• Title/Summary/Keyword: process optimization

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Optimization of the Extraction Process and Antioxidant Capacity of Coptis chinensis Franch Extract through Cluster Analysis (클러스터 분석을 이용한 황련 추출물 항산화 활성 최적화 추출공정)

  • Fu, Minmin;Xuan, Song Hua;Park, Soo Nam
    • Applied Chemistry for Engineering
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    • v.29 no.5
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    • pp.604-612
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    • 2018
  • Coptis chinensis Franch is a valuable traditional oriental medicinal plant used for the treatment of various diseases. The major factors affecting the content of bioactive compounds and the relationship between bioactive compounds and antioxidant capacities of Coptis chinensis Franch were poorly understood. Thus, effects of the solvent, temperature, and extraction time on the extraction yields of bioactive compounds and the antioxidant activity of C. chinensis Franch extracts were investigated in this work. Our cluster analysis indicated that the hydroalcoholic solvent (50% ethanol : 50% water) at $35^{\circ}C$ for 30 min (extract time) was the best extraction condition for a factory use because the highest level of bioactive compounds and antioxidant activities was achieved. Multiple linear regression analysis revealed that total phenolic content (TPC) contributed to the 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) scavenging activity, while both total alkaloid content (TAC) and total flavonoid content (TFC) were responsible for ferric reducing antioxidant power (FRAP) activity. These results indicated that extraction conditions controlled the yield of bioactive compounds and the antioxidant activity of C. chinensis Franch, which can provide important information for the industrial extraction.

Optimization of Nanoencapsulation Process for Azelaic Acid-Milk Nano Powder and Acne Nanocosmetics (Azelaic Acid 함유 밀크 나노분말과 여드름 나노화장품을 위한 나노캡슐의 최적화 공정)

  • Kim, Dong-Myong;Choi, Ji-Eun;Kim, Duck-Hoon;Lee, Jun-Tack
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.37 no.1
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    • pp.43-53
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    • 2011
  • The conditions in fluid-bed processor for nanoencapsulation of azelaic acid-milk nano powder for acne nanocosmetics were optimized by response surface methodology (RSM). The maximum value of yield was 70.97 %. The yield was appreciably influenced by inlet air temperature, atomizing pressure, and feeding speed. The particle size increased with an increase in the feeding speed and a decrease in the atomizing pressure. The elution rate in saline solutions was appreciably influenced by inlet air temperature and atomizing pressure. The moisture content increased with higher atomizing pressure, which was demonstrated to be similar to the nanoencapsulation characteristics related to water activity. The Hunter's L and b values increased with an increase in the inlet air temperature. The optimum conditions estimated by RSM for the maximized values of yield, moisture content, particle size and elution rate in skin suitability were $67{\sim}73^{\circ}C$ of inlet air temperature, 0.6 ~ 0.8 mL/min feeding speed and 1.8 ~ 2.0 kg/$cm^2$ of atomizing pressure, respectively. These estimated values were in agreement with those measured by real experiments.

Analysis of cause of engine failure during power generation using biogas in sewage treatment plant (하수처리장 바이오가스를 이용한 발전시 가스엔진의 고장원인 분석)

