• The Korean Journal of Food And Nutrition
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• v.27 no.1
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• pp.99-104
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• 2014

Platycodon grandiflorum have been used as a traditional remedy and food source. This study was performed to investigate the immunomodulating effects of Platycodon grandiflorum in mouse, using ex vivo experiments. Six to seven-week old mice were fed ad libitum on a chow diet, and water extract of Platycodon grandiflorum was orally administrated at two different concentractions (50 and 500 mg/kg B.W./day) every other day for four weeks. In ex vivo experiments, the highest proliferation of splenocytes and levels of cytokine (IL-$1{\beta}$, IL-6, TNF-${\alpha}$) production were observed in 500 mg/kg BW/day supplementation group for all three cytokines stimulated by LPS. In conclusion, this study suggests that Platycodon grandiflorum extracts may enhance the immune function by regulating the splenocytes proliferation and cytokine production capacity by activating macrophages in mice.

• Phonetics and Speech Sciences
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• v.4 no.3
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• pp.3-12
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• 2012

The primary goal of the current study was to examine category solidity of Korean alveolar fricatives in the Busan and Seoul dialects of Korean. Considering the common belief of $/s^h/-/s^*/$ neutralization in Kyungsang speech, plain $/s^h/$ and fortis $/s^*/$ fricatives of Busan speakers were examined against the same fricatives of Seoul speakers. Perceptual distance between Korean $/s^h/$ and $/s^*/$ on the one hand and English /s/ on the other was investigated by use of across-linguistic mapping method. Two experiments of a perceptual mapping task of English /s/ to Korean $/s^h/$ and $/s^*/$ and a $/s^*/$-production task were conducted on users of the Busan and Seoul dialects of Korean. The results from the perception and production experiments suggested that at a micro-level, younger Busan speakers have less solid category stability for Korean $/s^*/$ compared with Seoul speakers, although their production of $/s^h/$ and $/s^*/$ was as highly distinctive from each other as that of Seoul speakers.

• Journal of Veterinary Clinics
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• v.10 no.2
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• pp.243-249
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• 1993

Although plenty of experiments for production of genetically identical twins have been reported, most of these reports were focused on microsurgical bisection of morula stage embryos, and little research has been performed for the production with frozen emb교os. The objective of these experiments were to assess the in vitro and in vitro developmental potential of blastomeres isolated from frozen-thawed 4-cell and 8-cell mouse embryos and to produce the identical multiplets from those embryos. The percentages of isolated 1/4, 2/4, 4/4, (control), 1/8, 2/8, 3/8, 4/8 and 8/8(control) blastomeres of 4-cell and 8-cell mouse emb교os which developed to normal blastocyst were 38.7%, 73.6%, 96.2(control), 15.1%, 40.1%, 65.9%, 88.3%, and 98.5%(control), respectively. The percentages of isolated 1/4, 2/4, 4/4(control), 1/8, 2/8, 3/8, 4/8 and 8/8(control) blastomeres of frozen-thawed 4-cell and 8-cell mouse embryos which developed to normal blastocyst were 35.6%, 68.5%, 100.0%(control), 16.1%, 50.6%, 71.7%, 90.9% and 100.0%(control), respectively. Normal 26 pups were obtained by transfer of 240 blastocyts developed 1, on 1/4 to 8/8 blastomeres. Those 26 pups obtained, 4 identical twins were produced from 2/4, 2/8, 3/8 and 4/8 blastomeres.

• Speech Sciences
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• v.14 no.1
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• pp.7-19
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• 2007

The present study investigates the so-called frequency inheritance effect in word production. According to some earlier studies (e.g. Jescheniak & Levelt, 1994), retrieval of a low-frequency homophone benefits from its high-frequency homophone twin, and more specifically word-retrieval RT is determined by the frequency of the phonological form of the word (sum of homophone frequencies) rather than the frequency of the specific word. This result, however, has been challenged by later studies (e.g. Caramazza et al., 2001) and one possible resolution is that languages differ in the extent to which the inheritance effect occurs. Two experiments are reported to test whether the frequency inheritance effect depends on the target language, namely, if a language such as Korean with relatively many homophones tend not to show frequency inheritance, which is compared with the language with fewer homophones such as Dutch and German (Jescheniak & Levelt, 1994; Jescheniak et al., 2003). Experiment 1 was picture naming, and Experiment 2 used an English-to-Korean translation task. In both experiments, the homophones were actually slower than the low-frequency controls, suggesting that there was no evidence for the inheritance effect. These results imply that the issue of whether specific word or homophone frequency determines production can be properly assessed by taking into account the language-specific nature of the lexicon such as the percentage of the homophone words in that language.

