• Asian Pacific Journal of Cancer Prevention
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• v.13 no.5
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• pp.2021-2023
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• 2012

Purpose: DBC2 (Deleted in Breast Cancer 2) has been indicated to be a tumor suppressor gene in many cancers including lung adenocarcinoma recently. In this study, we aimed to explore the expression status of DBC2 in different subtypes of lung adenocarcinoma (from pre-invasive to invasive lesions), and to determine if downregulation becomes more marked with pathological progression. Methods: We collected 172 tissue samples from different subtypes of lung adenocarcinoma and investigated the frequency of DBC2 loss by immunohistochemistry. Results: Our results indicated that DBC2 downregulation is a relatively frequent event in lung adenocarcinoma. Moreover, as the adenocarcinoma subtype turns to be more invasive, more downregulation occurred. Conclusion: We conclude that loss of DBC2 expression is an early and progressive event in the pathogenesis of lung adenocarcinoma. Positive DBC2 immunohistochemistry may become an indicator for early stage disease and better prognosis of lung adenocarcinomas.

• Clinical and Experimental Pediatrics
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• v.59 no.sup1
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• pp.37-40
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• 2016

Mucopolysaccharidosis type III (MPS III) is a rare genetic disorder caused by lysosomal storage of heparan sulfate. MPS IIIB results from a deficiency in the enzyme alpha-N-acetyl-D-glucosaminidase (NAGLU). Affected patients begin showing behavioral changes, progressive profound mental retardation, and severe disability from the age of 2 to 6 years. We report a patient with MPS IIIB with a long-term follow-up duration. He showed normal development until 3 years. Subsequently, he presented behavioral changes, sleep disturbance, and progressive motor dysfunction. He had been hospitalized owing to recurrent pneumonia and epilepsy with severe cognitive dysfunction. The patient had compound heterozygous c.1444C>T (p.R482W) and c.1675G>T (p.D559Y) variants of NAGLU. Considering that individuals with MPS IIIB have less prominent facial features and skeletal changes, evaluation of long-term clinical course is important for diagnosis. Although no effective therapies for MPS IIIB have been developed yet, early and accurate diagnosis can provide important information for family planning in families at risk of the disorder.

• The Journal of the Korea Contents Association
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• v.10 no.6
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• pp.197-204
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• 2010

This study explains the planning practical training that researches the process of functional game planning approach by developing functional games. The main focus of this study is the practical training process of planning which is an important part of game development jobs by developing games with proper functional materials, 'Framework of Planning Functional Game', and the verification of framework by developing functional games. This paper suggests that the functional game planning approach with the right function requires progressive/quantitative standard, which is different from typical process. Therefore, this paper is useful as reference materials of a functional game education through the cases of games developed by the progressive/quantitative approach standard.

• Speech Sciences
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• v.12 no.4
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• pp.183-195
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• 2005

In the present study, we investigated development of verb inflections or endings in 3- to 5-year old Korean-speaking children using 28 action verbs for both comprehension and production tasks. For each verb, a l0-second long motion picture and a sheet of paper with three random-ordered color pictures representing 'before, in the middle of, at the end of' the action were generated. A past tense inflection' -et ta,' two present progressive verb endings '-enta' & '-ko itta.' a future tense ending '-elyeko hanta' were tested. In the comprehension task, children were asked to point to a picture correctly representing the tense of a presented verb. In the production task, children were asked to produce a verb with correctly marking the tense of a presented picture. The order of the two tasks were counterbalanced across the children, and the motion pictures were only presented in the first task. Across the ages, the performance accuracies on both comprehension and production tasks were the highest for the past tense marking followed by two present progressive and future tense markings. For each verb endings, the changes of accuracies across ages were analyzed in both tasks. The types of errors for production tasks were also reported.

• Proceedings of the KAIS Fall Conference
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• 2004.06a
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• pp.42-46
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• 2004

0.5mm thick steel is used to manufacture nail files. The first process is blanking the blank and then make about 300 holes of 0.8$\~$1.0mm in diameter. This process depends mainly on etching which takes $33\%$ of manufacturing cost and it can make manufacturing cost rise. The residual etching reagent is not environmentally friendly and the steel material is apt to rust as well. The key accomplishments of this research are to change the material from steel to stainless and develop a progressive perforating die in place of etching process.

