• Asian Pacific Journal of Cancer Prevention
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• v.15 no.10
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• pp.4147-4152
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• 2014

Standard therapy for advanced head and neck cancer consists of a combination of surgery and radiation. However, survival of this patient population has not improved during the past 20 years. Many different multimodality treatment schedules have been proposed, and chemotherapy is often used with the intent of organ preservation. The present study was intended to establish the efficacy of concomitant chemoradiation with a single agent carboplatin in advanced head and neck cancers.The objectives were to investigate the feasibility of concomitant administration of carboplatin, monitor acute toxicity during radiotherapy, and determine subacute side effects, such as wound healing following surgery after chemoradiotherapy. A prospective study was conducted wherein a total of 40 patients with stage III and IV squamous cell carcinomas of oral cavity, oropharynx, hypopharynx and larynx were enrolled. All patients were treated with external beam radiotherapy and weekly carboplatin area under curve (AUC of 5). Radiotherapy was given in single daily fractions of 1.8-2 grays (Gy) to a total dose of 66-72 Gy. Salvage surgery was performed for any residual or recurrent locoregional disease. Neck dissection was recommended for all patients with neck disease showing less than a complete response after chemoradiation. A total of 40 patients were enrolled of whom 32 were males and 8 were females. Highest incidence of cancer was seen in the 5th-6th decades of life with a median age of 47.7 years. Oropharyngeal tumours constituted a maximum of 21 patients followed by hypopharynx in 10, larynx in 7 and oral cavity in 2. 80% of the patients had a neck node on presentation of which 40% had N2-N3 nodal status. TNM staging revealed that 58% of patients were in stage III and 43% in stage IV. Evaluation of acute toxicity revealed that 50% had grade II mucositis, 25% grade III mucositis, 2.5% grade IV mucositis. 50% of patients had grade I skin reactions, 65% of patients had grade I thrombocytopenia, and 24% of patients had grade I anaemia. After completion of treatment 65% of patients had complete response at the primary and regional sites, and 35% of patients had a partial response of whom 23% underwent neck dissection and 5% of them underwent salvage surgery at the primary site. At the end of one year there were six deaths and four recurrences and 70% were free of disease. Concurrent chemoradiation with carboplatin provided good locoregional control for locally advanced head and neck cancers. This regimen, although toxic, is tolerable with appropriate supportive intervention. Primary site conservation is possible in many patients. Chemoradiotherapy appears to have an emerging role in the primary management of head and neck cancers.

• The Journal of the Korea Contents Association
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• v.17 no.9
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• pp.437-448
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• 2017

This study was conducted as a qualitative case study for examining what transformed primary concepts and transformed schemas were formed for the addition of decimals and how they were formed, and how the relational understanding of the addition of decimals was in three 3rd grade elementary school children who had studied the primary concepts of division, fraction and decimal. That is, this study investigated how the subjects approached problems of decimal addition using transformed primary concepts and transformed schemas formed by themselves, and how the subjects formed concepts and transformed schemas in problem solving. According to the results of this study, transformed primary concepts and transformed schemas formed through the learning of the primary concepts of division, fraction, and decimal functioned as important factors for the relational understanding of decimal addition.

• Education of Primary School Mathematics
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• v.4 no.1
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• pp.1-17
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• 2000

The purpose of this study is to analyze the articulation between the kindergarten and 1st grade in mathematics education. for this purpose, the problems of this study selected as follows ：(ⅰ) What is the mathematical concepts related between the kindergarten curriculum and the 1st grade curriculum\ulcorner (ⅱ) How is the mathematics classroom in the kindergarten and 1st grade\ulcorner (ⅲ) Which instructional materials are used in the kindergarten and the 1st grade\ulcorner (ⅳ) What is the new direction of articulation between the kindergarten and first grade in mathematics education\ulcorner The results of this study are as follows ： (ⅰ) According to examining each curriculum the focus is on understanding the basic concepts of number in the kindergarten, on the concepts of number, addition and subtraction in the 1st grade. (ⅱ) By being analyzed the mathematics classrooms of the kindergarten and the 1 st grade, it is different the focus of lessons or the teaching strategies. (ⅲ) As a result of analysing the teaching plans in the kindergarten and the survey in the first grade teachers, used instructional materials are manipulative ones. While mainly used materials are puzzles and blocks in kindergarten, a paduk stone, number cards, sankagi are used in 1st grade. (ⅳ) Finally, we propose the direction of articulation between the kindergarten and 1st grade in mathematics education.

