• IE interfaces
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• v.2 no.1
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• pp.23-27
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• 1989

The problem of planning national coal production is formulated as an optimal control problem. The model can be used to propose a proper government subsidy policy which will enhance the utilization of a nationally-owned resurce(coal) and maintain the optimal level of coal production.

• 제어로봇시스템학회:학술대회논문집
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• 2005.06a
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• pp.1118-1122
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• 2005

In order to keep production balance at a mixed-model assembly line and a painting line, large WIP(Work- In-Process) inventories are required between two lines. To increase the efficiency of line handling through reducing the inventories under this circumstance, this paper concerns with a sequencing problem for a mixed-model assembly line that includes a painting line where the uncertain elements regarding the defective products exist. Then, we formulate a new type of the sequencing problem minimizing the line stoppage time and the idle time with forecasting the supply time of the products from the painting line. Finally, we examine the effectiveness of the proposed sequencing through computer simulations.

• 제어로봇시스템학회:학술대회논문집
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• 2003.10a
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• pp.1826-1829
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• 2003

Fine chemical production must assure high-standard product quality as well as characterized as multi-product production in small volumes. Installing high-precision batch distillation is one of the common elements in the successful manufacturing of fine chemicals, and the importance of the process operation strategy with quality assurance cannot be overemphasized. In this study, we investigate the optimal operation strategy and production planning of a sequential multi-purpose plants consisting of batch processes and batch distillation with unlimited intermediate storage. We formulated this problem as an MILP model. A mixed-integer linear programming model is developed based on the time slot, which is used to determine the production sequence and the production path of each batch. Illustrative examples show the effectiveness of the approach.

• The Journal of Society for e-Business Studies
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• v.1 no.1
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• pp.227-247
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• 1996

Presented in this paper is a control model for developing virtual factory simulator, which is being operated under the distributed environment. The control model consists of production activity plan and information flows. To incorporate elements of the characteristics of the distributed control system, we suggested a collaboration model. This model is working under the client/server architecture, and also designed for cooperative-distributed shop control(CDSC) system in order to exploit several advantages of client/server architecture. Collaboration among each agent(or client) is done through negotiation and task sharing. Based on a contract net model, the CDSC system has three kinds of agents-order agent, resource agent, and communication forwarding agent. Each agent performs shop scheduling and control through negotiation on contract net. No node in CDSC system can have authority over other node. A bidding scheme is employed far negotiation between order agent and resource agents. The CDSC system can support re-negotiation among resource agents and an algorithm for re-negotiation is also developed. Experimental results are shown to advocate the effectiveness of the CDSC system for CIM environments.

• Journal of Korean Society of Rural Planning
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• v.27 no.2
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• pp.69-76
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• 2021

This study focuses on the relationship between ginseng production per area and meteorological factors. Four areas of major ginseng production are considered in the study. Chungcheongnam-do and Gyengsangbuk-do are selected as the original major production places and Gyeonggi-do and Kangwon-do are selected as the new major places. The meteorological factors applied for study are the average temperature, accumulated precipitation, and integrated sunshine hours. With the data collected across four areas, we used a panel data analysis. From the results of Hausman test, the fixed effects model allowing to control individual area effect is preferable to the random effects model. Based on the results of the fixed effects model, the accumulated precipitation statistically and significantly affect the decreases in ginseng production. Changes in the average temperature negatively affect ginseng production, but the value is not statistically significant. The integrated sunshine positively affect ginseng production, but the value is not statistically significant.

