• 한국해양공학회지
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• 제16권5호
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• pp.49-55
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• 2002

The compression anchor is characterized by decrement of progressive failure, simple site work, economy and durability compared with tension anchor. In this paper, compression anchor is analysed through the laboratory element tests. The formula to be estimate the grout strength in fixed part of compression anchor and the effective reinforcement method for several types of soil were suggested. The following conclusions were made from this study : (1) A formula, which is able to calculate the grout strength in the fixed part of the compression anchor, is suggested. (2) The strength increment ratios( $R_{si}$) are 100％, 132％, 147％, 217％ according to the reinforcement method of grout. The reinforcement method is Non, Outside spiral, Inside-Outside spiral, Steel pipe, respectively. (3) The strength increment ratios( $R_{si}$) by reinforcing can be 8.23 times the strength increment effect according to the reinforcement types and ground confining pressure. (4) The steel pipe reinforcement is most effective in decomposed soil while, in the case of hard rock ground, high confining pressure is exerted on the grout, so there is no need to use reinforcements.

• 한국지반공학회논문집
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• 제27권9호
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• pp.25-36
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• 2011

조적식 석축옹벽의 거동 특성을 규명하기 위하여 실내 모형시험과 수치해석을 수행하였다. 실내 모형시험에서 옹벽 블록과 뒤채움재의 변위를 측정하기 위해 PIV 기법의 디지털 이미지 해석을 실시하였다. 유한요소 수치해석을 위해 상용프로그램인 ABAQUS를 사용하였다. 모형시험에서 관찰된 뒤채움재의 변위 발생 과정은 파괴면의 형성이 점진적임을 보여준다. 수치해석 결과에서 석축옹벽의 시공 과정에서 발생하는 전체적인 수평 토압 분포는 기존의 Rankine 이론과 큰 차이가 없지만, 뒤채움재의 내부 마찰각과 석축을 구성하는 석재 간의 마찰각이 작으면 토압의 분포가 불규칙해짐을 확인하였다.

• Advanced Composite Materials
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• 제16권1호
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• pp.45-61
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• 2007

This paper describes a damage accumulation mechanism in cross-ply CFRP laminates $[0_2/90_2]_{2S}$ subjected to out-of-plane loading. Drop-weight impact and static indentation tests were carried out, and induced damage was observed by ultrasonic C-scan and an optical microscope. Both tests gave essentially the same results for damage modes, sizes, and load-deformation history. First, a crack occurred in the bottom $0^{\circ}$ layer accompanying some delamination along the crack caused by bending stress. Then, transverse cracks occurred in the middle $90^{\circ}$ layer with decreasing contact force between the specimen and the indenter. Measured local strains near the impact point showed that the stress state changed from a bending dominant state to an in-plane tensile dominant state. A cohesive interface element was used to simulate the propagation of multiple delaminations and transverse cracks under static indentation. Two types of analytical models are considered, one with multiple delaminations and the other with both multiple delaminations and transverse cracks. The damage obtained for the model with only multiple delaminations was quite different from that obtained from the experiment. However, the results obtained from the model with both delaminations and transverse cracks well explain the characteristics of the damage obtained in the experiment. The existence of the transverse cracks is essential to form the characteristic impact damage.

• Molecules and Cells
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• 제38권3호
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• pp.251-258
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• 2015

Germline mutations in the breast cancer type 2 susceptibility gene (BRCA2) are linked to familial breast cancer and the progressive bone marrow failure syndrome Fanconi anaemia. Established Brca2 mouse knockout models show embryonic lethality, but those with a truncating mutation at the C-terminus survive to birth and develop thymic lymphoma at an early age. To overcome early lethality and investigate the function of BRCA2, we used T cell-specific conditional Brca2 knockout mice, which were previously shown to develop thymic lymphoma at a low penetrance. In the current study we showed that the number of peripheral T cells, particularly na$\ddot{i}$ve pools, drastically declined with age. This decline was primarily ascribed to improper peripheral maintenance. Furthermore, heterozygous mice with one wild-type Brca2 allele manifested reduced T cell numbers, suggesting that Brca2 haploinsufficiency might also result in T cell loss. Our study reveals molecular events occurring in Brca2-deficient T cells and suggests that both heterozygous and homozygous Brca2 mutation may lead to dysfunction in T cell populations.

• Computers and Concrete
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• 제19권5호
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• pp.509-514
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• 2017

Concrete retaining walls are the most common types of geotechnical structures for controlling instable slopes resulting from lateral pressure. In analytical stability, calculation of the concrete retaining walls is regarded as a rigid mass when its safety is required. When cracks in these structures are created, the stability may be enforced and causes to defeat. Therefore, identification, creation and propagation of cracks are among the important steps in control of lacks and stabilization. Using the numerical methods for simulation of crack propagation in concrete retaining walls bodies are among the new aspects of geotechnical analysis. Among the considered analytical methods in geotechnical appraisal, the boundary element method (BEM) for simulation of crack propagation in concrete retaining walls is very convenient. Considered concrete retaining wall of this paper is Pars Power Plant structured in south side in Assalouyeh, SW of Iran. This wall's type is RW6 with 11 m height and 440 m length and endurance of refinery construction lateral forces. To evaluate displacement and stress distributions (${\sigma}_{1,max}/{\sigma}_{3,min}$), the surrounding, especially in tip and its opening crack BEM, is considered an appropriate method. By considering the result of this study, with accurate simulation of crack propagation, it is possible to determine the final status of progressive failure in concrete retaining walls and anticipate the suitable stabilization method.