  • Kim, Gill Jung;Kim, Lae Hyun
    • Journal of Energy Engineering
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    • v.25 no.4
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    • pp.13-29
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    • 2016
  • In this study, we analyzed the causes of major faults in the biogas plant through the case of gas engine failure when cogenerating electricity and heat using biogas as a fuel in the actual sewage treatment plant and suggested countermeasures. Hydrogen sulfide in the biogas entering the biogas engine and water caused by intermittent malfunction of the water removal system caused intercooler corrosion in the biogas engine. In addition, the siloxane in the biogas forms a silicate compound with silicon dioxide, which causes scratches and wear of the piston surface and the inner wall of the cylinder liner. The substances attached to the combustion chamber and the exhaust system were analyzed to be combined with hydrogen sulfide and other impurities. It is believed that hydrogen sulfide was supplied to the desulfurization plant for a long period of time because of the high content of hydrogen sulfide (more than 50ppm) in the biogas and the hydrogen sulfide was introduced into the engine due to the decrease of the removal efficiency due to the breakthrough point of the activated carbon in the desulfurization plant. In addition, the hydrogen sulfide degrades the function of the activated carbon for siloxane removal of the adsorption column, which is considered to be caused by the introduction of unremoved siloxane waste into the engine, resulting in various types of engine failure. Therefore, hydrogen sulfide, siloxane, and water can be regarded as the main causes of the failure of the biogas engine. Among them, hydrogen sulfide reacts with other materials causing failure and can be regarded as a substance having a great influence on the pretreatment process. As a result, optimization of $H_2S$ removal method seems to be an essential measure for stable operation of the biogas engine.

The Dynamics of Noise and Vibration Engineering Vibrant as ever, for years to come

  • Leuridan, Jan
    • Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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    • 2010.05a
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    • pp.47-47
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    • 2010
  • Over the past 20 years, constant progress in noise and vibration (NVH) engineering has enabled to constantly advance quality and comfort of operation and use of really any products - from automobiles to aircraft, to all kinds of industrial vehicles and machines - to the extend that for many products, supreme NVH performance has becomes part of its brand image in the market. At the same time, the product innovation agenda in the automotive, aircraft and really many other industries, has been extended very much in recent years by meeting ever more strict environmental regulations. Like in the automotive industry, the drive towards meeting emission and CO2 targets leads to very much accelerated adoption of new powertrain concepts (downsizing of ICE, hybrid-electrical...), and to new vehicle architectures and the application of new materials to reduce weight, which bring new challenges for not only maintaining but further improving NVH performance. This drives for innovation in NVH engineering, so as to succeed in meeting a product brand performance for NVH, while as the same time satisfying eco-constraints. Product innovation has also become increasingly dependent on the adoption of electronics and software, which drives for new solutions for NVH engineering that can be applied for NVH performance optimization of mechatronic products. Finally, relentless pressure to shorten time to market while maintaining overall product quality and reliability, mandates that the practice and solutions for NVH engineering can be optimally applied in all phases of product development. The presentation will first review the afore trends for product and process innovation, and discuss the challenges they represent for NVH engineering. Next, the presentation discusses new solutions for NVH engineering of products, so as to meet target brand values, while at the same time meeting ever more strict eco constraints, and this within a context of increasing adoption of electronics and controls to drive product innovation. NVH being very much defined by system level performance, these solutions implement the approach of "Model Based System Engineering" to increase the impact of system level analysis for NVH in all phases of product development: - At the Concept Phase, to be able to do business case analysis of new product concepts; to arrive at an optimized and robust product architecture (e.g. to hybrid powertrain lay-out, to optimize fuel economy); to enable target cascading, to subsystem and component level. - In Development Phase, to increase realism and productivity of simulation, so as to frontload virtual validation of components and subsystems and to further reduce reliance on physical testing. - During the final System Testing Phase, to enable subsystem testing by a combination of physical testing and simulation: using simulation models to simulate the final integration context when testing a subsystem, enabling to frontload subsystem testing before final system integration is possible. - To interconnect Mechanical, Electronical and Controls engineering, in all phases of development, by supporting model driven controls engineering (MIL, SIL, HIL). Finally, the presentation reviews examples of how LMS is implementing such new applications for NVH engineering with lead customers in Europe, Asia and US, with demonstrated benefits both in terms of shortening development cycles, and/or enabling a simulation based approach to reduce reliance on physical testing.

