• 대한교통학회지
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• 제10권2호
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• pp.25-42
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• 1992

The purpose of this paper is to construct a model to compute a progression adjustment factor on a signalized network. In a way to construct the model, a simulation method is introduced and the TRAF-NETSIM is used as a tool of simulation. The structure of the network chooses an urban arterial network so as to measure the effect of progression and compute average stopped delay on each link. A regression model is constructed by using the results of the simulation. The stepwise variable selection in the regression model in used. The findings of this paper are as follows: i)The secondary queue and platoon ratio are sensitive to the values of the progression adjustment factor ii) The continuous model can practically reflect on various situations in the real world. The platoon adjustment factor can be computed by this model and the data required for this model can be easily obtained in the field.

• Journal of Ginseng Research
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• 제21권1호
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• pp.49-52
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• 1997

There are many mechanisms that mediate progression of renal injury, such as abnormalities of nitric oxide (NO) regulation, increased Platelet aggregatlon, and oxygen free radical injury. Ginseng has been known to have NO dependent vasorelaxant effect and antioxidant effect, also inhibit thrombin stimulated platelet aggregation. And these effects of ginseng may have some roles in prevention of renal injury. So we studied 24 patients with mild pathologic proteinuria and hypertension to evaluate the effect of ginseng on progression of renal injury. After 1 month treatment, creatinine clearance was significantly increased especially in the patient group with normal serum creatinine level without specific side effect. The result of this study suggest that ginseng may pre vent or retard the progression of renal injury especially in early stage.

• 대한치과의사협회지
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• 제49권3호
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• pp.153-158
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• 2011

Oral precancerous lesion is a morphologically altered tissue in which oral cancer is more likely to occur than is apparently normal counterpart. As dentists always do oral examination and dental treatment, with fundamental knowledge and attention of this lesion, it is relatively easy to find one. If followed by proper treatment and management, it is possible to minimize its oral cancer progression, or at least delay it. Even if it were to progress to oral cancer, very early detection is possible. However, no specific biomarkers are present at the moment that could reveal oral precnacerous lesion that is high risk of oral cancer progression. Since early detection of oral cancer followed by treatment could show good prognosis with just a simple ablative surgery. Dentists should also instruct people to avoid risk factor related oral cancer progression and take natural compound having anticancer effect. Hereby, As a primary care givers, dentists play an important role in prevention of oral cancer.

• Smart Structures and Systems
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• 제23권2호
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• pp.173-184
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• 2019

The main objective of this study is to evaluate the true fracture energy and monitor the damage progression in steel fibre reinforced concrete (SFRC) specimens using acoustic emission (AE) features. Four point bending test is carried out using pre-notched plain and fibre reinforced (0.5% and 1% volume fraction) - concrete under monotonic loading. AE sensors are affixed at different locations of the specimens and AE parameters such as rise time, AE energy, hits, counts, amplitude and duration etc. are obtained. Using the captured and processed AE event data, fracture process zone is identified and the true fracture energy is evaluated. The AE data is also employed for tracing the damage progression in plain and fibre reinforced concrete, using both parametric- and signal- based techniques. Hilbert - Huang transform (HHT) is used in signal based processing for evaluating instantaneous frequency of the acoustic events. It is found that the appropriately processed and carefully analyzed acoustic data is capable of providing vital information on progression of damage on different types of concrete.

• Childhood Kidney Diseases
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• 제25권1호
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• pp.1-7
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• 2021

Chronic kidney disease (CKD) in children is associated with various complications, including poor growth and development, mineral bone disorder, cardiovascular disease, kidney failure, and mortality. Slowing down the progression of CKD is important since CKD is often not curable. Prospective cohort studies have been conducted to understand the progression and outcomes of CKD in children, and these studies have identified non-modifiable and modifiable risk factors. Recognition of known risk factors and early intervention are important to delay the progression of kidney function decline in children.

• 대한한의학회지
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• 제44권3호
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• pp.102-116
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• 2023

Objectives: To provide a case report of effective use of Korean herbal medicine treatment to reduce the development and progression of normal-tension glaucoma(NTG). Methods: This case involved a 52-year-old patient who had a history of excimer laser surgery at the age of 25 and was using prescriptions such as Cosopts2 and Xalatan for eye drops. We treated this patient with Korean herbal medicine treatment for 2 years and assessed the progression of NTG based on the optical coherence tomography test results that he recevied at the ophthalmology clinic every 6 months. Results: During the two years of treatment with Korean herbal medicine, it was observed that the progression of NTG was halted. However, after discontinuing the Korean herbal treatment, the progression resumed. Conclusion: Korean herbal medicine treatment was found to be effective in treating normal tension glaucoma, and a minimum treatment period of two years is necessary for an accurate evaluation of NTG.

