• Title/Summary/Keyword: prediction criteria

Search Result 515, Processing Time 0.022 seconds

Evaluation of Biochemical Recurrence-free Survival after Radical Prostatectomy by Cancer of the Prostate Risk Assessment Post-Surgical (CAPRA-S) Score

  • Aktas, Binhan Kagan;Ozden, Cuneyt;Bulut, Suleyman;Tagci, Suleyman;Erbay, Guven;Gokkaya, Cevdet Serkan;Baykam, Mehmet Murat;Memis, Ali
    • Asian Pacific Journal of Cancer Prevention
    • /
    • v.16 no.6
    • /
    • pp.2527-2530
    • /
    • 2015
  • Background: The cancer of the prostate risk assessment (CAPRA) score has been defined to predict prostate cancer recurrence based on the pre-clinical data, then pathological data have also been incorporated. Thus, CAPRA post-surgical (CAPRA-S) score has been developed based on six criteria (prostate specific antigen (PSA) at diagnosis, pathological Gleason score, and information on surgical margin, seminal vesicle invasion, extracapsular extension and lymph node involvement) for the prediction of post-surgical recurrences. In the present study, biochemical recurrence (BCR)-free probabilities after open retropubic radical prostatectomy (RP) were evaluated by the CAPRA-S scoring system and its three-risk level model. Materials and Methods: CAPRA-S scores (0-12) of our 240 radical prostatectomies performed between January 2000-May 2011 were calculated. Patients were distributed into CAPRA-S score groups and also into three-risk groups as low, intermediate and high. BCR-free probabilities were assessed and compared using Kaplan-Meier analysis and Cox proportional hazards regression. Ability of CAPRA-S in BCR detection was evaluated by concordance index (c-index). Results: BCR was present in 41 of total 240 patients (17.1%) and the mean follow-up time was $51.7{\pm}33.0$ months. Mean BCR-free survival time was 98.3 months (95% CI: 92.3-104.2). Of the patients in low, intermediate and high risk groups, 5.4%, 22.0% and 58.8% had BCR, respectively and the difference among the three groups was significant (P = 0.0001). C-indices of CAPRA-S score and three-risk groups for detecting BCR-free probabilities in 5-yr were 0.87 and 0.81, respectively. Conclusions: Both CAPRA-S score and its three-risk level model well predicted BCR after RP with high c-index levels in our center. Therefore, it is a clinically reliable post-operative risk stratifier and disease recurrence predictor for prostate cancer.

Impact Analysis of Complex Odor from Pigsty by Using ISCST3 (ISCST3을 이용한 돈사의 복합악취 영향 분석)

  • Kwon, Woo-Taeg;Hong, Sang-Pyo;Lee, Woo-Sik
    • Journal of the Korea Academia-Industrial cooperation Society
    • /
    • v.14 no.12
    • /
    • pp.6602-6609
    • /
    • 2013
  • This study is expected to provide background data for establishing mitigation measures for malodor and for comparing complex odor criteria. The impact of malodor at the afflicted locations was analyzed using Industrial Source Complex Short Term 3 (ISCST3) model, which was recommended by the EPA. The Odor Emission Rates (ODR) for piglets and hogs were predicted based on the average, minimum, and maximum emission rates as classification. The forecasting result of the complex odor modelling of pigsty showed that tolerance limit was exceeded at an adjacent administration building, but tolerance limit was not surpassed at an afflicted location which was within 185m from the pigsty. The ISCST3 modelling of the satisfactory ODR for tolerance limit was accomplished at the administration building. From the prediction of this modelling, maximum emission rates based on 1hr at administration building were 10.59~52.93, 19.05~31.76, and 10.59 $OU/m^3/s/m^2$ at emission rates of 50%, 30%, and 10%. This emission rate was slightly higher than the tolerance limit of 10.00 $OU/m^3/s/m^2$. However, it was inferred that the tolerance limit could be satisfied if the emission rate of 10% was controlled.

