• Journal of Information Processing Systems
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• 제17권2호
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• pp.297-305
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• 2021

Large amount of data is being generated in gaming servers due to the increase in the number of users and the variety of game services being provided. In particular, load balancing schemes for gaming servers are crucial consideration. The existing literature proposes algorithms that distribute loads in servers by mostly concentrating on load balancing and cooperative offloading. However, many proposed schemes impose heavy restrictions and assumptions, and such a limited service classification method is not enough to satisfy the wide range of service requirements. We propose a load balancing agent that combines the dynamic allocation programming method, a type of greedy algorithm, and proximal policy optimization, a reinforcement learning. Also, we compare performances of our proposed scheme and those of a scheme from previous literature, ProGreGA, by running a simulation.

• Nonlinear Functional Analysis and Applications
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• 제26권4호
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• pp.749-780
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• 2021

In this paper, we give the notion of M(., .)-𝜂-proximal mapping for a nonconvex, proper, lower semicontinuous and subdifferentiable functional on Banach space and prove its existence and Lipschitz continuity. As an application, we introduce and investigate a new system of variational-like inclusions in Banach spaces. By means of M(., .)-𝜂-proximal mapping method, we give the existence of solution for the system of variational inclusions. Further, propose an iterative algorithm for finding the approximate solution of this class of variational inclusions. Furthermore, we discuss the convergence and stability analysis of the iterative algorithm. The results presented in this paper may be further expolited to solve some more important classes of problems in this direction.

• Childhood Kidney Diseases
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• 제27권1호
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• pp.19-25
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• 2023

Proteinuria is an important risk factor for renal and cardiovascular disease. It is associated with a risk for glomerulonephritis, chronic kidney disease, and end-stage renal disease. Therefore, if persistent proteinuria is detected, kidney biopsy is considered to diagnose and treat the underlying disease. Recently, variants in the cubilin (CUBN) gene, which is associated with albuminuria, have been reported. This gene encodes cubilin, a membrane glycoprotein receptor expressed in the renal proximal tubules. Cubilin is a component of the megalin and cubilin-amnionless complex that mediates albumin reabsorption into the proximal tubules through endocytosis. A defect in cubilin leads to a reduction in albumin reuptake, resulting in albumin-dominant proteinuria. Although numerous controversies exist, several reports suggest that cubilin defects lead to proteinuria with a high portion of albuminuria but may not impair renal filtration function. If albuminuria due to reduced cubilin function is confirmed as a benign condition, we can consider using genetic studies to detect CUBN mutations in patients with proteinuria and they may not require any treatment or kidney biopsy. Here, we review recent papers on CUBN mutations and discuss the prognosis and management of individuals with this mutation.

• Asia pacific journal of information systems
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• 제30권4호
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• pp.695-718
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• 2020

Based on the Construal Level Theory, we aim to study a most favorable fit among the advertising model, media type, and message construals, which are important factors in an advertisement. A two (social distance of the ad model in an ad: distal (low similarity) vs proximal (high similarity) by two (social distance of a media type: distal (portal) vs. proximal (SNS)) by two (message construal: abstract vs concrete) laboratory experiment was conducted to examine attitude changes on ad messages. The results show that abstract messages were more effective in attitude toward advertisement and purchase intention under the distal social distance (i.e. advertising model in low-similarity and portal media type) while concrete messages were so under the proximal social distance and SNS media type.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제30권3호
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• pp.241-248
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• 2008

Tibial bone grafts provide an adequate volume of cancellous bone with cortical bone, high biologic value of bone, minimal gait disturbance and complications, and no special contraindications, and offer a superior clinical results than any other donor sites. Lateral appoach in tibial bone graft was used to gain large bone volume traditionally, but medial approach provides low morbidity associated with the tibial anatomic structure, simple and safety surgical procedure, and better comfortable to patients recently. We have undertaken clinical and retrospective studies on patients in Dept. of Oral and Maxillofacial Surgery, Inha University Hospital from April 2004 to January 2008. 50 patients have maxillofacial bony defect as resection of bening tumor, cyst enucleation, alveolar bone resorption, sinus pneumatization were received the tibial proximal autogenous particulated cancellous bone grafts. They were analyzed sex, age, diagnosis of recipient site, lesion size, dornor site, cortical bone repositioning, complications and we concluded favorable following results. 1. Medial approach for proximal tibia is safer and technically easier than lateral approach, associated with the proximal tibial anatomic structures, and short operative times. 2. Proximal tibia provides an adequate bone volume with predictability for oral and maxillofacial reconstruction. 3. Patients rarely complain of pain, swelling, discomfort and dysfunction such as gait disturbance. In conclusion, medial approach for proximal tibial graft seems to be a valuable tool for oral and maxillofacial reconstruction.