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Design of Aspheric Imaging Optical System having 24mm Focal Length for MWIR with Facing Symmetric Lenses (마주보는 대칭렌즈를 가지는 MWIR용 초점거리 24mm의 비구면 결상광학계 설계)

  • Lee, Sang-Kil;Kim, Boo-Tae;Lee, Dong-Hee
    • Journal of the Korea Convergence Society
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    • v.9 no.9
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    • pp.183-189
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    • 2018
  • This study deals with the design and development of imaging optics having 24mm focal length for MWIR ($3{\sim}5{\mu}m$) with two symmetrical lenses facing each other. We used CodeV in our optical design, and we performed the optimization process to have the resolution and angle of view satisfying the user's requirements. The materials of lenses were limited to two types, including KCIR035 with a refractive index of 1.7589, developed in Korea. The optical system designed in this way consists of two aspherical lenses made of KCIR035 material having the same shape and one spherical lens made of Si. Here, the arrangement of the two aspherical lenses is characterized by having a symmetrical structure facing each other. And this optical system has a resolution of MTF value of 0.35 or more at a line width of 20 lp / mm. Therefore, it is considered that this optical system has the capability to be applied to a thermal imaging camera using a $206{\times}156$ array MWIR detection device having a pixel size of $25{\mu}m$.

The Optimization of $0.5{\mu}m$ SONOS Flash Memory with Polycrystalline Silicon Thin Film Transistor (다결정 실리콘 박막 트랜지스터를 이용한 $0.5{\mu}m$ 급 SONOS 플래시 메모리 소자의 개발 및 최적화)

  • Kim, Sang Wan;Seo, Chang-Su;Park, Yu-Kyung;Jee, Sang-Yeop;Kim, Yun-Bin;Jung, Suk-Jin;Jeong, Min-Kyu;Lee, Jong-Ho;Shin, Hyungcheol;Park, Byung-Gook;Hwang, Cheol Seong
    • Journal of the Institute of Electronics and Information Engineers
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    • v.49 no.10
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    • pp.111-121
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    • 2012
  • In this paper, a poly-Si thin film transistor with ${\sim}0.5{\mu}m$ gate length was fabricated and its electrical characteristics are optimized. From the results, it was verified that making active region with larger grain size using low temperature annealing is an efficient way to enhance the subthreshold swing, drain-induced barrier lowering and on-current characteristics. A SONOS flash memory was fabricated using this poly-Si channel process and its performances are analyzed. It was necessary to optimize O/N/O thickness for the reduction of electron back tunneling and the enhancement of its memory operation. The optimized device showed 2.24 V of threshold voltage memory windows which coincided with a well operating flash memory.

Back Analysis of Field Measurements Around the Tunnel with the Application of Genetic Algorithms (유전자 알고리즘을 이용한 터널 현장 계측 결과의 역해석)

  • Kim Sun-Myung;Yoon Ji-Sun;Jun Duk-Chan;Yoon Sang-Gil
    • Journal of the Korean Geotechnical Society
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    • v.20 no.7
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    • pp.69-78
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    • 2004
  • In this study, the back analysis program was developed by applying the genetic algorithm, one of artificial intelligence fields, to the direct method. The optimization process which has influence on the efficiency of the direct method was modulated with genetic algorithm. On conditions that the displacement computed by forward analysis for a certain rock mass model was the same as the displacement measured at the tunnel section, back analysis was executed to verify the validity of the program. Usefulness of the program was confirmed by comparing relative errors calculated by back analysis, which is carried out under the same rock mass conditions as analysis model of Gens et at (1987), one of back analysis case in the past. We estimated the total displacement occurring by tunnelling with the crown settlement and convergence measured at the working faces in three tunnel sites of Kyungbu Express railway. Those data measured at the working face are used for back analysis as the input data after confidence test. As the results of the back analysis, we comprehended the tendency of tunnel behaviors with comparing the respective deformation characteristics obtained by the measurement at the working face and by back analysis. Also the usefulness and applicability of the back analysis program developed in this study were verified.

