• Asian Pacific Journal of Cancer Prevention
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• 제15권10호
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• pp.4147-4152
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• 2014

Standard therapy for advanced head and neck cancer consists of a combination of surgery and radiation. However, survival of this patient population has not improved during the past 20 years. Many different multimodality treatment schedules have been proposed, and chemotherapy is often used with the intent of organ preservation. The present study was intended to establish the efficacy of concomitant chemoradiation with a single agent carboplatin in advanced head and neck cancers.The objectives were to investigate the feasibility of concomitant administration of carboplatin, monitor acute toxicity during radiotherapy, and determine subacute side effects, such as wound healing following surgery after chemoradiotherapy. A prospective study was conducted wherein a total of 40 patients with stage III and IV squamous cell carcinomas of oral cavity, oropharynx, hypopharynx and larynx were enrolled. All patients were treated with external beam radiotherapy and weekly carboplatin area under curve (AUC of 5). Radiotherapy was given in single daily fractions of 1.8-2 grays (Gy) to a total dose of 66-72 Gy. Salvage surgery was performed for any residual or recurrent locoregional disease. Neck dissection was recommended for all patients with neck disease showing less than a complete response after chemoradiation. A total of 40 patients were enrolled of whom 32 were males and 8 were females. Highest incidence of cancer was seen in the 5th-6th decades of life with a median age of 47.7 years. Oropharyngeal tumours constituted a maximum of 21 patients followed by hypopharynx in 10, larynx in 7 and oral cavity in 2. 80% of the patients had a neck node on presentation of which 40% had N2-N3 nodal status. TNM staging revealed that 58% of patients were in stage III and 43% in stage IV. Evaluation of acute toxicity revealed that 50% had grade II mucositis, 25% grade III mucositis, 2.5% grade IV mucositis. 50% of patients had grade I skin reactions, 65% of patients had grade I thrombocytopenia, and 24% of patients had grade I anaemia. After completion of treatment 65% of patients had complete response at the primary and regional sites, and 35% of patients had a partial response of whom 23% underwent neck dissection and 5% of them underwent salvage surgery at the primary site. At the end of one year there were six deaths and four recurrences and 70% were free of disease. Concurrent chemoradiation with carboplatin provided good locoregional control for locally advanced head and neck cancers. This regimen, although toxic, is tolerable with appropriate supportive intervention. Primary site conservation is possible in many patients. Chemoradiotherapy appears to have an emerging role in the primary management of head and neck cancers.

• 한국콘텐츠학회논문지
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• 제17권9호
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• pp.437-448
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• 2017

본 연구에서는 나눗셈과 분수와 소수의 1차적 개념을 학습한 초등학교 3학년 영재아 2명을 대상으로 소수의 덧셈을 내용으로 하였을 때, 어떠한 변형된 1차적 개념[1]과 변형된 스키마[2]를 어떻게 구성하여 소수의 덧셈에 대한 관계적 이해를 하는지에 대해서 질적 사례연구를 통하여 알아보았다. 즉, 연구대상자들이 스스로 형성한 변형된 1차적 개념과 변형된 스키마를 어떻게 이용하여 소수의 덧셈에 대한 문제 해결에 접근을 하는지, 또한 연구대상자들이 개념구성과 문제해결력에서의 스키마는 어떻게 변형을 이루어 나가는지를 심도 있게 조사하였다. 그 결과 나눗셈과 분수와 소수의 1차적 개념에 대한 학습으로 형성된 변형된 1차적 개념과 변형된 스키마가 소수의 덧셈에 대한 관계적 이해에 중요한 요인으로 작용 한다는 것을 알 수 있었다.

• 한국수학교육학회지시리즈C:초등수학교육
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• 제4권1호
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• pp.1-17
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• 2000

The purpose of this study is to analyze the articulation between the kindergarten and 1st grade in mathematics education. for this purpose, the problems of this study selected as follows ：(ⅰ) What is the mathematical concepts related between the kindergarten curriculum and the 1st grade curriculum\ulcorner (ⅱ) How is the mathematics classroom in the kindergarten and 1st grade\ulcorner (ⅲ) Which instructional materials are used in the kindergarten and the 1st grade\ulcorner (ⅳ) What is the new direction of articulation between the kindergarten and first grade in mathematics education\ulcorner The results of this study are as follows ： (ⅰ) According to examining each curriculum the focus is on understanding the basic concepts of number in the kindergarten, on the concepts of number, addition and subtraction in the 1st grade. (ⅱ) By being analyzed the mathematics classrooms of the kindergarten and the 1 st grade, it is different the focus of lessons or the teaching strategies. (ⅲ) As a result of analysing the teaching plans in the kindergarten and the survey in the first grade teachers, used instructional materials are manipulative ones. While mainly used materials are puzzles and blocks in kindergarten, a paduk stone, number cards, sankagi are used in 1st grade. (ⅳ) Finally, we propose the direction of articulation between the kindergarten and 1st grade in mathematics education.