• 대한족부족관절학회지
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• 제1권1호
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• pp.5-11
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• 1997

국립의료인 정형외과에서 최근 10 년간 경도 및 중등도의 변형을 보인 무지외반증에 대해, 원위 연부조직 교정술을 시행받은 환자 12명, 20례(1군)와 원위 연부조직 교정술 및 근위 중족골 절골술을 시행받은 환자 6명, 9례 (2군)를 최초 6개월 이상 추시하여 다음과 같은 결과를 얻었다. 1. 최종 추시상 주관적 평가 및 합병증의 유무에 있어서 두 군간에 유의한 차이는 없었다. 환자의 주관적 만족도는 1군 80%, 2군 78%에서 만족으로 분류되었다. 2. 술전 무지외반각 및 중족골간각은 1군에서 평균 30.6도, 12.5도 였으며 수술 직후 각각 7.3도, 10.4도로 호전되었다. 술전 2군에서 평균 32.5도, 12.4도 였으며 순술 직후 각각 8.0도, 10.1도로 호전되었다. 두 군간에 유의한 차이는 없었다. 3. 최종 추시 상 교정각의 소실은 무지외반각의 경우 1군에서 평균 8.7도, 2군에서 평균 10.9도 로서 두 군 간에 유의한 차이는 없었다. 또한 중족골간각 친정의 소실은 1관에서 평균 0.4도, 2군에서 평균 2.7도 였다. 그러므로 중등도 이하의 변형을 보이는 무지외반증에서 원위 연부조직 교정술에 추가한 근위 절골술은 별다른 잇점이 없었다.

• Clinics in Shoulder and Elbow
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• 제11권2호
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• pp.143-149
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• 2008

목적: 근위 상완골 골절에서 잠김 압박 금속판과 비잠김 금속판 고정의 방사선학적 임상적 추시 결과를 비교 분석하고자 하였다. 대상 및 방법: 2003년부터 2007년 까지 본원에서 근위 상완골 골절로 입원하였던 87명의 환자중 금속판 고정술을 시행 받았던 환자 20명을 대상으로 하였으며 20명의 환자는 잠김 압박 금속판 고정을 시행하였던 환자 10명, 비잠김 금속판 고정을 시행하였던 환자 10명의 두 군으로 나뉘었다. 각각의 환자군은 수술 직후와 수술 후 6개월 뒤 방사선 사진상 상완골의 경간각, 골유합까지 소요된 시간, 합병증의 빈도 그리고 마지막 추시 당시의 Constant score를 측정하여 서로 비교 분석 하였다. 결과: 상완골의 경각간 및 골유합, Constant score에 대해서 두 군은 유의한 차이를 보이지 않았으나 비잠김 금속판을 사용한 군에서 나사 풀림 현상이 3례에서 발견되었다. 결론: 추시 결과상 잠김 압박 금속판의 사용이 비잠김 금속판에 비하여 임상적, 방사선학적으로 유의한 차이는 없었으나 근위 상완골 골절의 치료에서 나사 풀림 현상 등의 합병증이 적은 잠김 압박 금속판을 사용하는 것이 더 효과적일 것으로 사료된다.

• 대한약리학회지
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• 제7권1호
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• pp.67-76
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• 1971

