• 한국유통학회지:유통연구
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• 제15권5호
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• pp.175-193
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• 2010

본 연구는 한국 유통산업의 현황을 파악하고 국민경제적 파급효과를 분석하기 위해 이루어졌다. 한국의 유통산업은 GDP에서 8%내외의 비중을 차지하는 산업이며 최대의 고용처로 전체 취업자수에서 15%대의 비중을 점하고 있는 것으로 밝혀졌다. 그렇지만 주요 선진국에 비해 고용 비중은 유사하지만 GDP에서 차지하는 비중이 낮아 이를 향상시켜야 하는 과제가 있는 것으로 나타났다. 유통산업의 국민경제적 파급효과를 분석하기 위해 유통산업을 도소매업으로 파악하여 산업연관분석을 실시하였다. 산업연관분석을 통해 유통산업의 생산유발효과, 부가가치유발효과, 취업유발효과, 고용유발효과, 산업간 연쇄효과를 파악하고자 했다. 이를 달성하기 위해 유통산업의 산출이 자신에게 미치는 효과를 제외하는 외생화기법을 사용하여, 경제내 타부문에 대한 기여도를 도출하였다. 그리고 실증자료를 기반으로 유통산업이 자체에 미치는 직접적 효과와 타산업에 미치는 간접적 효과로 구분한 총효과도 분석하였다. 산업연관분석 결과, 유통산업은 높은 생산유발효과, 높은 취업유발효과, 높은 고용유발효과를 갖는 것으로 나타났다. 그리고 유통산업은 부동산 및 사업서비스, 운수 및 보관 부문 산업에 높은 생산유발효과 및 부가가치유발효과를 파급하는 것으로 나타났다. 산업간 연쇄효과 분석결과로 유통산업의 전방연쇄효과를 나타내는 감응도계수는 1보다 크고 후방연쇄효과를 나타내는 영향력계수는 1미만인 것으로 파악되었다. 후반부에 본 연구의 정책적 시사점, 한계에 대해 제시하였다.

• 지식경영연구
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• 제24권4호
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• pp.131-152
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• 2023

스마트관광 도시의 핵심 분야 중 하나인, 스마트 모빌리티는 개인형 교통수단인 공유 자전거, 공유 킥보드를 비롯해 공유 자동차 서비스, 스마트교통 인프라 등 ICT 기술을 기반으로 진보된 모든 수단과 서비스를 포함하며, 기존 교통수단의 한계를 극복하고 사람과 물자의 이동을 개선한다. 관광객에게는 관광지 간 이동 시 저렴하고 이용하기 쉬운 교통수단으로 활용될 뿐만 아니라, 관광 경험 그 자체가 되어 여행의 질을 향상시키는 역할도 한다. 이 연구는 스마트 모빌리티의 관광적 측면을 포함한 '스마트관광 모빌리티'를 '정보통신기술을 기반으로 뛰어난 연결성을 갖추고, 공익성을 가지고 있으며, 스마트관광 도시에서 거주민과 관광객 모두가 교통수단으로 사용함과 동시에 관광 경험 그 자체가 될 수 있는 모빌리티'로 정의하였다. 그리고 관련 산업의 범위를 전문가 델파이 조사를 기반으로 규명하고, 스마트관광도시에서 어떤 경제적 파급효과를 낳는지 파악하고자 했다. 구체적으로, RAS 기법과 입지계수법을 활용하여 산업연관표를 업데이트하고, 스마트관광 모빌리티에 대한 투자 증대가 서울시의 전 산업에 미치는 영향을 살펴보았다. 그 결과, 2022년 한 해 동안 예정된 서울시의 스마트관광 모빌리티에 대한 약 28억 원 규모의 투자로 인해 전 산업에 걸쳐 약 41억 4천만 원 이상의 생산유발효과가 창출될 것으로 추정되었으며, 이로 인해 약 16억 6천만 원의 소득유발효과, 약 36억 1천만 원의 부가가치유발효과, 그리고 약 54명을 위한 일자리가 창출될 것으로 예상되었다. 이러한 결과를 통해 스마트관광 모빌리티가 첨단기술과 관광·운송 서비스의 단순한 결합이 아니며, 도시 내·외부의 다양한 산업과 이해관계를 연계하는 생태계적 관점에서 발전해야함을 강조한다.

• Asian-Australasian Journal of Animal Sciences
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• 제13권9호
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• pp.1205-1209
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• 2000