• 대한한방소아과학회지
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• 제19권2호
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• pp.137-152
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• 2005

Objective : As the meaning of collective medical examination, the purpose of this study is to investigate distribution of weak children by measurement according to the five group of weakness (Lung, Heart, Pancreas, Liver, Kidney), and the relationship between the five group of weakness and the Growth failure on primary school children. Methods : This study is composed of 1078 children who attend A primary school in ${\bigcirc}{\bigcirc}$ city. They are divided into 6 groups by grade and for the purpose of effective comparison, The five weak symptoms are studied to determine the association with growth stature among children and we standardize the weak children's height into percent according to age. Results: When each weak children controled grade, sex, body-weight, existence or nonexistence of personal history, physical exercise so on, relatively group of weakness for kidney is statistically less then opposite group and the rest of the people statistically have no significant difference. Conclusions: From the above result, it is suggested that the statistical relationship between the weakness for kidney and growth(p<0.001). It looks forward to have contributed to collective medical examination and children's health care by oriental medical treatment.

• 대한지역사회영양학회지
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• 제6권3호
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• pp.475-485
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• 2001

This study was conducted to find the differences in the physical changes, eating habits and dietary intake by obseity index of sixth grade primary school students is Seoul.The subjests were classified into three groups, an underweight group(90% under, 12l Ug), normal group(between 90-110%, 153, NG), and obese group(110% over, 91, OG) according to WLI(Weight-Length Index)calculated with their present (6th grade) height and weight. The physical growth of the subjects was generally good, although problems of both underweight and obesity were existed together. The mean heigh growth velocity per year, weight growth velocity per year and WLI changes per year of OG were higher than those of the other groups(p〈0.01). The past physical status of the three groups were maintained from 1 st grade to sixth grade, As eating habits and lifestyles, they were not statistically significant but there were some differences among the three groups. More students of the UG disliked a certain food than those of the other groups. UG liked fried or roasted foods more(p〈0.001). NG tended to eat three meals more irregularly. OG tended to have meal times more regularly and do more regular exercise than the other groups. The dietary intakes of three groups were generally good. They were not statically significant among the three groups. With theses difference among the three groups, it is recommended to educate about unbalanced diet for the underweight group, regularity, of meals for the normal group, doing exercise for the obese for the obese group, and increasing Ca and vitamin A intake for most students, As the physical status for th lower grades have been maintained up to the sixth grade, nutrition education programs should be started at the lower grades in the elementary school.

• Asian Pacific Journal of Cancer Prevention
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• 제15권3호
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• pp.1447-1451
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• 2014

Purpose: To compare histopathologic findings of patients who underwent transurethral resection of a bladder tumor (TUR-B) between groups with and without the metabolic syndrome. Materials and Methods: We retrospectively analyzed data of 535 patients who underwent TUR-B in our department between October 2005 and March 2011. All patients had primary urethelial cell carcinoma (UCB). Histologic stage, grade, the presence of hypertension, diabetes mellitus, body mass index (BMI), waist circumference, HDL and trigliseride levels were evaluated. The TNM classification was used, with Ta tumor accepted as lower stage and T1 and T2 tumors as higher stage bladder cancers. Also, the pathological grading adopted by the 2004 World Health Organization grading system were applied. Non-invasive papillary urothelial neoplasms of low malignant potential were regarded as low grade. Results: Among the total of 509 patients analyzed in our study, there were 439 males (86.2%) and 70 females (13.8%). Metabolic syndrome was significantly associated with high histologic grade, and high pathologic stage (p<0.001). Conclusions: The patients with metabolic syndrome were found to have statistically significant higher T stage and grade of bladder cancer. Further studies with more patients are needed to confirm our study.

• 한국치위생학회지
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• 제11권1호
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• pp.113-126
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• 2011

Objectives : We supposed that identifying the influencing factors on DMFT index in the primary school children in Pocheon be indispensible for the primary school children's oral health program establishment in Pocheon. So, to prepare the basic materials for the primary school children's oral health program establishment in Pocheon, we analyzed the associated factors which could have an influence on the primary school children's DMFT index in Pocheon. Methods : We selected 3,676 primary school children in Pocheon, whose age were from 6 to 11, and surveyed those children by a questionnaire and the oral examination based on WHO's oral health survey method. Data were analyzed with a $x^2$-test and multiple regression analysis using SPSS $15.0^{(R)}$. Results : The results of oral survey in the primary school children in Pocheon revealed as follows: DMFT index, National Health Oral health survey of 2006 people nationwide in the results when compared to younger grade children and older grade in the low and the higher. Subjective oral health awareness, high of viscosity junk food snacks, fruit, gender, dental visits and humidity, oral health education classes, including the variable of attitude was 6(p<0.05). Their higher awareness of dental health, oral health education classes ever the more positive attitude to DMFT index was statistically significant(p<0.05). Solid in the habit of eating junk food snacks to the students of a liquid relative to student intake was higher DMFT index indices(p<0.05). Conclusions : We could reason that one's oral health recognition and behavior should have a relationship with his(her) DMFT index.

