• Title/Summary/Keyword: probabilistic approach method

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A Method for Protein Identification Based on MS/MS using Probabilistic Graphical Models (확률그래프모델을 이용한 MS/MS 기반 단백질 동정 기법)

  • Li, Hong-Lan;Hwang, Kyu-Baek
    • Proceedings of the Korean Information Science Society Conference
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    • 2012.06b
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    • pp.426-428
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    • 2012
  • In order to identify proteins that are present in biological samples, these samples are separated and analyzed under the sequential procedure as follows: protein purification and digestion, peptide fragmentation by tandem mass spectrometry (MS/MS) which breaks peptides into fragments, peptide identification, and protein identification. One of the widely used methods for protein identification is based on probabilistic approaches such as ProteinProphet and BaysPro. However, they do not consider the difference in peptide identification probabilities according to their length. Here, we propose a probabilistic graphical model-based approach to protein identification from MS/MS data considering peptide identification probabilities, number of sibling peptides, and peptide length. We compared our approach with ProteinProphet using a yeast MS/MS dataset. As a result, our model identified 27 more proteins than ProteinProphet at 1% of FDR (false discovery rate), confirming the importance of peptide length information in protein identification.

Probabilistic Forecasting of Seasonal Inflow to Reservoir (계절별 저수지 유입량의 확률예측)

  • Kang, Jaewon
    • Journal of Environmental Science International
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    • v.22 no.8
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    • pp.965-977
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    • 2013
  • Reliable long-term streamflow forecasting is invaluable for water resource planning and management which allocates water supply according to the demand of water users. It is necessary to get probabilistic forecasts to establish risk-based reservoir operation policies. Probabilistic forecasts may be useful for the users who assess and manage risks according to decision-making responding forecasting results. Probabilistic forecasting of seasonal inflow to Andong dam is performed and assessed using selected predictors from sea surface temperature and 500 hPa geopotential height data. Categorical probability forecast by Piechota's method and logistic regression analysis, and probability forecast by conditional probability density function are used to forecast seasonal inflow. Kernel density function is used in categorical probability forecast by Piechota's method and probability forecast by conditional probability density function. The results of categorical probability forecasts are assessed by Brier skill score. The assessment reveals that the categorical probability forecasts are better than the reference forecasts. The results of forecasts using conditional probability density function are assessed by qualitative approach and transformed categorical probability forecasts. The assessment of the forecasts which are transformed to categorical probability forecasts shows that the results of the forecasts by conditional probability density function are much better than those of the forecasts by Piechota's method and logistic regression analysis except for winter season data.

Probabilistic shear-lag analysis of structures using Systematic RSM

  • Cheng, Jin;Cai, C.S.;Xiao, Ru-Cheng
    • Structural Engineering and Mechanics
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    • v.21 no.5
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    • pp.507-518
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    • 2005
  • In the shear-lag analysis of structures deterministic procedure is insufficient to provide complete information. Probabilistic analysis is a holistic approach for analyzing shear-lag effects considering uncertainties in structural parameters. This paper proposes an efficient and accurate algorithm to analyze shear-lag effects of structures with parameter uncertainties. The proposed algorithm integrated the advantages of the response surface method (RSM), finite element method (FEM) and Monte Carlo simulation (MCS). Uncertainties in the structural parameters can be taken into account in this algorithm. The algorithm is verified using independently generated finite element data. The proposed algorithm is then used to analyze the shear-lag effects of a simply supported beam with parameter uncertainties. The results show that the proposed algorithm based on the central composite design is the most promising one in view of its accuracy and efficiency. Finally, a parametric study was conducted to investigate the effect of each of the random variables on the statistical moment of structural stress response.

