• Journal of Microbiology and Biotechnology
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• 제28권6호
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• pp.1022-1029
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• 2018

Tuberculosis (TB) remains a serious health issue around the word. Adenovirus (Ad)-based vaccine and modified vaccinia virus Ankara (MVA)-based vaccine have emerged as two of the most promising immunization candidates over the past few years. However, the performance of the homologous and heterologous prime-boost immunization regimens of these two viral vector-based vaccines remains unclear. In the present study, we constructed recombinant Ad and MVA expressing an Ag85B-TB10.4 fusion protein (AdH4 and MVAH4) and evaluated the impact of their different immunization regimens on the humoral and cellular immune responses. We found that the viral vector-based vaccines could generate significantly higher levels of antigen-specific antibodies, $IFN-{\gamma}$-producing splenocytes, $CD69^+CD8^+$ T cells, and $IFN-{\gamma}$ secretion when compared with bacillus Calmette-$Gu{\acute{e}}rin$ (BCG) in a mouse model. AdH4-containing immunization regimens (AdH4-AdH4, AdH4-MVAH4, and MVAH4-AdH4) induced significantly stronger antibody responses, much more $IFN-{\gamma}$-producing splenocytes and $CD69^+CD8^+$ T cells, and higher levels of $IFN-{\gamma}$ secretion when compared with the MVAH4-MVAH4 immunization regimen. The number of $IFN-{\gamma}$-producing splenocytes sensitive to $CD8^+$ T-cell restricted peptides of Ag85B (9-1p and 9-2p) and Th1-related cytokines ($IFN-{\gamma}$ and $TNF-{\alpha}$) in the AdH4-MVAH4 heterologous prime-boost regimen immunization group was significantly higher than that in the other viral vector-based vaccine- and BCG-immunized groups, respectively. These results indicate that an immunization regimen involving AdH4 may have a higher capacity to induce humoral and cellular immune responses against TB in mice than that by regimens containing BCG or MVAH4 alone, and the AdH4-MVAH4 prime-boost regimen may generate an ideal protective effect.

• Journal of Sasang Constitutional Medicine
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• 제32권3호
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• pp.46-54
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• 2020

Introduction This study aims to report a significant improvement of Sjögren's syndrome patient with irritable bladder, diagnosed as 'Soyangin chest-binding symptomatology' based on Sasang medicine. Methods The patient had treatment with 'Dojeokganggi-tang' and western medications. We evaluated the treatment outcome of Sjögren's syndrome symptoms by using a numerical score of 0 to 10, based on the patient's subjective discomfort of dry eye and dry mouth, and irritable bladder symptoms by recording the number of night urination every month. Results Sjögren's syndrome symptoms were significantly improved, and the number of night urination was decreased. After 41 weeks of treatment, the patient didn't have dry mouth any more and had only a little dry eye. The number of night urination was decreased from 3-4 times to once a night. Discussion The patient diagnosed with Sjögren's syndrome, treated with Dojeokganggi-tang and western medications for 41 weeks, showed a significant improvement in dry eye, dry mouth, and night urination compared to the first visit.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• 제11권2호
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• pp.107-112
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• 2011

It is very difficult to factorize composite number, $n=pq$ to integer factorization, p and q that is almost similar length of digits. Integer factorization algorithms, for the most part, find ($a,b$) that is congruence of squares ($a^2{\equiv}b^2$ (mod $n$)) with using factoring(factor base, B) and get the result, $p=GCD(a-b,n)$, $q=GCD(a+b,n)$ with taking the greatest common divisor of Euclid based on the formula $a^2-b^2=(a-b)(a+b)$. The efficiency of these algorithms hangs on finding ($a,b$) and deciding factor base, B. This paper proposes a efficient algorithm. The proposed algorithm extracts B from integer factorization with 3 digits prime numbers of $n+1$ and decides f, the combination of B. And then it obtains $x$(this is, $a=fxy$, $\sqrt{n}$ < $a$ < $\sqrt{2n}$) from integer factorization of $n-2$ and gets $y=\frac{a}{fx}$, $y_1$={1,3,7,9}. Our algorithm is much more effective in comparison with the conventional Fermat algorithm that sequentially finds $\sqrt{n}$ < $a$.

