• Title/Summary/Keyword: product distribution

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Pharmacokinetics of Haloperidol (III) -The Pharmacokinetics of Haloperidol after single oral and intravenous doses in schizophrenic patients- (Haloperidol의 약물속도론적 연구 (III) -정신분열증 환자에 있어서 Haloperidol의 일회 주사 및 경구투여시의 Pharmacokinetics-)

  • Park, Kyoung-Ho;Lee, Min-Hwa;Lee, Myung-Gull;Kwon, Jun-Soo;Park, Won-Myung;Park, Jin-Seng
    • YAKHAK HOEJI
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    • v.34 no.6
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    • pp.375-383
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    • 1990
  • The pharmacokinetics of haloperidol were determined after single oral and intravenous doses in 13 male schizophrenic patients. Plasma concentrations of haloperidol(HP) and reduced haloperidol(RH) were measured by high performance liquid chromatography. Plasma concentration data obtained were analyzed by obth model dependent (one-or two exponential decay models using nonlinear regression) and model independent (AUC and first moment curve) approaches. The two methods were found to be in close results. After intravenous injections of HP in 8 patients (10 mg/man), the mean central and peripheral volume of distributions were $2.85\;{\pm}\;1.70$ and $8.09\;{\pm}\;2.10\;l/kg$, respectively, and mean steady state volume of distribution was $11.87\;{\pm}\;3.21\;l/kg$. Mean clearance, MRT and elimination half life were $12.39\;{\pm}\;3.25\;ml/min/kg$, $925.10\;{\pm}\;166.79\;min$ and $676.35\;{\pm}\;126.45\;min$, respectively. After oral administrations of HP in 5 patients, mean peak time and peak concentration were $217.63\;{\pm}\;61.60\;min$ and $9.77\;{\pm}\;2.92\;ng/ml$, respectively. Mean MRT and elimination half life were $1112.23\;{\pm}\;131.73\;min$ and $724.02\;{\pm}\;120.03\;min$, respectively, and these parameters were not significantly different from those of intravenous injection of HP. Absolute bioavailability of HP oral product was found to be about 44%. The profiles of plasma RH concentration-time curves after oral or intravenous doses of HP were similar. Also it was found that the elimination rate of RH was solwer than that of HP by comparing the slopes of plasma concentration-time curves of HP and RH.

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An Analysis of $CO_2$ Emission Structure in Korean Industry Using Hybrid IO Table (하이브리드 산업연관표를 이용한 우리나라 $CO_2$ 배출 구조 분석)

  • Park, Chang-Gui
    • Journal of Environmental Policy
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    • v.8 no.1
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    • pp.49-72
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    • 2009
  • To analyze the direct and indirect $CO_2$ emission structure according to industries in Korea, a hybrid IO table quantifying the section of energy in the IO table is needed. However, the results of the recent researches revealed differences in the total amount of $CO_2$ emission by researchers in addition to significant standard deviation in industrial distribution. This study intends to make comparative analysis of the existing method of making an IO table for energy and environment and presents an improvement scheme to contribute to an improvement in calculation of the total amount of $CO_2$ emission and estimation of the emission by industries in Korea. For this purpose, division was made into use as raw materials of energy and that as fuel and a new hybrid IO table was made by removing confounding factors caused by the product tax and subsidies. As a result, the oil and coal industry emitted 5.2 times less $CO_2$ after removing energy inputted as raw materials from the transaction table than before. The amount of $CO_2$ emission estimated by using the IO table based on basic price was found to be 2.7% less than by using the IO table based on the producer price.

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Characteristics of Exposure Distribution to Hazard Factors in Indoor Swimming Pool Activity Areas in Gwangju (수영장 활동공간 내 유해인자 노출특성 연구)

