Browse > Article

Association between Quality of Life and Symptom Severity in Obsessive-Compulsive Disorder Patients Using EQ-5D  

Kim, Sung Nyun (Department of Neuropsychiatry, Seoul National University Hospital)
Moon, Woori (Department of Neuropsychiatry, Seoul National University Hospital)
Han, Jaewook (Department of Neuropsychiatry, Seoul National University Hospital)
Lee, Junhee (Department of Neuropsychiatry, Seoul National University Hospital)
Publication Information
Korean Journal of Biological Psychiatry / v.24, no.3, 2017 , pp. 129-133 More about this Journal
Abstract
Objectives Obsessive-compulsive disorder (OCD) is a disabling psychiatric disorder, and more attention is recently paid on the quality of life (QoL) in OCD patients. The Euro-QoL-5D (EQ-5D) is a widely used self-report to calculate a single score which represents 'health utilities'. The aim of this study was to assess the health-related QoL for patients with OCD using the EQ-5D and to examine the relationship between health-related QoL and symptom severity. Methods Seventy-three patients with a Diagnostic and Statistical Manual of Mental Disorders (DSM-5) diagnosis of OCD were recruited from the outpatient clinic in Seoul National University Hospital. Symptom severity was assessed using the Yale-Brown Obsessive-Compulsive Scale (YBOCS), and QoL was assessed with the EQ-5D-5L questionnaire. Using Korean valuation study, a single score of QoL was calculated. Results Most of the OCD patients were relatively young (< 45 years) with the mean YBOCS total score of 19.33. The mean EQ-5D score was 0.71 and significantly correlated with symptom severity (r = -0.483, p < 0.001). 25% of the EQ-5D score was predicted by the YBOCS total score (b = -0.011, p < 0.001) by regression analysis. Conclusions OCD patients suffer from lower health-related QoL and QoL significantly decreased as symptom severity increased. The results of the EQ-5D would enable further studies on QoL comparison across medical disease and mental disorders.
Keywords
Quality of life; EQ-5D; Obsessive-compulsive disorder; Symptom severity;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Rabin R, de Charro F. EQ-5D: a measure of health status from the EuroQoL Group. Ann Med 2001;33:337-343.   DOI
2 Kim SH, Ahn J, Ock M, Shin S, Park J, Luo N, et al. The EQ-5D-5L valuation study in Korea. Qual Life Res 2016;25:1845-1852.   DOI
3 Subramaniam M, Abdin E, Vaingankar JA, Nan L, Heng D, Mc-Crone P, et al. Impact of psychiatric disorders and chronic physical conditions on health-related quality of life: Singapore Mental Health Study. J Affect Disord 2013;147:325-330.   DOI
4 Roberts J, Lenton P, Keetharuth AD, Brazier J. Quality of life impact of mental health conditions in England: results from the adult psychiatric morbidity surveys. Health Qual Life Outcomes 2014;12:6.   DOI
5 Son SJ, Kim SJ, Kim CH. Quality of life for patients with obsessivecompulsive disorder and panic disorder. J Korean Neuropsychiatr Assoc 2006;45:438-443.
6 Eisen JL, Mancebo MA, Pinto A, Coles ME, Pagano ME, Stout R, et al. Impact of obsessive-compulsive disorder on quality of life. Compr Psychiatry 2006;47:270-275.   DOI
7 American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. Washington, DC;1995.
8 Goodman WK, Price LH, Rasmussen SA, Mazure C, Fleischmann RL, Hill CL, et al. The Yale-Brown Obsessive Compulsive Scale. I. development, use, and reliability. Arch Gen Psychiatry 1989;46:1006-1011.   DOI
9 Macy AS, Theo JN, Kaufmann SC, Ghazzaoui RB, Pawlowski PA, Fakhry HI, et al. Quality of life in obsessive compulsive disorder. CNS Spectr 2013;18:21-33.   DOI
10 Irvine EJ. Measuring quality of life: a review. Scand J Gastroenterol 1996;31:5-7.
11 Rapaport MH, Clary C, Fayyad R, Endicott J. Quality-of-life impairment in depressive and anxiety disorders. Am J Psychiatry 2005;162: 1171-1178.   DOI
12 Bobes J, Gonzalez MP, Bascaran MT, Arango C, Saiz PA, Bousono M. Quality of life and disability in patients with obsessive-compulsive disorder. Eur Psychiatry 2001;16:239-245.   DOI
13 Quilty LC, Van Ameringen M, Mancini C, Oakman J, Farvolden P. Quality of life and the anxiety disorders. J Anxiety Disord 2003;17: 405-426.   DOI
14 Gururaj GP, Math SB, Reddy JY, Chandrashekar CR. Family burden, quality of life and disability in obsessive compulsive disorder: an Indian perspective. J Postgrad Med 2008;54:91-97.   DOI
15 Stengler-Wenzke K, Kroll M, Riedel-Heller S, Matschinger H, Angermeyer MC. Quality of life in obsessive-compulsive disorder: the different impact of obsessions and compulsions. Psychopathology 2007;40:282-289.   DOI
16 Huppert JD, Simpson HB, Nissenson KJ, Liebowitz MR, Foa EB. Quality of life and functional impairment in obsessive-compulsive disorder: a comparison of patients with and without comorbidity, patients in remission, and healthy controls. Depress Anxiety 2009;26: 39-45.   DOI
17 Fontenelle IS, Fontenelle LF, Borges MC, Prazeres AM, Range BP, Mendlowicz MV, et al. Quality of life and symptom dimensions of patients with obsessive-compulsive disorder. Psychiatry Res 2010;179: 198-203.   DOI
18 Dolan P. Modeling valuations for EuroQoL health states. Med Care 1997;35:1095-1108.   DOI
19 Son MH, Byun KR, Choi BH, Woo JM. Assessment of health-related quality of life among patients with panic disorder using Euro-QoL in Korea. Anxiety and Mood 2012;8:9-15.
20 Skoog G, Skoog I. A 40-year follow-up of patients with obsessivecompulsive disorder [see commetns]. Arch Gen Psychiatry 1999;56: 121-127.   DOI
21 Subramaniam M, Soh P, Vaingankar JA, Picco L, Chong SA. Quality of life in obsessive-compulsive disorder: impact of the disorder and of treatment. CNS Drugs 2013;27:367-383.   DOI
22 Moritz S, Rufer M, Fricke S, Karow A, Morfeld M, Jelinek L, et al. Quality of life in obsessive-compulsive disorder before and after treatment. Compr Psychiatry 2005;46:453-459.   DOI
23 Angst J, Gamma A, Endrass J, Goodwin R, Ajdacic V, Eich D, et al. Obsessive-compulsive severity spectrum in the community: prevalence, comorbidity, and course. Eur Arch Psychiatry Clin Neurosci 2004;254:156-164.
24 Ruscio AM, Stein DJ, Chiu WT, Kessler RC. The epidemiology of obsessive-compulsive disorder in the National Comorbidity Survey Replication. Mol Psychiatry 2010;15:53-63.   DOI