• Title/Summary/Keyword: pulse profile

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Clinical trial to evaluate the efficacy and safety of Tongxinluo in high risk group of cardiovascular diseases (심혈관질환 고위험군에 대한 통심락(通心絡)의 유효성 및 안전성 평가를 위한 임상시험)

  • Park, Seong Uk;Jung, Woo Sang;Moon, Sang Kwan;Go, Chang Nam;Cho, Ki Ho;Kim, Young Suk;Bae, Hyung Sup
    • The Journal of the Society of Stroke on Korean Medicine
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    • v.6 no.1
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    • pp.25-32
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    • 2005
  • Background and purpose: Arterial stiffness is an important, independent determinant of cardiovascular risk. Pulse wave velocity (PWV) has been used as a valuable index of arterial stiffness and as a surrogate marker for atherosclerosis. The Framingham risk score was developed using categorized risk factors to predict the 10 year absolute risk of developing coronary heart disease (CHD). This algorithm is established using recommended guidelines for blood pressure, total cholesterol, and high density lipoprotein cholesterol in addition to age, smoking history and history of diabetes. Tongxinluo(TXL) has been shown to have anti hyperlipidemic activity and anti atherogenic effects. To determine its efficacy and safety, we examined whether TXL improves PWV, ABI, Framingham score, blood pressure, and lipid profile in high risk group of cardiovascular diseases. Subjects and methods: 49 subjects with the high risk of cardiovascular diseases were recruited. Subjects were administered TXL with the dose of 1110mg three times a day for 8 weeks. baPWV, ABI, Framingham risk score, Blood pressure and serum lipid profile were assessed at baseline and after 4 and 8weeks. Results: Total cholesterol, LDL cholesterol, triglyceride, total lipid and phospolipid significantly decreased after 4 weeks of medication. Total cholesterol, total lipid and phospolipid significantly decreased after 8 weeks of medication. There were no significant changes in Framingham risk scores, ABI, PWV and blood pressure. On safety assessment, there were no adverse effects, hepatic or renal toxicity. Conclusion: We suggest that TXL is a safe and useful herbal medicine for hyperlipidemia and as for anti-atherognic effects, further research would be necessary.

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Dynamic response of functionally gradient austenitic-ferritic steel composite panels under thermo-mechanical loadings

  • Isavand, S.;Bodaghi, M.;Shakeri, M.;Mohandesi, J. Aghazadeh
    • Steel and Composite Structures
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    • v.18 no.1
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    • pp.1-28
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    • 2015
  • In this paper, the dynamic response of functionally gradient steel (FGS) composite cylindrical panels in steady-state thermal environments subjected to impulsive loads is investigated for the first time. FGSs composed of graded ferritic and austenitic regions together with bainite and martensite intermediate layers are analyzed. Thermo-mechanical material properties of FGS composites are predicted according to the microhardness profile of FGS composites and approximated with appropriate functions. Based on the three-dimensional theory of thermo-elasticity, the governing equations of motionare derived in spatial and time domains. These equations are solved using the hybrid Fourier series expansion-Galerkin finite element method-Newmark approach for simply supported boundary conditions. The present solution is then applied to the thermo-elastic dynamic analysis of cylindrical panels with three different arrangements of material compositions of FGSs including ${\alpha}{\beta}{\gamma}M{\gamma}$, ${\alpha}{\beta}{\gamma}{\beta}{\alpha}$ and ${\gamma}{\beta}{\alpha}{\beta}{\gamma}$ composites. Benchmark results on the displacement and stress time-histories of FGS cylindrical panels in thermal environments under various pulse loads are presented and discussed in detail. Due to the absence of similar results in the specialized literature, this paper is likely to fill a gap in the state of the art of this problem, and provide pertinent results that are instrumental in the design of FGS structures under time-dependent mechanical loadings.

