• Journal of Ginseng Research
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• v.44 no.2
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• pp.267-273
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• 2020

Background: Continuous exposure to high temperatures can lead to heat stress. This stress response alters the expression of multiple genes and can contribute to the onset of various diseases. In particular, heat stress induces oxidative stress by increasing the production of reactive oxygen species. The liver is an essential organ that plays a variety of roles, such as detoxification and protein synthesis. Therefore, it is important to protect the liver from oxidative stress caused by heat stress. Korean ginseng has a variety of beneficial biological properties, and our previous studies showed that it provides an effective defense against heat stress. Methods: We investigated the ability of Korean Red Ginseng and Korean black ginseng extracts (JP5 and BG1) to protect against heat stress using a rat model. We then confirmed the active ingredients and mechanism of action using a cell-based model. Results: Heat stress significantly increased gene and protein expression of oxidative stress-related factors such as catalase and SOD2, but treatment with JP5 (Korean Red Ginseng extract) and BG1 (Korean black ginseng extract) abolished this response in both liver tissue and HepG2 cells. In addition, JP5 and BG1 inhibited the expression of inflammatory proteins such as p-NF-κB and tumor necrosis factor alpha-α. In particular, JP5 and BG1 decreased the expression of components of the NLRP3 inflammasome, a key inflammatory signaling factor. Thus, JP5 and BG1 inhibited both oxidative stress and inflammation. Conclusions: JP5 and BG1 protect against oxidative stress and inflammation induced by heat stress and help maintain liver function by preventing liver damage.

• Tribology and Lubricants
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• v.18 no.2
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• pp.160-166
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• 2002

In case of rough contact fatigue, the accurate calculation of surface tractions is essential to the prediction of crack initiation life. Accurate Surface tractions influencing shear stress amplitude can be obtained by contact analysis based on the morphology of contact surfaces. In this study, to simulate rough contact under sliding condition, gaussian rough surface generated numerically in the previous study was used and to calculate clack initiation life in the substrate, dislocation pileup theory was used.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 2000.10a
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• pp.174-181
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• 2000

A brief review of previous studies on the behaviour of concrete at extremely low temperature is presented in this paper. In addition, to describe temperature dependent behaviour of concrete, simple piecewise linear stress-strain relation is introduced. The proposed curve shows good agreement with experimental stress-strain curves at various temperature conditions. Moreover, numerical analyses for two PC beams are conducted to verify the influence of extremely low temperature to the structural behaviour.

• Proceedings of the Korean Society of Tribologists and Lubrication Engineers Conference
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• 2000.11a
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• pp.72-79
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• 2000

In case of rough contact fatigue, the accurate calculation of surface tractions is essential to the prediction of crack initiation life. Accurate Surface tractions influencing shear stress amplitude can be obtained by contact analysis based on tile morphology of contact surfaces. In this study, to simulate rough contact under sliding condition, gaussian rough surface generated numerically in the previous study was used and to calculate crack initiation life in the substrate, dislocation pileup theory was used.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2008.10a
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• pp.292-296
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• 2008

A new method of evaluating critical damage values of commercial materials is presented in this paper. The method is based on the previous study of the methodology [1] of acquisition of true stress-strain curves or flow stress curves over large strain from the tensile test in which the flow stress is described by the Hollomon law-like form, that is, by the strain dependent strength coefficient and the strain hardening exponent. The strain hardening exponent is calculated from the true strain at the necking point to meet the Considere condition. The strength coefficient is assumed to be constant before necking and represented by a piecewise linear function of strain after necking. With the predicted flow stress, a tensile test is simulated by a rigid-plastic finite element method with higher accuracy of less than 0.5% error between experiments and predictions. The instant when the fracture begins and thus the critical damage is obtained is determined by observing the stress variation at the necked region. It is assumed that the fracture due to damage begins when the pattern of stress around the necked region changes radically. The method is applied to evaluate the critical damage of a low carbon steel.

• Structural Engineering and Mechanics
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• v.63 no.3
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• pp.371-384
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• 2017

Ultra high performance concrete (UHPC) has recently been applied as an alternative to conventional concrete in construction due to its extremely high compressive and tensile strength, and enhanced durability. However, up to date, there has been insufficient information regarding the confinement behavior of UHPC columns. Therefore, this study aims to perform an assessment of axial stress-strain model for UHPC confined by circular steel tube stub columns. The equations for calculating the confined peak stress and its corresponding strain of confined concrete in existing models suggested by Johansson (2002), Sakino et al. (2004), Han et al. (2005), Hatzigeorgiou (2008) were modified based on the regression analysis of test results in Schneider (2006) in order to increase the prediction accuracy for the case of confined UHPC. Furthermore, a new axial stress-strain model for confined UHPC was developed. To examine the suitability of the modified models and the proposed model for confined UHPC, axial stress-strain curves derived from the proposed models were compared with those obtained from previous test results. After validating the proposed model, an extensive parametric study was undertaken to investigate the effects of diameter-to-thickness ratio, steel yield strength and concrete compressive strength on the complete axial stress-strain curves, the strength and strain enhancement of UHPC confined by circular steel tube stub columns.