A Study on the Prediction Model of the Elderly Depression

  • SEO, Beom-Seok;SUH, Eung-Kyo;KIM, Tae-Hyeong
    • The Journal of Industrial Distribution & Business
    • /
    • v.11 no.7
    • /
    • pp.29-40
    • /
    • 2020
  • Purpose: In modern society, many urban problems are occurring, such as aging, hollowing out old city centers and polarization within cities. In this study, we intend to apply big data and machine learning methodologies to predict depression symptoms in the elderly population early on, thus contributing to solving the problem of elderly depression. Research design, data and methodology: Machine learning techniques used random forest and analyzed the correlation between CES-D10 and other variables, which are widely used worldwide, to estimate important variables. Dependent variables were set up as two variables that distinguish normal/depression from moderate/severe depression, and a total of 106 independent variables were included, including subjective health conditions, cognitive abilities, and daily life quality surveys, as well as the objective characteristics of the elderly as well as the subjective health, health, employment, household background, income, consumption, assets, subjective expectations, and quality of life surveys. Results: Studies have shown that satisfaction with residential areas and quality of life and cognitive ability scores have important effects in classifying elderly depression, satisfaction with living quality and economic conditions, and number of outpatient care in living areas and clinics have been important variables. In addition, the results of a random forest performance evaluation, the accuracy of classification model that classify whether elderly depression or not was 86.3%, the sensitivity 79.5%, and the specificity 93.3%. And the accuracy of classification model the degree of elderly depression was 86.1%, sensitivity 93.9% and specificity 74.7%. Conclusions: In this study, the important variables of the estimated predictive model were identified using the random forest technique and the study was conducted with a focus on the predictive performance itself. Although there are limitations in research, such as the lack of clear criteria for the classification of depression levels and the failure to reflect variables other than KLoSA data, it is expected that if additional variables are secured in the future and high-performance predictive models are estimated and utilized through various machine learning techniques, it will be able to consider ways to improve the quality of life of senior citizens through early detection of depression and thus help them make public policy decisions.

Prediction Model of Suicidal Ideation in Elderly Men Living Alone Based on Ecological System Theory (생태학적 체계이론에 기반한 남자독거노인의 자살생각 예측모형)

  • Hong, Si Myung
    • Journal of agricultural medicine and community health
    • /
    • v.42 no.2
    • /
    • pp.57-68
    • /
    • 2017
  • Objectives: This study was performed to build the predictive model of suicidal ideation of elderly men living alone. Methods: As for the subject, 251 subjects suitable for the selection criteria were selected among elderly men living alone above 65 years old in one region in Gyeongnam and three regions in Gyeongbuk. The data were collected via questionnaires and analyzed using SPSS version 20.0 and Amos version 18.0. Results: The goodness-of-fit test result of hypothetical model were suitable for recommended level: ${\chi}^2/df=1.47$, RMR=.04, GFI=.92, AGFI=.90, CFI=.95, IFI=.95, RMSEA=.04. Self-esteem, individual coping, family cohesion, social support, social activity, and depression explained 55% of the model of suicidal ideation. The most influential direct factor of suicidal ideation was self-esteem, and social isolation was the most influential indirect influence on suicidal ideation. Conclusion: To sum up the above results, if we promote the researched variables of self-esteem, family cohesion, social activity, individual coping and social support in addition to developing and utilizing an efficient customized suicidal prevention nursing intervention program thereby reducing depression and social isolation, suicidal ideation of elderly men living alone would be prevented.

Application of Indicator Geostatistics for Probabilistic Uncertainty and Risk Analyses of Geochemical Data (지화학 자료의 확률론적 불확실성 및 위험성 분석을 위한 지시자 지구통계학의 응용)

  • Park, No-Wook
    • Journal of the Korean earth science society
    • /
    • v.31 no.4
    • /
    • pp.301-312
    • /
    • 2010
  • Geochemical data have been regarded as one of the important environmental variables in the environmental management. Since they are often sampled at sparse locations, it is important not only to predict attribute values at unsampled locations, but also to assess the uncertainty attached to the prediction for further analysis. The main objective of this paper is to exemplify how indicator geostatistics can be effectively applied to geochemical data processing for providing decision-supporting information as well as spatial distribution of the geochemical data. A whole geostatistical analysis framework, which includes probabilistic uncertainty modeling, classification and risk analysis, was illustrated through a case study of cadmium mapping. A conditional cumulative distribution function (ccdf) was first modeled by indicator kriging, and then e-type estimates and conditional variance were computed for spatial distribution of cadmium and quantitative uncertainty measures, respectively. Two different classification criteria such as a probability thresholding and an attribute thresholding were applied to delineate contaminated and safe areas. Finally, additional sampling locations were extracted from the coefficient of variation that accounts for both the conditional variance and the difference between attribute values and thresholding values. It is suggested that the indicator geostatistical framework illustrated in this study be a useful tool for analyzing any environmental variables including geochemical data for decision-making in the presence of uncertainty.

