• The Korean Journal of Physiology and Pharmacology
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• 제21권5호
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• pp.531-546
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• 2017

Activation of Toll-like receptor-4 (TLR-4) in articular chondrocytes increases the catabolic compartment and leads to matrix degradation during the development of osteoarthritis. In this study, we determined the proteomic and genomic alterations in human chondrocytes during lipopolysaccharide (LPS)-induced inflammation to elucidate the underlying mechanisms and consequences of TLR-4 activation. Human chondrocytes were cultured with LPS for 12, 24, and 36 h to induce TLR-4 activation. The TLR-4-induced inflammatory response was confirmed by real-time PCR analysis of increased interleukin-1 beta ($IL-1{\beta}$), interleukin-6 (IL-6), and tumor necrosis factor alpha ($TNF-{\alpha}$) expression levels. In TLR-4-activated chondrocytes, proteomic changes were determined by two-dimensional electrophoresis and matrix-assisted laser desorption/ionization-mass spectroscopy analysis, and genomic changes were determined by microarray and gene ontology analyses. Proteomics analysis identified 26 proteins with significantly altered expression levels; these proteins were related to the cytoskeleton and oxidative stress responses. Gene ontology analysis indicated that LPS treatment altered specific functional pathways including 'chemotaxis', 'hematopoietic organ development', 'positive regulation of cell proliferation', and 'regulation of cytokine biosynthetic process'. Nine of the 26 identified proteins displayed the same increased expression patterns in both proteomics and genomics analyses. Western blot analysis confirmed the LPS-induced increases in expression levels of lamin A/C and annexins 4/5/6. In conclusion, this study identified the time-dependent genomic, proteomic, and functional pathway alterations that occur in chondrocytes during LPS-induced TLR-4 activation. These results provide valuable new insights into the underlying mechanisms that control the development and progression of osteoarthritis.

• 한국추진공학회지
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• 제19권6호
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• pp.91-97
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• 2015

HTPB/AP/Al 계열의 혼합형 열경화 추진제를 적용한 로켓 연구개발에 있어서의 추진제 기계물성 규격을 정하는 일련의 과정을 고찰하고, 공정지수를 통하여 추진제 제조에서의 공정관리를 분석하였다. 이를 근간으로 기계물성간의 종속성을 분석하고 최적화 물성을 제시함으로서 불량률을 제거하는 공정 안전도 향상뿐만 아니라 추진제 그레인의 구조적 안전도 상승에도 기여할 것이다.

• Journal of Pharmaceutical Investigation
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• 제40권1호
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• pp.33-38
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• 2010

Sibutramine is a serotonin-norepinephrine reuptake inhibitor indicated for the management of obesity in conjunction with a reduced calorie diet. The oral administration of sibutramine is followed by its dose-related side effects. In this study, sibutramine was formulated into drug in adhesive (DIA) patches in an attempt to overcome these problems. The effects of different formulation variables including pressure-sensitive adhesive (PSA), loading amount of drug, thickness of matrix and enhancer on the skin permeation of the drug were evaluated using excised hairless mouse skin. In the acrylic adhesive with carboxyl functional group, low release of sibutramine was observed due to the strong interaction between carboxyl group of adhesive and amine group of sibutramine. The acrylic adhesive without functional group provided good adhesion force and allowed high drug loading. Changing drug load as well as thickness of the matrix was found to alter permeation rate. $Crovol^{(R)}$ PK40 and $Crovol^{(R)}$ A40, were found to be effective enhancers for sibutramine. The optimized patch contained 20% sibutramine, and 5% $Crovol^{(R)}$ A40 as permeation enhancer, in $80\;{\mu}m$ thick Duro-$Tak^{(R)}$ 87-9301 matrix.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2004년도 하계학술대회 논문집 Vol.5 No.2
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• pp.1104-1108
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• 2004

A Study has been made of surface modification of various polymers by ion implantation to change the optical transmittance property at ultraviolet ray (UV, $200\sim400nm$). The substrates were PC (Polycarbonate), PET(Polyethyleneteraphtalate) and PP (Polypropylene). The effects of ion implantation on the change of optical transmittance were investigated in relation to ion species, implantation energies and ion fluences. The N, Ar, Kr, Xe ion implantation performed at ion energies from 20 to 50keV. The fluences ranged from $5\times10^{15}$ to $7\times10^{16}ions/cm^2$. UV/Vis transmittance spectroscopy, FT-IR and XPS were used to investigate optical transmittance, chemical structure and surface chemical state of irradiated polymer. Surface color was changed from the yellow to the dark brown and the transmittance of UV ray in the range UV-A($320\sim400nm$) decreased more than 80% after ion implantation.

