• Communications of Mathematical Education
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• v.18 no.2 s.19
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• pp.9-33
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• 2004

The purpose of this paper is to contribute to the dialogue about the notion of advanced mathematical thinking by offering an alternative characterization for this idea, namely advancing mathematical activity. We use the term advancing (versus advanced) because we emphasize the progression and evolution of students' reasoning in relation to their previous activity. We also use the term activity, rather than thinking. This shift in language reflects our characterization of progression in mathematical thinking as acts of participation in a variety of different socially or culturally situated mathematical practices. We emphasize for these practices the changing nature of student' mathematical activity and frame the process of progression in terms of multiple layers of horizontal and vertical mathematizing.

• Nuclear Engineering and Technology
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• v.41 no.1
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• pp.63-70
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• 2009

A steam generator tube rupture (SGTR) accident, which is a partial reactor building bypass scenario, has a low probability and high consequences. SAMG has been used to manage the progression of severe accidents and the release of fission products induced by an SGTR at the Wolsong plants. Four of the six SAGs in the SAMG are used to manage the progression of a severe accident induced by an SGTR at the Wolsong plants. The results of the ISAAC code calculation have shown that the proper use the SAMG can stop a severe accident from progressing and keep the reactor building intact during a severe accident. These results confirm that the SAMG is an effective means of managing the progression of severe accidents initiated by an SGTR at the Wolsong plants.

• BMB Reports
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• v.46 no.3
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• pp.131-138
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• 2013

During cancer progression, bone marrow derived myeloid cells, including immature myeloid cells and macrophages, progressively accumulate at the primary tumour site where they contribute to the establishment of a tumour promoting microenvironment. A marked infiltration of macrophages into the stromal compartment and the generation of a desmoplastic stromal reaction is a particular characteristic of pancreatic ductal adenocarcinoma (PDA) and is thought to play a key role in disease progression and its response to therapy. Tumour associated macrophages (TAMs) foster PDA tumour progression by promoting angiogenesis, metastasis, and by suppressing an anti-tumourigenic immune response. Recent work also suggests that TAMs contribute to resistance to chemotherapy and to the emergence of cancer stem-like cells. Here we will review the current understanding of the biology and the pro-tumourigenic functions of TAMs in cancer and specifically in PDA, and highlight potential therapeutic strategies to target TAMs and to improve current therapies for pancreatic cancer.

• Nuclear Engineering and Technology
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• v.49 no.6
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• pp.1326-1338
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• 2017

The continuous energy Monte Carlo neutron transport code, MC21, was coupled to the CTF subchannel thermal-hydraulics code using a combination of Consortium for Advanced Simulation of Light Water Reactors (CASL) tools and in-house Python scripts. An MC21/CTF solution for VERA Core Physics Benchmark Progression Problem 6 demonstrated good agreement with MC21/COBRA-IE and VERA solutions. The MC21/CTF solution for VERA Core Physics Benchmark Progression Problem 7, Watts Bar Unit 1 at beginning of cycle hot full power equilibrium xenon conditions, is the first published coupled Monte Carlo neutronics/subchannel T-H solution for this problem. MC21/CTF predicted a critical boron concentration of 854.5 ppm, yielding a critical eigenvalue of $0.99994{\pm}6.8E-6$ (95% confidence interval). Excellent agreement with a VERA solution of Problem 7 was also demonstrated for integral and local power and temperature parameters.

• ETRI Journal
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• v.43 no.4
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• pp.650-659
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• 2021

Multi-carrier waveforms have several advantages over single-carrier waveforms for radar communication. Employing multi-carrier complementary phase-coded (MCPC) waveforms in radar applications has recently attracted significant attention. MCPC radar signals take advantage of orthogonal frequency division multiplexing properties, and several authors have explored the use of MCPC signals and the difficulties associated with their implementation. The sidelobe level and peak-to-mean-envelope-power ratio (PMEPR) are the key issues that must be addressed to improve the performance of radar signals. We propose a scheme that applies pattern-based scaling and geometric progression methods to enhance sidelobe and PMEPR levels in MCPC radar signals. Numerical results demonstrate the improvement of sidelobe and PMEPR levels in the proposed scheme. Additionally, autocorrelations are obtained and analyzed by applying the proposed scheme in extensive simulation experiments.

• Genomics & Informatics
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• v.21 no.1
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• pp.11.1-11.5
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• 2023

Breast cancer is the most common cancer worldwide, and advanced breast cancer with metastases is incurable mainly with currently available therapies. Therefore, it is essential to understand molecular characteristics during the progression of breast carcinogenesis. Here, we report a dataset of whole genomes from the human mammary epithelial cell system derived from a reduction mammoplasty specimen. This system comprises pre-stasis 184D cells, considered normal, and seven cell lines along cancer progression series that are immortalized or additionally acquired anchorage-independent growth. Our analysis of the whole-genome sequencing (WGS) data indicates that those seven cancer progression series cells have somatic mutations whose number ranges from 8,393 to 39,564 (with an average of 30,591) compared to 184D cells. These WGS data and our mutation analysis will provide helpful information to identify driver mutations and elucidate molecular mechanisms for breast carcinogenesis.

