• 펄프종이기술
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• 제36권2호
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• pp.39-46
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• 2004

In this paper, the effects of roll diameter and storage time in roll form, bending method and relative humidity on curl in copy paper and inkjet coated papers are investigated. In copy paper, more MD curl is showed at smaller roll diameter and the extension of bending time. However CD curl is hardly influenced by roll diameter and bending time. At high relative humidity, especially CD curl largely reduces. All inkjet coated papers without the primary or the secondary back coating during papermaking show the increase in MD curl and slight decrease in CD curl by MD bending regardless of the winding methods(TSO, TSI). The water spray as back coating results in the remarkable reduction of CD curl regardless of the winding methods. Drying on flat dryer after spraying the moisture on back side display the most excellent effect on the reduction of CD curl.

• Genomics & Informatics
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• 제16권2호
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• pp.30-35
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• 2018

Patient-derived xenograft (PDX) models are useful tools for tumor biology research and testing the efficacy of candidate anticancer drugs targeting the druggable mutations identified in tumor tissue. However, it is still unknown how much of the genetic alterations identified in primary tumors are consistently detected in tumor tissues in the PDX model. In this study, we analyzed the genetic alterations of three primary colorectal cancers (CRCs) and matched xenograft tissues in PDX models using a next-generation sequencing cancer panel. Of the 17 somatic mutations identified from the three CRCs, 14 (82.4%) were consistently identified in both primary and xenograft tumors. The other three mutations identified in the primary tumor were not detected in the xenograft tumor tissue. There was no newly identified mutation in the xenograft tumor tissues. In addition to the somatic mutations, the copy number alteration profiles were also largely consistent between the primary tumor and xenograft tissue. All of these data suggest that the PDX tumor model preserves the majority of the key mutations detected in the primary tumor site. This study provides evidence that the PDX model is useful for testing targeted therapies in the clinical field and research on precision medicine.

• 대한미생물학회지
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• 제22권2호
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• pp.167-174
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• 1987

N-myc, a DNA sequence related to the oncogene c-myc, was found to be amplified in untreated primary neuroblastomas and the amplification appeared to be associated with advanced disease at diagnosis and rapid tumor progression. Synthetic peptides have been useful immunogens for generating antisera and monoclonal antibodies to a number of native proteins. In order to identify myc-related protein in the tumor cells, an antiserum against a synthetic hexapeptide (-Glu-Asp-Ile-Trp-Lys-Lys-), whose sequence corresponds to a part of the exon 2 of oncogene N-myc, was prepared by immunizing a rabbit with BSA-conjugated peptide. After ammonium sulfate precipitation and affinity column chromatography, it appeared to be specific to the peptide. Strong nuclear staining in immunoperoxidase method using this serum was observed in both human promyeloid leukemic cell line, HL-60(containing high c-myc copy number), and human neuroblastoma cell line, LA-N-5 (containing high N-myc copy number), whereas LA351 (human lymphoid cell line) cells did not react with the serum. This reaction was completely abrogated by incubating the antiserum with soluble excess peptide. These data suggest that the protein encoded by N-myc could be localized in the nucleus as c-myc protein and this antiserum can be used to detect myc-related tumor cells in clinical samples and to determine if the N-myc expression correlates with genomic amplification in cell lines, untreated primary tumors, and untreated metastases.

• Journal of Applied Biological Chemistry
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• 제44권3호
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• pp.125-130
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• 2001

A putative protein encoded by Arabidopsis AtMTN3 gene, a homologue of Medicago truncatula MTN3, consists of 285 amino acid residues, and has a predicted molecular mass of 31.5 kDa and a calculated pI of 9.1. Primary amino acid sequence analyses have revealed that the protein contains seven putative transmembrane regions with N-terminus oriented to the outside of the membrane. The AtMTN3 protein shows overall 16.4% of amino acid identity with the rat GALR3 protein, known to be a G-protein-coupled receptor. The gene is present as a single copy in the Arabidopsis genome, and expressed in aerial parts but not in roots of Arabidopsis. Therefore, AtMTN3 appears not to be specifically involved in Rhizobium-induced nodule development, as was predicted for the MTN3 gene. These proteins possibly mediate signal transmission through G-protein-coupled pathways during general interactions between plants and symbiotic or pathogenic microbes.

