• Asian Pacific Journal of Cancer Prevention
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• 제15권15호
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• pp.6227-6232
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• 2014

Background: Oral squamous cell carcinoma (OSCC) remains as one of the most difficult malignancies to control because of its high propensity for local invasion and cervical lymph node dissemination. The aim of present study was to evaluate the efficacy of novel pH and temperature sensitive doxorubicin-methotrexate-loaded nanoparticles (DOX-MTX NP) in terms of their potential to change the VEGF-C expression profile in a rat OSCC model. Materials and Methods: 120 male rats were divided into 8 groups of 15 animals administrated with 4-nitroquinoline-1-oxide to induce OSCCs. Newly formulated doxorubicin-methotrexate-loaded nanoparticles (DOX-MTX NP) and free doxorubicin were IV and orally administered. Results: Results indicated that both oral and IV forms of DOX-MTX-nanoparticle complexes caused significant decrease in the mRNA level of VEGF-C compared to untreated cancerous rats (p<0.05). Surprisingly, the VEGF-C mRNA was not affected by free DOX in both IV and oral modalities (p>0.05). Furthermore, in DOX-MTX NP treated group, less tumors characterized with advanced stage and VEGF-C mRNA level paralleled with improved clinical outcome (p<0.05). In addition, compared to untreated healthy rats, the VEGF-C expression was not affected in healthy groups that were treated with IV and oral dosages of nanodrug (p>0.05). Conclusions: VEGF-C is one of the main prognosticators for lymph node metastasis in OSCC. Down-regulation of this lymph-angiogenesis promoting factor is a new feature acquired in group treated with dual action DOX-MTX-NPs. Beside the synergic apoptotic properties of concomitant use of DOX and MTX on OSCC, DOX-MTX NPs possessed anti-angiogenesis properties which was related to the improved clinical outcome in treated rats. Taking together, we conclude that our multifunctional doxorubicin-methotrexate complex exerts specific potent apoptotic and anti-angiogenesis properties that could ameliorate the clinical outcome presumably via down-regulating dissemination factor-VEGF-C expression in a rat OSCC model.

• 디지털융복합연구
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• 제19권3호
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• pp.65-79
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• 2021

본 연구에서는 특허의 유지 및 포기에 관한 의사 결정에 있어서 특허권자의 경제적이고 합리적인 의사결정 요소가 아닌 감정적 요소가 의사결정에 어떠한 영향을 미치는지를 파악하고, 이를 기반으로 특허정책의 새로운 기준을 제시하고자 하였다. 이를 위하여, 우선 한국특허의 특허권자별 특허보유기간에 따른 특허포기 유형을 분석하였으며, 설문조사 방법을 사용하여 매몰비용편향, 보유효과와 커플링 관점에서 특허권자에 따른 차이가 있는 지를 검증하였다. 연구결과, 개인과 중소기업이 대기업보다 상대적으로 의사결정에 있어서 매몰비용과 보유효과에 대한 감정적 편향이 크게 나타났으며, 의사결정 경험이 증가함에 따라 매몰비용효과가 감소하였다. 또한, 특허갱신료 지불주기 단축이 특허권의 사용의지의 상승에도 긍정적 영향을 미치는 것으로 파악되었으며, 특히 특허권자가 개인과 중소기업일 때 대기업인 경우보다 그 상승효과가 크게 나타남을 확인할 수 있었다. 본 연구결과는 특허권자의 성향을 기반으로 특허자산의 낭비적 요인을 최소화하는 정책을 수립함에 있어 일조를 할 수 있을 것으로 기대된다.

• Journal of Korean Neurosurgical Society
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• 제65권6호
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• pp.834-840
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• 2022

