• Title/Summary/Keyword: pre-activation

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Thermal Decomposition Kinetics of Copolymers Derived from p-dioxanone, L-lactide and Poly(ethylene glycol)

  • Bhattarai Narayan;Khil Myung Seob;Oh Seung Jin;Kim Hak Yong;Kim Kwan Woo
    • Fibers and Polymers
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    • v.5 no.4
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    • pp.289-296
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    • 2004
  • The kinetic parameters, including the activation energy E, the reaction order n, and the pre-exponential factor Z, of the degradation of the copolymers based on the poly(L-lactide) (PLLA) or poly(p-dioxanone-co-L-lactide) (PDO/PLLA) and diol-terminated poly(ethylene glycol) (PEG) segments have been evaluated by the single heating methods of Friedman and Freeman-Carroll. The experimental results showed that copolymers exhibited two degradation steps under nitrogen that can be ascribed to PLLA or PDO/PLLA and PEG segments, respectively. However, copolymers exhibited almost single degradation step in air. Although the values of initial decomposition temperature were scattered, copolymers showed the lower maximum weight loss rate and degradation-activation energy in air than in nitrogen whereas the higher value of temperature at the maximum rate of weight loss was observed in air.

Algorithm for Classifiation of Alzheimer's Dementia based on MRI Image (MRI 이미지 기반의 알츠하이머 치매분류 알고리즘)

  • Lee, Jae-kyung;Seo, Jin-beom;Cho, Young-bok
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2021.10a
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    • pp.97-99
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    • 2021
  • As the aging society continues in recent years, interest in dementia is increasing. Among them, Alzheimer's disease is a degenerative brain disease that accounts for the largest percentage of all dementia patients, with the medical community currently not offering clear prevention and treatment for Alzheimer's disease, and the importance of early treatment and early prevention is emphasized. In this paper, we intend to find the most efficient activation function by combining various activation functions centering on convolutional neural networks using MRI datasets of normal people and patients with Alzheimer's disease. In addition, it is intended to be used as a dementia classification modeling suitable for the medical field in the future through Alzheimer's dementia classification modeling.

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Mutagenicities of Workplace Chemicals in Korea

  • Maeng, Seung-Hee;Lee, Jong-Yun;Lee, Yong-Mook;Chung, Hai-Won;Yu, Il-Je
    • Environmental Mutagens and Carcinogens
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    • v.21 no.1
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    • pp.57-62
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    • 2001
  • Bacterial reverse mutation assays were performed for 20 workplace chemicals in Korea, which were selected among workplace chemicals under the Korea Industrial Safety and Health Act (KISHA) with the occupational exposure levels (OELs). The assays were carried out by using the pre-incubation method ($37 ^{\circ}C$, 20 min) with and without metabolic activation using Salmonella typhimurium TA98, TA100, TA1535, TA1537 and E. coli WP2uvrA. The chemicals were tested at 5 concentrations both in the preliminary and the second assays. Despite the cell toxicities, there were no chemical-induced mutagenicities with or without metabolic activation in any of 20 chemicals.

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Diallyl Disulfide Enhances Daunorubicin-Induced Apoptosis of HL-60 Cells (HL-60 세포에서 Diallyl Disulfide의 Daunorubicin 유발 Apoptosis 항진효과)

  • 구본선;양정예;손희숙;권강범;지은정
    • Journal of Nutrition and Health
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    • v.36 no.8
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    • pp.828-833
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    • 2003
  • Dially disulfide (DADS), a component of garlic (Allium sativum), has been known to exert potent chemopreventive activity against various cancers. In this study, the synergistic effect of DADS and daunorubicin on the cytotoxicity of HL-60 cells, a human leukemia cell line, was investigated. DADS at 25 M greatly potentiated daunorubicin-induced cell death, decreasing cell viabilityto50%ofthe control. Daunorubicin-induced apoptosis was accompanied by the activation of caspase-3, the degradation of poly-(ADP-ribose) polymerase (PARP) and D4-GDI, and DNA fragmentation, which were blocked by pre-treatment with acetyl-Asp-Glu-Val-Asp- dialdehyde (Ac-DEVD-CHO). Treatment that combined 25 M DADS and 100 nM daunorubicin caused a similar degree of caspase-3 activation, PARP and D4-GDI degradation, and DNA fragmentation to that caused by treatment with 250 nM daunorubicin alone. These results indicate that combined therapy using daunorubicin with DADS, a component of food, and garlic can effectively decrease the therapeutic dose of daunorubicin, preventing the severe side effects of daunorubicin.

SHS of Oxide Systems Based on MCR of Quartz Modified by Organometallic Compounds

  • Soh, Dea-Wha;Tlek, Ketegenov;Z.A., Mansurov
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 2002.07b
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    • pp.666-669
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    • 2002
  • The differences of the effects of mechanical substance pre-activation in the mills with divers force effect schemes on the self-propagating high temperature synthesis (SHS) of the $SiO_2$ + 37.5% Al system were investigated. The power saturation of activated material state are estimated referring on the variations of dilatometry curve paths. The effects of activation time on the temperature of sample self-ignited in the furnace, combustion temperature and completeness of the quartz reaction with aluminium were determined. The enhancing effects of organic modifiers of quartz particle surfaces on the further SHS synthesis development were shown.