• 한국한의학연구원논문집
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• 제10권1호
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• pp.97-105
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• 2004

1. To define 'Korean medicine industry' through study on existing medicine related industries, Korean medicine industry means all industrial activities related to Korean medicine. It covers material resources such as herbs and products made with herbs, medical instruments, Korean medical service and related information service based on Korean medicine theories. 2. According to Korea National Statistical Office standard industrial branch, Korean medicine industry was classified as a large branch. There were industries such as agriculture, food and beverage manufacture, publishing, copy of prints and record media, manufacture of compound and chemical products, medical service, manufacture of precise optical instruments, wholesale trade and product mediation, retail trade, restaurant, research and development, education service, health preservation service, entertainment, culture and sports industry related to the Korean medicine industry. 3. If we classify this according to the industry branch of English economists Clark, Colin Grant, herb cultivating industry will be classified as primary industry, manufacture of foot and beverage related to Korean medicine, secondary industry and wholesale and retail sales of herb, research and development, education, health preservation, social welfare, tertiary industries.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2001년도 ICCAS
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• pp.70.3-70
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• 2001

In this paper, we suggest a kernel level multi thread web accelerator (called the SCALA-AX), which significantly improves the performance of the web soerver. In comparison with a conventional proxy web cache that is generally called a caching server and a simple content-copy based system, the primary functions and goals of SCALA-AX are designed to maximize the content services of a front end web server with high performance. Specifically, the SCALA-AX runs on the kernel level of a web sorrel, based on the newest caching techniques. Moreover, the SCALA-AX supports the http 1.1 protocol and allows the dynamic pages as well as static pages to be processed.

• 한국콘텐츠학회논문지
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• 제3권3호
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• pp.40-46
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• 2003

본 논문은 안전하지 못한 DCPS(Digital Contents Protection Systems)와 HOST 사이의 통신채널을 통해 서로 일치하는 암호 키를 생성하기 위한 공개키 적용을 위해 1차적으로 이산대수와 난수를 이용한 Diffie-Hellman 알고리즘을 적용하고, 2차적으로 키 관리 표준인 ANSI X9.17, ISO 8732와 PEM(Privacy-Enhanced Mail) 등에서 채택하고 있는 2개의 서로 다른 암호키를 통해 Triple DES를 적용하여 전송 선로상의 디지털콘텐츠의 안전한 전송을 수행한다. 이에 따라 설계한 정보보호 모듈은 Key Exchange 모듈, Key Derivation 모듈, Copy Protection Processing 모듈로 구성되었으며 사용자 인증 기능과 디지털콘텐츠 암호화 기능을 통해 인가되지 않은 사용자에 의한 디지털콘텐츠의 불법 복제 및 배포를 방지하교 전송선로상의 디지털콘텐츠를 보호할 수 있도록 하였다.

• 디지털콘텐츠학회 논문지
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• 제14권2호
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• pp.247-254
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• 2013

PRAM, FRAM, MRAM 등 스토리지 클래스 메모리(SCM)는 가까운 미래에 접근 속도는 DRAM에 용량은 플래시 메모리에 근접할 것으로 예상된다. 따라서 SCM이 컴퓨터 시스템에서 메모리(DRAM)뿐만 아니라 스토리지(하드디스크 혹은 플래시 메모리)를 대체할 수 있을 것이다. 이 논문에서는 SCM 기반 컴퓨터 시스템을 위한 효율적인 파일 접근 프레임워크를 제안한다. 제안하는 프레임워크는 SCM에 파일 저장을 위한 영역과 메모리 사용을 위한 영역을 구분하지 않는다. 또한 제안하는 프레임워크는 파일 관리를 위하여 단일 데이터 접근 경로, 파일 매핑을 통한 제로 카피 데이터 읽기, 카피 온 라이트 기반 데이터 쓰기, 다수 페이지 프리 폴팅 등 다양한 메모리 관련 기술들을 사용한다. 주요 실험 결과를 통해서 논문에서 제안하는 프레임워크는 SCM 기반 컴퓨터 시스템의 운영체제 디자인을 위한 초석이 될 것이다.

