• Toxicological Research
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• v.23 no.3
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• pp.197-205
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• 2007

Cancer metastasis is a major determinant of cancer patient mortality. Mounting evidence favors a strong positive role for $TGF-{\beta}$ in human cancer progression. The complex pattern on cross-talk of $TGF-{\beta}$ and the related other signaling pathways is an important area of investigation that will ultimately contribute to understanding of the bifunctional role of $TGF-{\beta}$ in cancer progression. This review summarizes some of the current understanding of $TGF-{\beta}$ signaling with a major focus in its contribution to the tumor cell invasion and metastasis. Five issues are addressed in this review: (1) $TGF-{\beta}$ signaling, (2) $TGF-{\beta}$ and EMT, (3) $TGF-{\beta}$ and MMP, (4) $TGF-{\beta}$ and Ras, and (5) Role of $TGF-{\beta}$ in invasion and metastasis. Due to the bifunctional cellular effects of $TGF-{\beta}$, as a tumor promoter and a tumor suppressor, more precisely defined $TGF-{\beta}$ signaling pathways need to be elucidated. According to the current literature, $TGF-{\beta}$ is clearly a major factor stimulating tumor progression through a complex spectrum of the interplay and cross-talk between various signaling molecules. Understanding the role of $TGF-{\beta}$ in invasion and metastasis will provide valuable information on establishing strategies to manipulate $TGF-{\beta}$ signaling which should be a high priority for the development of anti-metastatic therapeutics.

• Journal of the Ergonomics Society of Korea
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• v.33 no.1
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• pp.49-58
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• 2014

Objective: The aim of this study is to enhance the efficiency of education and training through application and management of 'Transfer of Training' in nuclear power plants. Background: Despite the sophistication and standardization of job-related skills and techniques of workers, accidents/incidents keep taking place due to human errors and unsafe actions and behaviors, which translates into the necessity to review and examine the effectiveness and influence of education and training on the workers of nuclear power plants. Method/Results: This study drew the factors of 'Transfer of Training' through a review on the preceding studies and document research. In addition, through expert examination, this study explored the expected effects and possibility of application when managing the influencing factors of 'Transfer of Training' in nuclear power plants. And lastly, management priority order for nuclear power plants was drawn through an AHP analysis. Conclusion: Among the 'Transfer of Training' factors, the training design factor was the most important. In addition, the design of the training and transfer and goal setting showed a high degree of importance among the influencing factors. Application: The management of 'Transfer of Training' in nuclear power plants enhances the capability of workers and improves the operational integrity of nuclear power plants.

• Journal of the East Asian Society of Dietary Life
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• v.17 no.3
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• pp.456-462
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• 2007

Food safety has been a growing consumer concern over the last few decades, and remains a priority for consumers, the food industry, and regulatory agencies alike. Although consumer concern for food safety has increased, consumer confidence has decreased. The emphasis on food safety is related to that of preliminary risk management. The ability to collect and provide food risk information is a key element in enhancing the way food safety authorities protect consumers from risk. This review aims to investigate the current situations of international organizations, as well as several countries' systems for collecting and providing food risk information. Through the comparison and analysis of each system, this review proposes strategies to establish a systematic collecting of information and provision of infrastructure in Korea. To develop an information collection system suited to Korea's situation, it is necessary for Korea to strengthen interactions and cooperation with other trade partners through the enlargement of international networks. Such efforts on food risk communication should be made by providing high quality and clear information.

• Nuclear Engineering and Technology
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• v.37 no.6
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• pp.587-594
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• 2005

In an effort to develop a thermal-hydraulic (TH) safety analysis code for Gas-cooled Reactors (GCRs), the MARS code, which was primarily developed for TH analysis of water reactor systems, has been extended here for application to GCRs. The modeling requirements of the system code were derived from a review of major processes and phenomena that are expected to occur during normal and accident conditions of GCRs. Models fur code improvement were then identified through a review of existing MARS code capability. Among these, the following priority models necessary fur the analysis of limiting high and low pressure conduction cooling events were evaluated and incorporated in MARS-GCR/V1 : 1) Helium (He) and Carbon Dioxide ($CO_2$) as main system fluids, 2) gas convection heat transfer, 3) radiation heat transfer, and 4) contact heat transfer models. Each model has been assessed using various conceptual problems for code-to-code benchmarks and it was demonstrated that MARS-GCR/V1 is capable of capturing the relevant phenomena. This paper describes the models implemented in MARS-GCR/V1 and their verification and validation results.