The excretion of uric acid in man has been of great interest because of its importance as an end product in purine metabolism as well as of its role in causing gout. There are many differences in the modes of renal handling of urate among various species of animals. Uric acid actively secreted by the renal tubules of most vertebrate including amphibians, reptiles, and birds. On the other hand, in most mammals net tubular reabsorption of urate appears to be occurred with some exception, such, as Dalmatian dog. In the rabbits, however, the mechanism of renal excretion of uric acid has long been a subject of controversial results. Within a given group it was possible to find individuals with either net secretion or net reabsorption of urate depend on the experimental conditions. Excretion of urate can be depressed or enhanced by a variety of drugs belonging mainly to the aromatic acid group. Diodrast, probenecid, cinchophen and salicylates have been reported as uricosuric agents, on the other hand, lactate, benzoate, pyrazinoic acid, acetazolamide and chlorothiazide are known to be contraindicated to use for the patient with gout since these agents depress the excretion of uric acid from the kidney. However, complex and sometimes the paradoxical effects on the urate excretion by those above mentioned drugs are not uncommon. The experiments were designed to investigate the mechanisms of renal handling of urate as well as the effects of variety of drugs on the tubular transport of uric acid in the rabbits. Male or female white rabbits, from 1.5 to 2.5 kg in weight, were used. The experimental methods used in these studies were clearance, stop-flow, and retrograde injection techniques. The effects of saline, salicylate, chlorothiazide and probenecid were investigated in each experimental conditions. Results of the experiments were summarized as follows; 1. In the rabbits, the rate of urate clearance was always lower than the rate of inulin clearance. The filtration fraction of the urate was one third on an average, therefore, it is estimated that approximately two thirds of filtered urate was reabsorbed. 2. In the kidneys of rabbits, the urate clearance was increased significantly by administration of chlorothiazide and decreased by probenecid. The administration of salicylate had no effect on the rate of urate clearance. The filtration fraction of urate was increased by chlorothiazide and decreased by probenecid. 3. In the stop-flow studies, the U/P ratio of urate was higher than the U/P ratio of inulin in the proximal region, indicating the secretion of uric acid in the proximal tubules. The proximal peak was increased by chlorothiazide and inhibited by probenecid.4. In the retrograde injection studies, the reabsorption of urate in the proximal region was observed, and these reabsorptive transport of urate was depressed by either probenecid or by chlorothiazide. 5. No distal tubular activity was observed under any of these experimental conditions concerning urate transport. The results of these experiments show that probenecid inhibits both secretory and reabsorptive transport of uric acid in the kidney of the rabbits. The enhancement of secretory transport of urate by chlorothiazide in the clearance study was due to the secondary action of chlorothiazide which inhibits the reabsorptive transport of urate in the proximal tubules. It is evident that the urate transport in the kidneys of rabbits is bidirectional nondiffusive flux both secretory and reabsorptive directions in the proximal tubules.

• Journal of Ginseng Research
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• 제33권1호
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• pp.26-32
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• 2009

인삼은 전통적으로 항당뇨 효과가 있는 것으로 보고되고 있다. Insulin-like growth factor (IGF)-I 역시 당뇨병성 신증의 발병 초기에 중요한 역할을 하는 것으로 알려져 있다. 이에 본 연구에서는 신장 근위세뇨관 세포에서 고포도당에 의한 IGF-I 분비에 대한 ginsenoside의 차단 효과 및 이와 관련된 신호전달계를 알아보았다. 결과는 다음과 같다. 고포도당에 의해 증가되었던 IGF-I분비 촉진 작용은 GTS, PD 및 PT 처리 시 차단되었으며, 세포 성장 작용 (세포 비대)에서도 같은 효과를 볼 수 있었다. 아울러 고포도당에 의한 cAMP 및 PKC 활성은 GTS 처리시 현저하게 차단되었으며 PD 및 PT 처리 시 역시 부분적으로 억제되는 것으로 나타났다. 이상의 결과를 볼 때 신장 근위세뇨관 세포에서 ginsenoside는 cAMP 및 PKC 활성 경로를 억제하여 고포도당에 의한 IGFs 분비 작용을 차단하는 것으로 나타났다.

• Imaging Science in Dentistry
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• 제39권1호
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• pp.35-39
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• 2009

Purpose: The purpose of the experiment was to evaluating the diagnostic ability of dental caries detection using digital subtraction in the artificial caries activity model. Materials and Methods: Digital radiographies of five teeth with 8 proximal surfaces were obtained by CCD sensor (Kodak RVG 6100 using a size #2). The digital radiographic images and subtraction images from artificial proximal caries were examined and interpreted. In this study, we proposed novel caries detection method which could diagnose the dental proximal caries from single digital radiographic image. Results: In artificial caries activity model, the range of lesional depth was $572-1,374{\mu}m$ and the range of lesional area was $36.95-138.52mm^2$. The lesional depth and the area were significantly increased with demineralization time (p<0.001). Furthermore, the proximal caries detection using digital subtraction radiography showed high detection rate compared to the proximal caries examination using simple digital radiograph. Conclusion: The results demonstrated that the digital subtraction radiography from single radiographic image of artificial caries was highly efficient in the detection of dental caries compared to the data from simple digital radiograph.