Objective : C-reactive protein (CRP) level, erythrocyte sedimentation rate (ESR), and white blood cell (WBC) count are inflammatory markers used to evaluate postoperative infections. Although these markers are non-specific, understanding their normal kinetics after surgery may be helpful in the early detection of postoperative infections. To compliment the recent trend of reducing the duration of antibiotic use, this retrospective study investigated the inflammatory markers of patients who had received antibiotics within 24 hours after surgery according to the Health Insurance Review & Assessment Service guidelines and compared them with those of patients who had received antibiotics for 5 days, which was proven to be non-infectious. Methods : We enrolled 74 patients, divided into two groups. Patients underwent posterior lumbar interbody fusion (PLIF) at a single institution between 2019 and 2020. Group A included 37 patients who received antibiotics within 24 hours after the PLIF procedure, and group B comprised 37 patients who had used antibiotics for 5 days. A 1 : 1 nearest-neighbor propensity-matched analysis was used. The clinical variables included age, sex, medical history, body mass index, estimated blood loss, and operation time. Laboratory data included CRP, ESR, and WBC, which were measured preoperatively and on postoperative days (POD) 1, 3, 5, and 7. Results : CRP dynamics tended to decrease after peaking on POD 3, with a similar trend in both groups. The average CRP level in group B was slightly higher than that in group A; however, the difference was not statistically significant. Multiple linear regression analysis revealed operation time, number of fused levels, and estimated blood loss as significant predictors of a greater CRP peak value (r²=0.473, p<0.001) in patients. No trend (a tendency to decrease from the peak value) could be determined for ESR and WBC count on POD 7. Conclusion : Although slight differences were observed in numerical values and kinetics, sequential changes in inflammatory markers according to the duration of antibiotic administration showed similar patterns. Knowledge of CRP kinetics allows the assessment of the degree of difference between the clinical and expected values.

• Journal of Korean Neurosurgical Society
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• 제63권4호
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• pp.433-443
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• 2020

Objective : Osteoporosis is a disease of unbalanced bone metabolism that results in low bone mineral density with increased bone fragility and propensity for fractures. The increased rate of bone fracture due to osteoporosis places a significant burden on public health care expenditures. Therefore, numerous studies have been designed and performed to identify the drugs or health foods that can improve the bone quality or quantity. This study was designed to evaluate and analyze the therapeutic effects of rutin on histomorphometric values of the spine and femur in an osteoporotic mouse model induced by bilateral ovariectomy. Methods : Thirty female ICR mice (8 weeks old) underwent either a sham operation (only abdominal incision, sham group, n=10) or bilateral ovariectomy (n=20). The ovariectomized (OVX) animals were randomly divided into two groups : untreated OVX group (OVX-C, n=10), or rutin-administered group (OVX-R, n=10). The OVX-C group received weight-adjusted doses of saline vehicle and the OVX-R group received 50 mg/kg of rutin intraperitoneally, starting 1 day after surgery. At 4 and 8 weeks after surgery, serum estrogen, osteocalcin, alkaline phosphatase (ALP), and the telopeptide fragment of type I collagen C-terminus (CTX-1) were analyzed. Interleukin (IL)-1β, IL-6, IL-10, and tumor necrosis factor (TNF)-α were also analyzed. Bone histomorphometric parameters of the 4th lumbar vertebra and femur were determined by micro-computed tomography. Results : In OVX-C group, ALP, osteocalcin, CTX-1, IL-1β, IL-6, and TNF-α levels were significantly increased at 4 and 8 weeks compared to sham operation group. Rutin administration after OVX statistically significantly reduced ALP, CTX-1, IL-1β, IL-6, and TNF-α levels at 4 and 8 weeks. Rutin administration also improves bone histomorphometric parameters including trabecular bone volume fraction, trabecular thickness, and trabecular number. Trabecular separation was also decreased in OVX-R group compared to OVX-C group. Conclusion : The present study demonstrated that rutin has therapeutic effects on improving bone histomorphometric values in an OVX mouse model. The improvement in histomorphometric values may be associated with the reduction of osteoclastic activity via inhibition of IL-1β, IL-6, and TNF-α. In future studies, the mechanism for the effect of rutin on osteoporosis should be demonstrated more clearly to use rutin in human osteoporosis.

• 한국건축시공학회지
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• 제10권2호
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• pp.97-104
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• 2010

본 연구에서는 전열해석 프로그램인 피지벨(PHYSIBEL)을 사용하여 블라인드 내장형 창호시스템의 일사차단성능 및 단열성능에 따른 에너지 성능을 평가하였다. 피지벨 해석시 창호별 구성 재료의 열적특성과 해석조건을 결정하기 위해서 Mock-up시험을 실시하였으며, 컴퓨터 시뮬레이션을 통한 결과를 바탕으로 공동주택 기준층 1개 세대(33평형)를 대상으로 연간에너지 소비특성, 연간전열량, 연간 냉난방 비용을 분석하였다. 실험결과, 연간전열량은 일반 창호시스템 대비 블라인드 내장형 창호시스템에서 블라인드를 올린 경우 냉방시 10%, 난방시 11% 절감할 수 있으며, 블라인드를 내린 경우 냉방시 25%, 난방시 30%정도를 절감할 수 있는 것으로 나타났다. 블라인드 내장형 창호시스템의 냉 난방 부하 절감량은 일반 창호시스템에 비해 냉방시 283.3KWh, 난방시 76.3KWh 로 냉 난방 에너지 절감효과는 단위세대당 359.6KWh 절감시킬 수 있는 것으로 나타났으며, 이것은 단위세대당 연간 에너지원단위(TOE) 약 0.078toe, 이산화탄소톤($tCO_2$) $0.16tCO_2$을 절감시킬 수 있어 온실가스 저감에도 유리할 것으로 판단된다. 또한, 블라인드 내장형 창호시스템의 냉 난방비용 절감액은 일반창호시스템과 비교하여 연간 냉방비용 10만원, 난방비용 5만원으로 연간 냉 난방 비용을 약 15만원 정도 절감시킬 수 있는 것으로 나타났다.

