity of using meat for temple food had significant difference according to the gender and age, and 'need' (33.9%) showed rather higher tendency. The necessity of using osinchae, five forbidden pungent roots like garlic, green onions, Korean leeks, wild chives, and asafetida had significant difference according to the gender, age and size of family (p<0.05, P<0.001). The 'need' (61.3%) was considerably high. Based on the above results, general customers thought that the need for popularization of temple food and use of osinchae was very positive.

• Journal of Korean Medical Ki-Gong Academy
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• v.13 no.1
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• pp.77-104
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• 2013

In this study we examined the concerned literature for clinical use of Balsaminaceae plants focusing on the latest literature "zhong hua ben cao"(chinese materia medica, 1998). The findings were summarized as follows: 1. As an original plant, 27 species have been reviewed. 2. As a result of investigating oriental drug names by medicinal using part, a survey reported that the total of 22 species of oriental drug names, including 14 species of herba, 3 species of flos, 4 species of radix and rhizoma, and 1 species of semen, are being used for clinical use. 3. When we examined oriental drugs with five flavors by calculating and arranging their nature, effect, toxicity with points for conveniences sake, pungent and bitte showed 13 points, respectively, as main flavors. In drug nature, warm property of drug indicated 10 points and cold property of drug obtained 6 points. But as for other oriental drug, it is thought that we can recognize their significance. 4. With respect to efficacy, activating blood drug reached 10 kinds and wind- damp-dispelling 7 kinds, according to the examination. 5. In the examination on components and medicinal action, we examined that components are recorded in only impatiens balsamina's whole grass, flowers, root, root stems, and seeds, and Impatiens noli-tangere's whole grass. In medical action, we found out that the components are recorded in impatiens balsamina' flowers and seeds; impatiens noli-tangere's whole grass and flowers; and Impatiens textori' whole grass. 6. As a result of examining clinical prescription, the total of 84 kinds of clinical prescriptions by disease nature were examined, of which the prescription of Impatiens balsamina showed 19 cases in total, which was remarkable.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.5
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• pp.3123-3129
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• 2013

Background: The search for naturally occurring agents in routinely consumed foods that may inhibit cancer development is of high priority. [6]-Paradol is a pungent phenolic bioactive component from ginger with welldocumented health promoting antioxidant, antimutagenic, antigenotoxic and anti-inflammatory properties. However, anticarcinogenic effects have yet to be fully explored. The objectives of the present study were therefore to assess protective effects against 7,12-dimethylbenz(a)anthracene (DMBA) induced buccal pouch carcinogenesis in male golden Syrian hamsters. Methods: Oral squamous cell carcinomas developed in the left buccal pouch of hamsters on painting with 0.5% of DMBA, three times in a week. To assess the apoptotic associated gene expressing potential of [6]-paradol, it was orally administered to DMBA treated hamsters on alternate days from DMBA painting for 14 weeks. Results: We observed 100% tumor formation with marked levels of neoplastic changes and altered the expression of apoptotic associated gene (p53, bcl-2, caspase-3 and TNF-${\alpha}$) was observed in the DMBA alone painted hamsters as compared to control hamsters. Oral administration of [6]-paradol at a dose of 30 mg/kg b.wt to DMBA treated animals on alternative days for 14 weeks significantly reduced the neoplastic changes and improved the status of apoptosis associated gene expression. Conclusion: These observations confirmed that [6]-paradol acts as a tumor suppressing agent against DMBA induced oral carcinogenesis. We also conclude that [6]-paradol also effectively enhances apoptosis- associated gene expression in DMBA treated animals.

• Herbal Formula Science
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• v.14 no.1
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• pp.82-104
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• 2006

Objectives: The aim of this study is to find the therapeutic meaning of the Pyrite in herbal medication. Methods: About the origin, the component, the processing the drug, the properties and tastes of drugs, the meridian tropism, the effects, the treating disease, the contraindication and the method of administration. We have researched thirty three literatures to mention the pyrite in time sequence. Results: 1. The pyrite belongs to the metallic herbs and it consists of Iron sulfide, sometimes containing small amounts of cobalt, nickel. silver, and gold. 2. The processing the drug are the tempering, the annealing with vinegar. the refining drug with water or RADIX GLYCYRRHIZAE and et cetra, and accoring to these methods, the pyrite classified into three groups - the rough pyrite, the tempered pyrite, the annealed pyrite. 3. The properties and tastes of drugs is pungent and regular. If pyrite is well refine, it is nearly safe form the metallic virulence. the meridian tropism is mainly liver meridian. 4. From old times, pyrite has come into general use to treat the injury of muscles and tendons and bone facture because it is effective on dissipating blood stasis, alleviating pain and reunion of bone, muscles and ligament. 5. When the symptom is gone, a medicine to contain pyrite must be stoped taking. Because of pyrite's effect on regulateing Gi and promoting blood flow. Conclusions: This study showed that the pyrite is useful herb to treat the injury of muscles and tendons and bone facture.