• Journal of Korean Academy of Fundamentals of Nursing
• /
• v.17 no.4
• /
• pp.531-538
• /
• 2010

Purpose: This study was done to identify the effects of Qi hand reflexology on autonomic nerve activity in patients admitted to hospital. Method: A non-equivalent control group and quasi-experimental research with pre/post test design were used and 59 patients on a medical ward were assigned to either the experimental group (32) or the control group (27). The study variables included vital signs, autonomic nerve activities (ALF (absolute low frequency), AHF (absolute high frequency), nLF (normalized low frequency), nHF (normalized high frequency), SDNN (standard deviation of all normal-normal intervals)) and were evaluated using the QECG-3 system. The experimental group was treated with Qi hand reflexology for 10 minutes per day, for 3days. Results: Skin temperature and systolic blood pressure in the experimental decreased with treatment. ALF, AHF and SDNN for the experimental group increased with regulating proportion (nLF: nHF=6:4) and a significant difference between the groups was observed. Conclusion: The results indicated that application of Qi hand reflexology for patients in the hospital is effective in regulating the autonomic nervous system activation. Implication of finding should be useful for future research.

• Steel and Composite Structures
• /
• v.26 no.5
• /
• pp.573-582
• /
• 2018

This study develops and numerically verifies an innovative seismically resilient bracing system. The proposed self-centering tension-only brace (SC-TOB) is composed of a tensioning system to provide a self-centering response, a frictional device for energy dissipation, and a high-strength steel cable as a bracing element. It is considered to be an improvement over the traditional self-centering braces in terms of lightness, high bearing capacity, load relief, and double-elongation capacity. In this paper, the mechanics of the system are first described. Governing equations deduced from the developed analytical model to predict the behavior of the system are then provided. The results from a finite element validation confirm that the SC-TOB performs as analytically predicted. Key parameters including the activation displacement and load, the self-centering parameter, and equivalent viscous damping are investigated, and their influences on the system behavior are discussed. Finally, a design procedure considering controlled softening behavior is developed and illustrated through a design example.

• Land and Housing Review
• /
• v.9 no.3
• /
• pp.9-18
• /
• 2018

Administrative city has been developed step by step aiming to being a public transport-oriented new city. In spite of its primary goal, administrative city is dominated by car-oriented tansportaion system because the supply of public transportation has not been adequately and timely performed. In this study, we investigate the current situation related to (public) transportation use in administrative city. Also, we examine the issues of traffic system through a survey on residents' consciousness about public transportation use. Additionally, the analysis of demand elasticity according to the change of the conditions of using public transportation and passenger car is conducted for passenger car users. As a result, it is analyzed that as the neighborhood is more stabilized after the completion of development the resistance to the abandonment of passenger car is higher when the tide demand control method is introduced. Therefore, it is concluded that pre-emptive public transportation supply and the management of car demand management are necessary for the activation of public transportation in Administrative city.

• The Journal of Korean Medicine
• /
• v.31 no.2
• /
• pp.158-166
• /
• 2010

Objective: It has been reported that Polygonati rhizoma (Pr) has anti-hyperglycemia, anti-triglycemia, anti-diabetic, and anti-tumor activity. Total extract of Pr was tested to identify anti-adipogenic activity in 3T3-L1 differentiation and molecular mechanism of Pr in 3T3-L1 differentiation. Methods: Differentiation of 3T3-L1 pre-adipocyte was induced in the presence of Pr extract and kaempferol. The level of lipid accumulation was measured by Oil Red O staining. The expression of genes associated with adipocyte differentiation was measured by RT-PCR. Results: Extract of Pr and its component kaempferol reduced lipid accumulation in 3T3-L1 during adipogenesis and also reduced mRNA levels of genes associated with adipogenesis, such as adipsin, aP2, LPL, SERBP-1c and $PPAR{\gamma}$. Conclusions: In this study, we showed that the molecular mechanism of Pr and kaempferol activity is related to regulation of $PPAR{\gamma}$ expression and activation.

• Journal of Microbiology and Biotechnology
• /
• v.27 no.2
• /
• pp.405-411
• /
• 2017

Homologous recombination occurs between homologous chromosomes and is significantly involved in programmed double-strand break (DSB) repair. Activation of two recombinases, Rad51 and Dmc1, is essential for an interhomolog bias during meiosis. Rad51 participates in both mitotic and meiotic recombination, and its strand exchange activity is regulated by an inhibitory factor during meiosis. Thus, activities of Rad51 and Dmc1 are coordinated to promote homolog bias. It has been reported that Hed1, a meiosis-specific protein in budding yeast, regulates Rad51-dependent recombination activity. Here, we investigated the role of Hed1 in meiotic recombination by ectopic expression of the protein after pre-meiotic replication in Saccharomyces cerevisiae. DNA physical analysis revealed that the overexpression of Hed1 delays the DSB-to-joint molecule (JM) transition and promotes interhomolog JM formation. The study indicates a possible role of Hed1 in controlling the strand exchange activity of Rad51 and, eventually, meiotic crossover formation.

