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http://dx.doi.org/10.4062/biomolther.2008.16.2.113

Involvement of pCREB Expression in Inhibitory Effects of Coptis japonica on Morphine-induced Psychological Dependence  

Kwon, Seung-Hwan (Department of Pharmacology, College of Pharmacy, Sungkyunkwan University)
Ha, Ri-Ra (Department of Pharmacology, College of Pharmacy, Sungkyunkwan University)
Lee, Seok-Yong (Department of Pharmacology, College of Pharmacy, Sungkyunkwan University)
Jang, Choon-Gon (Department of Pharmacology, College of Pharmacy, Sungkyunkwan University)
Publication Information
Biomolecules & Therapeutics / v.16, no.2, 2008 , pp. 113-117 More about this Journal
Abstract
Morphine is a potent analgesic with significant abuse potential, because of drug craving and psychological dependence. It is reported that repeated treatment of morphine can produce conditioned place preference (CPP) showing a reinforcing effect in mice. Previously, we have reported the inhibitory effect of the methanolic extract of Coptis japonica (MCJ) on morphine-induced CPP in mice. The present study was employed whether p-CREB expression is involved in the inhibitory effect of MCJ on the morphine-induced CPP in the mouse hippocampus. Repeated administration of MCJ 100 mg/kg inhibited morphine-induced CPP. Expression of p-CREB was increased in the dentate gyrus of the hippocampus that had undergone morphineinduced CPP. This increase of expression was significantly inhibited by administration of MCJ 100 mg/kg, compared to the morphine control group. Taken together, these results suggest that MCJ inhibits morphine-induced CPP through the regulation of p-CREB expression in the mouse dentate gyrus of the hippocampus.
Keywords
Conditioned place preference; Coptis japonica; p-CREB; Immunohistochemistry;
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1 Klitenick, M.A., DeWitte, P., and Kalivas, P.W. (1992) Regulation of somatodendritic dopamine release in the ventral tegmental area by opioids and GABA: an in vivo microdialysis study. J. Neurosci. 12, 2623-2632
2 van der Kooy, D. (1987) Place conditioning: a simple and effective method for assessing the motivational properties of drugs. In Methods of Assessing the Reinforcing Properties of Abuse Drugs (M.A. Bozarth, Ed.), pp. 229-240. Springer, New York
3 Deisseroth, K, Bito, H, and Tsien, R.W. (1996) Signaling from synapse to nucleus: postsynaptic CREB phosphorylation during multiple forms of hippocampal synaptic plasticity. Neuron 16, 89-101   DOI   ScienceOn
4 Fan, G.H., Wang, L.Z., Qiu, H.C., Ma, L., and Pei, G. (1999) Inhibition of calcium/calmodulin-dependent protein kinase II in rat hippocampus attenuates morphine tolerance and dependence. Mol. Pharmacol. 56, 39-45   DOI
5 Gao, C., Che, L.W., Chen, J., Xu, X.J., and Chi, Z.Q. (2003) Ohmefentanyl stereoisomers induce changes of CREB phosphorylation in hippocampus of mice in conditioned place preference paradigm. Cell Res. 13, 29-34   DOI   ScienceOn
6 Graybiel, A.M., Moratalla, R., and Robertson, H.A. (1990) Amphetamine and cocaine induce drug-specific activation of the c-fos gene in striosome-matrix compartments and limbic subdivisions of the striatum. Proc. Natl. Acad. Sci. USA 87, 6912-6916   DOI   ScienceOn
7 Lee, M.K. and Zhang, Y.H. (1996) Inhibition of tyrosine hydroxylase by berberine. Med. Sci. Res. 24, 561-562
8 Kim, H.S., Jang, C.G., and Park, W.K. (1996) Inhibition by MK- 801 of morphine-induced conditioned place preference and postsynaptic dopamine receptor supersensitivity in mice. Pharmacol. Biochem. Behav. 55, 11-17   DOI   ScienceOn
9 Koob, G.F. and Bloom, F.E. (1988) Cellular and molecular mechanisms of drug dependence. Science 242, 715-723   DOI
10 Lee, M.K. and Kim, H.S. (1996) Inhibitory effects of protoberberine alkaloids from the roots of Coptis japonica on catecholamine biosynthesis in PC12 cells. Planta Med. 62, 31-34   DOI   ScienceOn
11 Lee, M.K., Zhang, Y.H., and Kim, H.S. (1996) Inhibition of tyrosine hydroxylase by palmatine. Arch. Pharm. Res. 19, 258-260   DOI
