• Title/Summary/Keyword: process diagnostics

Search Result 180, Processing Time 0.032 seconds

Purity assignment of 17β-estradiol by mass balance method

  • Lee, Hwa-Shim;Oh, Kwang-Hoon
    • Analytical Science and Technology
    • /
    • v.30 no.5
    • /
    • pp.226-233
    • /
    • 2017
  • In general, quantitative chemical analysis in various areas including food, the environment, in vitro diagnostics, etc., requires traceability in order to increase the reliability of the measurements. Measurement traceability is a property of an unbroken chain of comparisons relating an instrument's measurements to SI units. Purity analysis is the first process for establishing traceability to SI units in chemical measurements. The purpose of this study is to develop and validate a method of purity assignment for establishing the traceability of $17{\beta}$-estradiol measurements in an in vitro diagnostics field. The establishment of this method is very important as it can be applied to the development of CRM and to the analysis of the purity of other hormones. The method of assignment of the purity of $17{\beta}$-estradiol was developed using the mass balance method and was validated through participation in an International comparison. In the mass balance method, impurities are categorized into four classes as follows: total related structure impurities, water, residual organic solvents, and nonvolatiles/inorganics. In this study, total related structure impurities were characterized by a gas chromatography-flame ionization detector (GC-FID) and a high-performance liquid chromatography-ultraviolet (HPLC-UV) detector, water content was determined by a Karl-Fisher coulometer, and total residual solvents and nonvolatiles/inorganics were checked simultaneously by thermogravimetric analysis (TGA). The purity of the $17{\beta}$-estradiol was 985.6 mg/g and the expanded uncertainty was 2.1 mg/g at 95% confidence. The developed method can be applied to the development of certified reference materials, which play a critical role in traceability.

A Development of EMAS (Easy Maintenance Assistance Solution) for Industrial Gas Turbine (산업용 가스터빈을 위한 정비지원 시스템 개발에 관한 연구)

  • Kang, Myoungcheol;Ki, Jayoung
    • Journal of the Korean Society of Propulsion Engineers
    • /
    • v.21 no.3
    • /
    • pp.91-100
    • /
    • 2017
  • The solution was developed for the maintenance decision support of combined cycle power plant gas turbine. The developed solution was applied to MHI501G gas turbine and is, in present, on the process of field test at GUNSAN combined cycle power plant, South Korea. The developed solution provides the calculated result of optimal overhaul maintenance period through following modules: Real Time Performance Monitoring, Model-Based Diagnostics, Performance Trend Analysis, Optimal Overhaul Maintenance Interval, Compressor Washing Period Management, and Blade Path Temperature Analysis. Model-Based Diagnostics module analyzed the differences between the data of gas turbine performance model and the online measurement. Compressor washing management module suggests the optimal point of balancing between the compressor performance and the maintenance cost.

Colour Interpolation of Tongue Image in Digital Tongue Image System Blocking Out External Light (디지털 설진 시스템의 색상 보정)

  • Kim, Ji-Hye;Nam, Dong-Hyun
    • The Journal of the Society of Korean Medicine Diagnostics
    • /
    • v.16 no.1
    • /
    • pp.9-18
    • /
    • 2012
  • Objectives The aim of this study is to propose an optimized tongue colour interpolation method to achieve accurate tongue image rendering. Methods We selected 60 colour chips in the chips of DIC color guide selector, and then divided randomly the colour chips into two groups. The colour chips of a group (Gr I) were used for finding the optimized colour correction factor of error and those of the other group (Gr II) were used for verifying the correction factor. We measured colour value of the Gr I colour chips with spectrophotometer, and took the colour chips image with a digital tongue image system (DTIS). We adjusted colour correction factor of error to equal the chip colour from each method. Through that process, we obtained the optimized colour correction factor. To verify the correction factor, we measured colour value of the Gr II colour chips with a spectrophotometer, and took the colour chips image with the DTIS in the two types of colour interpolation mode (auto white balance mode and optimized colour correction factor mode). And then we calculated the CIE-$L^*ab$ colour difference (${\Delta}E$) between colour values measured with the spectrophotometer and those from images taken with the DTIS. Results In auto white balance mode, The mean ${\Delta}E$ between colour values measured with the spectrophotometer and those from images taken with the DTIS was 13.95. On the other hand, in optimized colour correction factor mode, The mean ${\Delta}E$ was 9.55. The correction rate was over 30%. Conclusions In case of interpolating colour of images taken with the DTIS, we suggest that procedure to search the optimized colour correction factor of error should be done first.