• Archives of Pharmacal Research
• /
• v.29 no.1
• /
• pp.67-72
• /
• 2006

The abnormal proliferation of aortic vascular smooth muscle cells (VSMCs) plays a central role in the pathogenesis of atherosclerosis and restenosis after angioplasty and possibly also in the development of hypertension. The present study was designed to examine the inhibitory effects and the mechanism of luteolin 7-glucoside (L7G) on the platelet-derived growth factor (PDGF)-BB-induced proliferation of VSMCs. L7G significantly inhibited the PDGF-BB-induced proliferation and the DNA synthesis of the VSMCs in a concentration-dependent manner. Pre-incubation of the VSMCs with L7G significantly inhibited the PDGF-BB-induced extracellular signal-regulated kinase 1/2 (ERK1/2), Akt and the phospholipase C $(PLC)-{\gamma}1$ activation. However, L7G had almost no affect on the phosphorylation of $PDGF-{\beta}$ receptor tyrosine kinase, which was induced by PDGF-BB. These results suggest that L7G inhibits the PDGF-BB-induced proliferation of VSMCs via the blocking of $(PLC)-{\gamma}1$, Akt, and ERK1/2 phosphorylation.

• YAKHAK HOEJI
• /
• v.60 no.1
• /
• pp.8-14
• /
• 2016

Endotoxemia induces production of inflammatory mediators and acute phase proteins, leading to multiorgan injury and systemic inflammation. Hypothalamic-pituitary-adrenal (HPA) axis activation and glucocorticoids (GCs) release modify endotoxemia-induced inflammatory responses. In the present study, we investigated whether pre-exposure of GCs influences endotoxin-induced production of inflammatory mediators in hepatocytes. Hepa1c1c-7 cells were pretreated with low concentrations of corticosterone for 24 h and then cultured without corticosterone in the presence or absence of LPS. Our results demonstrated that LPS alone significantly enhanced production of IL-6 and CRP but reduced vascular endothelial growth factor (VEGF) compared to controls. Combination of corticosterone pretreatment and LPS significantly upregulated production of IL-6, IL-$1{\beta}$, and VEGF but downregulated CRP compared to those in LPS alone. These findings suggest that in low concentration of corticosterone-preexposed hepatocytes, endotoxemia may induce upregulation of IL-6, IL-$1{\beta}$, VEGF and but downregulation of CRP.

• Transactions of the Korean hydrogen and new energy society
• /
• v.22 no.6
• /
• pp.827-834
• /
• 2011

Epoxy/graphite/expanded graphite composites have been prepared in various weight ratios and thermal degradation and electrical properties were estimated in order to use for the bipolar plate materials in PEMFC. Thermogravimetric analysis (TGA) showed that the epoxy/graphite system cured by a curing agent GX-533 was most proper because its weight loss until $80^{\circ}C$ at which PEMFC would be operated was 0.3 wt%, and differential scanning calorimetry (DSC) analysis showed its cure temperature would be sufficient at $80^{\circ}C$. The activation energy for the cure reaction was 132.0 kJ/mol and the pre-exponential factor was $1.76{\times}10^{17}min^{-1}$. Electrical conductivity on the surface of the bipolar plate prepared under a pressure of 200 $kgf/cm^2$ was increased from 4 to 25 $S/cm^2$ by increasing expanded graphite (EG) content from 50 phr to 90 phr. The percolation threshold was initiated around 75 phr and the corrosion rate at 80 phr was 1.903 $uA/cm^2$.

• Journal of the Korean Chemical Society
• /
• v.53 no.6
• /
• pp.635-639
• /
• 2009

Experimental work was carried out to study the combustion kinetics of the Indian coal-char in the varying mixture of carbon dioxide-oxygen ($CO_2-O_2$). The coal sample was pulverized and sieved to less than 58 microns and charred using volatile furnace by passing the nitrogen gas. The experiments were carried out using the Thermo Gravimetric Analyzer (TGA-50) at CPRI, Bangalore, different proportions of ($CO_2-O_2$) gas was allowed in to the TGA-50 (80-20, 60-40, 40-60, 20-80) mole basis were used to study the combustion kinetics of coal Isothermally, kinetic parameters like Activation energy (E) and the pre-exponential factors (A) are calculated using the unification approach and modified Arrhenius equation.

• Journal of International Academy of Physical Therapy Research
• /
• v.11 no.3
• /
• pp.2135-2139
• /
• 2020

Background: Recently, a new method of dysphagia rehabilitation using Kinesio taping (KT) has been attempted and demonstrated an immediate increase in the activation of the suprahyoid muscle during swallowing in healthy adults. Objectives: To investigate the effect of dysphagia rehabilitation using KT on the thickness change of the suprahyoid muscle in patients with dysphagia after stroke. Design: Two-group pre-post design. Methods: In this study, 20 patients with dysphagia after stroke were enrolled and assigned to the experimental and control groups. The experimental group applied KT to the front of the neck and repeatedly swallowed against the tension of the tape. On the other hand, the control group performed repeated swallowing without applying KT. Patients in both groups had swallowed 50 times a day/5 times a week for 4 weeks. For evaluation, the volume of the geniohyoid, mylohyoid, and digastric muscle was measured before and after the intervention using portable ultrasound equipment. Results: As a result of comparing the two groups after the intervention, the experimental group showed more volume increase in mylohyoid (P<.05) and digastric muscle (P<.05) than the control group. Conclusion: This study proved that suprahyoid muscle resistance exercise using KT is effective in increasing the volume of the suprahyoid muscle.