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Retardation of Degradation in Accelerated Aging of Cotton Cellulose Using Borohydride Reduction

  • Kim, Hye-Kyung;Choi, Hyung-Min
    • International Journal of Human Ecology
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    • v.8 no.1
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    • pp.1-8
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    • 2007
  • Degradation of cellulose during prolonged exposure in atmospheric conditions has been recognized as one of main problems in preserving cellulose-made products. The purpose of this research was therefore to study effects of borohydride reduction in improving both the color and strength retention of cotton fabrics artificially aged at temperatures ranging from $100^{\circ}C$ to $150^{\circ}C$. Results indicated that the fabrics treated with either sodium or tetramethylammonium borohydrides (TMA) were degraded at rates about one-half that of water-washed cotton. These results were consistent over the temperature range. Calculation of the activation energy (Ea) by different methods showed $Ea\;=\;25.5{\pm}\;1.5\;Kcal$, in keeping with measurements made by others at lower temperatures. The TMA-treatment was effective in minimizing discoloration of the fabrics with pre-baking, but not of the un-prebaked fabrics.

Mitogen-Activated Protein Kinase Kinase 3 Is Required for Regulation during Dark-Light Transition

  • Lee, Horim
    • Molecules and Cells
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    • v.38 no.7
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    • pp.651-656
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    • 2015
  • Plant growth and development are coordinately orchestrated by environmental cues and phytohormones. Light acts as a key environmental factor for fundamental plant growth and physiology through photosensory phytochromes and underlying molecular mechanisms. Although phytochromes are known to possess serine/threonine protein kinase activities, whether they trigger a signal transduction pathway via an intracellular protein kinase network remains unknown. In analyses of mitogen-activated protein kinase kinase (MAPKK, also called MKK) mutants, the mkk3 mutant has shown both a hypersensitive response in plant hormone gibberellin (GA) and a less sensitive response in red light signaling. Surprisingly, light-induced MAPK activation in wild-type (WT) seedlings and constitutive MAPK phosphorylation in dark-grown mkk3 mutant seedlings have also been found, respectively. Therefore, this study suggests that MKK3 acts in negative regulation in darkness and in light-induced MAPK activation during dark-light transition.

Positive Analysis for the Aged Volunteering Activation (노인자원봉사의 활성화를 위한 실증적인 분석연구 : 안양시 노인들을 중심으로)

  • Park, Yong-Soon
    • Korean Journal of Social Welfare
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    • v.46
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    • pp.89-117
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    • 2001
  • Owing to the increase of the aged, a positive analysis was carried out for developing the aged volunteering program. This study aiming at planning for the aged volunteering activation, desirable leasure activity in the dimension of social welfare, by assaying the real states of the aged making the use of the leasure and especially aiming at surveying the aged need in relation with the aged volunteering activity on which to present the revolving method and qualitative advance. The method of study was interview the aged over 60 with the questionnaire of the general features of the participants, the motive, the career, the participation method, the satisfaction degree, the cost necessity, the participation degree, the pre-education, and the desirable program of the volunteering and what is got from the volunteering, etc. The collected data were statistical-processed through Spss Win (Ver 8.0) and chi-square verified. As the result of this study, there are the needs for developing various program, the motivation for the participation and maintenance, and the suitable places for volunteering. The poly-dimensional social welfare approaches are presented for the above needs.

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Effect of MgO Addition on the Electrical Conductivity of Pb($Zr_{0.52}Ti_{0.48}$)$O_3$ (Pb($Zr_{0.52}Ti_{0.48}$)$O_3$의 전기전도도에 미치는 MgO의 첨가영향)

  • 전석택;최경만
    • Journal of the Korean Ceramic Society
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    • v.28 no.12
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    • pp.953-960
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    • 1991
  • Effect of MgO doping was studied by measuring complex impedance of PZT[Pb(Zr0.52Ti0.48)O3] samples doped with 0.25~6 mol% MgO. Electrical conductivity of PZT samples increased within 1.5 mol% of MgO doping. However above 1.5 mol%, no noticeable changes were found. Activation energy and pre-exponential factor of electrical conductivity were found to decrease within 1.5 mol% of MgO doping, but increase above 1.5 mol%. Therefore it was concluded that the decrease of electrical conductivity with MgO doping was due to the decrease of activation energy.

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Thermal Properties of Interpenetrating Polymer Network Epoxy-silicone Compound

  • Cho, Young-Shin;Shim, Mi-Ja;Klm, Sang-Wook
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 1999.11a
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    • pp.475-478
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    • 1999
  • The thermal properties of epoxy resin/siloxane for the electrical insulation were investigated by using dynamic DSC run method. As the heating rate increased, the peak temperature on dynamic DSC curve increased. From the linear relation on the Kissinger plot the curing reaction activation energy and pre-exponential factor could be obtained. The curing activation energy from the straight line of the Kissinger plot was 46.72 kJ/mol.

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