Project Approach in the Organization of Scientific and Methodological Work by Applying Information Technology in Higher Education Institutions

  • Bieliaiev, Serhii;Ponomarova, Halyna;Repko, Inna;Stepanets, Ivan;Chagovets, Alla;Mykhailichenko, Mykola
    • International Journal of Computer Science & Network Security
    • /
    • v.21 no.12spc
    • /
    • pp.620-628
    • /
    • 2021
  • The article is devoted to studying the development of scientific and methodological work and its impact on the quality of students' vocational training in higher pedagogical education institutions by applying information technology. The article aim is to development of the organizational methodological support and pedagogical diagnostics of the effectiveness of the project «Modelling scientific and methodological work in a higher education pedagogical institution by applying information technology » realization in the framework of increasing the level of scientific and methodological work in a higher education pedagogical institution as a factor contributing to enhancing the quality of pedagogical education. The research program of the project activity envisages stating and substantiating the problem of scientific and methodological work by applying information technology in the framework of increasing the level and quality of educational activities in a higher pedagogical education institution through the implementation of the project approach, developing a model for the system of organizational and methodological support of the project implementation as well as monitoring the process and evaluating the results of the project implementation in terms of developing teachers' scientific, methodological, information competency and enhancing students' progress in studying. The set of criteria were developed to evaluate the level of formation of scientific and methodological competency as a result of implementing the project for the development of scientific and methodological work. The scientific and methodological work by applying information technology in the academy was carried out in accordance with the following principles: systematic character, consistent diagnostics, practical focus, scientific organizational and methodological support.

Project Approach in the Organization of Scientific and Methodological Work by Applying Information Technology in Higher Education Institutions

  • Bieliaiev, Serhii;Ponomarova, Halyna;Repko, Inna;Stepanets, Ivan;Chagovets, Alla;Mykhailichenko, Mykola
    • International Journal of Computer Science & Network Security
    • /
    • v.21 no.12spc
    • /
    • pp.703-711
    • /
    • 2021
  • The article is devoted to studying the development of scientific and methodological work and its impact on the quality of students' vocational training in higher pedagogical education institutions by applying information technology. The article aim is to development of the organizational methodological support and pedagogical diagnostics of the effectiveness of the project «Modelling scientific and methodological work in a higher education pedagogical institution by applying information technology » realization in the framework of increasing the level of scientific and methodological work in a higher education pedagogical institution as a factor contributing to enhancing the quality of pedagogical education. The research program of the project activity envisages stating and substantiating the problem of scientific and methodological work by applying information technology in the framework of increasing the level and quality of educational activities in a higher pedagogical education institution through the implementation of the project approach, developing a model for the system of organizational and methodological support of the project implementation as well as monitoring the process and evaluating the results of the project implementation in terms of developing teachers' scientific, methodological, information competency and enhancing students' progress in studying. The set of criteria were developed to evaluate the level of formation of scientific and methodological competency as a result of implementing the project for the development of scientific and methodological work. The scientific and methodological work by applying information technology in the academy was carried out in accordance with the following principles: systematic character, consistent diagnostics, practical focus, scientific organizational and methodological support.

Novel synthesis of nanocrystalline thin films by design and control of deposition energy and plasma

  • Han, Jeon G.
    • Proceedings of the Korean Vacuum Society Conference
    • /
    • 2016.02a
    • /
    • pp.77-77
    • /
    • 2016
  • Thin films synthesized by plasma processes have been widely applied in a variety of industrial sectors. The structure control of thin film is one of prime factor in most of these applications. It is well known that the structure of this film is closely associated with plasma parameters and species of plasma which are electrons, ions, radical and neutrals in plasma processes. However the precise control of structure by plasma process is still limited due to inherent complexity, reproducibility and control problems in practical implementation of plasma processing. Therefore the study on the fundamental physical properties that govern the plasmas becomes more crucial for molecular scale control of film structure and corresponding properties for new generation nano scale film materials development and application. The thin films are formed through nucleation and growth stages during thin film depostion. Such stages involve adsorption, surface diffusion, chemical binding and other atomic processes at surfaces. This requires identification, determination and quantification of the surface activity of the species in the plasma. Specifically, the ions and neutrals have kinetic energies ranging from ~ thermal up to tens of eV, which are generated by electron impact of the polyatomic precursor, gas phase reaction, and interactions with the substrate and reactor walls. The present work highlights these aspects for the controlled and low-temperature plasma enhanced chemical vapour disposition (PECVD) of Si-based films like crystalline Si (c-Si), Si-quantum dot, and sputtered crystalline C by the design and control of radicals, plasmas and the deposition energy. Additionally, there is growing demand on the low-temperature deposition process with low hydrogen content by PECVD. The deposition temperature can be reduced significantly by utilizing alternative plasma concepts to lower the reaction activation energy. Evolution in this area continues and has recently produced solutions by increasing the plasma excitation frequency from radio frequency to ultra high frequency (UHF) and in the range of microwave. In this sense, the necessity of dedicated experimental studies, diagnostics and computer modelling of process plasmas to quantify the effect of the unique chemistry and structure of the growing film by radical and plasma control is realized. Different low-temperature PECVD processes using RF, UHF, and RF/UHF hybrid plasmas along with magnetron sputtering plasmas are investigated using numerous diagnostics and film analysis tools. The broad outlook of this work also outlines some of the 'Grand Scientific Challenges' to which significant contributions from plasma nanoscience-related research can be foreseen.