Basic Emotions Elicited by Korean Affective Picture System Can be Differentiated by Autonomic Responses

  • Sohn, Jin-Hun;Estate Sokhadze;Lee, Kyug-Hwa;Imgap Yi
    • Proceedings of the Korean Society for Emotion and Sensibility Conference
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    • 2000.04a
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    • pp.370-379
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    • 2000
  • Autonomic responses were analyzed in 323 college students exposed to visual stimulation with Korean Affective Picture System (KAPS). Cardiac, vascular and electrodermal variables were recorded during 30 sec of viewing affective pictures. The same slides intended to elicit basic emotions (fear, anger, surprise, disgust, sadness, happiness) were presented to subjects in 2 trials with different experimental context. The first time slides were shown without any instructions (passive viewing), while during the second with instruction to exert efforts to magnify experienced emotion induced by pictures (active viewing). The aim of the study was to differentiate autonomic manifestations of emotions elicited by KAPS stimulation and to identify the role of instructed emotional engagement on physiological response profiles. The obtained results demonstrated reproducibility of responses in both trials with different contexts. Pairwise comparison of physiological responses in emotion conditions revealed the most pronounced differentiation for "ear-anger" and "fear-sadness" pairs (in electrodermal and HR variability parameters). "Fear-surprise" pair was also well differentiable. The typical response profile for all emotions included HR acceleration (except happiness and surprise), an increase of electrodermal activity, and a decrease of pulse volume. Higher cardiovascular and electrodermal reactivity to fear observed in this study, e.g., as compared to data with IAPS as stimuli, can be explained by cultural relevance and higher effectiveness of KAPS as stimuli, can be explained by cultural relevance and higher effectiveness of KAPS in producing certain emotions such as fear in Koreans.

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Estimation of the hydraulic conductivity profile in fractured rocks using the borehole flowmeter test (시추공 유속 검층을 이용한 암반 대수층의 수리전도도 분포 산정)

  • 구민호;차장환
    • The Journal of Engineering Geology
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    • v.12 no.3
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    • pp.257-271
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    • 2002
  • The vertical distribution of hydraulic conductivity of 3 boreholes located at Kongju National University was estimated by the ambient flow and the pump-induced flow measurements using a heat-pulse flowmeter. The ambient flow measurements showed that a great amount of groundwater (1~2 m$^3$/day) flowed in the boreholes through the conductive fractures. The analyzed conductivity profiles we similar to those of the packer test performed for the same boreholes. The conductive fractures in which the differential net flow changed greatly could be identified by the BIPS logging. The water-quality logging data showed that quality of groundwater changed abruptly at some depths of the boreholes. This change in water quality can be attributed to the presence of conductive fractures that have resulted in the mixing of groundwater of different quality flowing in different fracture channels. However, compared to the flowmeter test, the water-quality logging showed low capability in identifying locations of conductive fractures.

ITO, PR, 격벽 재료의 레이저 직접 미세가공

  • Lee, Cheon;Lee, Gyung-Chul;Ahn, Min-Young;Lee, Hong-Gyu
    • Proceedings of the Korean Vacuum Society Conference
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    • 1999.07a
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    • pp.80-80
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    • 1999
  • 플라즈마 디스플레이 패널(PDP)의 공정을 간단히 하기 위하여 포토레지스트, ITO, 격벽재료를 Ar+ laser(λ-514 nm, CW)와 Nd:YAG laser(λ=532, 266nm, pulse)로 직접 패터닝 하였다. 레이저에 의한 포토레지스트의 패턴결과, 아르곤 이온 레이저의 포토레지스트 가공의 반응 메카니즘은 레이저 빔의 열에 의한 시료 표면의 국부적인 온도상승에 의한 용융작용이며, 그 결과 식각 후 형성된 패턴의 단면 모양도 레이저빔의 profile과 같은 가우시안 형태를 나타낸다. Nd:YAG 레이저의 4고조파(532nm)를 이용한 경우 200$\mu\textrm{m}$/sce의 주사속도에서 포토레지스트를 패턴하기 위한 임계에너지(threshold energy fluence) 값은 25J/cm2이며, 약 40J/cm2의 에너지 밀도에서 하부기판의 손상이 발생하기 시작하였다. 글미 1은 Nd:YAG 레이저 4고조파를 이용하여 포토레지스트를 식각한 경우 SEM 표면사진(위)과 단차특정기에 의한 단면형상(아래)이다. ITO 막의 레이저에 의한 직접 패턴 결과, ITO 막은 레이저 펄스에 의한 급속 가열 및 증발에 의한 메커니즘으로 식각이 이루어지며, 레이저 파장에 따른 광흡수 정도의 차이에 의해 2고조파 (532nm)에서 ITO 막의 가공 품질이 4고조파(266nm)에 비해 우수하며 패턴의 폭도 출력에 따라 제어가 용이하였다. 그림 2는 Nd:YAG 레이저 2고조파를 이용하여 ITO를 식각한 경우 SEM표면 사진(위)과 단차측정기에 의한 단면형상(아래)이다. 격벽 재료의 레이저에 의한 직접 패턴 결과, Ar+ 레이저(514nm)는 출력 밀도 32NW/cm2에서 격벽을 유리 기판의 경계면까지 식각하였다. Nd:YAG 레이저(532nm)는 laser fluence가 6.5mJ/cm2에서 격벽을 식각하기 시작하였으며, 19.5J/cm2에서 유리기판의 rudraus(격벽 두께 130$\mu\textrm{m}$)까지 식각하였다.