• Journal of Korean Institute of Industrial Engineers
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• v.1 no.1
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• pp.41-56
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• 1975

In the past the pattern of business down-trend usually appeared in the form of, first, decrease in facility investment, then decrease in inventory level, followed by reduced level of consumption. But the pattern nowadays is becoming just the opposite, that is, first, consumption decrease, then inventory level increase, followed by restriction of facility investment. Also in the past, the greater effort was placed in strengthening of hardware areas through optimization and modernization of production means on the premise of sales. But lately software areas take most of the main effort to establish production mean with sales as its objective. Under these circumstances one of the real problems facing production activities today is the conflicting relationship between sales and production functions. This occurs due to differences of their view points. Then, in order to achieve maximum profit at the least cost, which is the ultimate objective of a production activity, the need arises to effectively coordinate sales demand and plant production capacity. For this purpose strong control means and function must be devised. In our case study example we illustrate a management technique for a combined planning function, of optimal coordination of product mixes utilizing a computerized linear programming model as control means of attaining maximum profit. It is hoped that this example help achieve some of corporate objectives.

• YAKHAK HOEJI
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• v.60 no.1
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• pp.21-28
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• 2016

Systemic lupus erythematosus (SLE) is characterized by dysregulatory production of proinflammatory cytokines and helper T (Th) cytokine-dependent autoantibody production. This study aims to investigate the protective effect of baicalin on the dysregulatory production of proinflammatory cytokines and Th cytokines in pristane-induced lupus mice. Mice were received i.p. a single injection of 0.5 ml of pristane, and then, later about 3 months, were used as a pristane-induced lupus model. The pristane-induced lupus mice were administrated orally with baicalin 50 mg/kg once in a day for 10 days. Immune cells obtained from the pristane-primed lupus control group (lupus control) and baicalin-treated pristaneprimed lupus mouse group (BAC lupus) were cultured for 24 h or 36 h with/without mitogens. These results demonstrated that LPS-induced production of macrophage and splenic TNF-${\alpha}$ and Con A-induced production of thymic IFN-${\gamma}$ were attenuated in BAC lupus compared to lupus control, while LPS-stimulated production of macrophage IL-10, Con A-stimulated production of splenic IL-10 and, $PGE_2$-reduced production of splenic IFN-${\gamma}$ enhanced. Therefore, these findings suggest that baicalin may protect from autoimmunity and disease activity in lupus via modulatory effect of proinflammatory cytokine overproduction and Th cytokine imbalance.

• IE interfaces
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• v.5 no.2
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• pp.29-37
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• 1992

An approach to Just-In-Time for small job-shop-type manufacturers is presented. This is aimed at those who understand the pull production system, however, cannot afford either swift changeover in workcenters or frequent delivery to customers. First, as a production planning technique, a lot-sizing model entitled Multilevel Least Total Cost Model(MLTCM) is developed; The production order quantities of each components be those requiremensts of the end item production lot. The contribution of MLTCM is shown via simulation. Then, a framework of the Kanban operations is designed; A Production Control Kanban is introduced as a communication tool with Production Kanban in a job-shop.

• Journal of Microbiology and Biotechnology
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• v.18 no.2
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• pp.334-337
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• 2008

A tightly regulated gene expression system composed of a single-copy target gene under the control of a lac promoter derivative and lacI gene in a multicopy plasmid is proposed, and its ability to control the flux of a metabolic pathway is demonstrated. A model system to control the flux of acetyl-CoA to acetyl phosphate was constructed by integrating pta, a gene encoding phosphotransacetylase, under a tac promoter into the chromosome of E. coli with a pta-negative background and transforming a multicopy plasmid containing the $lacI^Q$ gene into the strain. The production rate of acetate was shown to be tightly controlled when varying the concentration of the inducer (IPTG) in he model system.

• 제어로봇시스템학회:학술대회논문집
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• 1987.10b
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• pp.300-306
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• 1987

This paper deals with a modeling of manufacturing system and a model analysis by a SIMAN language. A flow of production process is analyzed, and a mathematical model on the basis of the analyzed data is simulated by a SIMAN language. An object of this study is to achieve an optimization of production a reduction of cost, and an improvement of quality by a applicable line-balancing technique and an optimization technique in a real factor induced an analysis and synthesis of the result of simulation.