• Journal of Dental Anesthesia and Pain Medicine
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• v.17 no.4
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• pp.323-327
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• 2017

QT prolongation is an electrocardiographic change that can lead to lethal arrhythmia. Acquired QT prolongation is known to be caused by drugs and electrolyte abnormalities. We report three cases in which the prolonged QT interval was improved at the time of operation by briefly discontinuing the drugs suspected to have caused the QT prolongation observed on preoperative electrocardiography. The QTc of cases 1, 2, and 3 improved from 518 to 429 ms, 463 to 441 ms, and 473 to 443 ms on discontinuing the use of a gastrointestinal prokinetic agent, a proton pump inhibitor, and a molecular targeted drug, respectively. These cases were considered to have drug-induced QT prolongation. We reaffirmed that even drugs administered for conditions unrelated to cardiac diseases can have adverse side effect of QT prolongation. In conclusion, our cases indicate that dental surgeons should be aware of the dangerous and even potentially lethal side effects of QT prolongation. For safe oral and maxillofacial surgery, cooperation with medical departments in various fields is important.

• Korean Journal of Biological Psychiatry
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• v.11 no.1
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• pp.49-53
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• 2004

Objective:A Comparison of QTc prolongation for various antipsychotics and an analysis of QTc prolongation for the various types of serotonin transporter polymorphism were performed. Method:EKG was checked, followed by QTc measurement as Bazett's correction, and the serotonin transporter polymorphism was examined in 110 chronic schizophrenia patients were performed EKG before 24 weeks ago. We defiened QTc prolongation as over 450ms. The risk factor of sudden cardiac death were defiend as QTc prolongation and or 60ms in delta value. Result:The prevalence of QTc prolongation in this study was 7.3%, and the prevalence of over 60ms was 4.5%. Patients who had the risk factors were 10(9.1%). 6/52 who prescribed atypical antipsychotics and 2/58 who prescribed haloperidol showed QTc prolongation. The prevalence who had the risk factor of sudden cardiac death were 16% in atypical antipsychotics group, 3.4% in haloperidol group. QTc prolongation were observed more frequently in l/l type than s/s type. l allele frequency were 50% in QTc prolongated group, 19% in not prolongated group. l allele had an association with QTc prolongation(p<0.01). Conclusion:The prevalence of QTc prolongatin was frequent in chronic schizophrenia patients who were prescribed atypical antipsychotics. It has strong association with l allele of 5-HTTLPR.

• Journal of The Korean Society of Clinical Toxicology
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• v.3 no.2
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• pp.135-138
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• 2005

Amisulpride is a newly developed atypical antipsychotic agent effective in treating the positive and negative symptom of schizophrenia. Over-dose of amisulpride can cause hypocalcemia and thus may lead to QT prolongation. We report a case of hypocalcemia and QT prolongation. The QT prolongation was normalized after calcium supplement.

• Asian Journal of Turfgrass Science
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• v.4 no.1
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• pp.5-11
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• 1990

Korean Lawn. Zoysia japonica Steud. is the type of a perennial warm-season turfgrass keeping green leaf color for 5 months from May to September in natural condition in Korea. This Studies were carried out to obtain the effects of N-P-K fertilization, regrowth capacity after mowing and chlorophyll contents on prolongation of the green leaf color period in Zoysia japonica Steud turfgrass areas. The results obtained are summarized as follows ; 1.The effects of nitrogen fertilizer application in Zoysia japonica Steud, turfgrass areas were affected on regrowth ability after mowing green color of leaf canopies and chlorophyll contents, respectively(P<.05) 2.A experimental plots which applied 51 g/m$^2$/10 weeks of N$_3$P$_1$K$_1$fertilizer, there were high significant effects on prolongation of the green leaf color period and the plots of phosphorus and potassium had additive effects. 3.Prolongation of the green leaf color period to the last of October was obviously possible by slow degrees in proportation to increment of the fertilizer. However, it is interpreted that more prolongation of the green period is impossible with N-P-K fertilization and irrigation treatments. unless the intermediate turfgrasses between $C_3$ and $C_4$plants must be found and bred.

• Journal of the Chungcheong Mathematical Society
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• v.26 no.2
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• pp.351-356
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• 2013

In this article, we discuss the notions of chain prolongation functions on locally compact spaces and get some results for the concepts. We show that chain prolongation function is a cluster map.

