• 보건행정학회지
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• 제26권3호
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• pp.185-194
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• 2016

Background: The purpose of this study is to forecast changes in the prevalence of chronic diseases and health expenditure by age group. Methods: Based on the Future Elderly Model, this study projects the size of Korean population, the prevalence of chronic diseases, and health expenditure over the 2014-2040 period using two waves (2012, 2013) of the Korea Health Panel and National Health Insurance Service database. Results: First, the prevalence of chronic diseases increases by 2040. The population with hypertension increases 2.04 times; the diabetes increases 2.43 times; and the cancer increases 3.38 times. Second, health expenditure on chronic diseases increases as well. Health expenditure on hypertension increases 4.33 times (1,098,753 million won in 2014 to 4,760,811 million won in 2040); diabetes increases 5.34 times (792,444 million won in 2014 to 4,232,714 million won in 2040); and cancer increases 6.09 times (4,396,223 million won in 2014 to 26,776,724 million won in 2040). Third, men and women who belong to the early middle-aged group (44-55 years old) as of 2014, have the highest increase rate in health spending. Conclusion: Most Korean literature on health expenditure estimation employs a macro-simulation approach and does not fully take into account personal characteristics and behaviors. Thus, this study aims to benefit medical administrators and policy makers to frame effective and targeted health policies by analyzing personal-level data with a microsimulation model and providing health expenditure projections by age group.

• 한국보건간호학회지
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• 제27권2호
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• pp.327-337
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• 2013

Purpose: This study was conducted to determine the prevalence rate of depression and the associated factors affecting the depression among the elderly beneficiaries of the national basic livelihood scheme. Methods: From the beneficiaries of the "visiting health care program" in a city the beneficiaries (aged 65 years or older) of the national basic livelihood scheme were selected. A total of 677 subjects were included in the study and hence for data analyses. Results: The observed prevalence rate of depression was 80.5% (mild depression was 60.2%, and severe depression was 20.3%). The factors influencing depression were indicative of subjective health status, walking exercise, hypertension, and diabetes. Conclusion: On the basis of our study results, as a strategy to reduce the prevalence rate of depression among the elderly concerned, we are of the opinion that it is very much necessary to motivate them to practice continuous and regular walking exercises in easily accessible places by mobilizing community resources such as visiting nurses and volunteers. Such efforts may not only immediately reduce the morbidity rate of depression among the low-income elderly, but also, in the long run, prevent suicides and contribute to improving their mental health status to an appreciable extent.

• 한국식생활문화학회지
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• 제18권2호
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• pp.123-133
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• 2003

The purpose of this study is to compare the correlation of clinical characteristics and patterns of disease. Subjects of the study were the adults(207) living in Geoje City, the diabetes mellitus and the hypertension patients(166) and the normal people(41). In the diabetes mellitus group and the hypertension group, blood pressure, blood glucose, total cholestero LDL-cholesterol and atherogenic index(AI) were significantly high. As the obesity index was getting higher, the blood pressure of the diabetes mellitus group was high, and the HDL-cholesterol of the hypertension group was low, but AI of it was significantly high. The AI was significantly high as serum lipid index were getting higher in both groups. The rate of the prevalence was very high in the diabetes mellitus group(74.3%) and the hypertension group(73.7%). The pattern in the diabetes mellitus group was in order of the hypertension, the hyperlipidemia, and the obesity but, in the hypertension group was the hyperlipidemia, and the obesity. The obesity index and serum lipid index of complex patient group were higher than single patient group.

• 대한의생명과학회지
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• 제30권2호
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• pp.65-72
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• 2024

The national diabetes and prediabetes prevalence rate has risen among Korean adolescents and adults. Type 2 diabetes mellitus (T2DM) is commonly interrelated with genetic, metabolic, and environmental risk factors in clinical practice. In this study, we analyzed the association between genetic polymorphisms of the ABO gene with T2DM in the Korean population, we conducted an analysis of gene-phenotype correlation, based on an additive genetic model. A total of 8,840 subjects from the Korea Association REsource (KARE) were selected for this study. Using the genetic and epidemiologic data of 754 T2DM cases and 5721 normal controls from the KARE, single nucleotide polymorphisms (SNPs) in the ABO gene were analyzed for their genetic correlation. As a result, 8 SNPs out of the ABO gene demonstrated statistically significant association with T2DM. Among them, rs657152 in the ABO gene statistically showed the most significant correlation with T2DM (P-value=0.0084, OR=1.15, CI=1.04~1.28). The minor allele of A polymorphism within the intron genetic region of ABO directed increased risk of T2DM. This work reveals a significant association between genetic polymorphism in the ABO gene and T2DM. This finding suggested that ABO SNPs markers might be a genetic correlation to the etiology of T2DM.