• Korean Journal of Occupational Health Nursing
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• v.19 no.2
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• pp.223-235
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• 2010

Purpose: This study was done to investigate the prevalence of job stress and musculoskeletal symptoms, and to identify the factors that affect work-related musculoskeletal symptoms of the 119 Emergency medical technicians (EMT). Method: From August 26 to September 10, 2010, the data were obtained from 456 EMT working in Daejeon city or Choongnam province. For data analysis, descriptive statistics and multiple logistic regression were performed using SAS version 9.1. Results: Physical environment, job demand, interpersonal conflict, and occupational climate were stressful to 119 EMT. The prevalence of musculoskeletal symptoms of female EMT was higher than those of the male EMT's. After gender and age were adjusted, there ware significant relationships between musculoskeletal symptoms and some risk factors including occupational class, hours of intensive musculoskeletal use, previous injury or work-related injury, physical burden, and job stress. Overall, a higher degree of job stress increased musculoskeletal symptoms. Conclusion: Job stress is a major cause of musculoskeletal symptoms. To prevent and manage musculoskeletal disease of 119 EMT, there is a need to develop a management program for musculoskeletal symptoms to reduce occupational stress, considering gender differences.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.21 no.3
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• pp.447-456
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• 1997

Stress intensity factor of semi-infinite parallel crack propagation with constant velocity in dissimilar orthotropic strip under out-of-plane clamped desplacement is investigated. Using Fourier integral transforms the boundary value problem is derived by a pair of dual integral equation and finally reduced to a single Wiener-Hopf equation. By applying Wiener-Hopf technique the equation is solved. Applying this result the asymptotic stress fields near the crack tip are determined, from which the stress intensity factor is obtained in closed form. The more the ratio of anisotropy or the ratio of bi-material shear modulus increase in the main material including the crack, the more the stress intensity factor increases. Discontinuity in the stress intensity factor is found as the parallel crack approaches the interface. In special case, the results of isotropic materials agree well with those by the previous researchers.

• Transactions of the Korean Society of Mechanical Engineers
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• v.14 no.1
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• pp.119-129
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• 1990

In case that the body with a cusp crack is under uniform heat flow, thermal stress intensity factors are calculated by using boundary element method with linearized body force term. The crack surface is under insulated or fixed temperature condition and the types of crack are symmetric lip and airfoil cusps. Numerical values of thermal stress intensity factors for a Griffith crack and cusp cracks in infinite bodies are proved to be in good agreement within .+-.5% when compared with the previous numerical and exact solutions, respectively. The thermal stress intensity factors for symmetric lip and airfoil cusp cracks in finite bodies are calculated about various effective crack lengths, configuration parameters, and heat flow directions. With the same crack surface thermal boundary conditions, heat flow directions and crack lengths, there are no appreciable differences in variations of thermal stress intensity factors between symmetric lip and airfoil cusp cracks. The signs of thermal stress intensity factors for each cusp crack are changed with each crack surface thermal boundary condition.

• Transactions of the Korean Society of Pressure Vessels and Piping
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• v.12 no.2
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• pp.50-57
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• 2016

The study presents structural integrity assessment of ductility degradation of a baffle former assembly by performing finite element analysis considering real loading conditions and stress triaxiality. Variations of fracture strain curves of type 304 austenitic stainless steel with stress triaxiality are derived based on the previous study results. Temperature distributions during normal operation such as heat-up, steady state, and cool-down are calculated via finite element temperature analysis considering gamma heating and heat convection with reactor coolant. Variations of stress and strain state during long operation period are also calculated by performing sequentially coupled temperature-stress analysis. Fracture strain is derived by using the fracture curve and the stress triaxility. Finally, variations of ductility degradation damage indicator with the fracture strain and the equivalent inelastic strain are investigated. It is found that maximum value of the ductility degradation damage index continuously increases and becomes 0.4877 at 40 EFPYs. Also, the maximum value occurs at top and middle inner parts of the baffle former assembly before and after 20 EFPYs, respectively.