• 한국멀티미디어학회논문지
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• 제10권9호
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• pp.1153-1164
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• 2007

무선 이동 통신망을 통해 멀티미디어 서비스를 제공받기 위해 필요한 기술들 중에서 핸드오버 호에 대한 QoS 관리는 매우 중요한 기술이다. 본 논문에서는 2-레벨 핸드오버 제어 시스템을 제안한다. 2-레벨 핸드오버 제어 시스템은 자원 예약 기능과 호 수락 제어 기능을 구성된다. 자원 예약 기능은 Hard 자원 예약과 Soft 자원 예약 기능으로 구성된다. Hard 예약 자원은 핸드오버 호를 위해서만 사용되는 자원이며 Soft 예약 자원은 핸드오버 호와 신규 호를 위해 사용된다. 그리고 자윈 예약 기능은 핸드오버 호를 발생하는 경로와 발생 빈도의 정도에 따라 Primary 핸드오버 호와 Secondary 핸드오버 호로 구분하여 처리한다. 호 수락 제어 기능에서는 구분된 두 가지 핸드오프 호에 대한 처리를 각각 다르게 수행한다. 제안한 시스템의 성능 분석을 위해 시스템을 M/M/c/c 큐잉 모델을 이용하여 분석하였다. 분석 결과 기존의 시스템에 비해 QoS는 떨어지지 않고 무선 자원을 더 효율적으로 활용하는 것을 볼 수 있었다.

• 한국작물학회:학술대회논문집
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• 한국작물학회 2022년도 추계학술대회
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• pp.28-28
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• 2022

This paper presents the first genome assemblies of Philippine mangoes that provide valuable reference for varietal improvement and genomic studies on mango and related fruit crops. WE sequenced whole genomes of3 species, Mangifera odorata (Huani), Mangifera altissima (Paho), and Mangifera indica 'Carabao' (Sweet Elena). 'Carabao' is the major export variety of the Philippines; Paho is identified as vulnerable by the IUCN Red List of Threatened Species; Huani has fruit sap acrid which is the primary defense mechanism against insects and birds. We used Falcon, a diploid aware -de novo assembler to assemble SMRT generated long-read sequences. Falcon-unzip was employed to phase the output assembly producing larger contig sets (primary contigs) and shorter contigs corresponding to haplotypes (haplotigs). Assembly statistics were generated by comparing the assembly to a reference genome, Tommy Atkins, using Quality Assessment Tool (QUAST). Moreover, the extent of duplication and completeness of gene content was measured using Benchmarking Universal Single-Copy Orthologs (BUSCO). Draft assemblies with high duplications were processed using Purge Haplotigs and Purge Dups to lessen duplications with minimal impact on genome completeness. De novo assemblies of Huani, Paho and 'Carabao' were then generated with primary contig sizes of 463.64 Mb, 508.95 Mb and 401.51 Mb respectively. These draft assemblies of Huani, Paho and 'Carabao' showed 96.90%, 95.17% and 99.07% complete BUSCOs respectively which is comparable to 'Tommy Atkins' genome (98.6%). Using two mango transcriptome data (pooled RNA-seq from different mango varieties and tissues), 91-96% or 24-30 million reads were successfully mapped back for each generated assembly indicating high degree of completeness. The results obtained demonstrated the highly contiguous, phased, and near complete genome assembly of three Philippine mango species for structural and functional annotation of gene units, especially those with economic importance.