• 한국식품영양학회지
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• 제32권3호
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• pp.216-225
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• 2019

The objective of this study was to compare nutrients intake, health indices, and prevalence of chronic diseases by occupation in middle-aged men, using results from National Health and Nutrition Examination Survey. The subjects were divided into two groups by their occupation (Office worker (OW) and Agri-fishery worker (AFW)) and their percentages were 75.5% and 24.5% respectively. In health-related factors, drinking rate was higher in OW (p<0.001), while smoking rate was higher in AFW (p<0.001). Walking and strength exercise were both higher in OW group. In dietary behavior, the rate of skipping breakfast and eating out was higher in OW (p<0.001). Food supplement usage were consumed by OW more than AFW (p<0.001). Daily energy intake was higher in AFW (p<0.05). There were significant differences in nutrient density per 1,000 kcal of minerals and vitamins between the two groups (p<0.05~p<0.001), except calcium, potassium, vitamin A and thiamin. In body weight, BMI, waist circumference and blood pressures, OW was higher than AFW (p<0.05~p<0.001). Whereas, HDL and LDL-cholesterol were higher in AFW (p<0.001). The prevalence of diabetes was higher in AFW (p<0.001). The results of this study can be used as data to establish nutrition and health strategies for occupation in middle-aged men.

• International Journal of Computer Science & Network Security
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• 제23권8호
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• pp.17-25
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• 2023

The alarming global prevalence of Type 2 Diabetes Mellitus (T2DM) has catalyzed an urgent need for robust, early diagnostic methodologies. This study unveils a pioneering approach to predicting T2DM, employing the Extreme Gradient Boosting (XGBoost) algorithm, renowned for its predictive accuracy and computational efficiency. The investigation harnesses a meticulously curated dataset of 4303 samples, extracted from a comprehensive Chinese research study, scrupulously aligned with the World Health Organization's indicators and standards. The dataset encapsulates a multifaceted spectrum of clinical, demographic, and lifestyle attributes. Through an intricate process of hyperparameter optimization, the XGBoost model exhibited an unparalleled best score, elucidating a distinctive combination of parameters such as a learning rate of 0.1, max depth of 3, 150 estimators, and specific colsample strategies. The model's validation accuracy of 0.957, coupled with a sensitivity of 0.9898 and specificity of 0.8897, underlines its robustness in classifying T2DM. A detailed analysis of the confusion matrix further substantiated the model's diagnostic prowess, with an F1-score of 0.9308, illustrating its balanced performance in true positive and negative classifications. The precision and recall metrics provided nuanced insights into the model's ability to minimize false predictions, thereby enhancing its clinical applicability. The research findings not only underline the remarkable efficacy of XGBoost in T2DM prediction but also contribute to the burgeoning field of machine learning applications in personalized healthcare. By elucidating a novel paradigm that accentuates the synergistic integration of multifaceted clinical parameters, this study fosters a promising avenue for precise early detection, risk stratification, and patient-centric intervention in diabetes care. The research serves as a beacon, inspiring further exploration and innovation in leveraging advanced analytical techniques for transformative impacts on predictive diagnostics and chronic disease management.

• Journal of Nutrition and Health
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• 제50권2호
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• pp.158-170
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• 2017