The present study was undertaken to investigate the effect of stimulation of follicular development with eCG on the peripheral levels of inhibin and FSH in Murrah buffaloes. Estrus was synchronized in five normally cycling females by insertion of Crestar (Intervet, Boxmeer, Holland) implants for nine days. Estradiol valerate was administered i.m. on the day of implant insertion. On the 10th day of the induced estrous cycle a single dose of 3000 IU eCG (Folligon, Intervet, Boxmeer, Holland) was given, followed by treatment with 25 mg of $PGF_2$ alpha (Lutalyse, Upjohn, Belgium) 48 h later. Blood samples were obtained during the induced estrus, on cycle day 10 (luteal phase), at the superovulatory estrus (43 h after PGF) and during the periovulatory period (64 h after PGF). Ultrasonography was done daily to monitor follicular development. Plasma concentrations of inhibin and FSH were determined by specific radioimmunoassays. Differences between $mean{\pm}SEM$ values of different phases of the cycle were compared by ANOVA. The mean number of small (2-5 mm), medium (6-9 mm) and large (>10 mm) follicles observed two days after eCG treatment and on the day of superovulatory estrus was $2.8{\pm}0.31$, $5.2{\pm}0.30$ and $1.4{\pm}0.09$ and $1.9{\pm}0.21$, $2.8{\pm}0.40$ and $5.0{\pm}0.83$, respectively. The mean number of ovulations was $3.6{\pm}0.37$ and the mean number of unovulated follicles was $6.1{\pm}0.47$. Most of the follicles >10 mm in diameter had ovulated (72%). The mean ${\pm}SEM $ of plasma inhibin concentration $(2584.15{\pm}17.92pg/ml)$ during the superovulatory estrus was significantly higher $(p{\leq}0.05)$ than during the induced estrus $(749.87{\pm}17.29pg/ml)$, the luteal phase $(1099.54{\pm}24.98pg/ml)$ and periovulatory period $(1682.71{\pm}29.88pg/ml)$, respectively. $Mean{\pm}SEM$ plasma FSH concentration during the induced estrus $(10.35{\pm}0.41ng/ml)$ was not different from that during the superovulatory estrus $(8.52{\pm}0.39ng/ml)$, but was significantly higher $(p{\leq}0.05)$ than during the luteal phase $(2.81{\pm}0.42ng/ml)$ and periovulatory period $(5.7{\pm}0.28ng/ml)$. These data indicate that treatment with eCG in buffaloes for inducing superovulation results in a significant elevation in plasma inhibin levels and a decrease in plasma FSH levels during the superovulatory estrus. Thus, we suggest that the elevated plasma inhibin coming from fully developed follicles continued for a long time which results in inhibition of FSH leading to poor ovulation in the remaining follicles, which may be the cause of suboptimal superovulatory response.

• 대한본초학회지
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• 제35권1호
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• pp.1-8
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• 2020

Objectives : This study was conducted to evaluate the effects of Corni Fructus, the dried fruits of Cornus officinalis Sieb., on unilateral common carotid artery occlusion (UCCAO) in mouse model. Methods : The Corni Fructus used in the experiment was extracted with anhydrous methanol, then filtered and freeze-dried. C57BL/6 mice used in the experiments were conducted left UCCAO surgery to set up UCCAO rodent model for mice. The mice were divided into five groups for evaluate the effect of methanol extract of Corni Fructus (COM) on UCCAO induced ischemic brain injury. The expression levels of nitric oxide in cerebrum and serum, body weight change were measured. To determine the effect of UCCAO and COM administration on brain neurons, morphological changes of the cerebrum through a microscope was conducted. And western blot was performed to confirm the underlying mechanism of neuroprotective effect of COM administration. Results : COM administered UCCAO groups (CO50, CO150, and CO500) had no significant effects on nitric oxide production in ipsilateral hemisphere proteins and sera. The CO500, 500 mg/kg COM administration, attenuated UCCAO-induced p38 inflammatory signaling pathway and inflammatory mediators such as iNOS and COX-2. The CO500 group showed resilient morphological changes of hippocampus neuronal cells about brain damage caused by decreased flow of blood. These group also showed decreased inflammation and cellular stress response in neuronal cells. Conclusions : From these results, COM has a neuroprotective property via moderating inflammatory factors and cellular stress inducing factors in brain cells.

• 한국토양비료학회지
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• 제45권1호
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• pp.79-82
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• 2012

Blossom-end rot is probably the most recognizable Ca deficiency that affects fruit production including pepper. We investigated the induction of blossom-end rot during the period of rapid vegetative growth and fruit setting, and the effect of Ca fertilization on the suppression of blossom-end rot in pepper plants grown in a plastic-film house. During the first fruit setting period, more than 60% of pepper fruits larger than 8 cm showed the symptoms of blossom-end rot. Under the condition of transpiration occurring at a much faster rate, growing leaves of pepper plants could be the greater sinks for Ca than developing fruits. The incidence of blossom-end rot was significantly decreased after two weeks of Ca fertigation. Calcium application during the rapid vegetative growth and fruit setting period could be suggested as a preventive step to overcome the local Ca deficiency inducing blossom-end rot of pepper fruits.

• KSBB Journal
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• 제32권3호
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• pp.218-233
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• 2017

To identify the natural and novel cosmeceutical ingredients which have whitening function, we examined the effects of tyrosinase activity and melanin production on halophyte Limonium tetragonum (Thunb.) A. A. Bullock extracts. As a result, the extracts showed whitening effect with no cytotoxicity. Melanin contents of B16F10 melanoma cells were decreased in a dose-dependent manner at 50, 100, $200{\mu}g/mL$ treatment of the extracts. In tyrosinase activity inhibition test, L. tetragonum (Thunb.) A. A. Bullock extracts showed decreased tyrosinase activity as the concentration of ${\alpha}-MSH$ was increased. Furthermore, it was observed that the tyrosinase and MITF expression was significantly downregulated by adding L. tetragonum (Thunb.) A. A. Bullock extracts in ${\alpha}-MSH$, a melanogenesis inducing material, treated B16F10 melanoma cells. These results indicate that L. tetragonum (Thunb.) A. A. Bullock extract might be an effective whitening agent by inhibit melanin formation.

