Oral precancerous lesion and oral cancer prevention

구강 전암병소 및 구강암 예방

  • Cha, In-Ho (Department of Oral and Maxillofacial Surgery, Oral Cancer Research Institute, College of Dentistry, Yonsei University)
  • 차인호 (연세대학교 치과대학 구강악안면외과학교실, 구강종양연구소)
  • Received : 2011.02.14
  • Accepted : 2011.02.28
  • Published : 2011.03.01

Abstract

Oral precancerous lesion is a morphologically altered tissue in which oral cancer is more likely to occur than is apparently normal counterpart. As dentists always do oral examination and dental treatment, with fundamental knowledge and attention of this lesion, it is relatively easy to find one. If followed by proper treatment and management, it is possible to minimize its oral cancer progression, or at least delay it. Even if it were to progress to oral cancer, very early detection is possible. However, no specific biomarkers are present at the moment that could reveal oral precnacerous lesion that is high risk of oral cancer progression. Since early detection of oral cancer followed by treatment could show good prognosis with just a simple ablative surgery. Dentists should also instruct people to avoid risk factor related oral cancer progression and take natural compound having anticancer effect. Hereby, As a primary care givers, dentists play an important role in prevention of oral cancer.

Keywords

References

  1. Pindborg JJ, Reichart P, Smith CJ, van der Waal I. World Health Organization : histological typing of cancer and precancer of the oral mucosa. Springer-Verlag. 1997.
  2. Langdon JD, Henk JM. Malignant tumours of the mouthy, jaws & salivary glands. Secons edition. Edward Arnold. 1995.
  3. Reibel J. Prognosis of oral pre-malignant lesions: significance of clinical, histopathological, and molecular biological characteristics. Crit Rev Oral Biol Med 2003;14(1): 47-62. https://doi.org/10.1177/154411130301400105
  4. Lippman SM, Spitz MR. et al. Strateges for chemoprevention study of premalignancy and second primary tumors in the head and neck. Current Opinoin in Oncology 1995; 7:234-241. https://doi.org/10.1097/00001622-199505000-00008
  5. Papadimitrakopoulou V. Shin DM. Hong WK. Molecular and cellular biomarkers for field cancerization and multistep process in head and neck tumorigenesis. Cancer and Metastasis Reviews. 1996;15:53-76. https://doi.org/10.1007/BF00049487
  6. 박광균. 구강생화학. 군자출판사. 1999.
  7. Samaranayake LP. MacFarlane JW. A retrospective study of patients with recurrent chronic atrophic candidosis. Oral Surg. Oral Med. Oral Pathol. 1981;52:150-3. https://doi.org/10.1016/0030-4220(81)90312-1
  8. Epstein JB, Gorsky M.et al. A survey of the current approaches to the diagnosis and management of oral premalignant lesions. JADA. 2007;138(12):1555-62.
  9. Silverman, S., Jr., Gorsky, M., Lozada, F. Oral leukoplakia and malignant transformation. A follow-up study of 257 patients. Cancer 1984;53(3):563-568. https://doi.org/10.1002/1097-0142(19840201)53:3<563::AID-CNCR2820530332>3.0.CO;2-F
  10. 백지영, 윤정훈 등. 구강전암병소에서 암발생 위험도 예측을 위한 cyclin D1 발현 분석. 대한구강악안면병리학회지 2001;25(1):1-15.
  11. 황진하, 윤정훈 등. 구강전암병소에서 암발생 예측을 위한 p53과 p63의 발현 분석. 대한구강악안면병리학회지 2002;26(4):315-327.
  12. 길태준. 구강 백반증의 유전적 이상과 구강암 이행과의 연관성. 연세대학교 대학원. 2011.
  13. Gullett NP, Ruhul Amin ARM. et al. Cancer prevention with natural compounds. Semin Oncol. 2010 ;37(3):258-81. https://doi.org/10.1053/j.seminoncol.2010.06.014