• 한국생물공학회:학술대회논문집
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• 2003.04a
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• pp.274-278
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• 2003

Plackette-Burman method, one of the statistical experimental methods, was used for the screening of main factor for the enhanced production of hGM-CSF. A nine-runs Plackette-Burman design including one center point was the screening design selected for the initial set of experiments. The analysis of the data from the Plackette-Burman experiments showed main effect. Sucrose, nitrogen and temperature were determined to be main factors to enhance the production of hGM-CSF because the absolute values of main effect of sucrose, nitrogen and temperature were higher than the other factors. The production of hGM-CSF was improved when initial sucrose concentration was 50 g/L, initial nitrogen concentration was 90 mM and initial temperature was $20^{\circ}C$.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.38 no.6
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• pp.393-398
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• 2005

Codium fragile is commercially farmed in Korea by natural blooming zygote attachment. Experiments found optimum conditions for artificial seed production and nursery culture of C. fragile by asexual reproduction. Isolated utricles and medullary filaments were regenerated to erect thalli using both indoor and outdoor culture experiments. Under the indoor culture conditions, irradiance was an important factor to control the development of erect thalli. Formation of erect thallus from the isolated medullary filaments in the indoor culture was induced after 30 days under $20^{\circ}C$ and $60{\mu}mol/m^2/sec$. The detachment of isolated utricles and medullary filaments from the substrates of seed strings was reduced by exposure to the air during 2 hrs before the indoor culture of seed strings. The maximum growth and development of erect thalli in the nursery culture was induced at a water depth of 0.5 m. Depending on the substrates of the seed strings the growth of erect thalli was not significantly different (p>0.05).

• Journal of Drive and Control
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• v.17 no.3
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• pp.15-25
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• 2020

The cycle time and power saving effect of a hydraulic hybrid injection molding machine using a servo motor are considered in this paper. In order to verify control characteristics, such as pressure and speed, experiments were performed with the hydraulic hybrid injection molding machine, clamping force of 110 ton. The power consumption and production cycle time of a conventional hydraulic injection molding machine were measured to compare its performances with the hydraulic hybrid injection molding machine. An injection molding machine with a clamping force of 1300 ton was used as the conventional machine, the hybrid machine was implemented by replacing its induction motors with servo motors. In the remodeled hybrid machine, experiments were performed to investigate how the displacement of the mold clamping pump affects the power consumption and production cycle time. The results showed that the production cycle time of the hybrid injection molding is similar to a conventional hydraulic injection molding machine but with a significant energy saving of about 40%.

• Journal of Microbiology and Biotechnology
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• v.18 no.5
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• pp.908-912
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• 2008

To achieve a higher succinic acid productivity and evaluate the industrial applicability, this study used Mannheimia succiniciproducens LPK7 (knock-out: ldhA, pflB, pta-ackA), which was recently designed to enhance the productivity of succinic acid and reduce by-product secretion. Anaerobic continuous fermentation of Mannheimia succiniciproducens LPK7 was carried out at different glucose feed concentrations and dilution rates. After extensive fermentation experiments, a succinic acid yield and productivity of 0.38 mol/mol and 1.77 g/l/h, respectively, were achieved with a glucose feed concentration of 18.0 g/l and $0.2\;h^{-1}$ dilution rate. A similar amount of succinic acid production was also produced in batch culture experiments. Therefore, these optimal conditions can be industrially applied for the continuous production of succinic acid. To examine the quantitative balance of the metabolism, a flux distribution analysis was also performed using the metabolic network model of glycolysis and the pentose phosphate pathway.

• Korean Journal of Metals and Materials
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• v.50 no.2
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• pp.122-128
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• 2012

Water model experiments were carried out to understand the mixing behavior of reducing agents in molten slag through vortex stirrer, which makes use of a gravitational energy to mix reducing agent in the molten slag without imparting artificial energy. At a water flow rate of 6 L/min vortex was not generated, and a stable vortex was formed when the water flow rate was 7 L/min or higher with the present experimental apparatus. Water level increased linearly with increasing the water flow rate. In the upper vortex region, the vertical and horizontal velocities slightly decreased with increasing the water flow rate, whereas those in the lower vortex region increased remarkably. Accordingly, strong mixing behavior was obtained in the lower vortex region. Owing to the strong centrifugal force, particles move downwards with approaching the funnel wall. When 40 grams of polypropylene particles added to the lower vortex, they were instantaneously mixed well.

• Speech Sciences
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• v.13 no.1
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• pp.43-54
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• 2006

The purpose of this study is to examine temporal structures of English words beginning with an /s/ plus stop sequence through production experiments with native speakers of Korean learning English and native speakers of English. According to the results of our production experiment, both a beginner and an advanced group of Korean English learners produced /s/ shorter than a following stop, while the opposite pattern was observed in English native speakers' production. An advanced group of Korean English learners were good at producing a stop after /s/ as unaspirated, but their production of a stop following /s/ was different from English native speakers' production in that the closure duration of the stop was much longer.