A Basic Study on Composite Power System Expansion Planning Considering Probabilistic Reliability Criteria

  • Choi, Jae-Seok;Tinh, TranTrung;Kim, Hyung-Chul;El-Keib, A.;Thomas, R.;Billinton, R.
    • Proceedings of the KIEE Conference
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    • 2004.11b
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    • pp.297-300
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    • 2004
  • This paper proposes a method for choosing the best composite power system expansion plan considering probabilistic reliability criterion. The proposed method was modeled as the minimization of the investment budget (economics) for constructing new transmission lines subject to not only deterministic(demand constraint) but also probabilistic reliability criterion(LOLE) with considering the uncertainties of the system elements. This is achieved by modeling the power system expansion problem as an integer programming one. The method solves for the optimal strategy using a probabilistic theory based branch and bound method that utilizes a network flow approach and the maximum flow-minimum cut set theorem. Although the proposed method is applied to a simple sample study, the test results demonstrate a fact that the proposed method is suitable for solving the power system expansion planning problem subject to practical uncertainties for future.

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Probabilistic Durability Analysis of Concrete Structures by Numerical Method (수치해석에 의한 콘크리트 구조물의 확률론적인 내구성 해석)

  • Jung, Sang-Hwa;Kim, Joo-Hyung;Lee, Kwang-Myong;Kim, Jee-Sang;Bae, Su-Ho
    • Proceedings of the Korea Concrete Institute Conference
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    • 2006.05b
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    • pp.181-184
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    • 2006
  • Traditional durability analysis is not possible to provide a controlled durability and long-term performance of concrete structures. Recently, research works have shown that probabilistic approach based on the theory of structural reliability, would be very valuable for durability analysis. In this study, the probabilistic durability analysis based on a Monte Carlo Simulation was carried out using sample data selected from detailed field investigation. The probabilistic properties of some design variables, such as diffusion coefficients of concrete and surface chloride concentration, were newly determined using some experimental data. By applying a probabilistic durability analysis to an integral structural design, the durability performance of concrete structures would be remarkably improved.

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Systems Engineering Process Approach to the Probabilistic Safety Assessment for a Spent Fuel Pool of a Nuclear Power Plant (사용후핵연료저장조의 확률론적안전성평가 수행을 위한 시스템엔지니어링 프로세스 적용 연구)

  • Choi, Jin Tae;Cha, Woo Chang
    • Journal of the Korean Society of Systems Engineering
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    • v.17 no.2
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    • pp.82-90
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    • 2021
  • The spent fuel pool (SFP) of a nuclear power plant functions to store the spent fuel. The spent fuel pool is designed to properly remove the decay heat generated from the spent fuel. If the cooling function is lost and proper operator action is not taken, the spent fuel in the storage pool can be damaged. Probabilistic safety assessment (PSA) is a safety evaluation method that can evaluate the risk of a large and complex system. So far, the probabilistic safety assessment of nuclear power plants has been mainly performed on the reactor. This study defined the requirements and the functional architecture for the probabilistic safety assessment of the spent fuel pool (SFP-PSA) by applying the systems engineering process. And, a systematic and efficient methodology was defined according to the architecture.

Non-Gaussian approach for equivalent static wind loads from wind tunnel measurements

  • Kassir, Wafaa;Soize, Christian;Heck, Jean-Vivien;De Oliveira, Fabrice
    • Wind and Structures
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    • v.25 no.6
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    • pp.589-608
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    • 2017
  • A novel probabilistic approach is presented for estimating the equivalent static wind loads that produce a static response of the structure, which is "equivalent" in a probabilistic sense, to the extreme dynamic responses due to the unsteady pressure random field induced by the wind. This approach has especially been developed for complex structures (such as stadium roofs) for which the unsteady pressure field is measured in a boundary layer wind tunnel with a turbulent incident flow. The proposed method deals with the non-Gaussian nature of the unsteady pressure random field and presents a model that yields a good representation of both the quasi-static part and the dynamical part of the structural responses. The proposed approach is experimentally validated with a relatively simple application and is then applied to a stadium roof structure for which experimental measurements of unsteady pressures have been performed in boundary layer wind tunnel.