• Journal of the Korean Mathematical Society
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• v.40 no.4
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• pp.695-708
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• 2003

We study the existence of solutions for overdetermined PDE systems that admit prolongation to a complete system. We reduce the problem to a Pfaffian system on a submanifold of the jet space of unknown functions and then express the integrability conditions in terms of the coefficients of the original system. As possible applications we present some local problems in CR geometry: determining the CR embeddibility into spheres and the existence of infinitesimal CR automorphisms.

• Communications of the Korean Mathematical Society
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• v.13 no.1
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• pp.131-136
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• 1998

The proximal flow have been introduced and studied by J. Auslander [1] and R. Ellis [2]. S. Glasner showed the various properties of the proximal flow in [7]. S. K. Kaul [3] have introduced the first prolongation set which contains the orbit closure. We define the F-proximal flow and $FP_\pi(y)$ by using the first prolongation set and investigated its properties.

• Journal of the Korean Mathematical Society
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• v.39 no.2
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• pp.237-252
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• 2002

We study the compatibility conditions and the existence of solutions or overdetermined PDE systems that admit complete prolongation. For a complete system of order k there exists a submanifold of the ($\kappa$-1)st jet space of unknown functions that is the largest possible set on which the initial conditions of ($\kappa$-1)st order may take values. There exists a unique solution for any initial condition that belongs to this set if and only if the complete system satisfies the compatibility conditions on the initial data set. We prove by applying the Frobenius theorem to a Pfaffian differential system associated with the complete prolongation.

• Journal of The Korean Society of Clinical Toxicology
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• v.18 no.2
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• pp.66-77
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• 2020

Purpose: The aims of the present study were twofold. First, the research investigated the effect of an individual's risk factors and the prevalence of psychotropic drugs on QTc prolongation, TdP (torsades de pointes), and death. Second, the study compared the risk scoring systems (the Mayo Pro-QT risk score and the Tisadale risk score) on QTc prolongation. Methods: The medical records of intoxicated patients who visited the emergency department between March 2010 and February 2019 were reviewed retrospectively. Among 733 patients, the present study included 426 psychotropic drug-intoxicated patients. The patients were categorized according to the QTc value. The known risk factors of QTc prolongation were examined, and the Mayo Pro-QT risk score and the Tisadale risk score were calculated. The analysis was performed using multiple logistic regression, Spearman correlation, and ROC (receiver operating characteristic). Results: The numbers in the mild to moderate group (male: 470≤QTc<500 ms, female: 480≤QTc<500 ms) and severe group (QTc≥500 ms or increase of QTc at least 60ms from baseline, both sex) were 68 and 95, respectively. TdP did not occur, and the only cause of death was aspiration pneumonia. The statically significant risk factors were multidrug intoxications of TCA (tricyclic antidepressant), atypical antipsychotics, an atypical antidepressant, panic disorder, and hypokalemia. The Tisadale risk score was larger than the Mayo Pro-QT risk score. Conclusion: Multiple psychotropic drugs intoxication (TCA, an atypical antidepressant, and atypical antipsychotics), panic disorder, and hypokalemia have been proven to be the main risk factors of QTc prolongation, which require enhanced attention. The present study showed that the Tisadale score had a stronger correlation and predictive accuracy for QTc prolongation than the Mayo Pro-QT score. As a result, the Tisadale risk score is a crucial assessment tool for psychotropic drug-intoxicated patients in a clinical setting.

• Ocean and Polar Research
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• v.29 no.1
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• pp.55-67
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• 2007

A reference to natural prolongation appeared for the first time in the North Sea Judgement. Although it was not suggested that the concept of natural prolongation would automatically allow for the fixing of a continental shelf boundary, that concept encouraged States to request international tribunals to determine continental shelf boundaries on the basis of the geological and geomorphological features of the seabed. In the Libya v. Malta Case, however, the rejection of geological and geomorphological factors was total. Especially, Natural prolongation was the then checkmated as a relevant fact in delimitation between coasts situated less than 400 nm. apart. There can be no doubt that, in several disputed cases, prominent geomorphological variations are simply ignored ; nevertheless, there are also a few agreements where geological and geomorphological characteristics come into play and, to a certain extent, affect maritime boundaries. Physical characteristics of sea-bed are generally given serious consideration in the boundary delimitation such as the final negotiated boundary of the Australia-Indonesia Continental Shelf boundary Agreement(Timor and Arafura seas) which follows the continental slope bordering the Timor Trench.