• Korean Linguistics
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• v.79
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• pp.145-169
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• 2018

The purpose of this paper is to review critically the validity and relevance of the pan-national language culture improvement movement, Annyeong! Urimal(Hello! Our Language) implemented for the last three years as part of the government-driven projects, and to seek for improvement direction or fundamental reorientation of this movement. In order to accomplish this purpose, this paper firstly points out abstract and conventional aspects of the diagnosis for background and the purpose of projects, and suggests that this movement focuses on verbal abuse rather than language destruction and pays attention to positive aspects of newly rising language use. Then, with reference to main agent, this paper argues that the government must lead actively formation of voluntary nongovernmental agent with indirect financial and institutional support. Thirdly, it is suggested that public language should be the top priority target sphere and the language used by the leaders of society and the older generation should be also included in the target spheres of this movement. Finally, this paper indicates that enlightenment/public relation projects end often in one time events, imposing unilaterally the normative contents, and also emphasizes the importance of survey/research projects and deliberation/evaluation projects.

• International conference on construction engineering and project management
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• 2011.02a
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• pp.249-255
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• 2011

Poor safety management in construction management may adversely affect cost, schedule and quality of a project. Heavy fines upon safety offence becomes a burden to the budget; losing working hours as a result of safety incident impacts on the schedule, and compromising quality is always an indirect consequence when workers perform duties in an unsafe site environment. Therefore, promotion of safety management becomes the top priority in any construction manager's agenda. Working safely will benefit construction project and lead to a "real" success. This paper is a case study, based upon "Geller's 10 principles for achieving a total safety culture", reviewing how a Hong Kong leading construction company fosters the safety culture and possesses a pleasant safety record over years. Its safety performance is not only well ahead the local industry, but also ranges top within the Asia Pacific region and comparable to those mature Western industries. The review concluded that safety culture is one of the major components in construction management and collaboration is the essence to realize this positive culture within an organization. Safety management is not merely a "top down" approach, but requires the positive "bottom up" actions from the other end. The successful story of this company can demonstrate the contribution of safety management in construction management.

• Asian-Australasian Journal of Animal Sciences
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• v.12 no.4
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• pp.651-656
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• 1999

In current animal production in Japan, a large surplus of nitrogen and phosphorus is given to animals as their feed which are mostly imported from outside of our own country. Today, an excess of nitrogen and phosphorus from animal manure has been spread out of the area of animal production and the surroundings. These components have become the major reason for eutrophication of ground, surface and inland water. Nutritional studies for the reduction of nitrogen and phosphorus from animal waste has been done by many researchers. The reduction of excess protein in animal feed and the supplementation of deficient essential amino acids to feed have a possibility to increase the biological value of feed and to reduce nitrogen excretion, especially, via urine. The use of phytase activity to degrade phytate and to release utilizable inorganic phosphorus make it possible to cut an excess supply of feed additive inorganic phosphorus and to reduce phosphorus excretion from animal waste.

• Korean Business Review
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• v.23 no.1
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• pp.147-161
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• 2010

Ecotourism is regarded as an important alternative tourism for regional development and conservation of nature by country or international organization. The environmental importance were given priority by all the countries. The purpose of this study includes; (1) To identify the ecotourism definition. (2) To report the ecotourism development plan by the case study of ecotourism.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.19
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• pp.8007-8018
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• 2014

Cervical cancer is the most common gynecologic malignancy worldwide and development of new therapeutic strategies and anticancer agents is an urgent priority. Plants have remained an important source in the search for novel cytotoxic compounds and several polyphenolic flavonoids possess antitumor properties. In this review article, data about potential anticarcinogenic activity of common natural flavonoids on various human cervical cancer cell lines are compiled and analyzed showing perspectives for the use of these secondary metabolites in the treatment of cervical carcinoma as well as in the development of novel chemotherapeutic drugs. Such anticancer effects of flavonoids seem to differentially depend on the cellular type and origin of cervical carcinoma creating possibilities for specific targeting in the future. Besides the cytotoxic activity per se, several flavonoids can also contribute to the increase in efficacy of conventional therapies rendering tumor cells more sensitive to standard chemotherapeutics and irradiation. Although the current knowledge is still rather scarce and further studies are certainly needed, it is clear that natural flavonoids may have a great potential to benefit cervical cancer patients.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.10 no.8
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• pp.3986-4007
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• 2016

Business analysis is a key factor of project success or failure in information systems. However, there are few studies on business analysis competencies. The objective of this paper is to identify which competencies a business analyst (BA) needs, and analyze the importance weights and priorities of business analysis competencies. Literature review yielded 6 competency dimensions and 30 competencies. Based on interviews with 12 experts and analytic hierarchy process analysis, the relative importance weight and priority of each business analysis competency were analyzed. Moreover, an importance-perception gap between stakeholders in different positions was identified. This result can be used as selection and development criteria for superior BAs that are responsible for solving business problems using information systems solutions.