• Radiation Oncology Journal
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• 제32권2호
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• pp.63-69
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• 2014

Purpose: To find the applicability of adjuvant radiotherapy for extrahepatic bile duct cancer (EBDC), we analyzed the pattern of failure and evaluate prognostic factors of locoregional failure after curative resection without adjuvant treatment. Materials and Methods: In 97 patients with resected EBDC, the location of tumor was classified as proximal (n = 26) and distal (n = 71), using the junction of the cystic duct and common hepatic duct as the dividing point. Locoregional failure sites were categorized as follows: the hepatoduodenal ligament and tumor bed, the celiac artery and superior mesenteric artery, and other sites. Results: The median follow-up time was 29 months for surviving patients. Three-year locoregional progression-free survival, progression-free survival, and overall survival rates were 50%, 42%, and 52%, respectively. Regarding initial failures, 79% and 81% were locoregional failures in proximal and distal EBDC patients, respectively. The most common site was the hepatoduodenal ligament and tumor bed. In the multivariate analysis, perineural invasion was associated with poor locoregional progression-free survival (p = 0.023) and progression-free survival (p = 0.012); and elevated postoperative CA19-9 (${\geq}37U/mL$) did with poor locoregional progression-free survival (p = 0.002), progression-free survival (p < 0.001) and overall survival (p < 0.001). Conclusion: Both proximal and distal EBDC showed remarkable proportion of locoregional failure. Perineural invasion and elevated postoperative CA19-9 were risk factors of locoregional failure. In these patients with high risk of locoregional failure, adjuvant radiotherapy could be considered to improve locoregional control.

• 한국지구과학회지
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• 제39권1호
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• pp.103-116
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• 2018

이 연구의 목적은 초등학교 6학년 학생들의 달의 위상 변화에 대한 학습 발달과정을 천문학적 시스템 사고를 기반으로 탐색하는 것이다. 선행 연구 결과 분석을 통해 서답형 문항을 개발하고 가설적 학습 발달과정을 설정하였으며, 이를 토대로 문항 분석틀을 개발하였다. 달의 위상 변화에 대한 수업을 실시하기 전과 후에 서답형 문항을 이용한 검사 자료를 수집하였으며, 평가 결과를 이용하여 가설적 학습 발달과정의 타당성을 검증하였다. 이를 통하여, 상향식으로 지구-달 계에 대한 학습 발달과정을 탐색할 수 있었다. 연구 결과, 초등학생들은 지구 기반 관점과 우주 기반 관점 사이의 사고 전환에 어려움을 겪는 것으로 보인다. 또한, 달의 위상 변화에 대한 초등학생들의 학습 발달과정을 근거로 할 때, 달의 위상 변화의 개념은 교육과정 상에서 초등학교의 학습 내용으로 다소 높은 수준인 것으로 판단된다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권24호
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• pp.10837-10840
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• 2015

To assess survival outcomes in a retrospective study, recurrent epithelial ovarian cancer patients were divided into three groups according to the platinum free interval as follows: platinum refractory that included the patients with tumor progression during treatment; platinum resistant and platinum sensitive that included the patients with tumor progression less than or more than six months, respectively. Clinical data for tumor progression in epithelial ovarian cancer patients treated at Chiang Mai University Hospital between January, 2006 and December, 2010 were reviewed. Thirty-nine patients were in the platinum refractory group while 27 were in the platinum resistant group and 75 in the platinum sensitive group. The mean age, the parity, the administration of neoadjuvant chemotherapy and the serous type did not significantly different across groups while the mean total number of chemotherapy regimens, the early stage patients, the patients with complete surgery and the surviving patients were significant more frequent in the platinum sensitive group. Regarding subsequent treatment after tumor recurrence, 87.2% underwent chemotherapy. With the median follow up time at 29 months, the median overall survival rates were 20 months, 14 months and 42 months in platinum refractory, platinum resistant and platinum sensitive groups, respectively (p<0.001). In addition, when the platinum sensitive patients developed the next episode of tumor progression, the median progression free interval time was only three to four months. In conclusion, the outcomes for platinum refractory the and platinum resistant groups was poorer than the platinum sensitive group. However, subsequent progression in the platinum sensitive group was also associated with a poor outcome.

• Childhood Kidney Diseases
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• 제14권1호
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• pp.1-9
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• 2010

긴 잔여 수명을 가진 소아-청소년기에 발생한 만성 콩팥병의 진행을 억제하는 것은 매우 중요하다. 콩팥 기능의 변화는 공식을 이용하여 혈청 크레아틴이나 시스타틴 C 치를 이용한 사구체 여과율의 추정치를 계산하는 것이 비교적 정확하고 편리하다. 고혈압과 단백뇨는 엄격하게 조절되어야 하며 빈혈은 에리트로포이에틴으로 교정되어야 한다. 혈압이 정상인 경우에도 특별한 금기사항이 없는 한 ACE 억제제나 안지오텐신 수용체 차단제를 사용하는 것이 필요하나 부작용의 발생에 주의할 필요가 있다. 만성 콩팥병의 진행 억제를 위한 노력은 만성 콩팥병이 확인되는 대로 가능한 일찍 시작되어야 하며 콩팥 이식을 받을 때까지 잔여 신기능이 남아 있는 한 계속되어야 한다. 온라인 한국 소아 만성 콩팥병 등록 시스템이 만성 콩팥병의 진료에 도움을 준다.