Failure Pressure Prediction of Composite T-Joint for Hydrodynamic Ram Test (수압램 시험을 위한 복합재 T-Joint의 파손 압력 예측)

  • Kim, Dong-Geon;Go, Eun-Su;Kim, In-Gul;Woo, Kyung-Sik;Kim, Jong-Heon
    • Composites Research
    • /
    • v.29 no.2
    • /
    • pp.53-59
    • /
    • 2016
  • Aircraft wing structure is used as a fuel tank containing the fluid. Fuel tank and joint parts are consists of composite structure. Hydrodynamic Ram(HRAM) effect occurs when the high speed object pass through the aircraft wing or explosion and the high pressure are generated in the fuel tank by HRAM effect. High pressure can cause failure of the fuel tank and the joint parts as well as the aircraft wing structure. To ensure the aircraft survivability design, we shall examine the behavior of the joint parts in HRAM effect. In this study, static tensile tests were conducted on four kind of the composite T-Joints. The failure behavior of the composite T-joint was examined by strain gauges and high speed camera. We examine the validity of the Finite Element Modeling by comparing the results of FEA and static tensile tests. The failure stresses and failure pressure of the composite T-Joint were calculated by FEA.

The Study on the Characteristics of Mode I Crack for Cross-ply Carbon/Epoxy Composite Laminates Based on Stress Fields (응력장을 이용한 직교적층 탄소섬유/에폭시 복합재 적층판의 모드 I 균열 특성 연구)

  • Kang, Min-Song;Jeon, Min-Hyeok;Kim, In-Gul;Woo, Kyeong-Sik
    • Composites Research
    • /
    • v.32 no.6
    • /
    • pp.327-334
    • /
    • 2019
  • The delamination is a special mode of failure occurring in composite laminates. Several numerical studies with finite element analysis have been carried out on the delamination behavior of unidirectional composite laminates. On the other hand, the fracture for the multi-directional composite laminates may occur not only along the resin-fiber interface between plies known as interply or interlaminar fracture but also within a ply known as interyarn or intralaminar fracture accompanied by matrix cracking and fiber bridging. In addition, interlaminar and intralaminar cracks appear at irregular proportions and intralaminar cracks proceeded at arbitrary angle. The probabilistic analysis method for the prediction of crack growth behavior within a layer is more advantageous than the deterministic analysis method. In this paper, we analyze the crack path when the mode I load is applied to the cross-ply carbon/epoxy composite laminates and collect and analyze the probability data to be used as the basis of the probabilistic analysis in the future. Two criteria for the theoretical analysis of the crack growth direction were proposed by analyzing the stress field at the crack tip of orthotropic materials. Using the proposed method, the crack growth directions of the cross-ply carbon/epoxy laminates were analyzed qualitatively and quantitatively and compared with experimental results.

Study on the Meaning of Four Subjects and Four Species as a Disease-Prediction Data and Diagnostic Value on Ante-Disease (질병예측자료로서 사과(四科) . 사류형상(四類形象)의 의의와 미병진단적 가치 연구)