• Radiation Oncology Journal
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• 제30권4호
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• pp.182-188
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• 2012

Purpose: For recurrent esophageal cancer after primary definitive radiotherapy, no general treatment guidelines are available. We evaluated the toxicities and clinical outcomes of re-irradiation (re-RT) for recurrent esophageal cancer. Materials and Methods: We analyzed 10 patients with recurrent esophageal cancer treated with re-RT after primary definitive radiotherapy. The median time interval between primary radiotherapy and re-RT was 15.6 months (range, 4.8 to 36.4 months). The total dose of primary radiotherapy was a median of 50.4 Gy (range, 50.4 to 63.0 Gy). The total dose of re-RT was a median of 46.5 Gy (range, 44.0 to 50.4 Gy). Results: The median follow-up period was 4.9 months (range, 2.6 to 11.4 months). The tumor response at 3 months after the end of re-RT was complete response (n = 2), partial response (n = 1), stable disease (n = 2), and progressive disease (n = 5). Grade 5 tracheoesophageal fistula developed in three patients. The time interval between primary radiotherapy and re-RT was less than 12 months in two of these three patients. Late toxicities included grade 1 dysphagia (n = 1). Conclusion: Re-RT of recurrent esophageal cancer after primary radiotherapy can cause severe toxicity.

• 영재교육연구
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• 제24권3호
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• pp.339-358
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• 2014

본 연구에서는 나눗셈의 1차적 개념을 학습한 초등학교 3학년 영재아 3명을 대상으로 분수의 나눗셈을 내용으로 하였을 때, 정확한 개념의 인지와 개념의 연결로 스키마와 변형된 스키마를 어떻게 구성을 하는지에 대해 질적 사례연구를 통하여 알아보았다. 즉 나눗셈의 1차적 개념으로 어떠한 스키마와 변형된 스키마를 형성하여 분수의 나눗셈에 대한 관계적 이해를 하는지, 그리고 연구대상자들이 스스로 형성한 스키마와 변형된 스키마를 어떻게 이용하여 문제 해결에 접근을 하는지, 또한 연구대상자들의 개념구성과 문제해결력에서의 스키마는 어떻게 변형을 이루어 나가는지를 심도 있게 조사하였다. 그 결과 나눗셈의 1차적 개념에 대한 학습이 분수의 나눗셈을 해결하는데 필요한 스키마와 변형된 스키마를 형성하는데 중요한 역할을 한다는 것을 알 수 있었고 이 때, 나눗셈의 1차적 개념에 대한 인지로 인해서 만들어지는 변형된 1차적 개념과 변형된 스키마의 형성이 분수의 나눗셈에 대한 문제 해결에 무엇보다도 중요한 역할을 한다는 것을 알 수 있었다.

• Childhood Kidney Diseases
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• 제13권2호
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• pp.229-234
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• 2009

목적 : 방광요관역류에 대한 치료법으로 최근 시행되고 있는 내시경적 요관 점막하 $Deflux^{(R)}$ (Dextranomer/hyaluronic acid copolymer) 주사요법의 효과에 대해 알아보고자 하였다. 방법 : 2000년 3월부터 2006년 2월까지 경북대병원 소아과에 내원하여 일차성 방광요관역류로 진단받고 이후 비뇨기과에서 내시경적 $Deflux^{(R)}$ 주사요법을 시행 받은 38명(59요관)을 대상으로 하였다. 의무기록을 통한 후향적 연구를 시행하였으며, 시술 6개월 후에 VCUG를 시행하여 방광요관역류의 치료 성공 및 호전 정도를 조사하였다. 결과 : 대상 환아의 평균연령은 2년 7개월이었으며 남녀비는 17:21이었다. 양측성이 21명(55.3%), 일측성이 17명(44.7%)이었으며 역류를 처음으로 진단받은 뒤 평균 24개월 후에 내시경적 $Deflux^{(R)}$ 주사요법을 시행 받았고 평균 주입량은 0.77 cc 였다. 시행 후 성공률은 Grade 1에서 100%, Grade 2에서 87.5%, Grade 3에서 60%, Grade 4에서 20%, Grade 5에서 16.6%였으며(r=-0.99, P=0.02), 호전률은 단계별로 각각 100%, 75%, 100%, 80%, 83% 이었다(r=-0.39, P=0.21). 즉, 방광요관역류의 단계와 호전률 사이에는 의미 있는 상관관계가 없었으나, 방광요관역류의 단계가 높을수록 성공률이 의미 있게 감소하였다. 그밖에, 방광요관역류의 진단 당시 연령, $Deflux^{(R)}$ 시술까지의 시간, $Deflux^{(R)}$ 주입량, 배뇨장애 유무, 변비의 유무와 성공률은 통계학적으로 의미 있는 상관관계를 보이지 않았고, 항콜린제 사용군에서 성공률이 의미 있게 낮았다. 결론 : 내시경적 요관 점막하 $Deflux^{(R)}$ 주사요법은 역류단계가 낮은 환아에서는 효과적인 치료법으로, 예방적 항생제 요법을 대신하고 개복 수술 전 단계로 시행할 만한 바람직한 방법으로 생각된다.