본 연구는 사회경제적 요인, 식행동 및 신체활동에 의한 만성질환 (고혈압, 고중성지방혈중, 저HDL콜레스텔롤혈증, 당뇨병, 복부비만, 비만 및 대사증후군) 유병률에 우유와 유제품 섭취가 매개변인으로 작용하였을 때의 효과를 평가하고자 하였다. 본 연구에 활용한 자료는 제 5기, 6기 국민건강영양조사 (2010~2015) 자료를 활용하여, 만 30세이상의 성인 남녀를 대상으로 하였고, 질환이나 체중조절을 위해 식이요법을 실시하고 있거나 임산부는 분석대상에서 제외하였다. 고혈압, 고중성지방혈중, 당뇨병, 복부비만, 비만, 대사증후군의 유병률은 남자에서 유의적으로 높았고, 저HDL콜레스테롤혈증은 여자에서 유의적으로 높아 만성질환 유병률은 성별에 따라 차이를 보였다. 사회경제적요인, 식행동 및 신체활동은 남녀에 따라 차이를 보이고 있으나 만성질환 유병률에 영향을 미치는 요인 이었다. 복부비만과 비만을 제외한 고혈압, 고중성지방혈증, 저HDL콜레스테롤혈증, 당뇨병 및 대사증후군의 유병률은 남녀 모두 사회경제적 수준 (가구내 소득수준, 교육수준)이 낮을 경우 높았고, 신체활동 (걷기, 중등도 및 격렬한)을 실천할 경우 낮았다. 반면 복부비만과 비만의 유병률은 남자의 경우 사회경제적 수준이 높을수록, 여자 경우 사회경제적 수준이 낮을수록 높은 것으로 나타나 성별에 따라 유의적인 차이를 보였다. 흡연을 만성질환의 유병률을 증가시키는 요인이었고, 음주의 경우 저HDL콜레스테롤혈증을 제외한 질환의 유병률을 증가시키는 요인이었다. 외식은 남자의 비만 유병률을 증가시키는 요인이었으나, 성인 여자에서는 비만과 대사증후군의 유병률을 감소시키는 요인이었다. 만성질환과 유의한 관련성을 보인 사회경제적, 식행동 및 신체활동 요인 (설명변수)에 우유 섭취를 매개변인으로 추가한 후의 효과를 평가한 결과 성인 남자의 경우 교육수준은 당뇨병에서, 음주는 고혈압, 고중성지방혈증, 저HDL콜레스테롤혈증, 대사증후군에서, 아침식사는 대사증후군, 외식은 비만, 중등도 신체활동은 고중성지방혈증에서 부분통제됨으로서 하루 200 g 이상의 우유를 섭취할 경우 교육수준, 음주, 아침식사, 외식 및 중등도 신체활동에 의한 만성질환 유병률을 낮추는 효과가 있었다. 성인 여자의 경우 가구 내 소득수준은 고중성지방혈증, 당뇨병, 복부비만에서, 교육수준은 고혈압, 복부비만에서, 음주, 아침식사, 외식 및 걷기 실천은 저HDL콜레스테롤혈증에서, 중등도 신체활동은 고중성지방혈증과 저HDL콜레스테롤혈증에서 부분통제됨으로 인해 우유 섭취가 이들 설명변수에 의한 만성질환 유병률을 감소시키는 효과를 보였다. 이외 성인 남자와 여자에서 유의적인 관련성을 보인 변인은 우유, 유제품 섭취에 의해 완전통제 또는 완전매개 되어 우유 섭취 시 이들 설명변수가 만성질환 유병률에 미치는 영향은 사라졌다. 본 연구결과, 하루 200 g 이상의 우유를 섭취할 경우 사회경제적 요인, 식행동 및 신체활동에 의한 효과가 통제 또는 매개하는 영향이 있는 것으로 나타나고 있으므로 적정수준의 우유 섭취는 고혈압, 고중성지방혈증, 저HDL콜레스테롤혈증, 당뇨병, 비만, 복부비만 및 대사증후군을 예방하는 효과가 있었다. 그러나 본 연구는 국민건강영양조사 자료를 활용한 후향적 관측 연구이고, 우유 및 유제품 섭취에 의한 매개효과를 파악한 것이므로 추후 한국인의 만성질환 예방을 위한 적정수준의 우유 및 유제품 섭취 수준에 관한 가이드라인 선정을 위해서는 대단위 실험 설계나 코호트 자료 분석을 통한 다양한 연구가 수행되어야 할 것이다.