Studies on Mass Production of Intracellularly-Produced Secondary Metabolite, Cyclosporin A by Use of Immobilized Fungal Cells in Stirred-Tank Immobilized Perfusion Reactor System(IPRS) (교반식 perfusion 생물반응기(IPRS)에서 고밀도 고정상 곰팡이 세포를 이용한 세포내 축적 이차대사산물인 Cyclosporin A 대량생산에 관한 연구)

  • 전계택;이태호장용근
    • KSBB Journal
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    • v.11 no.1
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    • pp.22-29
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    • 1996
  • Immobilized bioprocess was carried out for continuous production of cyclosporin A (CyA) produced intracellularly as a secondary metabolite by a filamentous fungus, Tolypocladium inflatum. Immobilization procedure for entrapping conidiospores of the producer was significantly simplified by use of a modified immobilization technique. A newly-designed immobilized perfusion reactor system (IPRS) showed good process benefits as demonstrated by the role of the high density immobilized cells as an efficient biomass generator, continuously supplying highly active CyA-producing free cells (1.0g/$\ell$/hr) even at very high dilution rate ($0.1hr^{-1}$). IPRS bioprocess was possible since efficient decantor system developed in our laboratory separated the sloughed-off free cells from the immobilized biomass effectively, thus overcoming wash-out phenomenon frequently encountered in continuous free cell cultures. Furthermore the released-free cells remaining in the bulk solution did not appear to cause substrate mass transfer limitation which was often experienced in suspended mycelial fungal cell fermentations. The primary reason for this was that the suspension broth of the IPRS mainly consisted of roundshaped short mycelial fragments and conidiospores, still remaining Newtonian even at high cell density. In parallel with IPRS bioprocess development, other key factors to be considered necessarily for significant increase in CyA productivity would be strain improvement and medium optimization for the immobilized cells.

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A study on Engineering Professionals' Recognition about Engineering Education in Primary and Secondary School (초.중등교육에서의 공학교육에 대한 공학전문가들의 인식 연구)

  • Kim, Ki-Soo;Kim, Young-Min;Huh, Hye-Yeon;Lee, Chang-Hoon
    • 대한공업교육학회지
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    • v.38 no.2
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    • pp.136-155
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    • 2013
  • The purpose of this study is to analysis the recognition of engineering professionals in Primary and middle school education. For the study, survey was proceeded through experts in engineering. The result of research follows. First, experts in engineering recognized that engineering has a significant impact in the national economic development and competitiveness. Experts in engineering, had a recognition consistent to some extent for engineering. and we have found engineering's own characteristics that emphasize "problem solving and design, innovation and creativity, economy optimization". Second, experts in engineering recognized that engineering education in Primary and middle school rarely take place, and also does not provide enough information for students. Third, experts in engineering recognized that engineering education is very needed in Primary and middle school. Through this, students can understand creative design problem-solving process. In addition, Experts of engineering, have a variety of educational demands for School level to the level of engineering education should start, level educational purposes, how to apply effective and so on.

Optimal Design of Permanent Magnet Thrust Bearings (영구자석형 스러스트 베어링의 최적 설계)

  • Yoo, Seong-Yeol;Kim, Woo-Yeon;Kim, Seung-Jong;Lee, Wook-Ryun;Bae, Yong-Chae;Noh, Myoung-Gyu
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.35 no.4
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    • pp.353-358
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    • 2011
  • In this paper, we describe a process for optimally designing a ring-type permanent magnet thrust bearing. The bearing consists of two sets of permanent magnet rings. One set is located inside the other set. An axial offset between the two sets creates axial force, which results in a thrust bearing function. In order to realize an optimal design of the bearing where the required load capacity of the bearing is achieved with the least magnet volume, we derived analytical design equations by adopting the equivalent current sheet (ECS) method. We considered the following two types of magnet arrays: axial arrays and Halbach arrays. These two types of arrays are optimized using the analytical design equations. The results of the optimization are verified using three dimensional (3D) finite element analyses (FEA). The results show that the Halbach array can achieve the required load capacity with less amount of permanent magnet than the axial array does. The efficacy of the ECS method is also verified by using 3D FEA. It is found that the accuracy of ECS method is more sensitive to the underlying assumptions for the Halbach array than for the axial array.