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Femto-second Laser Ablation Process for Si Wafer Through-hole (펨토초 레이저 어블레이션을 이용한 Si 웨이퍼의 미세 관통 홀 가공)

  • Kim, Joo-Seok;Sim, Hyung-Sub;Lee, Seong-Hyuk;Shin, Young-Eui
    • Journal of the Microelectronics and Packaging Society
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    • v.14 no.3
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    • pp.29-36
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    • 2007
  • The main objectives of this study are to investigate the micro-scale energy transfer mechanism for silicon wafer and to find an efficient way for fabrication of silicon wafer through-hole by using the femtosecond pulse laser ablation. In addition, the electron-phonon interactions during laser irradiation are discussed and the carrier number density and temperatures are estimated. In particular, the present study observes the shapes of silicon wafer through-hole with $100\;{\mu}m$ diameter and it also measures the heat-affected area and the ablation depths fur different laser fluences by using the optic microscope and the three-dimensional profile measurement technique. First, from numerical investigation, it is found that the nonequilibrium state exists between electrons and phonons during laser irradiation. From experimental results, it should be noted that the heat-affected area increases with laser fluence, and the optimal conditions for through-hole formation with minimum heat affected zone are finally obtained.

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Infrared Spectral Signatures of Dust by Ground-based FT-IR and Space-borne AIRS (지상 및 위성 고분해 적외스펙트럼 센서에서 관측된 황사 특성)

  • Lee, Byung-Il;Sohn, Eun-Ha;Ou, Mi-Lim;Kim, Yoon-Jae
    • Atmosphere
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    • v.19 no.4
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    • pp.319-329
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    • 2009
  • The intensive dust observation experiment has been performed at Korea Global Atmosphere Watch Center (KGAW) in Anmyeon, Korea during each spring season from 2007 to 2009. Downward and upward hyper-spectral spectrums over the dust condition were measured to understand the hyper-spectral properties of Asian dust using both ground-based Fourier Transform Infrared Spectroscopy (FT-IR) and space-borne AIRS/Aqua. To understand the impact of the Asian dust, a Line-by-Line radiative transfer model runs to calculate the high resolution infrared spectrum over the wave number range of $500-500cm^{-1}$. Furthermore, the radiosonde, a $PM_{10}$ Sampler, a Micro Pulse Lidar (MPL), and an Aerodynamic Particle Sizer (APS) are used to understand the vertical profile of temperature and humidity and the properties of Asian dust like concentration, altitude of dust layer, and size distribution. In this study, we found the Asian dust distributed from surface up to 3-4 km and volume concentration is increased at the size range between 2 and $8{\mu}m$ The observed dust spectrums are larger than the calculated clear sky spectrums by 15~60K for downward and lower by around 2~6K for upward in the wave number range of $800-1200cm^{-1}$. For the characteristics of the spectrum during the Asian dust, the downward spectrum is revealed a positive slope for $800-1000cm^{-1}$ region and negative slope over $1100-1200cm^{-1}$ region. In the upward spectrum, slopes are opposed to the downward one. It is inferred that the difference between measured and calculated spectrum is mostly due to the contribution of emission and/or absorption of the dust particles by the aerosol amount, size distribution, altitude, and composition.