  • Lee, Youn-Goog;Kim, Nan-Hee;Choi, Young-Seop;Kim, Sun-Jung;Park, Ju-Hyun;Kang, Yu-Mi;Bae, Seok-Jin;Seo, Kye-Won;Kim, Jong-Min
    • Journal of Environmental Health Sciences
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    • v.46 no.2
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    • pp.150-158
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    • 2020
  • Objective: This study is designed to measure the concentration of DBPs (disinfection by-products) in pool water and in air and to estimate the carcinogenic potential through the evaluation of inhalation exposure. Methods: The subjects were six indoor swimming pools with many users in Gwangju. Samples of pool water and indoor air were taken every one month from August 2018 to August 2019 and analyzed for eight swimming pool standards. Three-liter air samples were collected and the VOCs were analyzed using GC/MS directly connected to thermal desorption. Results: pH was 6.8-7.5 and the concentration of free residual chlorine in pool water was 0.40-0.96 ?/ℓ. Physicochemical test items such as KMnO4 consumption and heavy metal items such as Aluminum met existing pool hygiene standards. No VOC materials were detected except for the DBPs. The concentration of THMs in the pool water was 11.05-41.77 ㎍/L and the THMs mainly consist of Chloroform (63-97%) and BDCM (3-31%). The concentration of indoor air THMs is 13.24-32.48 ㎍/㎥ and consists of Chloroform. The results of carcinogenic assessment of chloroform in the indoor swimming pool via inhalation exposure were 2.0 to 6.4 times higher than the 'acceptable risk level' suggested by the US EPA. Conclusions: The concentration of THMs in the pool water is 11.05-41.77 ㎍/L, most of which is chloroform. In addition, the concentration of indoor air THMs is 13.24-32.48 ㎍/㎥. The result of carcinogenic assessment of chloroform was 2.0 to 6.4 times higher than the 'acceptable risk level' suggested by the US EPA.

Thermal Degradation Characteristics of Carbon Tetrachloride in Excess Hydrogen Atmosphere (과잉수소 반응조건하에서 사염화탄소의 고온 분해반응 특성 연구)

  • Won, Yang-Soo;Jun, Kwan-Soo;Choi, Seong-Pil
    • Journal of Environmental Science International
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    • v.5 no.5
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    • pp.569-577
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    • 1996
  • pure compound chloromethanes; methyl chloride, methylene chloride, chloroform and The carbon tetrachloride were used as a model of chlorocarbon system with Cl/H ratio to investigate thermal stability and hydrodechlorination process of carbon tetrachloride under excess hydrogen atmosphere. The parent thermal stability on basis of temperature required for 99% destruction at 1 second no was evaluated as $875^{\circ}C$ for $CH_3Cl$, $780^{\circ}C$ for $CH_2Cl_2$, $675^{\circ}C$ for $CHCl_3$ and $635^{\circ}C$ for $CCl_4$. Chloroform was thermally less stable than $CCl_4$ at fairly low temperatures $(<570^{\circ}C).$ The lion of $CCl_4$ became more sensitive to increasing temperature, and $CCl_4$ was degraded CHCl3 at above $570^{\circ}C.$ The number and quantity of chlorinated products decreases with increasing temperature for the Product distribution of $CCl_4$ decomposition reaction system. Formation of non-chlorinated hydrocarbons such as $CH_4$, $C_2H_4$ and C_2H_6$ increased as the temperature rise and particularly small amount of methyl chloride was observed above $850^{\circ}C$ in $CC1_4$/$H_2$ reaction system. The less chlorinated products are more stable, with methyl chloride the most stable chlorocarbon in this reaction system.

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Optimum Carbonation Reforming Period of Recycled Aggregate Based on the Microscopic Carbonation Conduct (미시적 탄산화 거동에 기초한 순환 골재의 최적 탄산화 개질 기간)

  • Shin, Jin-Hak;Kim, Han-Sic;Ha, Jung-Soo;Chung, Lan
    • Journal of the Korea Concrete Institute
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    • v.28 no.3
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    • pp.329-340
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    • 2016
  • Increase in demotion and repair works on buildings in the construction market generates a large amount of construction waste. Recycling of construction waste is important for saving of resources, preservation of environment and constant advance of the construction industry. Accordingly, the environmental and economic value of recycled aggregate, which is produced after waste concrete is crushed, is increasingly highlighted. It is generally known that compared to concrete made of ordinary aggregate, concrete made of recycled aggregate has low quality, and the low quality is dependent on the amount of the bonding heterogeneous (cement paste and mortar) as well as the amount of the pores within the bonding heterogeneous. Reports on carbonation mechanism shows that the pores of cement-based materials are filled up by the progress of carbonation. Therefore, this study aims at an estimation of the period for optimum carbonation reforming appropriate for the thickness of the bonding heterogeneous of recycled aggregate, based on carbonation mechanism, with a view to improving the product quality by means of filling up the pores of the bonding heterogeneous of recycled aggregate. This study drew the carbonation depth according to the passage of age by calculating the bonding ratio and bonding thickness of the bonding heterogeneous as against the particle size distribution of recycled aggregate as well as by chemical quantitative analysis according to the age of accelerated carbonation of mock-up samples imitating bonding heterogeneous. Based on the correlation between the age of accelerated carbonation and carbonation depth, this study also proposed the estimated period of carbonation reforming of recycled aggregate appropriate for the thickness of the bonding heterogeneous.

