• Korean Journal of Human Ecology
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• v.23 no.6
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• pp.999-1012
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• 2014

The purpose of this study is to examine depression in adulthood caused by the influence of negative life events (disaster accident, physical violence and emotional abuse) in pre-adulthood and explore the mediator effect of interpersonal maladjustment. To carry out such task, 974 people who have had negative life event experiences before the age of 18 were chosen based on the data from the 2012 Korean General Social Survey(KGSS) and Stata 10.0 was used to do the analysis. As a result, it was found that there was a direct relationship between negative life events in pre-adulthood and depression in adulthood. Specifically, experiences from an accident or disaster had a direct impact on depression. Moreover, experiences of physical violence and emotional abuse not only had a direct influence on depression, but also through maladjustment, it had an indirectly partial mediator effect that increases the chances of depression. Through this result, it was evident that negative life events from pre-adulthood had a negative effect on continuous interpersonal maladjustment as well as psychological welfare throughout the adulthood. Therefore, there needs to be thorough prevention measures on negative life events in pre-adulthood and strongly take post treatment into consideration. Through building a safe life environment, great deal of social support from social organizations should be prepared systematically.

• The Journal of Korean Academic Society of Nursing Education
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• v.25 no.2
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• pp.263-272
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• 2019

Purpose: The purpose of this study was to identify the moderating effect of interpersonal skills on the relationship between childhood emotional trauma and depression. Methods: From June to July, 2017, a convenience sample of 226 nursing students was recruited. Research data were collected through self-report questionnaires and analyzed using SPSS version 22.0. Results: 68.1% (154) respondents experienced emotional abuse, and 48.1% (110) emotional neglect in childhood emotional trauma. The average depression score was 10.76. There were 54.4% (123), 34.5% (78), 12.8% (29), and 7.1% (16) of respondents with mild, moderate, and severe depression, respectively. The average interpersonal skills score was 3.59. There was a significant correlation between childhood emotional trauma (emotional abuse, emotional neglect), interpersonal skills and depression. And the moderating effect of interpersonal skills on the relationship between childhood emotional neglect and depression was significant. Conclusion: Interpersonal skills play a role as a moderating variable influencing the relationship between emotional neglect of childhood emotional trauma and depression, and also reduce the effects of childhood emotional trauma on depression. When developing a depression prevention program for nursing college students, such programs should consider strategies to reduce the negative effects of childhood emotional trauma and to improve interpersonal skills.

• Industry Promotion Research
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• v.3 no.2
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• pp.41-51
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• 2018

This study is to see the problem of child abuse as a social problem and sees that the society as a whole needs to find a solution and suggest solutions. The results of this study are as follows. First, legal supplement should be given priority. This can be solved through legal amendments to relevant laws and legislative amendments. Second, institutional complement should be done. Physical and psychological treatment is more urgent for school children than school education for victim child. In the future, children's welfare facilities should be expanded to include child counseling centers for children who are living in homes rather than nursing homes but who have problematic behaviors and treatment facilities for children who need professional treatment. Third, measures should be taken against abused children. Results of action for affected children include home care, separation protection, home return, and death.

• Biomolecules & Therapeutics
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• v.21 no.4
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• pp.307-312
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• 2013

Quetiapine is an atypical or second-generation antipsychotic agent and has been a subject of a series of case report and suggested to have the potential for misuse or abuse. However, it is not a controlled substance and is not generally considered addictive. In this study, we examined quetiapine's dependence potential and abuse liability through animal behavioral tests using rodents to study the mechanism of quetiapine. Molecular biology techniques were also used to find out the action mechanisms of the drug. In the animal behavioral tests, quetiapine did not show any positive effect on the experimental animals in the climbing, jumping, and conditioned place preference tests. However, in the head twitch and self-administration tests, the experimental animals showed significant positive responses. In addition, the action mechanism of quetiapine was found being related to dopamine and serotonin release. These results demonstrate that quetiapine affects the neurological systems related to abuse liability and has the potential to lead psychological dependence, as well.

• The Korean Journal of Nuclear Medicine
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• v.27 no.1
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• pp.22-27
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• 1993

Drug abuse is widespread in worldwide and has been associated with neurologic complication. Zipeprol is one of the drugs which been abused for psychological satisfaction in some adolescents. This agent is non-opioid antitussive agent, which is not legally considered as being capable of creating dependence or abuse liability at therapeutic serum levels. But it has been reported that acute or chronic overdose create neurologic complication such as convulsion as well as dependence. Recently we experienced six zipeprol abusers who admitted due to convulsion and variable neurologic symptoms. The aim of our study was to determine the role of $^{99m}Tc$-HMPAO brain SPECT in those patients. EEG and brain CT showed no abnormal finding, but brain SPECT showed focal or multiple perfusion abnormalities in frontal, parietal, occipital cortex, basal ganglia, thalamus and especially at temporal cortex. These results suggest that brain SPECT may be a useful diagnostic tool to evaluate the cerebral dysfunction infused by zipeprol abuse.

