• Genomics & Informatics
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• v.21 no.1
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• pp.6.1-6.8
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• 2023

Glaucoma is the second leading cause of irreversible blindness, and primary open-angle glaucoma (POAG) is the most common type. Due to inadequate diagnosis, treatment is often not administered until symptoms occur. Hence, approaches enabling earlier prediction or diagnosis of POAG are necessary. We aimed to identify novel drugs for glaucoma through bioinformatics and network analysis. Data from 36 samples, obtained from the trabecular meshwork of healthy individuals and patients with POAG, were acquired from a dataset. Next, differentially expressed genes (DEGs) were identified to construct a protein-protein interaction (PPI) network. In both stages, the genes were enriched by studying the critical biological processes and pathways related to POAG. Finally, a drug-gene network was constructed, and novel drugs for POAG treatment were proposed. Genes with p < 0.01 and |log fold change| > 0.3 (1,350 genes) were considered DEGs and utilized to construct a PPI network. Enrichment analysis yielded several key pathways that were upregulated or downregulated. For example, extracellular matrix organization, the immune system, neutrophil degranulation, and cytokine signaling were upregulated among immune pathways, while signal transduction, the immune system, extracellular matrix organization, and receptor tyrosine kinase signaling were downregulated. Finally, novel drugs including metformin hydrochloride, ixazomib citrate, and cisplatin warrant further analysis of their potential roles in POAG treatment. The candidate drugs identified in this computational analysis require in vitro and in vivo validation to confirm their effectiveness in POAG treatment. This may pave the way for understanding life-threatening disorders such as cancer.

• Steel and Composite Structures
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• v.33 no.2
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• pp.225-243
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• 2019

Cold-formed steel (CFS) sections when used as primary load carrying members often require additional strengthening for retrofitting purposes. In some cases, it is also necessary to reduce deflections in order to satisfy serviceability requirements. The introduction of angle sections, screwed to the webs so as to act as external stiffeners, has the potential to both increase flexural strength as well as reduce deflections. This paper presents the results of ten four-point bending tests, on built-up CFS sections, both open and closed, with different stiffening arrangements. In the laboratory tests, the stiffening arrangements increased the moment capacity and stiffness of the CFS beams by up to 85% and 100% respectively. The increase in moment capacity was more evident for the open sections, while that reduction in deflection was largest for the closed sections.

• Tunnel and Underground Space
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• v.18 no.6
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• pp.447-456
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• 2008

Open-pit mine slope design must be carried out from the economical efficiency and stability point of view. The overall slope angle is the primary design variable because of limited support or reinforce options available. In this study, the slope angle and critical slope height of large coal mine located in Pasir, Kalimantan, Indonesia were determined from safety point of view. Failure time prediction based on the monitored displacement using inverse velocity was also conducted to make up fir the uncertainty of the slope design. From the study, critical slope height was calculated as $353{\sim}438m$ under safety factor guideline (SF>1.5) and $30^{\circ}$ overall slope angle but loom is recommended as a critical slope height considering the results of sensitivity analysis of strength parameters. The results of inverse velocity analysis also showed good agreement with field slope cases. Therefore, failure of unstable slope can be roughly detected before real slope failure.

• Korean Journal of Clinical Pharmacy
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• v.31 no.3
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• pp.205-215
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• 2021

Background: The treatment of primary open-angle glaucoma (POAG) or ocular hypertension (OHT) for intraocular pressure (IOP) reduction is recommended to proceed with the use of the compound. Therefore, this study aimed to evaluate the efficacy and safety of brinzolamide combination therapy on POAG and OHT following the subgroup analysis among types of brinzolamide combined medications. Methods: By June 2019, PubMed, EMBASE and Cochrane Library were searched to find a study that met our inclusion criteria. Based on randomized control trials (RCTs), we collected studies that tested the brinzolamide combination therapy in POAG and OHT patients, and analyzed the literature identified by the results of the study on IOP reduction and adverse reactions. Results: A total of 13 literature was collected to conduct an analysis including 2,197 patients. The intervention included brinzolamide combination therapies, combined with timolol, brimonidine, PGA or combined with both brimonidine and PGA. The analysis showed significant decreasing tendency for values at morning and end treatment per day in the use of brinzolamide combination therapy in the absolute IOP change (mean difference (MD) -1.41; 95% CI -1.92, -0.90; p<0.001 vs. MD -1.46; 95% CI -2.03, -0.89; p<0.00001, respectively). We could see higher adverse reactions in the brinzolamide combination group using intervention (odds ratio 1.43; 95% CI 1.20, 1.71; p<0.0001). Conclusion: Regarding IOP reduction in POAG and OHT patients, brinzolamide combination therapy is more effective but less safe than control treatment, which diverse among types of combined medications. Thus, more individualized therapy should be applied in real-world practice.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2005.11a
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• pp.159-160
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• 2005

The superconducting fault current limiter(SFCLs) provides the effect such as enhancement in the power system reliability due to limiting fault current in a few miliseconds. The Flux-lock type SFCL using the YBCO film among various type SFCLs consists of the primary and the secondary copper coils that are wound in parallel each other through the iron core. The operation can be controlled by adjusting the inductances and the winging directions of each the coil. We compared the current limiting performance on the additive and the subtractive polarity winding directions in case of an open-loop iron core. To analyze quench characteristics, we experimented various phase angle.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2012.04a
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• pp.763-768
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• 2012