• Steel and Composite Structures
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• v.35 no.2
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• pp.279-294
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• 2020

Foundation of a building is damaged under service loads during construction. First visit shows that the foundation has been punched at the 6 column's foot region led to building rotation. Foundation shear punching occurring has made some stresses and deflections in construction. In this study, progressing of damage caused by foundation shear punching and inverse loading in order to resolve the building rotation has been evaluated in the foundation and frame of building by finite element modeling in ABAQUS software. The stress values of bars in punched regions of foundation has been deeply exceeded from steel yielding strength and experienced large displacement based on software's results. On the other hand, the values of created stresses in the frame are not too big to make serious damage. In the beams and columns of ground floor, some partial cracks has been occurred and in other floors, the values of stresses are in the elastic zone of materials. Finally, by inverse loading to the frame, the horizontal displacement of floors has been resolved and the values of stresses in frame has been significantly reduced.

• Wind and Structures
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• v.28 no.6
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• pp.389-404
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• 2019

In coastal regions, it is common to witness significant damages on low-rise buildings caused by hurricanes and other extreme wind events. These damages start at high pressure zones or weak building components, and then cascade to other building parts. The state-of-the-art in experimental and numerical aerodynamic load evaluation is to assume buildings with intact envelopes where wind acts only on the external walls and correct for internal pressure through separate aerodynamic studies. This approach fails to explain the effect of openings on (i) the external pressure, (ii) internal partition walls; and (iii) the load sharing between internal and external walls. During extreme events, non-structural components (e.g., windows, doors or rooftiles) could fail allowing the wind flow to enter the building, which can subject the internal walls to lateral loads that potentially can exceed their load capacities. Internal walls are typically designed for lower capacities compared to external walls. In the present work, an anticipated damage development scenario is modelled for a four-story building with a stepped gable roof. LES is used to examine the change in the internal and external wind flows for different level of assumed damages (starting from an intact building up to a case with failure in most windows and doors are observed). This study demonstrates that damages in non-structural components can increase the wind risk on the structural elements due to changes in the loading patterns. It also highlights the load sharing mechanisms in low rise buildings.

• Steel and Composite Structures
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• v.42 no.2
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• pp.161-172
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• 2022

In this paper, four specimens of CFST column joints with endplates and long bolts are tested in the scenario of progressive collapse. Flush endplate and extended endplate are both adopted in this study. The experimental results show that increasing the thickness of the endplate could improve the behavior of the joint, but delay the mobilization of catenary action. The thickness of the endplate should not be relatively thick in comparison to the diameter of the bolts, otherwise catenary action would not be mobilized or work effectively. Effective bending deformation of the endplate could help the formation and development of catenary action in the joints. The performance of flexural action in the joint would affect the formation of catenary action in the joint. Extra middle-row bolts set at the endplates and structural components set below the bottom beam flange should be used to enhance the robustness of joints. A special weld access hole between beam and endplate should be adopted to mitigate the chain damage potential of welds. It is suggested that the structural components of joints should be independent of each other to enhance the robustness of joints. Based on the component method, a formula calculating the stiffness coefficient of preloaded long bolts was proposed whose results matched well with the experimental results.

• Journal of the Korean Society of Radiology
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• v.83 no.5
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• pp.979-990
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• 2022

Biliary atresia is a progressive, idiopathic, obliterative disease of the extrahepatic biliary tree that presents with biliary obstruction in the neonatal period. It is the most common indication for liver transplantation in children. If untreated, progressive liver cirrhosis leads to death by two years of age. Nowadays, more than 90% of biliary atresia patients survive into adulthood with the development of Kasai portoenterostomy and liver transplantation technology. Early diagnosis is critical since the success rate of the Kasai portoenterostomy decreases with time. This study comprehensively reviews the recent advances in the etiology, classification, prevalence, clinical manifestations, treatment, and prognosis of biliary atresia.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2006.06a
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• pp.68-71
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• 2006

Traditional section-based method develops blank along section planes and find trimming line by generating loop of end points. This method suffers from inaccurate results for regions with out-of-section motion. In this study, new fast method to find feasible trimming line is proposed. One step FEM is used to analyze the flanging and incremental development method is proposed to handle bad-shaped mesh and undercut part. Also in order to remedy mesh distortion during development, energy minimization technique is utilized. The proposed method is verified by shrink/stretch flange forming and successfully applied to the complex industrial applications such as door outer flanging process.