Analysis of Fundamental Properties of Concrete Using Mix of Coarse Aggregate With Formation Causes (성인이 다른 굵은 골재를 혼합사용한 콘크리트의 기초적 특성 분석)

  • Noh, Sang-Kyun;Kim, Young-Hee;Kim, Jeong-Bin;Han, Cheon-Goo
    • Journal of the Korean Recycled Construction Resources Institute
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    • v.3 no.1
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    • pp.15-21
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    • 2015
  • Recently, attempts of replacing some of natural aggregate with mix of low quality aggregate are carried out for stable supply of aggregate. However, low quality aggregate such as recycled aggregate produced during the disposal process of construction wastes and by-product aggregate produced by industrial activities has problem of failing to comply to KS Standards. Therefore, we have compared fundamental properties of concrete by using granite crushed aggregate, recycled aggregate, blast furnace and electric arc furnace slag aggregate for effective utilization of lacking aggregate resources. As the result, slump in case of mixed use of aggregate was increased 0~10% compared to single use. Therefore, it is judged to be economically advantageous as it can expect effects in unit quantity or reduction of SP agent. Compressive strength in case of mixed use of aggregate was increased 0~10% compared to single use as it filled internal crevice of concrete with continuous particle size distribution. Accordingly, if we utilize by satisfying standard particle scope through mix of aggregate with different cause of formation in proper ratio, it was possible to confirm utility of mixed aggregate with demonstration of effects of increases of fluidity and compressive strength of concrete.

Womenswear Collections based on Italian Fashion Market Trends-utilizing 1990's demographics data- (이태리 패션시장 트렌드 분석을 통한 여성복 컬렉션 기획-1990년대 통계자료를 중심으로-)

  • 김유경
    • Journal of the Korean Society of Costume
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    • v.38
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    • pp.193-211
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    • 1998
  • Without a solid marketing system in placed, the fashion industry cannot flourish on out-standing design or technology alone. Even though the significance of collecting and analyzing information, merchandising, and retail distribution is recognized, these functions are not firmly rooted or prevalent in our industry. In contrast, Italy which possesses similar demographic traits such as the lack of natural resources and other physical factors has succeed-ed in globalizing its fashion market by responding swiftly and exercising flexiblity to its constantly changing consumer demand. This in turn has earned Italy the competitive edge in the global fashion arena. Italy's unique management skills and operation know-how, along with successful market strategies come into play in bringing competitiveness to Italy's fashion market. Firstly, smaller companies with ability to adopt swiftly to the ever changing market. Secondly, fashion friendly social environment. Thirdly, niche marketing through highly specialized system and differentiation. Fourthly, timeless innovation through intense corporate competition. Lastly, establishment of foundations to support the industry through diverse networking. The alone building blocks have formed a basis for erecting an unparalleled market with a reputation for excellence in design and quality in the global fashion world. This study has examined how Italy's fashion industry has evolved from an underdeveloped textile business into a cutting edge fashion in-dustry. Italy's unique business processes and practices were studied to come up with a collection and merchandising ideas in a niche market. By selecting this venue we are able to continuously grow and develop in a market with diverse consumer needs. To analyze the Italian fashion market, data from 3 institutions were utilized, namely, CIT-ER which has provided consumer trends and sales analysis, SITA,a data service provided statistics from the textile and apparel businesses, and NBI has also furnished valuable data. Italian consumer preference, buying behavior, consumer profile, retail channels and other related data from the above institutions has formed a backbone for market segmentation and target markets, and as a result, we were able to zero in on the type of consumer, produce, pricing and retail channels for our womenswear. Going forward the direction is to elevate product image and pretige, and create syn-ergy between related industries, and at the same note, in order to develop internationally recognized brands such as Max Mara and Benetton. Certain elements such as the specialization of the fashion industry, alon-g with fashion-related data base and systems support, and most importantly experts with acute fashion sense and capacity to analyze pertinent data are in need. I firmly believe that we can achieve Italy's level in the fashion market with support from the government and unrelenting effort within the industry itself, and hope that this report can prove to be useful.