• Asian-Australasian Journal of Animal Sciences
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• 제25권3호
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• pp.304-310
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• 2012

The present study showed that Transforming growth factor beta 1 (TGF-${\beta}_1$) can induce apoptosis of bovine mammary epithelial cells. This apoptosis was also observed with phosphorylation of Smad2/3 within 0.5-2 h. Afterwards the signal transferred into the nucleus. Moreover, intracellular free $Ca^{2+}$ concentration was significantly elevated as well as Caspase-3 activated and DNA lysised, thereby inducing the programmed cell death. This signaling pathway of TGF-${\beta}_1$ was blocked by SB-431542 ($10^{-2}{\mu}M$) via inhibiting ALK-5 kinase activity, which thus reversed the anti-proliferation and apoptosis effect of TGF-${\beta}_1$ in mammary epithelial cells. These results indicated that TGF-${\beta}_1$ induced apoptosis of bovine mammary epithelial cells through the ALK-5-Smad2/3 pathway, which plays an important role in inhibiting survival of mammary epithelial cells. Moreover, intracellular $Ca^{2+}$ also played a critical role in TGF-${\beta}_1$-induced cell apoptosis.

• 대한한의학회지
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• 제24권3호
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• pp.84-95
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• 2003

Objective : This study was carried out to investigate the effects of Kamisopunghwalhyeol-tang (Jiaweishujenghuoxie-tang; Kami-SPHHT) on the immunity responses of the Synoviocytes isolated from the patients on rheumatoid arthritis. Methods : Cells were stimulated by $Interleukin-1{\beta}$ and Tumor Necrosis $Factor-{\alpha}$ in the presence or absence of Kami-SPHHT, and then induced cytokine mRNA levels were determined by RT-PCR and real-time quantitative RT-PCR. Results : Levels of $IL-1{\beta},{\;}IL-6,{\;}TNF-{\alpha}$, COX-2, and NOS II mRNA expressions significantly decreased in Kami-SPHHT treated cells compared to non-treated control cells. Also, DNA-binding activity of $NF-{\kappa}B$ and AP-l decreased in Kami- SPHHT treated hFLSs. Conclusion : These results suggest that Kami-SPHHT may be involved in anti-inflammatory reactions by inducing cytokine gene expression in synoviocytes, and further in vivo examination on its efficacy can provide potential application for the treatment of rheumatoid arthritis.

• 고려인삼학회:학술대회논문집
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• 고려인삼학회 1998년도 Advances in Ginseng Research - Proceedings of the 7th International Symposium on Ginseng -
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• pp.83-89
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• 1998

Ginseng total saponins (GTS) injected intracerebroventricularly (i.c.v.) at doses from 0.1-1 vs inhibited the i.c.v. injection stress-induced plasma corticosterone levels in mice. The inhibitory action of GTS was blocked by co-administered NG-nitro-L-arginine methyl ester (L-NAME; 1.5 us, i.c.v.), an. inhibitor of nitric oxide synthase (NOS). Of the ginsenosides Rbl, Rba, Rc, Rd, Re, Rf, Rgl,20(S)-Rg3, and 20(R)-Rg3 injected i.c.v. at doses from 0.01 to 0.3ug(or 1 uE),20(5)-Rg3 and Rc significantly inhibited the o.c.v. injection stress-induced Plasma corticosterone levels. The inhibitory actions of 20(S)-Rg3 and Rc were blocked by co-administered L-NAME (1.5 n, i.c.v.). These results suggest that G75, 20(S)-Rg3 and Rc may inhibit the i.c.v. injection stress-induced hypothalamo-pituitary-adrenal response by inducing NO production in the brain.

• 한국동물위생학회지
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• 제35권2호
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• pp.105-109
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• 2012

Apoptosis is a host defense mechanism that the cell uses to limit production of infectious pathogens. Although many bacteria, viruses and parasites can induce apoptosis in infected cells, some pathogens usually exhibit the ability to suppress the induction of apoptosis in the infected cells. Sophisticated evasion strategies of obligate intracellular parasites, in particular prevention of host cell apoptosis, are necessary to ensure successful replication. To study the ability of Eimeria tenella in this regard, in vitro experiments were performed applying Madin-Darby bovine kidney (MDBK) cells as host cell. We have demonstrated that productive infection of adherent cell lines by E. tenella resulted in an anti-apototic effect. This phenomenon was confirmed using in situ terminal deoxynucleotidyl transferase-mediated (TdT) deoxyuridine triphosphates (dUTP)-fluorescein nick end labeling (TUNEL) assay to detect apoptosis. Therefore, E. tenella could complete its cycle of productive infection while inducing anti-apoptosis in the infected cells. This finding might have implications for the pathobiology of E. tenella and other Eimeria species.