• Journal of Yeungnam Medical Science
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• 제38권4호
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• pp.326-336
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• 2021

Background: Sulfation of heparan sulfate proteoglycans (HSPGs) is critical for the binding and signaling of ligands that mediate inflammation. Extracellular 6-O-endosulfatases regulate posttranslational sulfation levels and patterns of HSPGs. In this study, extracellular 6-O-endosulfatases, sulfatase (Sulf)-1 and Sulf-2, were evaluated for their expression and function in inflammatory cells and tissues. Methods: Harvested human peripheral blood mononuclear cells were treated with phytohemagglutinin and lipopolysaccharide, and murine peritoneal macrophages were stimulated with interleukin (IL)-1β for the evaluation of Sulf-1 and Sulf-2 expression. Sulf expression in inflammatory cells was examined in the human rheumatoid arthritis (RA) synovium by immunofluorescence staining. The antigen presentation and phagocytic activities of macrophages were compared according to the expression state of Sulfs. Sulfs-knockdown macrophages and Sulfs-overexpressing macrophages were generated using small interfering RNAs and pcDNA3.1 plasmids for Sulf-1 and Sulf-2, respectively. Results: Lymphocytes and monocytes showed weak Sulf expression, which remained unaffected by IL-1β. However, peritoneal macrophages showed increased expression of Sulfs upon stimulation with IL-1β. In human RA synovium, two-colored double immunofluorescent staining of Sulfs and CD68 revealed active upregulation of Sulfs in macrophages of inflamed tissues, but not in lymphocytes of lymphoid follicles. Macrophages are professional antigen-presenting cells. The antigen presentation and phagocytic activities of macrophages were dependent on the level of Sulf expression, suppressed in Sulfs-knockdown macrophages, and enhanced in Sulfs-overexpressing macrophages. Conclusion: The results demonstrate that upregulation of Sulfs in macrophages occurs in response to inflammation, and Sulfs actively regulate the antigen presentation and phagocytic activities of macrophages as novel immune regulators.

• 한국인터넷방송통신학회논문지
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• 제23권2호
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• pp.7-14
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• 2023

최근 소비 패러다임이 '소유(possession)' 중심에서 '구독(subscription)'으로 변화하면서 구독경제 시장이 빠르게 성장하고 있다. 구독경제는 소비자가 제품 및 서비스를 비용을 지불하고 구매하여 한정된 시간 동안 제한적으로 이용이 가능하다는 특징을 가지고 있다. 이에 본 연구는 구독 서비스의 이용에 대한 시간제시 방식(기간/ 날짜)에 따라 소비자의 구독 서비스 이용 시간(기간)에 대한 주관적 인식이 구독 의도에 미치는 영향을 살펴보았다. 또한, 구독 서비스의 유형(실용/쾌락)에 따른 시간제시 방식의 차이가 구독 의도에 미치는 영향을 살펴보았다. 연구 결과, 기간으로 제시할때, 날짜로 제사할 때 보다 더 높은 구독 의사를 보였다. 또한, 실용적 목적으로 소비하는 구독 서비스는 시간제시 방식에 따른 구독 의도에 미치는 영향이 차이가 없었으나, 쾌락적 목적으로 소비하는 구독 서비스는 날짜보다 기간으로 이용시간을 제시하는 것이 더 큰 구독 의사를 보이는 것으로 나타났다. 이 결과를 토대로 본 연구의 이론적 의의와 실무적 함의를 제시하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권10호
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• pp.5817-5823
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• 2013

Background: It is important to understand the perceptions of oncologists to understand the comprehensive picture of clinical presentation of breast cancer. In the absence of clear evidence, clinical practice involving patients of breast cancer in India should provide insights into stages of breast cancer with which women present to their clinics and mode of screening of breast cancer prevalent in Andhra Pradesh. Materials and Methods: A qualitative study was conducted to understand the perceptions of oncologists regarding clinical presentation of breast cancer, stages at which women present to clinics, and mode of screening of breast cancer prevalent in Andhra Pradesh. In-depth interviews (IDI) were conducted with ten practising oncologists from various public and private cancer hospitals in Hyderabad city to understand their perspectives on breast cancer and screening. The data were triangulated to draw inferences suitable for the current public Health scenario. Results: Late presentation was indicated as the most important cause of decreased survival among women. Most women present at Stage 3 and 4 when there is no opportunity for surgical intervention. The results indicate that there is a huge gap in awareness about breast cancer, especially in rural areas and among poor socioeconomic groups. Even despite knowledge, most women delay in reporting due to reasons like fear, embarrassment, cost, ignorance, negligence, and easy going attitude. Conclusions: It is important to improve awareness about breast cancer and screening methods for promoting early screening. The study inferred that it would be beneficial to establish cancer registries in rural areas. Also, the policymakers need to make key decisions which among three methods (breast self examination (BSE), clinical breast examination and mammography) can best be used as a screening tool and how to successfully implement population wide screening program to prevent mortality and morbidity from breast cancer in India.