• 한국수학교육학회지시리즈C:초등수학교육
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• 제18권3호
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• pp.175-190
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• 2015

연구에서는 게임개발을 위한 팀 프로젝트 활동이 수학영재의 공동체배려와 조직관리능력 기술에 미치는 효과를 확인하고 영재를 위한 리더십교육의 방향을 제시하고자 하였다. G교육지원청 영재교육원 초등수학반 4학년 학생을 대상으로 연구를 수행한 결과, 영재학생들은 15차시의 팀 프로젝트 활동을 통해 공동체배려와 조직관리능력 요인의 기술점수가 유의미하게 향상되었으며, 이는 동료들과 함께 수학이론 학습, 게임규칙 확인, 게임 개발 아이디어 회의, 게임 자료 제작, 산출물발표 준비 등의 과정을 경험하며 성장한 것으로 나타났다. 이러한 결과는 전공과목과 분리된 리더십교육이 아닌 수업주제의 특성과 융합된 리더십교육으로도 영재학생들에게 리더로서의 역량을 길러줄 수 있음을 시사한다.

• 한국추진공학회지
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• 제21권1호
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• pp.84-90
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• 2017

추진제의 주 바인더로 사용하고 있는 폴리부타디엔 계열인 HTPB (Hydroxyl Terminated Polybutadiene)는 합성 뱃취에 따라 분자량 및 관능기수 등 바인더 특성이 달랐으며 이는 바인더 자체와 추진제의 경화 반응 속도에 영향을 미치는 것으로 분석되었다. 최종적으로 이러한 추진제의 경화 반응 속도가 추진제 물성에 영향을 미치며, 우수한 물성의 추진제를 제조하기 위해서는 적절한 수준의 바인더의 경화 반응이 필요한 것으로 분석되었다.

• Child Health Nursing Research
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• 제27권4호
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• pp.354-364
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• 2021

Purpose: Kangaroo mother care (KMC) was introduced in Indonesia 30 years ago, but the extent of its use has not been fully documented. Therefore, this study aimed to examine the use of KMC and evaluate the characteristics of infants who received KMC at Koja District Hospital in North Jakarta, Indonesia. This retrospective cohort study recorded the characteristics of infants with birthweights less than or equal to 2,200 g at the above-mentioned hospital. Methods: Data collected from infant registers included gestational age, birthweight, Apgar score, number of complications, history of neonatal intensive care unit treatment, and KMC status. Cox regression analysis was conducted. Results: This study found that 57.7% of infants received KMC. Infants with birthweights over 1,500 g were 2.16 times (95% CI: 1.20-3.89) more likely to receive KMC. Conclusion: Efforts to promote KMC are recommended, specifically for infants with birthweights greater than 1,500 g. KMC for infants with other conditions can also be considered based on the infants' stability.

• 컴퓨터교육학회논문지
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• 제22권2호
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• pp.39-50
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• 2019

본 논문에서는 효과적인 컴퓨터 프로그래밍 학습을 위하여 팀 프로젝트 기반 학습을 설계하여 적용하고 학습효과에 미치는 영향을 분석하였다. 이론 강의 및 실습 최소화, 무작위 추첨에 의한 팀 구성, 각 팀원별 책임과 권한의 설정, 주어진 과제에 대한 경쟁 방식 문제 해결 프로젝트 진행, 팀 프로젝트가 끝날 때까지 매주 단계별 진행사항 발표를 통한 자연스러운 정보 공유 및 학습 사이클 반복 등을 통하여 학생들이 능동적으로 학습에 참여하는 모습이 관찰되었다. 과정 종료 후, 학습효과에 대한 분석을 위하여 학습자를 대상으로 설문조사를 실시하였으며, 그 결과 팀 프로젝트 기반 교육이 컴퓨터 프로그래밍 학습에 긍정적인 영향을 미치는 것으로 파악되었다. 본 논문에서는 도출된 요인 간 관계분석을 바탕으로 보다 효과적인 컴퓨터 프로그래밍 학습 방법을 논하고자 한다.

• 한국군사과학기술학회지
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• 제22권1호
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• pp.11-19
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• 2019

The waveguide slotted active phased array radar is characterized in that the beam is tilt in a specific direction when the feeding position of the antenna is not in the center of the antenna. If the beam deflection phenomenon is not properly compensated, error bias is generated in the target information collected by the radar, and the target accuracy is lowered. In this paper, we describe a technique to compensate the error of the target information that is collected in the active phased array radar of the waveguide slot type instead of the center of the antenna.

• 한국멀티미디어학회논문지
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• 제25권3호
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• pp.546-557
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• 2022

Recently, the demand to interpret image data with artificial intelligence in various fields is rapidly increasing. Object recognition and detection techniques using deep learning are mainly used, and video integration analysis to determine unstructured object recognition is a particularly important problem. In the case of natural disasters or social disasters, there is a limit to the object recognition structure alone because it has an unstructured shape. In this paper, we propose intelligent video integration analysis system that can recognize unstructured objects based on video turning point and object detection. We also introduce a method to apply and evaluate object recognition using virtual augmented images from 2D to 3D through GAN.