• The Journal of Pediatrics of Korean Medicine
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• v.19 no.2
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• pp.137-152
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• 2005

Objective : As the meaning of collective medical examination, the purpose of this study is to investigate distribution of weak children by measurement according to the five group of weakness (Lung, Heart, Pancreas, Liver, Kidney), and the relationship between the five group of weakness and the Growth failure on primary school children. Methods : This study is composed of 1078 children who attend A primary school in ${\bigcirc}{\bigcirc}$ city. They are divided into 6 groups by grade and for the purpose of effective comparison, The five weak symptoms are studied to determine the association with growth stature among children and we standardize the weak children's height into percent according to age. Results: When each weak children controled grade, sex, body-weight, existence or nonexistence of personal history, physical exercise so on, relatively group of weakness for kidney is statistically less then opposite group and the rest of the people statistically have no significant difference. Conclusions: From the above result, it is suggested that the statistical relationship between the weakness for kidney and growth(p<0.001). It looks forward to have contributed to collective medical examination and children's health care by oriental medical treatment.

• Korean Journal of Community Nutrition
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• v.6 no.3
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• pp.475-485
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• 2001

This study was conducted to find the differences in the physical changes, eating habits and dietary intake by obseity index of sixth grade primary school students is Seoul.The subjests were classified into three groups, an underweight group(90% under, 12l Ug), normal group(between 90-110%, 153, NG), and obese group(110% over, 91, OG) according to WLI(Weight-Length Index)calculated with their present (6th grade) height and weight. The physical growth of the subjects was generally good, although problems of both underweight and obesity were existed together. The mean heigh growth velocity per year, weight growth velocity per year and WLI changes per year of OG were higher than those of the other groups(p〈0.01). The past physical status of the three groups were maintained from 1 st grade to sixth grade, As eating habits and lifestyles, they were not statistically significant but there were some differences among the three groups. More students of the UG disliked a certain food than those of the other groups. UG liked fried or roasted foods more(p〈0.001). NG tended to eat three meals more irregularly. OG tended to have meal times more regularly and do more regular exercise than the other groups. The dietary intakes of three groups were generally good. They were not statically significant among the three groups. With theses difference among the three groups, it is recommended to educate about unbalanced diet for the underweight group, regularity, of meals for the normal group, doing exercise for the obese for the obese group, and increasing Ca and vitamin A intake for most students, As the physical status for th lower grades have been maintained up to the sixth grade, nutrition education programs should be started at the lower grades in the elementary school.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.3
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• pp.1447-1451
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• 2014

Purpose: To compare histopathologic findings of patients who underwent transurethral resection of a bladder tumor (TUR-B) between groups with and without the metabolic syndrome. Materials and Methods: We retrospectively analyzed data of 535 patients who underwent TUR-B in our department between October 2005 and March 2011. All patients had primary urethelial cell carcinoma (UCB). Histologic stage, grade, the presence of hypertension, diabetes mellitus, body mass index (BMI), waist circumference, HDL and trigliseride levels were evaluated. The TNM classification was used, with Ta tumor accepted as lower stage and T1 and T2 tumors as higher stage bladder cancers. Also, the pathological grading adopted by the 2004 World Health Organization grading system were applied. Non-invasive papillary urothelial neoplasms of low malignant potential were regarded as low grade. Results: Among the total of 509 patients analyzed in our study, there were 439 males (86.2%) and 70 females (13.8%). Metabolic syndrome was significantly associated with high histologic grade, and high pathologic stage (p<0.001). Conclusions: The patients with metabolic syndrome were found to have statistically significant higher T stage and grade of bladder cancer. Further studies with more patients are needed to confirm our study.