Active window system which can reduce the environmental noises, such as traffic noise and construction noise, from an open window into a room was proposed in the previous works. The key idea of the proposed active window system was that the control sources are approximately collocated with the primary noise source in terms of the acoustic power for global noise reduction throughout the interior room. Moreover, because it is important not to intrude into the living space in the building environment, no error sensors were used and an open-loop control method using control sources at the window frame and the reference sensors outside the room was used for the proposed system. The open-loop control gain was calculated by the interior room model assumed as the semi-infinite space, and the interior sound field was estimated by Rayleigh integral equation under the baffled window model assumption. However, windows with a finite thickness should were considered for the calculation of the open-loop control gain of the active window system since these are representative of most window cases. Therefore, the finite thickness window model based on the Sgard's model was derived and the open-loop control gain using the interior sound field estimated by that model was calculated for active window system. To compare the performance of these two models, a scale-model experiment was performed in an anechoic chamber according to noise source directions. Experimental results showed that the performance for the thickness window model is better than the baffled window model as the angle with respect to the perpendicular direction is larger.

• International Journal of High-Rise Buildings
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• v.7 no.4
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• pp.397-408
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• 2018

In a recent tragic fire incident, the Plasco Tower collapsed after an intense outburst of fire lasting for three and a half hours and claiming the lives of 16 firefighters and 6 civilians. This paper will present continuing collaborative work between Hong Kong Polytechnic University and Queen's University in Canada to model the progressive collapse of the tower. The fire started at the 10th floor and was observed to have travelled along the floor horizontally and through the staircase and windows vertically. Plasco Tower was steel structure and all the steel sections were fabricated by welding standard European channel or angle profiles and no fire protection was applied. Four internal columns carried the loads transferred by the primary beams, and box columns were constructed along the perimeter of the building as a braced tube for resisting seismic loading. OpenSees fibre-based sections and displacement-based beam-column elements are used to model the frames, while shell elements are used for the reinforced concrete floor slabs. The thermal properties and elevated temperature mechanical properties are as recommended in the Eurocodes. The results in this preliminarily analysis are based on rough estimations of the structure's configuration. The ongoing work looks at modeling the Plasco Tower based on the most accurate findings from reviewing many photographs and collected data.

• Korean Journal of Clinical Pharmacy
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• v.20 no.3
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• pp.278-287
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• 2010

The main objective of this study is to evaluate the cost-effectiveness of tafluprost compared with latanoprost in primry open Angle Glaucoma (POAG) or ocular hypertension OH patients in Korea. A decision analytic model was developed from a societal perspective to estimate clinical outcome, drug cost and glaucoma related cost. The model assumes branch like following: successful treatment, switching to other drug, adding other drug, laser or surgery. Treatment success rate is defined as the percentage of patients with elevated IOP achieving <20% reduction, and discontinuation rate is the percentage of patients who were withdrawn due to severe adverse events. A model that is comprised of 1 month cycle length has 1 year. Treatment success rate and discontinuation rate were obtained from published literatures searched in database. Resource utilizations and costs were calculated with national health insurance data and clinical expert opinions. Sensitivity analyses were performed on crucial parameters. Tafluprost is less costly than latanoprost, $609.0 vs $651.2 expected cost. Thus tafluprost was shown to be dominant compared with latanoprost. The results of sensitivity analysis revealed stable across most of the included parameters. According to this study, tafluprost shows more clinical outcome for 1 year than latanoprost. In addition, first-line treatment of tafluprost is a more cost-minimizing strategy associated with POAG or OH compared with latanoprost.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 1996.04a
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• pp.9-18
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• 1996

The primary objective of this paper is to grasp many characteristics of buckling behavior of latticed spherical domes under various conditions. The Arc-Length Method proposed by E.Riks is used for the computation and evaluation of geometrically nonlinear fundamental equilibrium paths and bifurcation points. And the direction of the path after the bifurcation point is decided by means of Hosono's concept. Three different nonlinear stiffness matrices of the Slope-Deflection Method are derived for the system with rigid nodes and results of the numerical analysis are examined in regard in geometrical parameters such as slenderness ratio, half-open angle, boundary conditions, and various loading types. But in case of analytical model 2 (rigid node), the post-buckling path could not be surveyed because of Newton-Raphson iteration process being diversed on the critical point since many eigenvalues become zero simultaneously.

• Education of Primary School Mathematics
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• v.2 no.1
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• pp.53-64
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• 1998

Two different CAI programs have been developed to study the affect of CAI element for the types of learners'performance; (i) one is the 'CAI program 1' including the open questions for the fourth grade (the fourth period of the 'Time and Angle' in chapter 3 of the first term) of the mathematics class in the elementary school, and (il) the other is 'CAI program 2' for the existing methods. The fourth grade of Andong Songhyun elementary school has been chosen as the study subjects (243 learners), and the t-test and learners'interview have also been used to analysis the results of CAI programs. The CAI programs have only been used as the control variable. The developed CAI programs have been applied two different learners'groups to investigate the degree of performance among the superior, average, and inferior learners. For the superior group (p＜.0023) at the t＜3.2268 level and for the average group (p＜.0706) at the t＜1.8211 level the learner' group using CAI program 1 shows the higher performance compared with the learners' group using the CAI program 2, whereas fur the inferior group (p＜.8073) at the t＜.2458 level two programs did not show any difference. The learners interviews show that the superior and average groups have an interest for the open problems, whereas the inferior group do not shows an interest for the open problems. Thus, the CAI programs including the open questions (open fields, open evaluation) will be helped to the learners' group with the individual differences. Furthermore, it is expected that the CAI programs including the open questions as the mathematics and the program model of CAI can be used to develope the CAI program in future.