• Genomics & Informatics
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• 제21권4호
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• pp.48.1-48.8
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• 2023

Liver cancer is the fourth leading cause of death worldwide. Well-known risk factors include hepatitis B virus and hepatitis C virus, along with exposure to aflatoxins, excessive alcohol consumption, obesity, and type 2 diabetes. Genomic variants play a crucial role in mediating the associations between these risk factors and liver cancer. However, the specific variants involved in this process remain under-explored. This study utilized a bioinformatics approach to identify genetic variants associated with liver cancer from various continents. Single-nucleotide polymorphisms associated with liver cancer were retrieved from the genome-wide association studies catalog. Prioritization was then performed using functional annotation with HaploReg v4.1 and the Ensembl database. The prevalence and allele frequencies of each variant were evaluated using Pearson correlation coefficients. Two variants, rs2294915 and rs2896019, encoded by the PNPLA3 gene, were found to be highly expressed in the liver tissue, as well as in the skin, cell-cultured fibroblasts, and adipose-subcutaneous tissue, all of which contribute to the risk of liver cancer. We further found that these two SNPs (rs2294915 and rs2896019) were positively correlated with the prevalence rate. Positive associations with the prevalence rate were more frequent in East Asian and African populations. We highlight the utility of this population-specific PNPLA3 genetic variant for genetic association studies and for the early prognosis and treatment of liver cancer. This study highlights the potential of integrating genomic databases with bioinformatic analysis to identify genetic variations involved in the pathogenesis of liver cancer. The genetic variants investigated in this study are likely to predispose to liver cancer and could affect its progression and aggressiveness. We recommend future research prioritizing the validation of these variations in clinical settings.

• Korean Circulation Journal
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• 제53권5호
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• pp.313-327
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• 2023

Background and Objectives: Pulmonary arterial hypertension (PAH) is a rare but fatal disease. Recent advances in PAH-specific drugs have improved its outcomes, although the healthcare burden of novel therapeutics may lead to a discrepancy in outcomes between developing and developed countries. We analyzed how the epidemiology and clinical features of PAH has changed through the rapidly advancing healthcare infrastructure in South Korea. Methods: PAH was defined according to a newly devised 3-component algorithm. Using a nationwide health insurance claims database, we delineated annual trends in the prevalence, incidence, medication prescription pattern, and 5-year survival of PAH in Korea. Cumulative survival and potential predictors of mortality were also assessed among 2,151 incident PAH cases. Results: Between 2002 or 2004 and 2018, the prevalence and incidence of PAH increased 75-fold (0.4 to 29.9 per million people) and 12-fold (0.5 to 6.3 per million person-years), respectively. The proportion of patients on combination PAH-specific drug therapy has also steadily increased up to 29.0% in 2018. Among 2,151 incident PAH cases (median [interquartile range] age, 50 [37-62] years; 67.2% female), the 5-year survival rate and median survival duration were 71.8% and 13.1 years, respectively. Independent predictors of mortality were age, sex, etiology of PAH, diabetes, dyslipidemia, and chronic kidney disease. Conclusions: This nationwide study delineated that the prevalence and incidence of PAH have grown rapidly in Korea since the early 2000s. The use of combination therapy has also increased, and the 5-year survival rate of PAH in Korea was similar to those in western countries.

• Journal of Preventive Medicine and Public Health
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• 제48권3호
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• pp.170-177
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• 2015

Objectives: The goal of this study was to examine the association of various demographic and socioeconomic factors with risk factors for chronic kidney disease (CKD). Methods: We used nationally representative pooled data from the Korea National Health and Nutrition Examination Survey (KNHANES), 2007-2013. We estimated the glomerular filtration rate (GFR) using the Modification of Diet in Renal Disease equation. We defined CKD as a GFR <60 mL/min/$1.73m^2$, and 1304 of the 45 208 individuals included in the KNHANES were found to have CKD by this definition. The outcome variable was whether individual subjects adhered to the CKD prevention and management guidelines recommended by the Korea Centers for Disease Control and Prevention. The guidelines suggest that individuals maintain a normal weight, abstain from alcohol consumption and smoking, manage diabetes and hypertension, and engage in regular exercise in order to prevent and manage CKD. Results: This study found that individuals with CKD were more likely to be obese and have hypertension or diabetes than individuals without CKD. In particular, male and less-educated CKD patients were less likely to adhere to the guidelines. Conclusions: Although the prevalence of CKD, as indicated by the KNHANES data, decreased from 2007 to 2013, the prevalence of most risk factors associated with CKD fluctuated over the same time period. Since a variety of demographic and socioeconomic factors are related to the successful implementation of guidelines for preventing and managing CKD, individually tailored prevention activities should be developed.