• The Journal of Korean Institute of Communications and Information Sciences
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• 제30권5A
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• pp.359-369
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• 2005

For large capacity optical CDMA networks, we propose a shared-type encoder/decoders based on an tunable wavelength converter(TWC) and an arrayed waveguide grating (AWG) router. The proposed encoder/decoder treats codewords of wavelength/time 2-D code simultaneously using the dynamic code allocation property of the TWC and the cyclic property of the AWG router, and multiple subscribers can share the encoder/decoder in networks. Feasibility of the structure of the proposed encoder/decoder for dynamic code allocation is tested through simulations using two wavelength/time 2-D codes, which are the generalized multi-wavelength prime code(GMWPC) and the generalized multi-wavelength Reed-Solomon code(GMWRSC). Test results show that the proposed encoder/decoder can increase the channel efficiency not only by increasing the number of simultaneous users without any multiple-access interference but by using a relatively short length CDMA codes.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제14권9호
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• pp.3841-3857
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• 2020

RSA is one of the best well-known public key cryptosystems. This methodology is widely used at present because there is not any algorithm which can break this system that has all strong parameters within polynomial time. However, it may be easily broken when at least one parameter is weak. In fact, many weak parameters are already found and are solved by some algorithms. Some examples of weak parameters consist of a small private key, a large private key, a small prime factor and a small result of the difference between two prime factors. In this paper, the new weakness of RSA is proposed. Assuming Euler's totient value, Φ (n), can be rewritten as Φ (n) = ad + b, where d is the private key and a, b ∈ ℤ, if a divides both of Φ (n) and b and the new exponent for the decryption equation is a small integer, this condition is assigned as the new weakness for breaking RSA. Firstly, the specific algorithm which is created for this weakness directly is proposed. Secondly, two equations are presented to find a, b and d. In fact, one of two equations must be implemented to find a and b at first. After that, the other equation is chosen to find d. The experimental results show that if this weakness has happened and the new exponent is small, original plaintext, m, will be recovered very fast. Furthermore, number of steps to recover d are very small when a is large. However, if a is too large, d may not be recovered because m which must be always written as m = h^a is higher than modulus.

• Journal of Korean Society of Steel Construction
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• 제26권2호
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• pp.133-142
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• 2014

Double split tee connection is a full strength-partial restrained connection that suitable for ordinary moment frame and special moment frame which demonstrates behavior characteristics depending on the stiffness ratio of columns and beams, changes in the geometric shape of the T-stub, number of fasteners and effect of panel zone. For the double split tee connection to ensure structurally safe behavior, it needs to exhibit sufficient strength, stiffness and ductile capacity. This study sought to investigate the effects of the moment-rotation angle relationship of the double split tee connection and to evaluate the initial rotational stiffness of the double split tee connection depending on changes in the geometric shape of the T-stub. To this end, two different double split tee connection specimens are experimented which designed to change geometric parameter values (${\alpha}^{\prime}$) of the T-stub, and a three-dimensional finite element analysis was performed.

• Journal of the Korea Furniture Society
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• 제28권3호
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• pp.248-258
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• 2017

A study was carried out to observe the 1% aqueous safranine solution flow speed in longitudinal and radial directions of softwood Thuja orientalis L., diffuse-porous wood Gmelina arborea Roxb., and ring-porous wood Phellodendron amurense Rupr., Longitudinal flow was considered from bottom to top while the radial flow was considered from bark to pith directions. In radial direction, ray cells and in longitudinal direction tracheids, vessel and wood fiber were considered for the measurement of liquid penetration speed at less than 12% moisture contents(MC). The variation of penetration speed for different species was observed and the reasons behind for this variation were explored. The highest radial penetration depth was found in ray parenchyma of T. orientalis but the lowest one was found in ray parenchyma of P. amurense. The average liquid penetration depth in longitudinal trachied of T. orientalis was found the highest among all the other cells. The penetration depth in fiber of G. arborea was found the lowest among the other longitudinal cells. It was found that cell dimension and also meniscus angle of safranine solution with cell walls were the prime factors for the variation of liquid flow speed in wood. Vessel was found to facilitate prime role in longitudinal penetration for hardwood species. The penetration depth in vessel of G. arborea was found highest among all vessels. Anatomical features like ray parenchyma cell length and diameter, end-wall pits number were found also responsible fluid flow differences. Initially liquid penetration speed was high and the nit gradually decreased in an uneven rate. Liquid flow was captured via video and the penetration depths in those cells were measured. It was found that even in presence of abundant rays in hardwood species, penetration depth of liquid in radial direction of softwood species was found high. Herein the ray length, lumen area, end wall pit diameter determined the radial permeability. On the other hand, vessel and fiber structure affected the longitudinal flow of liquids. Following a go-stop-go cycle, the penetration speed of a liquid decreased over time.