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Analysis of Flavor Components of Coffee Beans in Polyethylene and Polypropylene Packaging Materials during Storage (원두커피 향미 성분의 폴리에틸렌과 폴리프로필렌 포장재에서의 저장 차이 분석)

  • Yu, Ha Kyoung;Lee, Seung Uk;Oh, Jae Young
    • KOREAN JOURNAL OF PACKAGING SCIENCE & TECHNOLOGY
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    • v.23 no.2
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    • pp.89-95
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    • 2017
  • Although the global coffee market is growing every year and the demand for coffee wrapping paper is increasing accordingly, research on the effect of PE material and PP material on the coffee aroma used in the sealant layer, which will directly contact the product, is lacking. In this study, we studied the change of aroma patterns and flavor materials by adding coffee to PP and PE pouches. In addition, we observed changes in aroma patterns depending on the temperature and the presence of the deoxidizer. As a result, it was found that the PP type packaging material was slightly better than the PE type packaging material, but the performance was hardly changed by the material. Rather, the change in the aroma pattern due to temperature was dominant rather than the material. It is ideal that refrigerated distribution ($4^{\circ}C$) is the best storage temperature and sales are done within a short period of time. Among the indicators, pyridine was the most suitable material to study and there are many data about pyridine. Therefore, it is expected that the results can be derived by using pyridine.

Hydrogen Production by Auto-thermal Reforming of Ethanol over $M/Al_2O_3$ (M = Mn, Fe, Co, Ni, Cu) Catalysts ($M/Al_2O_3$ (M = Mn, Fe, Co, Ni, Cu) 촉매 상에서 에탄올 자열개질반응에 의한 수소 제조)

  • Youn, Min-Hye;Seo, Jeong-Gil;Cho, Kyung-Min;Park, Sun-Young;Kim, Pil;Song, In-Kyu
    • Clean Technology
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    • v.13 no.4
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    • pp.287-292
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    • 2007
  • [ $M/Al_2O_3$ ] (M = Mn, Fe, Co, Ni, Cu) catalysts supported on commercial alumina ($Al_2O_3$) were prepared by an impregnation method, and were applied to the hydrogen production by auto-thermal reforming of ethanol. It was revealed that each catalyst retained its own metallic phase and product distribution strongly depended on the identity of active metal. Among the catalysts prepared, $Ni/Al_2O_3$ and $Co/Al_2O_3$ showed the best catalytic performance in the auto-thermal reforming of ethanol. However, the reaction mechanisms over these two catalysts were different. Ni/Al_2O_3 catalyst showed 100% ethanol conversion at $500^{\circ}C$, but it exhibited a rapid decrease in hydrogen selectivity. Although $Co/Al_2O_3$ catalyst showed an excellent performance in hydrogen selectivity, on the other hand, no significant improvement in hydrogen yield was observed due to the low ethanol conversion over the catalyst.

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A Study on the Effects of Consumer Self-Determination Psychological Needs and Perceived Influence for Fair Trade Products (공정무역제품에 대한 소비자의 자기결정성 심리 욕구와 지각된 영향력의 효과에 관한 연구)

  • Ock, Jung-Won
    • Management & Information Systems Review
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    • v.37 no.2
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    • pp.283-297
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    • 2018
  • This research focuses on the perceived marketplace influence(PMI: A belief that recognizes the effect that an individual's actions will have on the behavior of other consumers in the market and thus drives them to act on fair trade consumption) of consumers who may act as a more fundamental explanatory alternative to the gap in attitudes and behaviors of fair trade products. The purpose of this study is to investigate the relationship between consumer's self - determination psychological needs (autonomy, competence, relevance), influence (personal influence, market influence), and the assets of fair trade products. As a result of the empirical analysis, it was found that among the major psychological needs related to self-determination, the variables other than competence and the perceived influence relations of consumers can be directly formed, and the perceived consumer effectiveness(PCE) has a positive influence on perceived marketplace influence(PMI). It is also found that the perceived influence of consumers(PCE, PMI) has an influence on the consumers' perceived equity of Fair Trade products. The results of this study will provide an opportunity to theoretically explain the gap between consumers' attitudes and behaviors of Fair Trade products, which is a part of ethical consumption, and provide important implications for the establishment of marketing strategies.