• Biomolecules & Therapeutics
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• v.22 no.6
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• pp.558-562
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• 2014

Tramadol is an opioid analgesic agent that has been the subject of a series of case reports suggesting potential for misuse or abuse. However, it is not a controlled substance and is not generally considered addictive in Korea. In this study, we examined the dependence potential and abuse liability of tramadol as well as its effect on the dopaminergic and serotonergic systems in rodents. In animal behavioral tests, tramadol did not show any positive effects on the experimental animals in climbing, jumping, and head twitch tests. However, in the conditioned place preference and self-administration tests, the experimental animals showed significant positive responses. Taken together, tramadol affected the neurological systems related to abuse liability and has the potential to lead psychological dependence.

• Korean Journal of Social Welfare
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• v.61 no.2
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• pp.277-301
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• 2009

The purpose of this study is to examine those factors affecting Male Abusive Behavior on Intimate Female Partner Violence. The primary aim of this study is to determine the association between Intimate Partner Violence and coping strategies of male abusive behavior. The sample included 121 male abusive behavior who are referred by Counsel for Family Violence. For statistical analysis, descriptive statistical methods and hierarchical multiple regression were employed. Results indicated that male abusive behavior expressed more aggressive cognitive biases and irrational beliefs than nonviolent men. Both of problem-solving and avoidance coping to deal with relationship conflicts were related to abusive behavior of male. Specially, men who used higher levels of avoidance coping strategies was more likely related to physical abuse, less use of problem-solving coping was related to psychological abuse. Hostility and low marital satisfaction have also been associated with Intimate Partner Violence. Drinking is a risk factor for psychological abuse. Results are discussed implication for developing theoretical and interventional meanings of social welfare practice.

• Journal of Families and Better Life
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• v.21 no.6
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• pp.53-67
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• 2003

The aim of this research is to verify the assumption that the husband-to-wife violence lies upon a continuum of severity and to study how the premarital violence experience of husbands, along with their psychological characteristics and various marital interactions, can be the cause of husbands' violence against their wives. At the same time, the research aims at constructing a causal model of the husband-to-wife violence. For the purpose, this research surveyed 242 husbands residing in Pusan and another 50 husbands as violent assaulters in major cities of Korea. The following is a summary of the results of this research. First, the research can verify the two assumptions that “the group which has once inflicted a severe form of violence can easily inflict minor violences” and that “the factors related to violence play a far greater role in severe violences than in weaker violences.” As a result, it may be concluded that the study of a regular household violence can be based on the continuum of violence assumption. Secondly, In the husbands' experience of violence, dating violence and their experienced childhood abuse from their parents, in their psychological characteristics, temper control ability and their patriarchal sex role attitude, and finally in marital interactions, marital conflicts and distractor of communication played great role in their influence on the husband-to-wife violence. Thirdly, as the various factors which contribute to the violence against the wife have cause-and-effect rule, we shall be able to make a model which can be conceptualized.

• Archives of Pharmacal Research
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• v.26 no.7
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• pp.540-544
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• 2003

Morphine, an analgesic with significant abuse potential, is considered addictive because of drug craving and psychological dependence. It is reported that repeated treatment of morphine can produce conditioned place preference (CPP) showing a reinforcing effect in mice. CPP is a useful method for the screening of morphine-induced psychological dependence. In the present study, we investigated the effect of the methanolic extract of Coptis japonica (MCJ) on morphine-induced CPP in mice. Furthermore, we examined c-fos expression in the parietal cortex, piriform cortex, striatum, nucleus accumbens, and hippocampus of the morphine-induced CPP mouse brain. Treatment of MCJ 100 mg/kg inhibited morphine-induced CPP. Expression of c-fos was increased in the cortex, striatum, nucleus accumbens, and hippocampus of the morphine-induced CPP mouse brain. These increases of expression were inhibited by treatment with MCJ 100 mg/kg, compared to the morphine control group. Taken together, these results suggest that MCJ inhibits morphine-induced CPP through the regulation of c-fos expression in the mouse brain.

• Biomolecules & Therapeutics
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• v.16 no.2
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• pp.113-117
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• 2008

Morphine is a potent analgesic with significant abuse potential, because of drug craving and psychological dependence. It is reported that repeated treatment of morphine can produce conditioned place preference (CPP) showing a reinforcing effect in mice. Previously, we have reported the inhibitory effect of the methanolic extract of Coptis japonica (MCJ) on morphine-induced CPP in mice. The present study was employed whether p-CREB expression is involved in the inhibitory effect of MCJ on the morphine-induced CPP in the mouse hippocampus. Repeated administration of MCJ 100 mg/kg inhibited morphine-induced CPP. Expression of p-CREB was increased in the dentate gyrus of the hippocampus that had undergone morphineinduced CPP. This increase of expression was significantly inhibited by administration of MCJ 100 mg/kg, compared to the morphine control group. Taken together, these results suggest that MCJ inhibits morphine-induced CPP through the regulation of p-CREB expression in the mouse dentate gyrus of the hippocampus.