• 생명과학회지
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• 제23권8호
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• pp.1064-1072
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• 2013

일주기 리듬은 모든 살아있는 유기체의 생리현상을 지배하는 호르몬의 변화에 의해서 조절된다. 포유동물에서 송과체의 주된 기능은 시상 하부 시교차 상핵에서 발생되는 일주기 리듬을 주로 어두울 때 증가하는 순환성 멜라토닌의 리듬 신호로 변화시키는 것이다. 송과체는 직접적인 광감도는 없지만, 망막신경절세포로 하부조직을 포함하는 멀티 시냅스 경로를 통하여 빛에 반응한다. 주기적인 리듬 조절은 주위환경의 빛과 멜라토닌 생성의 리듬조절 효소인 arylalkylamine-N-acetyltransferase (AANAT)의 발현과 긴밀한 관계를 통해 이루어진다. 이전 실험에서 AANAT 단백질이 어두울 때의 발현이 전사 조절, 전사 후 조절, 번역 후 조절 메커니즘으로 설명되었다. AANAT 단백질 발현에 관한 분자적 기전은 멜라토닌의 일주기 리듬에 대한 새로운 견해를 제공한다. 광범위한 동물 연구에서 많은 포유류의 계절 리듬을 위한 송과체 멜라토닌은 일주기 리듬의 조절과 수면 조절에 관련이 있는 것으로 알려졌다. 이것은 시차증이나 교대 근무 수면 장애와 같은 일주기 리듬 수면 장애를 치료하는 데 있어서 가치가 있다. 또한 멜라토닌은 다른 영역에도 영향을 미치는데 특히 몸의 생리적 기능을 조절하는데 영향을 미친다. 게다가 정신의학적 질환뿐 만 아니라 생식기 질환, 심혈관 질환, 면역 조절 질환도 이 호르몬에 의해 영향을 받는 것으로 밝혀졌다.

• 생물정신의학
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• 제24권3호
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• pp.129-133
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• 2017

Objectives Obsessive-compulsive disorder (OCD) is a disabling psychiatric disorder, and more attention is recently paid on the quality of life (QoL) in OCD patients. The Euro-QoL-5D (EQ-5D) is a widely used self-report to calculate a single score which represents 'health utilities'. The aim of this study was to assess the health-related QoL for patients with OCD using the EQ-5D and to examine the relationship between health-related QoL and symptom severity. Methods Seventy-three patients with a Diagnostic and Statistical Manual of Mental Disorders (DSM-5) diagnosis of OCD were recruited from the outpatient clinic in Seoul National University Hospital. Symptom severity was assessed using the Yale-Brown Obsessive-Compulsive Scale (YBOCS), and QoL was assessed with the EQ-5D-5L questionnaire. Using Korean valuation study, a single score of QoL was calculated. Results Most of the OCD patients were relatively young (< 45 years) with the mean YBOCS total score of 19.33. The mean EQ-5D score was 0.71 and significantly correlated with symptom severity (r = -0.483, p < 0.001). 25% of the EQ-5D score was predicted by the YBOCS total score (b = -0.011, p < 0.001) by regression analysis. Conclusions OCD patients suffer from lower health-related QoL and QoL significantly decreased as symptom severity increased. The results of the EQ-5D would enable further studies on QoL comparison across medical disease and mental disorders.

• 대한한의학회지
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• 제39권3호
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• pp.17-27
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• 2018

Objectives: Ukgan-san does not appear in Traditional Korean Medicine classics. However, it has been used in research and clinical applications in Korea. In this paper, we are aiming to examine the records concerned with Ukgan-san to the present, and announce the present usage state in Korea. Methods: We searched and summarized the contents of previous medical books about Ukgan-san. In order to investigate the current status of utilization of Ukgan-san in Korea, a bibliographic database of Korea, a database of clinical researches, and a database of pharmaceuticals of the Korea Food and Drug Administration were searched. Results: As a result of searching Ukgan-san related documents, Ukgan-san has been developed in China (Ming dynasty). However, its clinical application has been expanded by modern Japanese kampo medicine doctors. In Korea, cases of Parkinson's disease, other movement disorders, and psychiatric disorders have been reported, and randomized controlled trials had been done and planned. In addition, some extracts which are consisted of Ukgan-san are also available. Conclusions: In Korea, Ukgan-san has been influenced by Japan and has been used for clinical and research purposes. The utilization rate in Korea is still small, but the utilization rate will increase according to the results of clinical studies.