  • PDF

On-line Process Data-driven Diagnostics Using Statistical Techniques (실시간 공정 데이터와 통계적 방법에 기반한 이상진단)

  • Cho, Hyun-Woo
    • Journal of the Korea Academia-Industrial cooperation Society
    • /
    • v.19 no.3
    • /
    • pp.40-45
    • /
    • 2018
  • Intelligent monitoring and diagnosis of production processes based on multivariate statistical methods has been one of important tasks for safety and quality issues. This is due to the fact that faults and unexpected events may have serious impacts on the operation of processes. This study proposes a diagnostic scheme based on effective representation of process measurement data and is evaluated using simulation process data. The effects of utilizing a preprocessing step and nonlinear statistical methods are also tested using fifteen faults of the simulation process. Results show that the proposed scheme produced more reliable results and outperformed other tested schemes with none of the filtering step and nonlinear methods. The proposed scheme is expected to be robust to process noises and easy to develop due to the lack of required rigorous mathematical process models or expert knowledge.

A Unique Strategy for Recovering Recombinant Proteins from Molecular Farming: Affinity Couture on Engineered Oilbodies

  • Seon, Jeong-Hoon;J.Steven Szarka;Maurice M. Moloney
    • Journal of Plant Biotechnology
    • /
    • v.4 no.3
    • /
    • pp.95-101
    • /
    • 2002
  • Molecular faming has the potential to provide large amounts of recombinant protein for use in diagnostics and as therapeutics. Various strategies have been developed to enhance the expression level, stability, and native folding of recombinant proteins produced in plants. Few investigations into the subcellular distribution of recombinant proteins within plant cells have been published despite the potential to increase the expression level and impact the purification process. This review article discusses the current strategies used for targeting recombinant proteins to various subcellular locations and the advantages of targeting to seed oil bodies for molecular farming applications. Specifically, the affinity capture of antibodies using recombinant oilbodies is discussed.

Cutting force estimation using spindle and feeddrive motor currents in milling processes (밀링공정에서 이송모터와 주축모터의 전류신호를 이용한 절삭력 추정)

  • 김승철;정성종
    • 제어로봇시스템학회:학술대회논문집
    • /
    • 1997.10a
    • /
    • pp.1407-1410
    • /
    • 1997
  • Advanced sensor design and filtering technology have been studied to obtain information for condition monitoring and diagnostics inmachining processes. To develope and economic monitoring system in end milling processes, indirect and reliable type of cutting force estimators were required. In this paper, an estimation method of cutting forces during end milling processes was studied through the measurement of current signals obtained from spindle and feeddrive motors. Cutting force and torque models were derived from the cutting geometry in down milling processes. Relationships between motor currents and cutting forces were also developed in the form of AC and DC components from the developed force models. The validity of the cutting force estimator was confirmed by the experiments under various cutting conditions.

  • PDF

Effects of Fuel Injection Conditions on Combustion Characteristics of a DI Diesel Engine (직접분사식 디젤 엔진에서 연료 분사 인자에 따른 연소 특성)

  • Kook, Sang-Hoon;Yu, Jun;Park, Cheol-Woong;Bae, Choong-Sik
    • 한국연소학회:학술대회논문집
    • /
    • 2002.06a
    • /
    • pp.33-38
    • /
    • 2002
  • An optical single cylinder diesel engine equipped with a common-rail injection system has been built to investigate diesel combustion and emission characteristics. Three optical widows (piston crown quartz for bottom view of the cylinder, upper piston quartz for allowing laser sheet and liner quartz for side view) have been placed in the optical engine to visualize spray characteristics and combustion process inside the cylinder. Before doing further research using various optical diagnostics with the optical engine, fundamental combustion experiments and flame visualization incorporating a high speed motion analyser have been carried out with a wide range of engine operating conditions.

  • PDF