• 한국전자거래학회지
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• 제25권1호
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• pp.13-33
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• 2020

본 연구는 자모 단위의 임베딩과 회선 신경망을 활용한 한국어 감성 분석 알고리즘을 제안한다. 감성 분석은 텍스트에서 나타난 사람의 태도, 의견, 성향과 같은 주관적인 데이터 분석을 위한 자연어 처리 기술이다. 최근 한국어 감성 분석을 위한 연구는 꾸준히 증가하고 있지만, 범용 감성 사전을 사용하지 못하고 각 분야에서 자체적인 감성 사전을 구축하여 사용하고 있다. 이와 같은 현상의 문제는 한국어 특성에 맞지 않게 형태소 분석을 수행한다는 것이다. 따라서 본 연구에서는 감성 분석 절차 중 형태소 분석을 배제하고 초성, 중성, 종성을 기반으로 음절 벡터를 생성하여 감성 분석을 하는 모델을 개발하였다. 그 결과 단어 학습 문제와 미등록 단어의 문제점을 최소화할 수 있었고 모델의 정확도는 88% 나타내었다. 해당 모델은 입력 데이터의 비 정형성에 대한 영향을 적게 받으며, 텍스트의 맥락에 따른 극성 분류가 가능하게 되었다. 한국어 특성을 고려하여 개발된 본 모델이 한국어 감성 분석을 수행하고자 하는 비전문가에게 보다 쉽게 이용될 수 있기를 기대한다.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제22권2호
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• pp.103-111
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• 2011

Objectives : This study compared covert narcissistic propensity in adolescents with internet addiction tendency to normal adolescents. Further, we investigated the correlation between such propensities and anonymity in cyberspace, presence feeling and interactivity in internet gaming, and achievement motivation in adolescents with internet addiction tendencies. Methods : Male middle school students with internet addiction tendencies (Addiction Tendency Group, N=27) and normal students (Control Group, N=29) were recruited. The scale of internet use, Covert Narcissism Scale, scale of achievement motivation, scale of anonymity in cyberspace, scale of presence feeling in internet games, and the scale of interactivity in internet games were administered. A comparison of the average scores and correlation analyses were performed. Results : 1) Compared with Control Group, the Addiction Tendency Group showed significantly higher scores on all subscales of the Covert Narcissism Scale, and both the scale of presence feeling and that of interactivity in internet games. Further, the score on the scale of achievement motivation for the Addiction Tendency Group was significantly lower than that of the Control Group. 2) In the Addiction Tendency Group, the scores on several subscales of the Covert Narcissism Scale were significantly positively correlated with the scores on the scale of presence feeling in internet games, anonymity in cyberspace, and interactivity in internet games. However, in the Control Group, the scores of several subscales on the Covert Narcissism Scale were significantly negatively correlated with the score on the scale of achievement motivation, and was significantly positively correlated with the score on the scale of interactivity in internet games. There were no other significant correlations between the scores on the subscales of the Covert Narcissism Scale and the scores of either presence feeling in internet games or anonymity in cyberspace. Conclusion : These results suggested that adolescents with a tendency to be addicted to the internet exhibited higher covert narcissistic propensities than normal adolescents and that the covert narcissistic tendencies were related with presence feeling in cyber games as well as with anonymity in cyberspace.