12 Bardo, M.T., Miller, J.S., and Neisewander, J.S. (1984) Conditioned place preference with morphine: The effect of extinction training on the reinforcing CR. Pharmacol. Biochem. Behav. 21, 545-549   DOI   ScienceOn
13 Berke, J.D. and Hyman, S.E. (2000) Addiction, dopamine, and the molecular mechanisms of memory. Neuron 25, 515-532   DOI   ScienceOn
14 Bozarth, M.A. (1986) Neural basis of psychomotor stimulant and opiate reward: evidence suggesting the involvement of a common dopaminergic system. Behav. Brain Res. 22, 107- 116   DOI   ScienceOn
15 Hsieh, M.T., Peng, W.H., Wu, C.R., and Wang, W.H. (2000) The ameliorating effects of the cognitive-enhancing Chinese herbs on scopolamine-induced amnesia in rats. Phytotherapy Res. 14, 375-377   DOI   ScienceOn
16 Lee, S.Y, Song, D.K, and Jang, C.G. (2003) Effects of Coptis japonica on morphine-induced conditioned place preference in mice. Arch Pharm Res. 26, 540-544   DOI   ScienceOn
17 Hyman, S.E. (1996) Shaking out the cause of addiction. Science 273, 611-612   DOI   ScienceOn
18 Ivanovska, N. and Philipov, S. (1996) Study on the anti-inflammatory action of Berberis vulgaris root extract, alkaloid fractions and pure alkaloids. Int. J. Immunopharmacol. 18, 553- 561   DOI   ScienceOn
19 Johnson, S.W. and North, R.A. (1992) Opioids excite dopamine neurons by hyperpolarization of local interneurons. J. Neurosci. 12, 483-488
20 Lou, L.G., Zhou, T.H., Wang, P., and Pei, G. (1999) Modulation of $Ca^{2+}$/Calmodulin-dependent protein kinase II activity by acute and chronic morphine administration in rat hippocampus: differential regulation of a and b isoforms. Mol. Pharmacol. 55, 557-563
21 Mucha, R.F., van der Kooy, D., O'Shaughnessy, M., and Bucenieks, P. (1982) Drug reinforcement studied by the use of place conditioning in rat. Brain Res. 243, 91-105   DOI   ScienceOn
22 Nestler, E.J. (2001) Molecular basis of long-term plasticity underlying addiction. Nat. Rev. Neurosci. 2, 119-128   DOI   ScienceOn
23 Ro, J.S., Lee, S.S., Lee, K.S., and Lee, M.K. (2001) Inhibition of type A monoamine oxidase by coptisine in mouse brain. Life Sci. 70, 639-645   DOI   ScienceOn
24 Robbins, T.W. and Everiff, B.J. (1999) Drug addiction: bad habits add up. Nature 398, 567-570   DOI   ScienceOn
25 Wise, R.A. and Rompre, P.P. (1989) Brain dopamine and reward. Ann. Rev. Psychol. 40, 191-225   DOI   ScienceOn
26 Schmeller, T., Latz-Bruning, B., and Wink, M. (1997) Biochemical activities of berberine, palmatine and sanguinarine mediating chemical defense against microorganisms and herbivores. Phytochemistry 44, 257-266   DOI   ScienceOn
27 Shin, J.S., Kim, E.I., Kai, M., and Lee, M.K. (2000) Inhibition of dopamine biosynthesis by protoberberine alkaloids in PC12 cells. Neurochem. Res. 25, 363-368   DOI   ScienceOn
28 Tolliver, B.K., Sganga, M.W., and Sharp, F.R. (2000) Suppression of c-fos induction in the nucleus accumbens prevents acquisition but not expression of morphine-conditioned place preference. Eur. J. Neurosci. 12, 3399-3406
29 Wise, R.A. and Bozarth, M.A. (1987) A psychomotor stimulant theory of addiction. Psychol. Rev. 94, 469-492   DOI   ScienceOn
30 Yoo, J.H., Yang, E.M., Cho, J.H., Lee, J.H., Jeong, S.M., Nah, S.Y., Kim, H.C., Kim, K.W., Kim, S.H., Lee, S.Y., and Jang, C.G., (2006) Inhibitory effects of berberine against morphineinduced locomotor sensitization and analgesic tolerance in mice. Neuroscience 142, 953-961   DOI   ScienceOn
31 Young, S.T., Porrino, L.J., and Iadarola, M.J. (1991) Cocaine induces striatal c-fos-immunoreactive proteins via dopaminergic D1 receptors. Proc. Natl. Acad. Sci. USA 88, 1291-1295   DOI   ScienceOn
32 Baker, H. and Farbman, A.I. (1993) Olfactory afferent regulation of the dopamine phenotype in the fetal rat olfactory system. Neuroscience 52, 115-134   DOI   ScienceOn
33 Shuster, L., Hannam, R.V., and Boyle, W.E.Jr. (1963) A simple method for producing tolerance to dihydromorphine in mice. J. Pharmacol. Exp. Ther. 140, 149-153