• BMB Reports
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• 제37권5호
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• pp.612-617
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• 2004

Autosomal dominant polycystic kidney disease (ADPKD) is a common genetic disorder characterized by the formation of fluid-filled cysts in the kidney and progressive renal failure. Other manifestations of ADPKD include the formation of cysts in other organs (liver, pancreas, and spleen), hypertension, cardiac defects, and cerebral aneurysms. The loss of function of the polycystin -1 and -2 results in the formation of epithelium-lined cysts, a process that depends on initial epithelial proliferation. cDNA microarrays powerfully monitor gene expression and have led to the discoveries of pathways regulating complex biological processes. We undertook to profile the gene expression patterns of epithelial cells derived from the cysts of ADPKD patients using the cDNA microarray technique. Candidate genes that were differently expressed in cyst tissues were identified. 19 genes were up-regulated, and 6 down-regulated. Semi-quantitative RT-PCR results were consistent with the microarray findings. To distinguish between normal and epithelial cells, we used the hierarchical method. The results obtained may provide a molecular basis for understanding the biological meaning of cytogenesis.

• Geomechanics and Engineering
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• 제14권1호
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• pp.83-90
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• 2018

A series of pullout tests were carried out on waste tire treadmats of various weave arrangements, with confining stresses ranging from 9 to 59 kPa approximately, in order to investigate the pullout behavior and to apply the results to the design of treadmat reinforced soil structures. A treadmat reinforcement can be considered as belonging to the extensible type thus progressive failure would develop in every tread. The pullout capacity of a treadmat was found to be generally equal to the sum of capacities of the longitudinal treads, with minor enhancement realized due to the presence of transverse treads. Pullout failures occurred in treadmats under light surcharge and with treadmats with higher material presence per unit area, while breakage failures occurred in treadmats under heavier surcharge and with treadmats with higher ratio of opening. The pullout capacity of a treadmat increased with increasing surcharge height and treadmat stiffness. A pullout test on a commercially available geogrid was also carried out for comparison and the pullout capacity of a treadmat was found higher than that of the comparable geogrid under identical loading conditions, indicating the merit of using the treadmat as an alternative to the chosen geogrid.

• Journal of mucopolysaccharidosis and rare diseases
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• 제2권1호
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• pp.23-26
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• 2016

Mucopolysaccharidosis (MPS) I is a rare, progressive and multisystemic disease with insidious initial signs and symptoms, and making an early diagnosis can be a challenge for the first-line general medical practitioner. We report a 6-month-old girl who was brought to our well baby clinic for regular immunization with the manifestations of lumbar gibbus, hirsutism, large Mongolian spots over back and buttock, and mild bilateral legs spasticity noticed by the general pediatrician, and then newly diagnosed with MPS I after referral to the geneticist in time. Her surgical history included inguinal hernia repair at 1 month old, $CO_2$ laser supraglottoplasty for laryngomalacia and tracheostomy due to chronic respiratory failure with ventilator dependence at 2 months old. Understanding and identification of the early signs and symptoms of this disease have the potential to early diagnosis and timely appropriate treatment, which could contribute to a better clinical outcome.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제35권4호
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• pp.276-279
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• 2009

The aim of this case study was to report the clinical outcome of immediate provisionalization using one-piece narrow diameter (3.0mm) implants in missing maxillary lateral or mandibular incisors. The present study included 36 patients who were treated with 62 one-piece narrow diameter implants. After implant placement, immediate provisional restorations were delivered. All implants showed favorable osseointegration and after progressive loading from 3 months to 9 months (average of 5 months), final restorations were completed without failure in all cases. A survival rate of 100 % (62 of 62) was observed up to 23 months of observation (average of 12.6 months).

• Structural Engineering and Mechanics
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• 제49권6호
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• pp.775-792
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• 2014

Static loading tests were carried out in this study to investigate the effect of bar cutoff on the resistance of RC beam-column sub-assemblages under column loss. Two specimens were designed with continuous main reinforcement. Four others were designed with different types of bar cutoff in the mid-span and/or the beam-end regions. Compressive arch and tensile catenary responses of the specimens under gravitational loading were compared. Test results indicated that those specimens with approximately equal moment strength at the beam ends had similar peak loading resistance in the compressive arch phase but varied resistance degradation in the transition phase because of bar cutoff. The compressive bars terminated at one-third span could help to mitigate the degradation although they had minor contribution to the catenary action. Among those cutoff patterns, the K-type cutoff presented the best strength enhancement. It revealed that it is better to extend the steel bars beyond the mid-span before cutoff for the two-span beams bridging over a column vulnerable to sudden failure. For general cutoff patterns dominated by gravitational and seismic designs, they may be appropriately modified to minimize the influence of bar cutoff on the progressive collapse resistance.