• Journal of Science Education
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• v.41 no.3
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• pp.382-404
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• 2017

This study aims to explore a learning progression for eight core concepts of middle school science using constructed response items in the national assessment of educational achievement (NAEA). For this purpose, a total of 7,390 responses of the 9th graders on 8 constructed response items in NAEA conducted in 2015 were inputted by computer and the inputted answers were analyzed and classified into different levels. After completing this process, five levels were set for each construct and a construct map was created according to the levels. In this study, the construct map was written in a progression-based rubric format, which was used as a criterion for leveling the answers of all students. In addition, the Rasch model was applied to measure the scores and achievements of the respondents by means of statistical analysis to correlate the scores of the students with the achievement levels of the constructs. Lastly, a preliminary learning progression was created by revising the construct map reflecting the results of Rasch model application. This study was meaningful in that it explored the possibility of developing the learning process by using constructed response items in NAEA. However, the preliminary learning progression developed in this study is still hypothetical and inferential because it is not longitudinally traced to individual students. Therefore, it is necessary to continually revise and supplement through iterative research process.

• Journal of Korean Ophthalmic Optics Society
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• v.17 no.1
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• pp.19-26
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• 2012

Purpose: This paper was to study the clinical effects of moderating myopia by comparing the myopia control lens, which was being recently recognized as a method of inhibiting the progression of myopia, with the wearers of single vision lens. Methods: Using 56 subjects between the ages of 8-15 years (112 eyes) with myopia in the areas of City of Daegu and Gyeongsangbuk Province as study subjects, refractive error, axial length, near point of convergence and accommodative near point were measured and compared a total of 3 times at the baseline, after 1-month and after 6-months. Results: For refractive error, suppression and mitigation were seen in the progression of spherical equivalent when MC lens was worn, as compared to using SV lens, and, when axial length MC lens was worn, the axial progression was significantly suppressed and delayed (p < 0.05). The near point of convergence became shorter with the use of MC lens, and the amplitude of convergence was improved when MC lens was worn. Accommodative near point became shorter with the use of MC lens, and focus ability was significantly improved (p <0.05). Conclusions: It was shown that MC lens, compared to SV lens, could alleviate myopia progression in school-age children and youth. It is considered that MC lens can be used as a useful therapy for the inhibition of myopia progression in the increasing number of myopic children and adolescents.

• Journal of the Korean earth science society
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• v.38 no.3
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• pp.222-238
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• 2017

The purpose of this study is to explore a learning progression for integrated process skills in Earth science inquiry. For the purpose, a hypothetical learning progression (HLP) that capture how students' integrated process skills of science become sophisticated over time is developed through the literature review. This learning progression contains four components of the integrated process skills of science: designing inquiry, collecting data, analyzing data, and forming conclusion. Three hypothetico-deductive inquiry tasks of Earth science that start from recognition of the given problem to the forming conclusion are developed in order to document students' integrated process skills. A total of 126 students from middle, high, college level students participated in this study. After conducting the Earth science inquiry tasks, the integrated process skills of individual students are assessed by element based on HLP. In addition, the validation process for HLP was administered by applying the Rasch model using the students' assessment data. Finally, based on the analyzed data, the empirical learning progression (ELP) is developed by revising and supplementing the HLP. This study can help to find scaffolding methods to effectively improve the students' integrated process skills in Earth science inquiry class by identifying the factors that affect students' development of integrated process skills. It also provide implications for improving teachers' PCK of Earth science inquiry instruction.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.9
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• pp.4127-4131
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• 2015

Background: For HER2 positive metastatic breast cancer (MBC), continuing anti-HER2 therapy beyond progression is associated with improved outcome. However retreatment with trastuzumab after lapatinib progression is controversial. We retrospectively analyzed the efficacy of trastuzumab-based chemotherapy in HER2+ metastatic breast cancer patients whose disease progressed after lapatinib. Materials and Methods: Between October 2010 and May 2013, 54 patients whose disease progressed after lapatinib were retreated with trastuzumab-based chemotherapy. Efficacy and toxicity results were evaluated retrospectively. Results: The median age of patients was 46 (range 27-67). Fourteen patients (26%) had metastases at the time of diagnosis. All of the patients had received trastuzumab in an adjuvant or metastatic setting, while 16 (30%) had received two lines of trastuzumab. All patients had received lapatinib plus capecitabine. The median chemotherapy line for the metastatic setting was 2 (range 1-7). Cranial metastases were identified in 27 (50%) patients. 53 patients received trastuzumab-based chemotherapy following lapatinib progression while one patient received trastuzumab monotherapy. Combination chemotherapy consisted of navelbin (n=33), taxane (n=10), gemcitabine (n=2), platinum (n=2) and platinum with taxane (n=6). The median treatment cycle was 5 (range 1-44). Among 49 patients assessed for response 2 (4%) showed CR, 12 (25%) PR, 11 (22%) SD and 24 (49%) disease progression. Asymptomatic cardiotoxicity was reported in 2 (4%) of the patients. At a median follow-up of 9 months (1-39), median progression-free survival was 5 months (95% CI 4.1-5.9) and median overall survival was 10 months (95% CI 6.9-13.0). PFS and OS were not affected by the absence/presence of cranial metastases. Conclusions: Retreatment with trastuzumab-based therapy after lapatinib progression showed efficacy in heavily treated MBC patients.