• Toxicological Research
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• 제31권4호
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• pp.347-354
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• 2015

Excess manganese (Mn) is neurotoxic. Increased manganese stores in the brain are associated with a number of behavioral problems, including motor dysfunction, memory loss and psychiatric disorders. We previously showed that the transport and neurotoxicity of manganese after intranasal instillation of the metal are altered in Hfe-deficient mice, a mouse model of the iron overload disorder hereditary hemochromatosis (HH). However, it is not fully understood whether loss of Hfe function modifies Mn neurotoxicity after ingestion. To investigate the role of Hfe in oral Mn toxicity, we exposed Hfe-knockout ($Hfe^{-/-}$) and their control wild-type ($Hfe^{+/+}$) mice to $MnCl_2$ in drinking water (5 mg/mL) for 5 weeks. Motor coordination and spatial memory capacity were determined by the rotarod test and the Barnes maze test, respectively. Brain and liver metal levels were analyzed by inductively coupled plasma mass spectrometry. Compared with the water-drinking group, mice drinking Mn significantly increased Mn concentrations in the liver and brain of both genotypes. Mn exposure decreased iron levels in the liver, but not in the brain. Neither Mn nor Hfe deficiency altered tissue concentrations of copper or zinc. The rotarod test showed that Mn exposure decreased motor skills in $Hfe^{+/+}$ mice, but not in $Hfe^{-/-}$ mice (p = 0.023). In the Barns maze test, latency to find the target hole was not altered in Mn-exposed $Hfe^{+/+}$ compared with water-drinking $Hfe^{+/+}$ mice. However, Mn-exposed $Hfe^{-/-}$ mice spent more time to find the target hole than Mn-drinking $Hfe^{+/+}$ mice (p = 0.028). These data indicate that loss of Hfe function impairs spatial memory upon Mn exposure in drinking water. Our results suggest that individuals with hemochromatosis could be more vulnerable to memory deficits induced by Mn ingestion from our environment. The pathophysiological role of HFE in manganese neurotoxicity should be carefully examined in patients with HFE-associated hemochromatosis and other iron overload disorders.

• 대한불안의학회지
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• 제2권1호
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• pp.28-32
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• 2006

Objectives : Non-cardiac chest pain (NCCP) can be divided into gastroesophageal reflux disease (GERD) related NCCP and non-GERD related NCCP. Our study was designed to examine the differences in clinical characteristics and psychological mood states between the two clinical syndromes. Methods : After some cardiologic evaluations such as treadmill exercise, coronary angiography, and echocardiography, 27 patients with NCCP were enrolled in this study. They were divided into patients with GERD related NCCP (12 patients) and those with non-GERD related NCCP (15 patients) using the upper gastrointestinal endoscopy and the ambulatory 24 hour esophageal pH monitoring. Clinical characteristics such as typical reflux symptoms and psychological mood states were measured. Patients who showed scores more than 10 on the Beck Depression Inventory (BDI) or Beck Anxiety Inventory (BAI) were defined as depressed or anxious group. Anxiety sensitivity Index (ASI) was also measured in all patients. All parameters were compared between patients with GERD related NCCP and those with non-GERD related NCCP. Results : The two groups showed a difference in typical reflux symptoms. Patients with non-GERD related NCCP had higher scores on the BDI, BAI and ASI than those with GERD related NCCP. Among all NCCP patients, 14 patients (51.9%) were suggested to have possible depression or anxiety disorders. Conclusion : The non-GERD related NCCP was shown to be associated with psychological mood states such as anxiety and depression. Thus, we suggest that routine measurement of psychological mood states should be necessary in the evaluation and treatment of NCCP.

• 대한불안의학회지
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• 제13권2호
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• pp.141-147
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• 2017

Objective : This study aimed to evaluate the relationship between comorbid obsessive compulsive disorder (OCD) and quality of life in stable patients with schizophrenia. Methods : We interviewed 162 symptom-stable inpatients who have been on a constant dose of antipsychotics for at least 3 months prior and diagnosed as chronic schizophrenia. Subsequently, patients were classified according to the existence of OCD as evaluated using the Diagnostic and Statistical Manual of Mental Disorders-IV (DSM-IV). Further, all clinical and demographic data were collected and evaluated. To investigate potential interrelationships, the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), Korea-Positive and Negative Symptom Scale (K-PANSS), Korean Modification of the Scale to Measure Subjective Well-Being under Neuroleptic Treatment (KmSWN) and Korean Version Quality of Life Scale (K-QOLS) were performed. Independent t-test and Chi-square test were used to compare groups and regression analysis was done to assess the relationship between the Y-BOCS and quality of life. Results : Schizophrenia patients with OCD showed significantly earlier onset of schizophrenia, more severe psychiatric symptoms and lower quality of life, compared to those without comorbid OCD. OCD might be associated with lower quality of life in schizophrenia. Conclusion : Schizophrenia patients with OCD showed lower quality of life than those without OCD. In the treatment for schizophrenia, evaluation of OCD might be needed to improve their quality of life and social function.