• 사회복지연구
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• 제40권3호
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• pp.5-40
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• 2009

2008년 6월 현재 전국의 노인요양시설 충족률은 96.4%로, 장기요양인프라 확대정책은 양적인 측면에서 가시적인 성과를 이루었으나 여전히 시설 인프라의 부족, 지역적 편중, 정부의 책임성 저하 등 정책집행의 실효성 문제가 지적되고 있다. 본 연구는 장기요양보장 인프라 확대정책의 집행과정과 이에 영향을 미친 요인을 규명하여 정책집행과정에서 나타난 문제점을 살펴보고 향후 인프라 확대정책의 발전방안을 제시하고자 수행되었다. 연구방법은 중앙정부가 수립한 인프라 확대정책을 확인하기 위해 문헌을 검토하였고, 지방정부차원의 실질적인 집행과정을 살펴보고자 K도, C시, C시 내 노인요양시설 4곳을 대상으로 사례연구를 진행하여, Alexander(1985)의 분석틀로 정책집행의 영향요인을 분석하였다. 연구결과, 정책목표의 명확성과 적절성, 서비스 공급주체의 성격, 정부 간 역할과 책임 등 정책변수와 재정부담 및 예산배정 의지, 예산의 신속한 집행 및 절차의 간소화, 재량권, 집행기관 간 상호관계 등 집행변수가 정책집행의 주요 영향요인으로 나타났다. 이에 지역 실수요를 기초로 한 시설필요도 산출, 민간참여에 대한 보완 등 몇 가지 정책개선과제를 제언하였다.

• Journal of Gastric Cancer
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• 제18권3호
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• pp.230-241
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• 2018

Purpose: Enhanced recovery after surgery (ERAS) protocols for gastric cancer patients have shown improved outcomes in Asia. However, data on gastric cancer ERAS (GCERAS) programs in the United States are sparse. The purpose of this study was to compare perioperative outcomes before and after implementation of an GC-ERAS protocol at a National Comprehensive Cancer Center in the United States. Materials and Methods: We reviewed medical records of patients surgically treated for gastric cancer with curative intent from January 2012 to October 2016 and compared the GC-ERAS group (November 1, 2015-October 1, 2016) with the historical control (HC) group (January 1, 2012-October 31, 2015). Propensity score matching was used to adjust for age, sex, number of comorbidities, body mass index, stage of disease, and distal versus total gastrectomy. Results: Of a total of 95 identified patients, matching analysis resulted in 20 and 40 patients in the GC-ERAS and HC groups, respectively. Lower rates of nasogastric tube (35% vs. 100%, P<0.001) and intraabdominal drain placement (25% vs. 85%, P<0.001), faster advancement of diet (P<0.001), and shorter length of hospital stay (5.5 vs. 7.8 days, P=0.01) were observed in the GC-ERAS group than in the HC group. The GC-ERAS group showed a trend toward increased use of minimally invasive surgery (P=0.06). There were similar complication and 30-day readmission rates between the two groups (P=0.57 and P=0.66, respectively). Conclusions: The implementation of a GC-ERAS protocol significantly improved perioperative outcomes in a western cancer center. This finding warrants further prospective investigation.

• 대한임상독성학회지
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• 제21권2호
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• pp.117-127
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• 2023

Purpose: No consensus currently exists regarding the maximal pressure of hyperbaric oxygen (HBO₂) therapy performed within 24 hours of acute carbon monoxide (CO) poisoning. This study aimed to evaluate the difference in therapeutic effects according to the first HBO₂ pressure (3.0 atmospheres absolute [ATA] vs. 2.8 ATA). Methods: We used prospectively collected registry data on CO poisoning at a tertiary academic hospital in the Republic of Korea. Adult patients with acute CO poisoning treated with HBO₂ within 24 hours after arrival at the emergency department and without the use of additional HBO₂ after 24 hours between January 2007 and February 2022 were included. Data from 595 patients were analyzed using propensity score matching (PSM). Patients with mild (non-intubated) and severe (intubated) poisoning were also compared. Neurocognitive outcomes at 1 month after CO poisoning were evaluated using the Global Deterioration Scale combined with neurological impairment. Results: After PSM, the neurocognitive outcomes at 1-month post-CO exposure were not significantly different between the 2.8 ATA (110 patients) and 3.0 ATA (55 patients) groups (p=1.000). Similarly, there was also no significant difference in outcomes in a subgroup analysis according to poisoning severity in matched patients (165 patients) (mild [non-intubated]: p=0.053; severe [intubated]: p=1.000). Conclusion: Neurocognitive sequelae at 1 month were not significantly different between HBO₂ therapy pressures of 2.8 ATA and 3.0 ATA in patients with acute CO poisoning. In addition, the 1-month neurocognitive sequelae did not differ significantly between intubated and non-intubated patients.