The detection of cavitation in hydraulic machines by use of ultrasonic signal analysis

  • Gruber, P.;Farhat, M.;Odermatt, P.;Etterlin, M.;Lerch, T.;Frei, M.
    • International Journal of Fluid Machinery and Systems
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    • v.8 no.4
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    • pp.264-273
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    • 2015
  • This presentation describes an experimental approach for the detection of cavitation in hydraulic machines by use of ultrasonic signal analysis. Instead of using the high frequency pulses (typically 1MHz) only for transit time measurement different other signal characteristics are extracted from the individual signals and its correlation function with reference signals in order to gain knowledge of the water conditions. As the pulse repetition rate is high (typically 100Hz), statistical parameters can be extracted of the signals. The idea is to find patterns in the parameters by a classifier that can distinguish between the different water states. This classification scheme has been applied to different cavitation sections: a sphere in a water flow in circular tube at the HSLU in Lucerne, a NACA profile in a cavitation tunnel and two Francis model test turbines all at LMH in Lausanne. From the signal raw data several statistical parameters in the time and frequency domain as well as from the correlation function with reference signals have been determined. As classifiers two methods were used: neural feed forward networks and decision trees. For both classification methods realizations with lowest complexity as possible are of special interest. It is shown that two to three signal characteristics, two from the signal itself and one from the correlation function are in many cases sufficient for the detection capability. The final goal is to combine these results with operating point, vibration, acoustic emission and dynamic pressure information such that a distinction between dangerous and not dangerous cavitation is possible.

Visual Demonstration of Simulated Moving Bed (Simulated Moving Bed Chromatography의 시각적 설명)

  • Oh, Nan Suk;Lee, Chong-Ho;Kim, Jin Il;Koo, Yoon-Mo
    • Korean Chemical Engineering Research
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    • v.43 no.3
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    • pp.360-365
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    • 2005
  • SMB (simulated moving bed) is a continuous chromatographic process by shifting periodically port position. Binary of mixture, Blue dextran and Orange G, was separated by SMB. These components have unique color individually, that is, Blue dextran is blue and Orange G is orange. It is easy to understand SMB process by observing the shift of color changes in SMB. These components was not adsorbed to stationary phase and isolated by difference of size exclusion factor. Mass transfer coefficient was determined by single pulse test under several flow rate conditions. Operation condition was obtained by standing wave theory and optimized for high purities in extract and raffinate streams. Experiment was performed in open loop 4 zone (2-2-2-2) SMB. There are several advantages in open loop SMB, where extract is product for high purity. It is also easy to control flow rate and monitor experimental state during operation. Experimental, extract and raffinate history is well fitted with simulation results, however, column concentration profile is a little different from simulation results. Purities were 99.5% for extract and 98.9% for raffinate and extract and raffinate yields were obtained as 98.9% and 99.4% respectively.

A Bridgeless Half-Bridge AC-DC Converter with High-Efficiency (정류용 브릿지 다이오드가 없는 고효율 하프 브릿지 AC-DC 컨버터)

  • Choi, Woo-Young;Yoo, Ju-Seung;Choi, Jae-Yeon
    • The Transactions of the Korean Institute of Power Electronics
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    • v.16 no.3
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    • pp.293-301
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    • 2011
  • This paper proposes a bridgeless half-bridge AC-DC converter with high-efficiency. The proposed converter integrates the bridgeless power factor correction (PFC) circuit with the asymmetrical pulse-width modulated (APWM) half-bridge DC-DC converter. It provides the isolated DC output voltage from the AC line voltage without using any full-bridge diode rectifier. Conduction losses are lowered with a simple circuit structure. Switching losses are also reduced by achieving zero-voltage switching (ZVS) of the power switches. By using series-connected two transformers, the proposed converter provides a low-profile and high power density for AC-DC converters. The performance of the proposed converter is verified from a 250 W (48 V / 5.2 A) experimental prototype circuit at $90 \;V_{rms}$ line voltage.