• Advances in pediatric surgery
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• 제10권1호
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• pp.9-16
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• 2004

Intestinal duplication is a rare congenital anomaly. The diagnostic approach is difficult because of the differences in its location and clinical presentation. To evaluate the diagnostic as well as the therapeutic approaches in children, the medical records of 20 patients with intestinal duplications which had been operated upon from July 1980 to October 2002 were analyzed, retrospectively. The range of age was from 1 day to 11 years. The variables, such as age, sex, clinical presentation, diagnostic method, localization, anatomic type, treatment, complication, and combined anomalies were analyzed. Most of the cases were presented as incidental finding. The majority of the duplications except hindgut were cystic type. Treatment included segmental intestinal resection, excision of the lesion without intestinal resection, and septotomy. Seventy-five percent of the patients were detected before 1 year of age. The anatomic type of the lesion was closely related with its location. The cases of hindgut were almost always tubular type except 1 case. Clinical presentation was related to age, location, and anatomic type. There were no specific diagnostic methods. Perfect localization and application of appropriate operation are the most important requirements for successful treatment.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제44권5호
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• pp.237-241
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• 2018

Objectives: The aim of this study was to determine the rate of peer-reviewed publication of abstracts presented at the annual meetings of the Turkish Association of Oral and Maxillofacial Surgeons (TAOMS) and to identify the time to publication, subspecialty, and study design. Materials and Methods: All abstracts accepted for presentation at a TAOMS meeting between 2007 and 2009 were identified from a book of abstracts and were searched for publication using PubMed and Google Scholar. The following variables were evaluated: publication rate, type of presentation (oral or poster), time to publication, subspecialty, study design, and name of the journal in which the article was published. Results: A total of 478 abstracts were presented at the TAOMS meetings between 2007 and 2009. Of these, 140 abstracts (29.3%) were subsequently published in peer-reviewed journals, including 38.2% of oral presentations and 26.6% of poster presentations. The mean time from presentation to publication was 22 months. Regarding publication fields, research and emerging technologies presentations had the highest publication rate (100%). With regard to study type, animal study (70.0%) and basic research (55.0%) had the highest publication rates. Conclusion: Only 29.3% of abstracts presented at the TAOMS meeting were subsequently published as full-text articles. This rate was found to be similar to the previously reported publication rates in the field of oral and maxillofacial surgery.

• 한국어교육
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• 제29권4호
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• pp.93-112
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• 2018

The purpose of this study is to deal with vocabulary in KFL. As a result of this study, learners learned vocabulary on average 43 points through contextual inference and introduction of the class to activate background knowledge. In particular, the implicit method showed the highest learning rate of 52 points, and the thematic method had a 41 point-learning rate. In contrast, the semantic method was the lowest with a 25 point-learning rate. There was no significant difference in the improvement rate of upper vocabulary learners, but in the case of the lower learner, there was significant difference in the improvement rate. The difference was not significant in the post-test relative gain rate of upper learners, but there was significant in lower learners. In the delayed test relative gain rate, the difference was significant in all groups. There was correlation between vocabulary difficulty and score, but there was no correlation with the thematic method. And there was no correlation between vocabulary difficulty, improvement rate and relative gain rate in all three classes. However, content understanding, lexical grade, improvement rate, and relative gain rate showed a significant correlation.