Probabilistic Approach for Fighter Inlet Hammershock Design Pressure (전투기 흡입구 해머쇼크 설계압력에 대한 확률론적 접근법)

  • Bae, Hyo-gil;Lee, Hoon Sik;Kim, Yun-mi;Jeong, In Myon;Lee, SangHyo;Cho, Dae-yeong
    • Journal of Aerospace System Engineering
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    • v.13 no.5
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    • pp.72-78
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    • 2019
  • Inlet hammershock is the critical loads condition for designing the inlet duct structure of a fighter. The sudden flow reduction in engine compressor causes inlet hammershock with high pressure. The traditional method was used to combine extreme conditions (maximum speed, sea level altitude, and cold day) to analyze this compression wave inlet hammershock pressure. However, after the 90s there have been papers that presented the probabilistic approach for the inlet hammershock to achieve the appropriate design pressure. This study shows how to analyze the inlet hammershock pressure by making practical use of the Republic of Korea Air Force real flight usage data under probabilistic approach and then analyze approximately 30% decreased inlet hammershock pressure compared with the traditional valve.

Construction of Logic Trees and Hazard Curves for Probabilistic Tsunami Hazard Analysis (확률론적 지진해일 재해도평가를 위한 로직트리 작성 및 재해곡선 산출 방법)

  • Jho, Myeong Hwan;Kim, Gun Hyeong;Yoon, Sung Bum
    • Journal of Korean Society of Coastal and Ocean Engineers
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    • v.31 no.2
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    • pp.62-72
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    • 2019
  • Due to the difficulties in forecasting the intensity and the source location of tsunami the countermeasures prepared based on the deterministic approach fail to work properly. Thus, there is an increasing demand of the tsunami hazard analyses that consider the uncertainties of tsunami behavior in probabilistic approach. In this paper a fundamental study is conducted to perform the probabilistic tsunami hazard analysis (PTHA) for the tsunamis that caused the disaster to the east coast of Korea. A logic tree approach is employed to consider the uncertainties of the initial free surface displacement and the tsunami height distribution along the coast. The branches of the logic tree are constructed by reflecting characteristics of tsunamis that have attacked the east coast of Korea. The computational time is nonlinearly increasing if the number of branches increases in the process of extracting the fractile curves. Thus, an improved method valid even for the case of a huge number of branches is proposed to save the computational time. The performance of the discrete weight distribution method proposed first in this study is compared with those of the conventional sorting method and the Monte Carlo method. The present method is comparable to the conventional methods in its accuracy, and is efficient in the sense of computational time when compared with the conventional sorting method. The Monte Carlo method, however, is more efficient than the other two methods if the number of branches and the number of fault segments increase significantly.

Evaluation of Soil Stiffness Variability Effects on Soil-Structure Interaction Response of Nuclear Power Plant Structure (지반강성의 변동성이 원전구조물의 지반-구조물 상호작용 응답에 미치는 영향 분석)

  • Kim, Jae Min;Noh, Tae Yong;Huh, Jungwon;Kim, Moon Soo;Hyun, Chang Hun
    • Journal of the Earthquake Engineering Society of Korea
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    • v.19 no.2
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    • pp.63-74
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    • 2015
  • This study investigated the influence of probabilistic variability in stiffness and nonlinearity of soil on response of nuclear power plant (NPP) structure subjected to seismic loads considering the soil-structure interaction (SSI). Both deterministic and probabilistic methods have been employed to evaluate the dynamic responses of the structure. For the deterministic method, $SRP_{min}$ method given in USNRC SRP 3.7.2(2013) (envelope of responses using three shear modulus profiles of lower bound($G_{LB}$), best estimate($G_{BE}$) and upper bound($G_{UB}$)) and $SRP_{max}$ method (envelope of responses by more than three ground profiles within range of $G_{LB}{\leq}G{\leq}G_{UB}$) have been considered. The probabilistic method uses the Latin Hypercube Sampling (LHS) that can capture probabilistic feature of soil stiffness defined by the median and the standard deviation. These analysis results indicated that 1) number of samples shall be larger than 60 to apply the probabilistic approach in SSI analysis and 2) in-structure response spectra using equivalent linear soil profiles considering the nonlinear behavior of soil medium can be larger than those based on low-strain soil profiles.