• 대한간호학회지
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• 제28권3호
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• pp.801-809
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• 1998

This study was carried out the group communication program which I had composed of using the Satir's communication family theory and skills. The purpose of this study was to investigate the effects on the dysfunctional communication self-esteem and depression, executed this program for the mothers group with caring the mental disorders. and then for the test of some hypotheses it was devided two groups ; the experimental group(n=20) and control group(n=25). In the control group they were learned two session family education program in the psychiatric clinics of Pusan National University Hospital and in the experimental group they had experienced during the 10 session by the group communication program. In the methods of the statistics on this datas, it was to statistics X²test for the comparison between the experimental group and control group with general characteristics. The effect of the Group Communication Program was to analyse ANCOVA between pre-post test on the disfunctional communication, self-esteem and depression in the control group and experimental group. The conclusions were derived from the results and test of hypothesis as followings ; 1) The results were tested the differentiation between the experimental and control group, and the pre-post test in the experimental group with dysfunctional communication self-esteem and depression. Some hypothesis were tested and supported as followings : It was supported that the level of dysfunctional communication of the experimental group would be lower than the control group (Hypothesis 1) It was supported that the level of self-esteem of the experimental group would be higher than the control group (Hypothesis 2). It was supported that the level of depression of the experimental group would be lower than the control group (Hypothesis 3). 2) The relation of the dysfunctional communication with the self-esteem was presented negative correlation and with the depression was not correlation. The relation of the self-esteem with the depression was presented significantly negative correlation. The relation of the sacrificuny pattern of dysfuntional communication with the self-esteem was presented negative correlation and with the depression positive correlation.

• Journal of Korean Biological Nursing Science
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• 제19권1호
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• pp.48-54
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• 2017

Purpose: This study was done to identify the influence of severity of drinking problem, circadian rhythm and sleep quality in patients with alcohol use. Methods: A descriptive study design was utilized. Data were collected using self-report questionnaires from 139 patients with alcohol use disorder who were admitted to a psychiatric hospital in D city, Korea. The questionnaires included Alcohol Use Disorders Identification Test (AUDIT), Composite Scale of Morningness (CMS), Pittsburgh Sleep Quality Index (PSQI), and Korea sleep scale A. Data were analyzed using descriptive statistics, Pearson's correlation coefficients, and multiple regressions using the SPSS 20.0 program. Results: There was significant correlations among severity of problem drinking, circadian rhythm, sleep quality and sleep disorder. The significant factors influencing sleep disorder were severity of problem drinking(${\beta}=.12$, p= .042), circadian rhythm(${\beta}=-.14$, p= .039) and sleep quality(${\beta}=.63$, p= < .001). This model explained 56% of variance in sleep disorder(F = 57.34, p= < .001). Conclusion: The results of this study suggest that the development of sleep intervention programs for alcohol use disorder patients needs to consider severity of alcohol use, circadian rhythm and sleep quality, and sleep assessment and intervention are needed the early stage of the treatment and recovery process.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제19권2호
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• pp.112-119
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• 2008

Objectives : This study was conducted to examine whether there are qualitative differences in attention problem among children with various psychiatric disorders, including attention-deficit hyperactivity disorder (ADHD), depressive disorder, anxiety disorder, and tic disorder using clinical ADHD diagnostic system (ADS) T-scores. Methods : The subjects were 794 outpatient children aged from 5 to 15 years, including 540 children with ADHD, 95 children with depressive disorder, 86 children with anxiety disorder, and 73 children with tic disorder. Clinical T-scores on the ADS were calculated using the mean and standard deviations of four ADS variables for the ADHD group. Results : All four groups had T-scores on the ADS in the abnormal range. However, when comparing the clinical T-scores, the children with depressive and anxiety disorders performed better than the children with ADHD. We also found that although the four groups seemed to be similar in terms of clinical T-scores for omission and commission errors, there were significant differences in clinical T-scores for reaction time and the standard deviation of response time (RT) between the ADHD and other groups. Conclusions : We concluded that inattention and impulsivity might not be specific only to ADHD and that the clinical T-scores of RT and standard deviation of RT on the ADS could be used to discriminate between ADHD and other clinical groups.

• 대한불안의학회지
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• 제11권1호
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• pp.38-46
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• 2015

Objective : This study investigated the job stress and their association with depression and anxiety among Korean employees. Method : We retrospectively studied 80,842 employees, who receive regular checkups in the Health Screening Center of a one hospital from May, 2012 to April, 2013. A total of 73,975 people were analyzed, who completed a short form of Korean Occupational Stress Scale (KOSS), Center for Epidemiologic Study-Depression (CES-D) and Beck Anxiety Inventory (BAI). Results : Each of the seven subscales of KOSS was categorized into 4 quartile groups. Higher quartile of KOSS was associated with higher CES-D and BAI score an individual reported. The significantly increased odds ratios (ORs) in the higher scoring group compared to the lower scoring group for the effect of job stress on depression and anxiety remained after adjusting for age, sex, marital status, education, income, BMI, and smoking status. Conclusion : These results from a large number of respondents suggested that job stress might be related to depression and anxiety. Future investigations should design a prospective study to understand a causal relationship between job stress and psychiatric symptoms or disorders.