• 정보과학회 컴퓨팅의 실제 논문지
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• 제23권12호
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• pp.684-690
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• 2017

IoT 환경에서 사용자들이 여러 종류의 서비스를 활용하는 방법에 대해 많은 연구가 진행되어 왔다. 기존의 연구들은 이 목적을 달성하기 위해 사용자로 하여금 새로운 도구의 사용법이나 전문 기술을 학습하도록 요구했다. 본 논문에서는 프레젠테이션 작성 스킴을 사용하여 최종 사용자가 IoT 서비스 매쉬업을 만들 수 있는 패러다임과 이를 위한 프레임워크를 제안한다. 여기에서 사용하는 매쉬업 모델은 태스크 중심 서비스 프레임워크에 기반을 두어 설계되었다. 제안된 프레임워크를 사용하여 사용자는 프레젠테이션 파일 형태로 매쉬업을 작성하고, 흐름 기반의 서비스 흐름으로 변환하고, 이를 IoT 환경에 배포하여 실행할 수 있다. 또한, 사례 연구를 통해 이 패러다임과 프레임워크가 최종 사용자의 IoT 환경에서의 서비스 매쉬업을 어떻게 지원하는지를 보인다.

• 한국실내디자인학회:학술대회논문집
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• 한국실내디자인학회 2003년도 춘계학술발표대회 논문집
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• pp.104-111
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• 2003

Today, design is considered to have competitive power for a county, so there has been various efforts such as education, publicity and development, etc. Design has long been a national material, and Korea Institute of Design Promotion(KIDP) was inaugurated for the purpose of education, publicity, development and the management, public ownership, support of the contents. Laying stress on the results, however, the design education for children which would be the heart of a world design power is short of both investment and systematic study of education. Now that the design education for children is being active, the cultural spaces are needed to transform the current system focused on schooling and textbooks into the participating, experiential ones by the interesting, educational, and entertaining presentation. The children design exploratorium should make children have their own feelings, and present communicative methods considering children's cognition and behaviors. So, in this study, I'd like to analyze characteristics of the participating and experiential exhibition, and present a children design exploratorium as an alternative plan by the application of adequate methods to the exhibition medium, and the analysis of current exploratoriums' features case by case. The children design exploratorium is the place to maximize the educational effect of design by children's easier and exciting participation, which would offer an unique exhibition place for children to comprehend designs. In this study, on the basis of the alternative presentation of children design exploratoriums, I would refer to the future direction of the 21st century pavilions, the search for the exhibition items for active design education, and the contribution to practical plans.

• 한국지능시스템학회논문지
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• 제19권4호
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• pp.485-492
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• 2009

모바일 서비스 환경에서 시간 동기화에 의해 생성된 패턴들은 데이터 스트리밍으로 인하여 인스턴스 값들이 다르게 스트리밍 된다. 본 논문에서는 유연한 클러스터링을 지원하기 위해 가변클러스터링 관리 기법을 제안하며, 이 구조는 다중 데이터 스트리밍을 동적으로 관리하도록 지원한다. 제안되는 기법은 일반적인 스트리밍기법과 달리 데이터 스트림 환경에서 동기화를 효율적으로 지원하는 기능을 수행하며, 구조적 표현단계와 적합성 표현단계를 거쳐 클러스터링 스트리밍이 관리된다. 구조적 표현 단계는 레벨정합과 누적정합을 수행하여 스트림 구조가 표현되며, 동적 세그먼트와 정적세그먼트 관리를 통해서 클러스터링 관리가 가변적으로 수행되도록 하였다. 제안된 기법의 성능 평가를 위해서 k-means 기법, C/S 서버기법 그리고 CDN 기법과 시뮬레이션평가를 수행하였으며 그 결과 제안된 기법의 성능이 효율적임을 알 수 있었다.

• 한국학교수학회논문집
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• 제12권1호
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• pp.1-25
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• 2009

본 연구는 다양한 교수 학습 방법에 대한 예비 교사들의 성향을 알아봄으로써 그러한 성향을 교사 교육 프로그램에 충분히 활용하여 예비 교사들의 적극적인 참여와 사고를 확장시켜, 반성적 사고에 적합한 실천적 지식을 형성 시키는데 목적이 있다. 본 연구를 위하여 다양한 자료를 수집하였으며, 예비교사들은 조사발표, 수학의 실용느낌과 생각을 표현하고 반성하는 기회를 많이 갖게 되었으며 실제와 가장 가까운 모의 수업을 가장 선호했다. 조사발표에 대해서는 고쳐야 할 부분이 있다는 의견을 드러내었다. 이로 볼 때 예비교사 교육 프로그램은 이론과 실제를 봉합하는 프로그램을 통해 수학 교수 학습 과정과 관련된 수학 교수학적 내용 지식에 대한 예비 교사들의 관심과 민감성을 높여 줌으로써 더 깊이 있는 지식을 습득하는 기반이 되도록 해야 할 것이다.