• Journal of Korean society of Dental Hygiene
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• v.11 no.1
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• pp.113-126
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• 2011

Objectives : We supposed that identifying the influencing factors on DMFT index in the primary school children in Pocheon be indispensible for the primary school children's oral health program establishment in Pocheon. So, to prepare the basic materials for the primary school children's oral health program establishment in Pocheon, we analyzed the associated factors which could have an influence on the primary school children's DMFT index in Pocheon. Methods : We selected 3,676 primary school children in Pocheon, whose age were from 6 to 11, and surveyed those children by a questionnaire and the oral examination based on WHO's oral health survey method. Data were analyzed with a $x^2$-test and multiple regression analysis using SPSS $15.0^{(R)}$. Results : The results of oral survey in the primary school children in Pocheon revealed as follows: DMFT index, National Health Oral health survey of 2006 people nationwide in the results when compared to younger grade children and older grade in the low and the higher. Subjective oral health awareness, high of viscosity junk food snacks, fruit, gender, dental visits and humidity, oral health education classes, including the variable of attitude was 6(p<0.05). Their higher awareness of dental health, oral health education classes ever the more positive attitude to DMFT index was statistically significant(p<0.05). Solid in the habit of eating junk food snacks to the students of a liquid relative to student intake was higher DMFT index indices(p<0.05). Conclusions : We could reason that one's oral health recognition and behavior should have a relationship with his(her) DMFT index.

• Radiation Oncology Journal
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• v.30 no.4
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• pp.182-188
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• 2012

Purpose: For recurrent esophageal cancer after primary definitive radiotherapy, no general treatment guidelines are available. We evaluated the toxicities and clinical outcomes of re-irradiation (re-RT) for recurrent esophageal cancer. Materials and Methods: We analyzed 10 patients with recurrent esophageal cancer treated with re-RT after primary definitive radiotherapy. The median time interval between primary radiotherapy and re-RT was 15.6 months (range, 4.8 to 36.4 months). The total dose of primary radiotherapy was a median of 50.4 Gy (range, 50.4 to 63.0 Gy). The total dose of re-RT was a median of 46.5 Gy (range, 44.0 to 50.4 Gy). Results: The median follow-up period was 4.9 months (range, 2.6 to 11.4 months). The tumor response at 3 months after the end of re-RT was complete response (n = 2), partial response (n = 1), stable disease (n = 2), and progressive disease (n = 5). Grade 5 tracheoesophageal fistula developed in three patients. The time interval between primary radiotherapy and re-RT was less than 12 months in two of these three patients. Late toxicities included grade 1 dysphagia (n = 1). Conclusion: Re-RT of recurrent esophageal cancer after primary radiotherapy can cause severe toxicity.

• Journal of Gifted/Talented Education
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• v.24 no.3
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• pp.339-358
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• 2014

On the subjects of elementary 3-rd grade three child prodigies who learned primary concept of division, this study explored how they could compose schema and transformed schema through recognition of precise concepts and linking with the contents of division of fraction. That is to say, this study examined in depth what schema and transformed schema as primary concept of division they composed to get relational understanding of division of fraction, and how they used the schema and transformed schema composed by themselves to approach problem solving as well as how they transformed the schema in their concept composition and problem solving competence. As a result, it was found that learning of primary concept of division played a key role of composing schema and transformed schema needed for coping with division of fraction, and that at this time, composition of the transformed schema and transformed schema derived from the recognition of primary concept of division could play the inevitable role of problem solving for division of fraction.

• Childhood Kidney Diseases
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• v.13 no.2
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• pp.229-234
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• 2009

Purpose : The aim of this study was evaluating the efficacy of endoscopic $Deflux^{(R)}$ submucosal injection in children with primary vesicoureteral reflux (VUR). Methods : Retrospective analysis of medical record was conducted on 38 children (59 ureters) who underwent endoscopic $Deflux^{(R)}$ injection due to primary VUR. Data were collected from March 2000 to February 2006. Mean infused amount of $Deflux^{(R)}$ was 0.77 cc. After $Deflux^{(R)}$ injection, patients were reassessed by voiding cystourethrogram (VCUG) 6 months later. Results : The success rate of endoscopic $Deflux^{(R)}$ submucosal injection 6 months later by VCUG was 100% for grade 1 VUR, 87.5% for grade 2, 60% for grade 3, 26.6% for grade 4, 16.6% for grade 5, respectively and there was negatively significant correlation between success rate and grade of VUR (P<.01). Degree of improvement of VUR by endoscopic $Deflux^{(R)}$ submucosal injection was not related to age at diagnosis, time to operation, existence of voiding dysfunction or constipation and infused amount of $Deflux^{(R)}$. However, group with anticholinergics medication had significantly lower success rate than non-medication group (P<0.047). Conclusion : Endoscopic $Deflux^{(R)}$ submucosal injection is effective therapy in patient with primary VUR, especially low grade VUR. It can be not only a useful substitute for prophylaxis with antibiotics, but also an effective management prior to ureteroneocystostomy in children with primary VUR.