• Economic and Environmental Geology
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• 제21권3호
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• pp.287-307
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• 1988

The Cheongju gold-silver mine is located at approximately $36^{\circ}28^{\prime}$north latitude and $127^{\circ}31^{\prime}$ east longitude in the Cheongju City of the Chung cheong bug Do, South Korea. Gold-Silver bearing hydrothermal quartz veins, occur in Cheongju Granit of Jurassic age. K-Ar isotope data for sericite in quartz vein indicate that the Au-Ag mineralization took place in early Cretaceous ($97.5{\pm}2.18$ MA. Park, et ai, 1986). Three stage of mineralization recognized anre, from early to later, (I) Sulide stage: pyrite, arsenopyrite, pyrrhotite (Hpo), sphalerite, chalcopyrite, electrum and quartz (II) Electrum stage: pyrite, sphalerite, galena, chalcopyrite, electrum and quartz. (III) Silver mineral stage: pyrite, marcasite, pyrrhotite (Mpo), sphalerite, galena, electrum, native silver argentite, fluorite, calcite and quartz. In this paper, mode of occurrences and chemical compositions of electum and native silver have been investigated by means of microscope and EPMA. Electron probe microanalysis shows that an individual grain of electrum is almost homogeneous in composition. Silver content of electrum ranges from 44.7-67.1 atom.%. Gold content of native silver ranges below 0.2 atom. %. Vicker's hardness number (VHN) of electrum and native silver ranges $78.2-81.8kg/mm^{2}$ respectively. The filling temperature of fluid inclusions in quartz ranges from $130-280^{\circ}C$. On the basis of arsenpyrite geothemometer, the equilibrium temperature and sulfur fugacity of the pyrite-arsenopyrite-pyrrhotite(Hpo) assemblage is assumed to be in ange from $300-310^{\circ}C$ and $10^{-10}$ to $10^{-11}$ atm. The estimated ore reserviors on Cheongju mine area are calculated to 8000 T/M, averaing 8.6g/t Au, 27.8 g/t Ag, 1.25% Pb, l.65% Zn.

• Proceedings of the Korean Society of Crop Science Conference
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• 한국작물학회 2017년도 9th Asian Crop Science Association conference
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• pp.323-323
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• 2017

In many sub-Saharan African countries, boosting rice production is a pressing food security issue. To contribute to the increase in rice production, we have developed lines of NERICA 1 introgressed with the gene for spikelet number, Gn1a, and the gene for primary rachis-branch number, WFP by cross breeding. The performance of rice lines introgressed with the genes for yield related traits can be affected by cultivation environment and management. Thus, in this study, we aimed to evaluate the lines of NERICA 1 introgressed with Gn1a or/and WFP for yield and yield components under different nitrogen fertilization conditions in Kenya. A field trial was conducted at a paddy field in Kenya Agricultural and Livestock Research Organization-Mwea, Kirinyaga County ($0^{\circ}39^{\prime}S$, $0^{\circ}20^{\prime}E$) from August 2016 to January 2017. Eight lines of NERICA 1 introgressed with Gn1a and/or WFP, and their parents, NERICA 1 and ST12, were grown under 0 (NF) and $75(SF)kg\;N\;ha^{-1}$. At maturity, five hills per plot were harvested to determine the yield and yield components. The number of primary and secondary rachis-branches per panicle was measured on the longest panicle in each hill. Under SF, the introgression of WFP to NERICA 1 increased the number of primary and secondary rachis-branches by 27 and 25%, respectively. On the other hand, Gn1a did not increase the number of primary rachis-branches, whereas the number of secondary rachis-branches was increased by 38% on average. The number of primary and secondary rachis-branches of the lines introgressed with both genes increased by 25 and 56%, respectively. Although grain number per panicle increased 33% by Gn1a, 34% by WFP, and 43% by Gn1a+WFP, the yield increase by Gn1a, WFP, and Gn1a+WFP was only 14, 7, and 14%, respectively. The suppression of the yield increase was mainly attributed to the decline in the filled grain ratio. Under NF, WFP increased the number of primary and secondary rachis-branches by 20 and 19%, respectively. The introgression of both genes increased the former and the later by 19 and 35%, respectively. However, Gn1a did not change them under NF. Thus, even under NF, grain yield increased 11% by WFP and 24% by Gn1a+WFP due to the increased grain number although filled grain ratio declined. Our findings suggest that the introgression of Gn1a and WFP could contribute to the rice productivity improvement in sub-Saharan Africa even under low fertility conditions. Improving filled grain ratio of the lines introgressed with these genes by further breeding and fertilization management will be the focus of subsequent work.

• International Journal of Reliability and Applications
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• 제2권3호
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• pp.147-160
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• 2001

The reliability of computer software is of prime importance for all developers of software. The complicated nature of detecting and removing faults from software has led to a plethora of models for reliability growth. One of the most basic of these is the Jelinski Moranda model, where it is assumed that there are N faults in the software, and that in testing, bugs (or faults) are encountered (and removed when defected) according to a stochastic process at a rate which at a given point in time is proportional to the number of bugs remaining in the system. In this research, we consider the possibility that imperfect repair may occur in any attempt to remove a detected bug in the Jelinski Moranda model. We let p represent the probability that a fault which is discovered or detected is actually perfectly repaired. The possibility that the probability p may differ before and after release of the software is also considered. The distribution of both the number of bugs detected and perfectly repaired in a given time period is studied. Cost models for the development and release of software are investigated, and the impact of the parameter p on the optimal release time minimizing expected costs is assessed.