  • Kim, Jong-Won;Jeon, Soo-Hyung;Lee, In-Seon;Kim, Kyu-Kon;Lee, Yong-Tae;Kim, Kyung-Chul;Eom, Hyun-Sup;Chi, Gyoo-Yong
    • Journal of Physiology & Pathology in Korean Medicine
    • /
    • v.23 no.2
    • /
    • pp.325-330
    • /
    • 2009
  • In Korea, medical diagnostic equipments and biochemical examination can not be used in order for diagnosing sub-healthy state or ante-disease state in oriental medicine clinic. So morphic analogical method used in oriental medicine can be a good tool as a disease-predictable signs in order to enable preventive diagnosis and therapy. Therefore the four geometrical subjects; Essence, Pneuma, Spirit, Blood(四科;精氣紳血) and the four taxonomical species; Pisces, Quadruped, Aves, Carapaces(四類;魚走鳥甲) are chosen as morphic models in this paper. The differences of two classifying methods with four subjects and four species were as follows. The diagnostic category was meta-medical and synthetic against medical specific. The diagnostic object was body in contrast with face. They were able to be applicant in psychology and classification of characteristics against diagnostics and therapeutics directly in oriental medicine. The theoretical basis was basic diagrams of four unit-fluids of body and morphological analogy with four animal species respectively. And the therapeutic aims were systemic pathogenesis following five phase theory against congestion and deficiency of Essence, Pneuma, Spirit, Blood. The four subjects and four species are mixed each other practically in clinic. But it should be used limitedly because of the above reasons described and must divide the principal and secondary factors and follow the pathology of principal shape factor. In order to improve the diagnostic value of ante-disease state, the discriminable standards, measurement methods, limit of interrelating interpretation and the criteria of abnormal disproportion were needed to be defined more clearly in advance.

The Usefulness of Liver Fibroscan Test Using Ultrasound Image (초음파영상을 이용한 간탄력도 검사의 유용성)

  • An, Hyun;Lee, Jin-Soo;Im, In-Chul;Yang, Sung-Hee
    • Journal of the Korean Society of Radiology
    • /
    • v.11 no.4
    • /
    • pp.205-212
    • /
    • 2017
  • Chronic diffuse hepatopathy is one of the important clinical tasks to reduce mortality and morbidity due to liver cirrhosis, liver failure, and liver cancer. The purpose of this study was to evaluate the criteria for predicting liver and chronic liver disease using Fibroscan based on ultrasound diagnosis. Serum and liver stiffness measurement(kPa) were analyzed in 280 patients and cut-off values of liver stiffness measurement for predicting fatty liver and chronic diffuse hepatopathy were determined using ROC curve analysis. Bilirubin and PT(prothrombin time) were not related to disease prediction(p=0.243, p=0.115). Serum glucose and triglyceride levels were significantly higher in the liver (p<0.05). The cut-off value for predicting chronic diffuse hepatopathy was determined as 10.3 kPa(AUC 0.98, sensitivity 94.94%, specificity 94.93%) in the order of control group, fatty liver and chronic diffuse hepatopathy. Therefore, it will be used as a primary tool for the diagnosis of chronic liver disease patients with quantitative evaluation.

Cyclic Seismic Performance of Reduced Beam Section Steel Moment Connections: Effects of Panel Zone Strength and Beam Web Connection Type (패널존 강도 및 보 웨브 접합방식이 RBS 철골 모멘트접합부의 내진거동에 미치는 영향에 관한 연구)

  • Lee, Cheol-Ho;Jeon, Sang-Woo;Kim, Jin-Ho
    • Journal of the Earthquake Engineering Society of Korea
    • /
    • v.7 no.3
    • /
    • pp.69-77
    • /
    • 2003
  • This paper presents test results on eight reduced beam section(RBS) steel moment connections. The testing program addressed bolted versus welded web connection and panel zone(PZ) strength as key variables, Specimens with medium PZ strength were designed to promote energy dissipation from both PZ and RBS regions such that the requirement for expensive doublet plates could be reduced. Both strong and medium PZ specimens with a welded web connection were able to provide satisfactory connection rotation capacity for special moment-resisting frames. On the other hand, specimens with a bolted web connection performed poorly due to premature brittle fracture of the beam flange of the weld access hole. If fracture within the beam flange groove weld was avoided using quality welding, the fracture tended to move into the beam flange base metal of the weld access hole. Plausible explanation of a higher incidence of base metal fracture in bolted web specimens was presented. The measured strain data confirmed that the classical beam theory dose not provide reliable shear transfer prediction in the connection. The practice of providing web bolts uniformly along the beam depth was brought into question. Criteria for a balanced PZ strength improves the plastic rotation capacity while reduces the amount of beam distortion ore also proposed.